Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells.

abstract：:On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical effica...

journal_title：Diabetes

authors： Lampeter EF,Klinghammer A,Scherbaum WA,Heinze E,Haastert B,Giani G,Kolb H

更新日期：1998-06-01 00:00:00

abstract：:Liver fat accumulation is proposed to link obesity and insulin resistance. To dissect the role of liver fat in the insulin resistance of diet-induced obesity, we altered liver fat using a choline-deficient diet. C57Bl/6 mice were fed a low-fat (10% of calories) or high-fat (45% of calories) diet for 8 weeks; during th...

journal_title：Diabetes

authors： Raubenheimer PJ,Nyirenda MJ,Walker BR

更新日期：2006-07-01 00:00:00

abstract：:A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...

journal_title：Diabetes

authors： Alvarez-Reynolds M,Dominguez JM

更新日期：1977-07-01 00:00:00

abstract：:The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and known functions of IDE...

journal_title：Diabetes

authors： Groves CJ,Wiltshire S,Smedley D,Owen KR,Frayling TM,Walker M,Hitman GA,Levy JC,O'Rahilly S,Menzel S,Hattersley AT,McCarthy MI

更新日期：2003-05-01 00:00:00

abstract：:The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER are only partially defined in these cells, ...

journal_title：Diabetes

authors： Varadi A,Rutter GA

更新日期：2002-02-01 00:00:00

abstract：:The farnesoid X receptor (FXR) and the liver x receptors (LXRs) are bile acid-activated receptors that are highly expressed in the enterohepatic tissues. The mechanisms that support the beneficial effects of bariatric surgery are only partially defined. We have investigated the effects of ileal interposition (IT), a s...

journal_title：Diabetes

authors： Mencarelli A,Renga B,D'Amore C,Santorelli C,Graziosi L,Bruno A,Monti MC,Distrutti E,Cipriani S,Donini A,Fiorucci S

更新日期：2013-10-01 00:00:00

abstract：:Circadian rhythms are integral to the normal functioning of numerous physiological processes. Evidence from human and mouse studies suggests that loss of rhythm occurs in obesity and cardiovascular disease and may be a neglected contributor to pathophysiology. Obesity has been shown to impair the circadian clock mecha...

journal_title：Diabetes

authors： Prasai MJ,Mughal RS,Wheatcroft SB,Kearney MT,Grant PJ,Scott EM

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type 1 diabetes. RESEARCH DESIGN AND METHODS:Recombinant TRAIL was added in vitro to primary human and mouse peripheral blood mononuclear cells (PBMC...

journal_title：Diabetes

authors： Zauli G,Toffoli B,di Iasio MG,Celeghini C,Fabris B,Secchiero P

更新日期：2010-05-01 00:00:00

abstract：:Mammalian erythrocytes have been shown to bind, but not to respond to, physiologic doses of insulin. Insulin binding was studied in normal rat erythrocytes and erythroblastic leukemic (EBL) cells by standard 125I-insulin competitive binding assays. EBL cells exhibited marked insulin degradation, which was time, temper...

journal_title：Diabetes

authors： Galbraith RA,Wise C,Buse MG

更新日期：1980-07-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：:Triglycerides in the beta-cell may be important for stimulus-secretion coupling, through provision of a lipid-derived signal, and for pathogenetic events in NIDDM, where lipids may adversely affect beta-cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in triglyceride hydrolysis. Here,...

journal_title：Diabetes

authors： Mulder H,Holst LS,Svensson H,Degerman E,Sundler F,Ahrén B,Rorsman P,Holm C

更新日期：1999-01-01 00:00:00

abstract：:Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese adolescents. We investigated interactions between glucose tolerance, insulin sensitivity, and the expression of lipogenic genes in abdominal subcutaneous adipose and liver tissue in 53 obese ado...

journal_title：Diabetes

authors： Kursawe R,Caprio S,Giannini C,Narayan D,Lin A,D'Adamo E,Shaw M,Pierpont B,Cushman SW,Shulman GI

更新日期：2013-03-01 00:00:00

abstract：:Earlier investigations have revealed that polyethylene glycol-B1-insulin (PEG insulin) causes lower utilization of glucose in fat cells than does the unaltered hormone, even though the blood glucose-lowering activity of both preparations in intact animals is identical. The present study was aimed to establish whether ...

journal_title：Diabetes

authors： Neubauer HP,Obermeier R,Schöne HH

更新日期：1983-10-01 00:00:00

abstract：:Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...

journal_title：Diabetes

authors： Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

更新日期：2005-03-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism. PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. The aim of this study was to test the hypothesis that statins reduce PLTP activity and to examine the p...

journal_title：Diabetes

authors： Dallinga-Thie GM,van Tol A,Hattori H,Rensen PC,Sijbrands EJ

更新日期：2006-05-01 00:00:00

abstract：:The effects of variations of glycemia from 1.7 to 35 mM on the activity of glycogen synthase and phosphorylase, on glycogen content, and on U-14C-glucose incorporation into glycogen in the liver of the near-term rat fetus were investigated. Hypoglycemia did not affect the activities of phosphorylase and synthase; tota...

journal_title：Diabetes

authors： Gilbert M,Bourbon J

更新日期：1980-04-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Leptin is an adipocyte hormone that plays a major role in energy balance. Leptin receptors in the hypothalamus are known to signal via distinct mechanisms, including signal transducer and activator of transcription-3 (STAT3) and phosphoinositol-3 kinase (PI 3-kinase). Here, we tested the hypothesis that extra...

journal_title：Diabetes

authors： Rahmouni K,Sigmund CD,Haynes WG,Mark AL

更新日期：2009-03-01 00:00:00

abstract：:To investigate the short-term effects of didecanoyl-L-alpha-phosphatidylcholine on the nasal mucosa and the mechanism by which didecanoyl-L-alpha-phosphatidylcholine enhances the nasal absorption of insulin, an in vitro model was developed. The mucosa from the posterior part of the rabbit nasal septum was mounted in a...

journal_title：Diabetes

authors： Carstens S,Danielsen G,Guldhammer B,Frederiksen O

更新日期：1993-07-01 00:00:00

abstract：:Abnormalities in the incorporation of heparan sulfate proteoglycan into the glomerular basement membrane have been implicated in the pathogenesis of various proteinuric states, including diabetes mellitus. To understand further the interactions between proteoglycans and glomerular extracellular matrices, glomeruli wer...

journal_title：Diabetes

authors： Klein DJ,Oegema TR Jr,Brown DM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：:Islets from male B10.BR mice (H-2k) were isolated by the collagenase technique, handpicked with a Pasteur pipette, and incubated (either intact or after dispersion with Dispase) for 0, 3, 5, 7, 10, or 14 days in tissue culture medium supplemented with either lymphokine supernatants or recombinant murine interferon-gam...

journal_title：Diabetes

authors： Wright JR Jr,Lacy PE,Unanue ER,Muszynski C,Hauptfeld V

更新日期：1986-10-01 00:00:00

abstract：:To evaluate the correlation between heat-shock protein (HSP) and insulitis, we compared lymphocyte proliferative response to Mycobacterium leprae HSP65 of NOD mice with that of I-E alpha d transgenic NOD (I-E+NOD) mice, which show no insulitis. We found that splenocytes from 15-week-old NOD mice showed a more marked p...

journal_title：Diabetes

authors： Shimada A,Kasatani T,Takei I,Maruyama T,Nomaguchi H,Ozawa Y,Ishii M,Kasuga A,Tashiro F,Miyazaki J,Yamamura K,Saruta T

更新日期：1996-02-01 00:00:00

abstract：:Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not known. We sought to determine whether the mechanism by which PMI 5011 improves insulin signaling is thr...

journal_title：Diabetes

authors： Obanda DN,Hernandez A,Ribnicky D,Yu Y,Zhang XH,Wang ZQ,Cefalu WT

更新日期：2012-03-01 00:00:00

abstract：:Duct-occluded segmental-pancreas transplants develop progressive fibrotic atrophy, even though endocrine function seems to be unaffected. To determine end-stage size of the graft and to evaluate magnetic resonance imaging (MRI) and computed tomography (CT), these imaging techniques were applied in eight patients with ...

journal_title：Diabetes

authors： Schlumpf R,Marincek B,Von Schulthess G,Decurtins M,Largiadèr F

更新日期：1989-01-01 00:00:00

abstract：:An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen...

journal_title：Diabetes

authors： Cohen WR,Deutsch J

更新日期：1994-05-01 00:00:00

abstract：:Glucokinase from rat liver or transplantable, radiation-induced insulinomas was partially purified by ion exchange chromatography using DEAE-Cibacron Blue F3GA agarose. Phosphorylation of alpha,beta-D-mannose by glucokinase occurred with cooperative rate dependence on mannose concentration (nH: 1.50). Half-maximal pho...

journal_title：Diabetes

authors： Meglasson MD,Schinco M,Matschinsky FM

更新日期：1983-12-01 00:00:00

abstract：:Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic inflammation in obesity are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) allevia...

journal_title：Diabetes

authors： Nagata N,Xu L,Kohno S,Ushida Y,Aoki Y,Umeda R,Fuke N,Zhuge F,Ni Y,Nagashimada M,Takahashi C,Suganuma H,Kaneko S,Ota T

更新日期：2017-05-01 00:00:00

abstract：:Photoelectric plethysmography (PPG) was used to investigate blood flow changes close to superficial subcutaneous injection sites. As a validation procedure, the PPG response to subcutaneous injection of a known hyperemic agent, prostaglandin E1 (10(-5) M), was shown to correlate strongly with subcutaneous blood flow c...

journal_title：Diabetes

authors： Williams G,Pickup J,Clark A,Bowcock S,Cooke E,Keen H

更新日期：1983-05-01 00:00:00