PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.

abstract：:The exposure of primary cultures of hepatocytes to insulin. 10(-8) M, for 16 h results in a decrease in high affinity insulin binding with no alterations in lower affinity binding. This is reflected in a decrease in the sensitivity, but normal responsiveness, of cultured hepatocytes to the acute effect of insulin on t...

journal_title：Diabetes

authors： Amatruda JM,Newmeyer HW,Chang CL

更新日期：1982-02-01 00:00:00

abstract：:Finland has the world's highest incidence of type 1 diabetes, and it is steadily increasing. We determined concordance rates and estimated heritability for type 1 diabetes in the Finnish Twin Cohort, a population-based twin cohort of 22,650 twin pairs. In addition, we studied age of onset in the first affected twin an...

journal_title：Diabetes

authors： Hyttinen V,Kaprio J,Kinnunen L,Koskenvuo M,Tuomilehto J

更新日期：2003-04-01 00:00:00

abstract：:A 5-day culture of adult rat islets with human recombinant IL-1 beta (3 U/ml) resulted in the death of most alpha-cells and 50% of beta-cells. The IL-1--exposed islet tissue contained--in addition to poorly granulated beta-cells--patches of outgrowing monolayers and dispersed activated macrophages. In purified alpha- ...

journal_title：Diabetes

authors： Ling Z,In't Veld PA,Pipeleers DG

更新日期：1993-01-01 00:00:00

abstract：:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allo...

journal_title：Diabetes

authors： Guy AJ,Griffin SM,Alderson D,Farndon JR

更新日期：1989-01-01 00:00:00

abstract：:In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein (UCP)-2 is proposed to catalyze a m...

journal_title：Diabetes

authors： Chan CB,De Leo D,Joseph JW,McQuaid TS,Ha XF,Xu F,Tsushima RG,Pennefather PS,Salapatek AM,Wheeler MB

更新日期：2001-06-01 00:00:00

abstract：:Development of a robust insulin secretory response to glucose occurs during the early neonatal period. To determine if neuroendocrine agents play a role during this time, we studied the effects of selected peptides and neurotransmitters on insulin release and polyphosphoinositide metabolism in islets isolated from 1- ...

journal_title：Diabetes

authors： Fletcher DJ,Rowley WH,Pabst SJ,Brinn JE

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in this phenomenon of...

journal_title：Diabetes

authors： Lovis P,Roggli E,Laybutt DR,Gattesco S,Yang JY,Widmann C,Abderrahmani A,Regazzi R

更新日期：2008-10-01 00:00:00

abstract：:Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treat...

journal_title：Diabetes

authors： Sorenson RL,Grouse LH,Elde RP

更新日期：1983-04-01 00:00:00

abstract：:The IGF system is increasingly implicated in the development of cardiovascular disease. The effects of circulating IGFs on the vasculature are largely modulated by IGFBPs, which control their access to cell-surface IGF receptors. IGFBP-1 has been proposed as the acute regulator of IGF bioavailability because of its me...

journal_title：Diabetes

authors： Heald AH,Siddals KW,Fraser W,Taylor W,Kaushal K,Morris J,Young RJ,White A,Gibson JM

更新日期：2002-08-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps ...

journal_title：Diabetes

authors： Hamid YH,Urhammer SA,Jensen DP,Glümer C,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：:Many humans with IDDM eventually lose the capacity to secrete epinephrine from their adrenal medullae. The mechanism for this pathological change is unknown. We hypothesized that this abnormality is attributable to neuropathic changes in the greater splanchnic nerves or in the chromaffin cells that they innervate. To ...

journal_title：Diabetes

authors： Wilke RA,Riley DA,Lelkes PI,Hillard CJ

更新日期：1993-06-01 00:00:00

abstract：:We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes me...

journal_title：Diabetes

authors： Matarese G,Sanna V,Lechler RI,Sarvetnick N,Fontana S,Zappacosta S,La Cava A

更新日期：2002-05-01 00:00:00

abstract：:Insulin receptors from rat hepatoma cells (Fao) and human placenta were partially purified by detergent solubilization and lectin purification. The insulin receptor preparations were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under reducing or nonreducing conditions. The proteins were...

journal_title：Diabetes

authors： Maron R,Kahn CR,Jacobs S,Fujita-Yamaguchi Y

更新日期：1984-10-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：:Rosiglitazone therapy improves insulin sensitivity and glucose uptake in patients with uncomplicated type 2 diabetes. In coronary artery disease (CAD), glucose is an important source of energy and preserved myocardial glucose uptake is essential for the viability of jeopardized myocardium. The aim was to test whether ...

journal_title：Diabetes

authors： Lautamäki R,Airaksinen KE,Seppänen M,Toikka J,Luotolahti M,Ball E,Borra R,Härkönen R,Iozzo P,Stewart M,Knuuti J,Nuutila P

更新日期：2005-09-01 00:00:00

abstract：:To treat insulin lipoatrophy, small amounts of dexamethasone (4 micrograms/unit) were added to insulin injections in nine patients. Six cases showed significant improvement of dexamethasone-treated sites over that of control sites in six months. With the continued use of dexamethasone-containing insulin, they remained...

journal_title：Diabetes

authors： Kumar O,Miller L,Mehtalia S

更新日期：1977-04-01 00:00:00

abstract：:Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular...

journal_title：Diabetes

authors： McMillan DE

更新日期：1976-01-01 00:00:00

abstract：:Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates autophagy. Using a mouse model with β-cell-specific deletion of Tsc2 (βTsc...

journal_title：Diabetes

authors： Bartolomé A,Kimura-Koyanagi M,Asahara S,Guillén C,Inoue H,Teruyama K,Shimizu S,Kanno A,García-Aguilar A,Koike M,Uchiyama Y,Benito M,Noda T,Kido Y

更新日期：2014-09-01 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) has been suggested to have direct effects on nonislet tissues. GIP also reportedly increased glucose uptake and inhibition of lipolysis in adipocytes after inhibition of the intracellular cortisone-cortisol shuttle 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). W...

journal_title：Diabetes

authors： Gögebakan Ö,Andres J,Biedasek K,Mai K,Kühnen P,Krude H,Isken F,Rudovich N,Osterhoff MA,Kintscher U,Nauck M,Pfeiffer AF,Spranger J

更新日期：2012-02-01 00:00:00

abstract：:O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment ofN-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. Glucose-induced insulin resistance is mediated by increased ac...

journal_title：Diabetes

authors： Akimoto Y,Kreppel LK,Hirano H,Hart GW

更新日期：1999-12-01 00:00:00

abstract：:Hyperinsulinemia is commonly associated with obesity, but it has not been determined which defect comes first. Some have proposed that hyperinsulinemia may precede obesity in populations prone to NIDDM, such as Pima Indians or Pacific Islanders. In contrast, longitudinal studies in adults show that insulin sensitivity...

journal_title：Diabetes

authors： Odeleye OE,de Courten M,Pettitt DJ,Ravussin E

更新日期：1997-08-01 00:00:00

abstract：:Glucose metabolism affects most major signal pathways in pancreatic beta-cells. Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are involved in these effects; however, their role is poorly defined. Moreover, the dynamics of kinase isoenzyme activation in reference to the biphasic insulin secreti...

journal_title：Diabetes

authors： Warwar N,Efendic S,Ostenson CG,Haber EP,Cerasi E,Nesher R

更新日期：2006-03-01 00:00:00

abstract：:Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 ob...

journal_title：Diabetes

authors： Johnson ML,Distelmaier K,Lanza IR,Irving BA,Robinson MM,Konopka AR,Shulman GI,Nair KS

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

journal_title：Diabetes

authors： Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

更新日期：2014-07-01 00:00:00

abstract：:Islet transplantation is a promising treatment for type 1 diabetes. However, islet grafts are submitted to multiple injuries, including immunosuppressive drug toxicity, hyperglycemia, hypoxia, unspecific inflammatory reactions, as well as allo- and autoimmune destruction. Therapeutic approaches to these damage mechani...

journal_title：Diabetes

authors： Ritz-Laser B,Oberholzer J,Toso C,Brulhart MC,Zakrzewska K,Ris F,Bucher P,Morel P,Philippe J

更新日期：2002-03-01 00:00:00

abstract：:Not all patients with type 2 diabetes develop renal dysfunction. Identifying those at risk is problematic because even microalbuminuria, often used clinically as an indicator of future renal dysfunction, does not always precede worsening renal function. We sought to identify clinical risk factors at diagnosis of type ...

journal_title：Diabetes

authors： Retnakaran R,Cull CA,Thorne KI,Adler AI,Holman RR,UKPDS Study Group.

更新日期：2006-06-01 00:00:00

abstract：:Accumulation of brown products in long-lived proteins might be an important factor in determining long-term diabetic complications. Fluorescent chromophore 2-(2-furoyl)-4-(5)-(2-furanyl)-1H-imidazole (FFI), isolated from hydrolyzed brown products synthesized in vitro, was proposed as a specific brown product responsib...

journal_title：Diabetes

authors： Lapolla A,Gerhardinger C,Pelli B,Sturaro A,Del Favero E,Traldi P,Crepaldi G,Fedele D

更新日期：1990-01-01 00:00:00

abstract：:For the period of 1 January 1979 through 31 December 1985, an average annual incidence rate (IR) of 12.1/100,000 (95% confidence interval [10.4/100,000, 14.0/100,000]) of insulin-dependent diabetes mellitus (IDDM) was observed in Jefferson County, Alabama, among people less than 20 yr old. Hospital medical-record revi...

journal_title：Diabetes

authors： Wagenknecht LE,Roseman JM,Alexander WJ

更新日期：1989-05-01 00:00:00

abstract：:Exosomes are important for intercellular communication, but the role of exosomes in the communication between adipose tissue (AT) and the liver remains unknown. The aim of this study is to determine the contribution of AT-derived exosomes in nonalcoholic fatty liver disease (NAFLD). Exosome components, liver fat conte...

journal_title：Diabetes

authors： Yan C,Tian X,Li J,Liu D,Ye D,Xie Z,Han Y,Zou MH

更新日期：2021-02-01 00:00:00