Hyperglycemia suppresses the adrenal medullary response to hypoxemia.

abstract：OBJECTIVE:The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney...

journal_title：Diabetes

authors： Puri S,Cano DA,Hebrok M

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Offspring of mothers with diabetes are at risk of obesity and glucose intolerance in later life. In adults, markers of subclinical inflammation (C-reactive protein [CRP] and interleukin [IL]-6) and endothelial activation (intracellular adhesion molecule [ICAM]-1) are associated with obesity and higher risk fo...

journal_title：Diabetes

authors： Nelson SM,Sattar N,Freeman DJ,Walker JD,Lindsay RS

更新日期：2007-11-01 00:00:00

abstract：:The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and known functions of IDE...

journal_title：Diabetes

authors： Groves CJ,Wiltshire S,Smedley D,Owen KR,Frayling TM,Walker M,Hitman GA,Levy JC,O'Rahilly S,Menzel S,Hattersley AT,McCarthy MI

更新日期：2003-05-01 00:00:00

abstract：:To evaluate possible advantages of human insulin of recombinant DNA origin (HI) in the treatment of diabetic patients, we compared cellular and humoral immunoreactivities of HI and porcine insulin (PI). Anti-insulin IgE bound equal amounts of 125I-HI and 125I-PI. There was no difference between HI- and PI-stimulated l...

journal_title：Diabetes

authors： Kumar D,Alexander CM,Zeidler A,Rhodes JJ,Boarman CC,Hoopes MT

更新日期：1983-06-01 00:00:00

abstract：:Our aim was to isolate and determine the contribution of partial pancreatectomy, systemic delivery of pancreatic hormones, and duct obliteration to glucose regulation after segmental pancreas transplantation in dogs. Fasting, postprandial, and intravenous glucose-stimulated glucose, insulin, glucagon, pancreatic polyp...

journal_title：Diabetes

authors： van der Burg MP,Gooszen HG,Guicherit OR,Jansen JB,Frölich M,van Haastert FA,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Insulin resistance is an underappreciated facet of type 1 diabetes that occurs with remarkable consistency and considerable magnitude. Although therapeutic innovations are continuing to normalize dysglycemia, a sizable body of data suggests a second metabolic abnormality-iatrogenic hyperinsulinemia-principally drives ...

journal_title：Diabetes

authors： Gregory JM,Cherrington AD,Moore DJ

更新日期：2020-05-01 00:00:00

abstract：:Plasma and urine fibrinopeptide-A (FPA) levels were investigated in type I and II diabetic patients. Plasma FPA and 24-h urinary excretion of FPA were significantly elevated in diabetic patients compared with normal volunteers, indicating augmented thrombin activity in diabetes. Plasma and urine FPA did not differ bet...

journal_title：Diabetes

authors： Jones RL

更新日期：1985-09-01 00:00:00

abstract：:Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

journal_title：Diabetes

authors： Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

更新日期：2005-04-01 00:00:00

abstract：:Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., r...

journal_title：Diabetes

authors： Lara-Castro C,Luo N,Wallace P,Klein RL,Garvey WT

更新日期：2006-01-01 00:00:00

abstract：:Using the hyperglycemic and euglycemic clamp, we demonstrated impaired β-cell function in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test (OGTT)-modeled β-cell function and incretin effect in obese adolescents spanning the range of glucose tolerance. β-Cell function parameters w...

journal_title：Diabetes

authors： Michaliszyn SF,Mari A,Lee S,Bacha F,Tfayli H,Farchoukh L,Ferrannini E,Arslanian S

更新日期：2014-11-01 00:00:00

abstract：:Most studies dealing with the pathogenesis of IDDM have emphasized the immune assault against beta-cells. In this perspective, we review the data that suggest that the beta-cell destruction of IDDM depends on a balance between beta-cell damage and repair. The progressive beta-cell damage leading to IDDM seems to follo...

journal_title：Diabetes

authors： Eizirik DL,Sandler S,Palmer JP

更新日期：1993-10-01 00:00:00

abstract：:Ghrelin, an endogenous ligand for growth hormone secretagogue (GHS) receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons containing neuropeptide Y (NPY), suggesting the involve...

journal_title：Diabetes

authors： Shintani M,Ogawa Y,Ebihara K,Aizawa-Abe M,Miyanaga F,Takaya K,Hayashi T,Inoue G,Hosoda K,Kojima M,Kangawa K,Nakao K

更新日期：2001-02-01 00:00:00

abstract：:To explain the contradictory data on the secretion of prostacyclin (PGI2) in clinical and experimental diabetes, we have investigated the effect of each of the major metabolic abnormalities in uncontrolled diabetes on vascular PGI2 synthesis. An increase in fatty acid concentrations caused a dose-dependent inhibition ...

journal_title：Diabetes

authors： Jeremy JY,Mikhailidis DP,Dandona P

更新日期：1983-03-01 00:00:00

abstract：:In the oral glucose tolerance test (OGTT), divergent doses of glucose remain in use by virtue of the prevailing conviction that the size of the loading dose hardly affects the outcome of the test. We compared the results of OGTTs with 100-gm. and 50-gm. loads in 85 patients, who were selected for slightly impaired glu...

journal_title：Diabetes

authors： de Nobel E,van't Laar A

更新日期：1978-01-01 00:00:00

abstract：:It has been hypothesized that type 1 diabetes is initiated by neonatal physiological pancreatic beta-cell death, indicating that the early stages of this autoimmune response may reflect a dysregulated response to immune "danger" signals. One potential danger signal is ATP, high concentrations of which stimulate the pu...

journal_title：Diabetes

authors： Elliott JI,Higgins CF

更新日期：2004-08-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in many insulin-resistant states, although the mechanism for this downregulation is unclear. In this study, we have investigated the early events in the insulin pathway that trigger the degradation of IRS-1. Incubation of the adipocytes with ins...

journal_title：Diabetes

authors： Pederson TM,Kramer DL,Rondinone CM

更新日期：2001-01-01 00:00:00

abstract：:The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

journal_title：Diabetes

authors： Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

更新日期：2002-12-01 00:00:00

abstract：:Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves' disease in comparison to healthy control subjects by st...

journal_title：Diabetes

authors： Kallmann BA,Hüther M,Tubes M,Feldkamp J,Bertrams J,Gries FA,Lampeter EF,Kolb H

更新日期：1997-02-01 00:00:00

abstract：:Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructiv...

journal_title：Diabetes

authors： Duennwald T,Bernardi L,Gordin D,Sandelin A,Syreeni A,Fogarty C,Kytö JP,Gatterer H,Lehto M,Hörkkö S,Forsblom C,Burtscher M,Groop PH,FinnDiane Study Group.

更新日期：2013-12-01 00:00:00

abstract：:A cohort of 372 insulin-dependent diabetic children, diagnosed between October 1949 and December 1960, were followed-up until December 1976 by the same team of physicians. At the time of diagnosis all patients were under 16 yr of age and were given standardized treatment which did not change from 1949 to 1976. The the...

journal_title：Diabetes

authors： Lestradet H,Papoz L,Hellouin de Menibus C,Levavasseur F,Besse J,Billaud L,Battistelli F,Tric P,Lestradet F

更新日期：1981-03-01 00:00:00

abstract：:Evidence in rodents suggests that islet pretreatment to reduce islet immunogenicity will also require some form of immunosuppression of the recipient for islet allograft acceptance in highly reactive donor-recipient pairs. We attempted to ascertain whether outbred dogs would also require treatment of both donor islets...

journal_title：Diabetes

authors： Alejandro R,Latif Z,Noel J,Shienvold FL,Mintz DH

更新日期：1987-03-01 00:00:00

abstract：:Defects in insulin secretion, resulting from loss of function or destruction of pancreatic beta-cells, trigger diabetes. Interleukin (IL)-1beta is a proinflammatory cytokine that is involved in type 1 and type 2 diabetes development and impairs beta-cell survival and function. Because effective insulin signaling is re...

journal_title：Diabetes

authors： Emanuelli B,Glondu M,Filloux C,Peraldi P,Van Obberghen E

更新日期：2004-12-01 00:00:00

abstract：:Rosiglitazone therapy improves insulin sensitivity and glucose uptake in patients with uncomplicated type 2 diabetes. In coronary artery disease (CAD), glucose is an important source of energy and preserved myocardial glucose uptake is essential for the viability of jeopardized myocardium. The aim was to test whether ...

journal_title：Diabetes

authors： Lautamäki R,Airaksinen KE,Seppänen M,Toikka J,Luotolahti M,Ball E,Borra R,Härkönen R,Iozzo P,Stewart M,Knuuti J,Nuutila P

更新日期：2005-09-01 00:00:00

abstract：:Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases, but this is impaired in diabetes. We hypothesized that breaking advanced glycation end product (AGE) cross-links could improve remodeling in mesenteric resistance arteries in Zucker diabetic fatty (ZDF) rats compar...

journal_title：Diabetes

authors： Freidja ML,Tarhouni K,Toutain B,Fassot C,Loufrani L,Henrion D

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type 1 diabetes. RESEARCH DESIGN AND METHODS:Recombinant TRAIL was added in vitro to primary human and mouse peripheral blood mononuclear cells (PBMC...

journal_title：Diabetes

authors： Zauli G,Toffoli B,di Iasio MG,Celeghini C,Fabris B,Secchiero P

更新日期：2010-05-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：:Impairment of suppressor-cell activity may be important in the pathogenesis and maintenance of insulin-dependent diabetes mellitus (IDDM). In 23 recent-onset IDDM patients, lymphocyte sensitivity in vitro to theophylline was tested both in basal conditions and after improvement of metabolic control. This pharmacologic...

journal_title：Diabetes

authors： Crosti F,Secchi A,Ferrero E,Falqui L,Inverardi L,Pontiroli AE,Ciboddo GF,Pavoni D,Protti P,Rugarli C

更新日期：1986-09-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：:Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model...

journal_title：Diabetes

authors： Ehrich TH,Hrbek T,Kenney-Hunt JP,Pletscher LS,Wang B,Semenkovich CF,Cheverud JM

更新日期：2005-06-01 00:00:00