The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities.

abstract：:Livers from 9-10-wk-old genetically obese and hyperinsulinemic (fa/fa) rats contained more DNA, proteins, and lipids than livers of age-matched controls. Actually, the increase in liver mass of fa/fa rats was mainly due to an increased cell number. On perfusion with insulin (1.75-16 nM), livers of obese fa/fa rats rem...

journal_title：Diabetes

authors： Karakash C,Jeanrenaud B

更新日期：1983-07-01 00:00:00

abstract：:Activation of the hepatoportal glucose sensors by portal glucose infusion leads to increased glucose clearance and induction of hypoglycemia. Here, we investigated whether glucagon-like peptide-1 (GLP-1) could modulate the activity of these sensors. Mice were therefore infused with saline (S-mice) or glucose (P-mice) ...

journal_title：Diabetes

authors： Burcelin R,Da Costa A,Drucker D,Thorens B

更新日期：2001-08-01 00:00:00

abstract：:To define the mechanisms involved in the evolution of diabetes in the Zucker diabetic fatty (ZDF) rat, beta-cell mass and replication rates were determined by immunochemistry, point-counting morphometry, and 6-h 5-bromo-2'-deoxyuridine (BrdU) incorporation. The beta-cell mass in 5- to 7-week-old prediabetic ZDF rats (...

journal_title：Diabetes

authors： Pick A,Clark J,Kubstrup C,Levisetti M,Pugh W,Bonner-Weir S,Polonsky KS

更新日期：1998-03-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE recept...

journal_title：Diabetes

authors： Poirier O,Nicaud V,Vionnet N,Raoux S,Tarnow L,Vlassara H,Parving HH,Cambien F

更新日期：2001-05-01 00:00:00

abstract：:In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to palmitate) on the function and survival of isolated human islets and investigated some of the possible mechanisms. Compared with ...

journal_title：Diabetes

authors： Lupi R,Dotta F,Marselli L,Del Guerra S,Masini M,Santangelo C,Patané G,Boggi U,Piro S,Anello M,Bergamini E,Mosca F,Di Mario U,Del Prato S,Marchetti P

更新日期：2002-05-01 00:00:00

abstract：:The molecular mechanism by which some, but not all, variants of encephalomyocarditis (EMC) virus selectively infect pancreatic beta-cells in mice and induce IDDM has been an enigma for more than a decade. We report here that the binding site of the EMC viral capsid protein VP1 determines viral diabetogenicity. Recombi...

journal_title：Diabetes

authors： Jun HS,Kang Y,Yoon HS,Kim KH,Notkins AL,Yoon JW

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:In mammals, proper storage and distribution of lipids in and between tissues is essential for the maintenance of energy homeostasis. In contrast, aberrantly high levels of triglycerides in the blood ("hypertriglyceridemia") represent a hallmark of the metabolic syndrome and type 2 diabetes. As hypertriglyceri...

journal_title：Diabetes

authors： Narvekar P,Berriel Diaz M,Krones-Herzig A,Hardeland U,Strzoda D,Stöhr S,Frohme M,Herzig S

更新日期：2009-05-01 00:00:00

abstract：:The strategy of positional cloning has been highly successful in identifying a number of single gene disorders that exhibit clear Mendelian patterns of inheritance. Positional cloning of insulin-dependent diabetes mellitus (IDDM) has been assisted by the expansion of molecular genetic tools and highly informative mark...

journal_title：Diabetes

authors： Rich SS

更新日期：1995-02-01 00:00:00

abstract：:Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is well characterized. It involves the following sequence of events: entry of glucose by facilitated diffusion, metabolism of glucose by oxidative glycolysis, rise in the ATP-to-ADP ratio, closure...

journal_title：Diabetes

authors： Henquin JC

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic insulin resistance. However, growth retardation is only reported with ho...

journal_title：Diabetes

authors： Suliman SG,Stanik J,McCulloch LJ,Wilson N,Edghill EL,Misovicova N,Gasperikova D,Sandrikova V,Elliott KS,Barak L,Ellard S,Volpi EV,Klimes I,Gloyn AL

更新日期：2009-12-01 00:00:00

abstract：:Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cells. Insulin receptor...

journal_title：Diabetes

authors： Ren D,Sun J,Mao L,Ye H,Polonsky KS

更新日期：2014-10-01 00:00:00

abstract：:G(M), the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1) targeted to the sarcoplasmic reticulum, was proposed to regulate recovery of glycogen in exercised muscle, whereas mutation truncation of its COOH-terminal domain is known to be associated with type 2 diabetes. Here, we demonstrate dif...

journal_title：Diabetes

authors： Lerín C,Montell E,Nolasco T,Clark C,Brady MJ,Newgard CB,Gómez-Foix AM

更新日期：2003-09-01 00:00:00

abstract：:The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreas development and in beta-cell function. Upstream sequences of the gene up to about -6 kb show islet-specific activity in transgenic mice. Attempts to identify functional regulatory elements involved in th...

journal_title：Diabetes

authors： Melloul D,Marshak S,Cerasi E

更新日期：2002-12-01 00:00:00

abstract：:Glucokinase from rat liver or transplantable, radiation-induced insulinomas was partially purified by ion exchange chromatography using DEAE-Cibacron Blue F3GA agarose. Phosphorylation of alpha,beta-D-mannose by glucokinase occurred with cooperative rate dependence on mannose concentration (nH: 1.50). Half-maximal pho...

journal_title：Diabetes

authors： Meglasson MD,Schinco M,Matschinsky FM

更新日期：1983-12-01 00:00:00

abstract：:We have examined the effects of underfeeding and obesity on the density of hypothalamic melanocortin MC3 and MC4 receptors (MC3-R and MC4-R, respectively), which may mediate the hypophagic effects of alpha-melanocyte-stimulating hormone (MSH) in the rat. MC3-R and MC4-R were measured by quantitative autoradiography in...

journal_title：Diabetes

authors： Harrold JA,Widdowson PS,Williams G

更新日期：1999-02-01 00:00:00

abstract：:The effect of elevated glucagon concentrations on insulin requirements and on blood glucose concentrations was studied in five insulin-requiring diabetic subjects during feedback control of hyperglycemia with an automated glucose-controlled insulin infusion system (artificial endocrine pancreas) for six to eight hours...

journal_title：Diabetes

authors： Clarke WL,Santiago JV,Kipnis DM

更新日期：1978-06-01 00:00:00

abstract：:Insulin secretion from the pancreas is pulsatile. The precise site and function of the pacemaker that regulates insulin periodicity in humans have not been determined. We isolated human pancreatic islets from five cadaver organ donors by collagenase digestion and density gradient purification. After 24 h of culture in...

journal_title：Diabetes

authors： Marchetti P,Scharp DW,Mclear M,Gingerich R,Finke E,Olack B,Swanson C,Giannarelli R,Navalesi R,Lacy PE

更新日期：1994-06-01 00:00:00

abstract：:Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes. This may enable them to participate in both anabolic and catabolic processes. The adiponutrin gene (ADPN) is down...

journal_title：Diabetes

authors： Johansson LE,Hoffstedt J,Parikh H,Carlsson E,Wabitsch M,Bondeson AG,Hedenbro J,Tornqvist H,Groop L,Ridderstråle M

更新日期：2006-03-01 00:00:00

abstract：:Numerous reports have confirmed the presence of islet cell antibodies in diabetic patients. These are found mostly in newly diagnosed insulin-dependent diabetic patients and in patients who have autoimmune polyendocrine disorders. Antibodies to beta cells, somatostatin, and glucagon-producing cells have been described...

journal_title：Diabetes

authors： Kaldany A

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:Reactive oxygen species (ROS) is one of most important factors in impaired metabolism secretion coupling in pancreatic β-cells. We recently reported that elevated ROS production and impaired ATP production at high glucose in diabetic Goto-Kakizaki (GK) rat islets are effectively ameliorated by Src inhibition,...

journal_title：Diabetes

authors： Mukai E,Fujimoto S,Sato H,Oneyama C,Kominato R,Sato Y,Sasaki M,Nishi Y,Okada M,Inagaki N

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior. Immunoprecipitation, immunofluorescent staining, and RT-PCR of human VSMCs showed that elevat...

journal_title：Diabetes

authors： Campbell M,Allen WE,Silversides JA,Trimble ER

更新日期：2003-02-01 00:00:00

abstract：:In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K) enzyme system. In the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. To ...

journal_title：Diabetes

authors： Niswender KD,Morrison CD,Clegg DJ,Olson R,Baskin DG,Myers MG Jr,Seeley RJ,Schwartz MW

更新日期：2003-02-01 00:00:00

abstract：:Protein kinase C (PKC) has been suggested as a mediator of insulin's effect on glucose transport, and PKC-mediated modulation of tyrosine kinase activity in the insulin receptor has been implicated in regulating the insulin sensitivity of tissues. Because skeletal muscle is a major target of insulin action, we examine...

journal_title：Diabetes

authors： Sowell MO,Treutelaar MK,Burant CF,Buse MG

更新日期：1988-05-01 00:00:00

abstract：:Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential ...

journal_title：Diabetes

authors： Suzuki K,Hata S,Kawabata Y,Sorimachi H

更新日期：2004-02-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the content and mRNA level of insulin in a mouse beta-cell line, MIN6, and primary-cultured mouse islets. We examined the mechanism of PTHrP-induced insulin expression. The PTHrP effect was markedly augmented by SB203580, a mitogen-activated protein (MAP) kinase in...

journal_title：Diabetes

authors： Zhang B,Hosaka M,Sawada Y,Torii S,Mizutani S,Ogata M,Izumi T,Takeuchi T

更新日期：2003-11-01 00:00:00

abstract：:Patients with diabetes are at an increased risk for developing corneal disorders, often as a result of surgical and nonsurgical trauma. This study investigated whether intensive treatment of diabetes with the goal of maintaining blood glucose concentrations close to the normal range could ameliorate the delayed cornea...

journal_title：Diabetes

authors： Zagon IS,Sassani JW,McLaughlin PJ

更新日期：2006-04-01 00:00:00

abstract：:Cultured skin fibroblasts from clinically normal offspring of two parents with non-insulin-dependent diabetes have demonstrated premature senescence as a decreased ability of cells to establish colonies when inoculated at low density (plating efficiency). The present study tested the hypothesis that there is an inhere...

journal_title：Diabetes

authors： Rosenbloom AL,Rosenbloom EK

更新日期：1978-03-01 00:00:00

abstract：:Subjects with low serum HDL cholesterol levels are reported to be susceptible to diabetes, with insulin resistance believed to be the underlying pathological mechanism. Apolipoprotein M (apoM) is a carrier of sphingosine-1-phosphate (S1P), a multifunctional lipid mediator, on HDL, and the pleiotropic effects of HDL ar...

journal_title：Diabetes

authors： Kurano M,Tsukamoto K,Shimizu T,Kassai H,Nakao K,Aiba A,Hara M,Yatomi Y

更新日期：2020-05-01 00:00:00

abstract：:Polyalkylcyanoacrylate nanocapsules (mean size 220 nm), composed of spheric polymeric structures, have been used as a drug carrier for insulin. The rate of encapsulation of insulin is 54.9%, and we studied the therapeutic efficiency of the nanocapsules in diabetic and normal rats. When administered subcutaneously, ins...

journal_title：Diabetes

authors： Damgé C,Michel C,Aprahamian M,Couvreur P

更新日期：1988-02-01 00:00:00

abstract：:Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...

journal_title：Diabetes

authors： Henquin JC,Ishiyama N,Nenquin M,Ravier MA,Jonas JC

更新日期：2002-02-01 00:00:00