Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children.

abstract：OBJECTIVE:Adiponectin is one of several important metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low-circulating levels of this adipokine with multiple metabolic disorders including obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. To investiga...

journal_title：Diabetes

authors： Luo N,Liu J,Chung BH,Yang Q,Klein RL,Garvey WT,Fu Y

更新日期：2010-04-01 00:00:00

abstract：:It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nerv...

journal_title：Diabetes

authors： Bohlooly-Y M,Olsson B,Bruder CE,Lindén D,Sjögren K,Bjursell M,Egecioglu E,Svensson L,Brodin P,Waterton JC,Isaksson OG,Sundler F,Ahrén B,Ohlsson C,Oscarsson J,Törnell J

更新日期：2005-01-01 00:00:00

abstract：:A chronic diabetic state was produced in Macaca fuscatus , and these diabetic monkeys were kept without insulin treatment for up to 25 mo. The metabolic derangements were characterized by hyperglycemia, insulinopenia, hyperglucagonemia, ketonemia, and hyperlipidemia. Significant thickening of the capillary basement me...

journal_title：Diabetes

authors： Yasuda H,Harano Y,Kosugi K,Nakano T,Suzuki M,Tsuruoka Y,Taniguchi Y,Nishimori T,Kikkawa R,Shigeta Y

更新日期：1984-05-01 00:00:00

abstract：:Effects of epinephrine (Epi) infusion on the absorption of subcutaneously injected 125I-labeled soluble human insulin (10 U) from the thigh or the abdomen were studied in 16 healthy subjects and from the thigh in 10 insulin-dependent diabetic (IDDM) patients. Epi was infused at 0.3 (high dose) or 0.1 (low dose; health...

journal_title：Diabetes

authors： Fernqvist E,Gunnarsson R,Linde B

更新日期：1988-06-01 00:00:00

abstract：:Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...

journal_title：Diabetes

authors： MacDonald MJ,Kowluru A

更新日期：1982-06-01 00:00:00

abstract：:Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions. Because hypoalphalipoproteinemia is highly prevalent in Mexico, we screened the ABCA1 coding sequence in Mexican individual...

journal_title：Diabetes

authors： Villarreal-Molina MT,Aguilar-Salinas CA,Rodríguez-Cruz M,Riaño D,Villalobos-Comparan M,Coral-Vazquez R,Menjivar M,Yescas-Gomez P,Königsoerg-Fainstein M,Romero-Hidalgo S,Tusie-Luna MT,Canizales-Quinteros S,Metabolic Study Group.

更新日期：2007-07-01 00:00:00

abstract：:Type 1 diabetes is a major histocompatibility complex (MHC) class II-associated autoimmune disease mediated by beta-cell-specific T-cells and characterized by circulating autoantibodies to beta-cell molecules. In the BB/Wor diabetes-prone (DP) rat, type 1 diabetes develops spontaneously with an incidence of >90%. BB d...

journal_title：Diabetes

authors： Ellerman KE,Like AA

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

journal_title：Diabetes

authors： Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

更新日期：2010-04-01 00:00:00

abstract：:The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum-associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1...

journal_title：Diabetes

authors： Hu Y,Gao Y,Zhang M,Deng KY,Singh R,Tian Q,Gong Y,Pan Z,Liu Q,Boisclair YR,Long Q

更新日期：2019-04-01 00:00:00

abstract：:The effect of combined antisense oligonucleotides (AS-oligos) against overexpression of extracellular matrix (ECM) components, fibronectin, laminin, and collagen IV and on cell monolayer permeability was examined in rat microvascular endothelial cells (RMECs) grown in high glucose medium and on retinal vascular permea...

journal_title：Diabetes

authors： Oshitari T,Polewski P,Chadda M,Li AF,Sato T,Roy S

更新日期：2006-01-01 00:00:00

abstract：:Agonist-induced activation of peroxisome proliferator-activated receptor-γ (PPARγ) stimulates adipocyte differentiation and insulin sensitivity. Patients with heterozygous PPARγ dominant-negative mutation develop partial lipodystrophy and insulin resistance. Inconsistent with this evidence in humans, it was reported t...

journal_title：Diabetes

authors： Gumbilai V,Ebihara K,Aizawa-Abe M,Ebihara C,Zhao M,Yamamoto Y,Mashimo T,Hosoda K,Serikawa T,Nakao K

更新日期：2016-10-01 00:00:00

abstract：:This study measured the accumulation of substance P-like immunoreactivity (SPLI) proximal and distal to 12-h constricting ligatures applied to rat sciatic nerves. There were three separate experiments, and the baseline for each consisted of control and age-matched rats with 3 wk of untreated streptozocin-induced diabe...

journal_title：Diabetes

authors： Tomlinson DR,Robinson JP,Willars GB,Keen P

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-ce...

journal_title：Diabetes

authors： Cui J,Wang Z,Cheng Q,Lin R,Zhang XM,Leung PS,Copeland NG,Jenkins NA,Yao KM,Huang JD

更新日期：2011-01-01 00:00:00

abstract：:This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...

journal_title：Diabetes

authors： Edgerton DS,Cherrington AD,Williams P,Neal DW,Scott M,Bowen L,Wilson W,Hobbs CH,Leach C,Kuo MC,Strack TR

更新日期：2006-12-01 00:00:00

abstract：:Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evalua...

journal_title：Diabetes

authors： Véricel E,Januel C,Carreras M,Moulin P,Lagarde M

更新日期：2004-04-01 00:00:00

abstract：:The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...

journal_title：Diabetes

authors： Ikeda H,Shino A,Matsuo T,Iwatsuka H,Suzuoki Z

更新日期：1981-12-01 00:00:00

abstract：:Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. ...

journal_title：Diabetes

authors： Bartos V,Vanĕk I,Dryáková M,Saudek F,Malý J

更新日期：1989-01-01 00:00:00

abstract：:Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7's precise exocytotic actions in β-cells remain unknown. We show that Syt-7 is abundant in human β-cells. Adeno...

journal_title：Diabetes

authors： Dolai S,Xie L,Zhu D,Liang T,Qin T,Xie H,Kang Y,Chapman ER,Gaisano HY

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and development of the dia...

journal_title：Diabetes

authors： Wong FS,Siew LK,Scott G,Thomas IJ,Chapman S,Viret C,Wen L

更新日期：2009-05-01 00:00:00

abstract：:We have attempted to define the nature of insulin secretory defect(s) in aged animals. In these studies, pancreatic islets were isolated from 2- and 18-mo-old Fischer 344 rats. Margination of secretion vesicles during exocytosis was assessed by measuring the recruitment of somatostatin (SRIF) receptors to the surface ...

journal_title：Diabetes

authors： Draznin B,Steinberg JP,Leitner JW,Sussman KE

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown. Here, we describe the effect of PIKE deletion in mice and explore the role of PIKE-A in o...

journal_title：Diabetes

authors： Chan CB,Liu X,Jung DY,Jun JY,Luo HR,Kim JK,Ye K

更新日期：2010-04-01 00:00:00

abstract：:Ghrelin stimulates, while glucagon-like peptide-1 (GLP-1) and peptide YY(3-36) [PYY(3-36)] inhibit, food intake and gastric emptying in rats. We determined the dose-dependent effects of a 3-h intravenous infusion of ghrelin at dark onset on food intake in freely feeding rats, and on the inhibitory effects of intraveno...

journal_title：Diabetes

authors： Chelikani PK,Haver AC,Reidelberger RD

更新日期：2006-11-01 00:00:00

abstract：:Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-...

journal_title：Diabetes

authors： Li G,Mobbs CV,Scarpace PJ

更新日期：2003-08-01 00:00:00

abstract：:Dietary methionine restriction (MR) produces a rapid and persistent remodeling of white adipose tissue (WAT), an increase in energy expenditure (EE), and enhancement of insulin sensitivity. Recent work established that hepatic expression of FGF21 is robustly increased by MR. Fgf21-/- mice were used to test whether FGF...

journal_title：Diabetes

authors： Wanders D,Forney LA,Stone KP,Burk DH,Pierse A,Gettys TW

更新日期：2017-04-01 00:00:00

abstract：:β-Cell function improves in patients with type 2 diabetes in response to an oral glucose stimulus after Roux-en-Y gastric bypass (RYGB) surgery. This has been linked to the exaggerated secretion of glucagon-like peptide 1 (GLP-1), but causality has not been established. The aim of this study was to investigate the rol...

journal_title：Diabetes

authors： Jørgensen NB,Dirksen C,Bojsen-Møller KN,Jacobsen SH,Worm D,Hansen DL,Kristiansen VB,Naver L,Madsbad S,Holst JJ

更新日期：2013-09-01 00:00:00

abstract：:Two previously described pedigrees with familial hyperproinsulinemia have elevated proinsulin conversion intermediates resulting from amino acid substitutions in the proinsulin molecule. In contrast, a third family with elevated levels of an apparently normal proinsulin molecule may have a defect in the converting pro...

journal_title：Diabetes

authors： Elbein SC,Gruppuso P,Schwartz R,Skolnick M,Permutt MA

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...

journal_title：Diabetes

authors： Klinger S,Poussin C,Debril MB,Dolci W,Halban PA,Thorens B

更新日期：2008-03-01 00:00:00

abstract：:Current evidence suggests that reactive oxygen species (ROS) may participate in the destruction of pancreatic beta-cells leading to type 1 diabetes. Genetic factors pre-disposing individual susceptibility to type 1 diabetes might therefore include those affecting the efficacy of ROS metabolism. In a direct in vivo tes...

journal_title：Diabetes

authors： Kubisch HM,Wang J,Bray TM,Phillips JP

更新日期：1997-10-01 00:00:00

abstract：:A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely,...

journal_title：Diabetes

authors： Srikanta S,Krisch K,Eisenbarth GS

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:Rosiglitazone (RSG) is an insulin-sensitizing drug used to treat type 2 diabetes mellitus. The A Diabetes Outcome Progression Trial (ADOPT) shows that women taking RSG experienced more fractures than patients taking other type 2 diabetes drugs. These were not osteoporotic vertebral fractures but, rather, occu...

journal_title：Diabetes

authors： Sardone LD,Renlund R,Willett TL,Fantus IG,Grynpas MD

更新日期：2011-12-01 00:00:00