A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet.

abstract：:There is evidence from animal models of obesity and type 2 diabetes that increased parasympathetic vagal input to the pancreas contributes to hyperinsulinemia. Compared with Caucasians, Pima Indians have a high risk of type 2 diabetes and exhibit marked hyperinsulinemia and elevated plasma levels of pancreatic polypep...

journal_title：Diabetes

authors： Vozarova de Courten B,Weyer C,Stefan N,Horton M,DelParigi A,Havel P,Bogardus C,Tataranni PA

更新日期：2004-03-01 00:00:00

abstract：:The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

journal_title：Diabetes

authors： Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

更新日期：2002-12-01 00:00:00

abstract：:Mice genetically deficient in the glucagon receptor (Gcgr(-/-)) show improved glucose tolerance, insulin sensitivity, and α-cell hyperplasia. In addition, Gcgr(-/-) mice do not develop diabetes after chemical destruction of β-cells. Since fibroblast growth factor 21 (FGF21) has insulin-independent glucose-lowering pro...

journal_title：Diabetes

authors： Omar BA,Andersen B,Hald J,Raun K,Nishimura E,Ahrén B

更新日期：2014-01-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:Although non-insulin-dependent diabetes mellitus (NIDDM) is associated with defects in insulin action, the molecular basis of this resistance is unknown. We studied fibroblasts from a markedly insulin-resistant patient with NIDDM but without acanthosis nigricans. Her fibroblasts were resistant to insulin when alpha-am...

journal_title：Diabetes

authors： Sbraccia P,Goodman PA,Maddux BA,Wong KY,Chen YD,Reaven GM,Goldfine ID

更新日期：1991-02-01 00:00:00

abstract：:To clarify the relationship between abnormality of sorbitol and/or myo-inositol metabolism caused by hyperglycemia and diabetic macroangiopathy, we investigated the effects of high glucose concentrations and epalrestat, an aldose reductase inhibitor, on the metabolism of sorbitol and myo-inositol in cultured rabbit ao...

journal_title：Diabetes

authors： Sakakibara F,Hotta N,Koh N,Sakamoto N

更新日期：1993-11-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：:A number of patients with type 2 diabetes are GAD antibody positive. A Diabetes Outcome Progression Trial (ADOPT) is a randomized, double-blind clinical trial in recently diagnosed drug-naive patients with type 2 diabetes that allows for the evaluation of GAD positivity in the context of anthropometric and biochemical...

journal_title：Diabetes

authors： Zinman B,Kahn SE,Haffner SM,O'Neill MC,Heise MA,Freed MI,ADOPT Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：:The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...

journal_title：Diabetes

authors： Eto M,Watanabe K,Iwashima Y,Morikawa A,Chonan N,Oshima E,Sekiguchi M,Ishii K

更新日期：1987-11-01 00:00:00

abstract：:Nonhuman primate models of gestational diabetes have produced fetopathies most similar to those of the human infant of the mother with gestational diabetes (IGDM). Fetal hyperglycemia, hyperinsulinemia, macrosomia, selective organomegaly, intrauterine death, and placental hyperplasia are hallmarks of the fetopathy of ...

journal_title：Diabetes

authors： Susa JB,Schwartz R

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:Obesity causes insulin resistance, which has been interpreted as reduced downstream insulin signaling. However, changes in access of insulin to sensitive tissues such as skeletal muscle may also play a role. Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to caus...

journal_title：Diabetes

authors： Kolka CM,Harrison LN,Lottati M,Chiu JD,Kirkman EL,Bergman RN

更新日期：2010-03-01 00:00:00

abstract：:It is well described that excessive lipid metabolism can cause insulin resistance in both animals and humans, and this has been implicated as a causative factor in the development of insulin resistance and type 2 diabetes in humans. Recently, we have shown that intravenous lipid emulsion (liposyn) infusion during a 12...

journal_title：Diabetes

authors： Hevener A,Reichart D,Janez A,Olefsky J

更新日期：2002-06-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Rapamycin is used frequently in both transplantation and oncology. Although historically thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This Review draws evidence for rapamycin toxicity from clinical studies of islet and renal transplantation, and of rapamycin as an anticance...

journal_title：Diabetes

authors： Barlow AD,Nicholson ML,Herbert TP

更新日期：2013-08-01 00:00:00

abstract：:GAD is a pancreatic beta-cell autoantigen in humans and nonobese diabetic (NOD) mice. Modulation of GAD expression in pancreatic beta-cells has been suggested to be associated with the development of autoimmune diabetes. Hormonal changes through environmental stimuli are considered to influence the expression of the d...

journal_title：Diabetes

authors： Kim KS,Kang Y,Choi SE,Kim JH,Kim HM,Sun B,Jun HS,Yoon JW

更新日期：2002-09-01 00:00:00

abstract：:We tested the hypothesis that activation of the protective arm of the renin angiotensin system, the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)]/Mas receptor axis, corrects the vasoreparative dysfunction typically seen in the CD34(+) cells isolated from diabetic individuals. Peripheral blood CD...

journal_title：Diabetes

authors： Jarajapu YP,Bhatwadekar AD,Caballero S,Hazra S,Shenoy V,Medina R,Kent D,Stitt AW,Thut C,Finney EM,Raizada MK,Grant MB

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS:We screened INS in 62 probands with MODY, 30 probands with suspected MODY,...

journal_title：Diabetes

authors： Molven A,Ringdal M,Nordbø AM,Raeder H,Støy J,Lipkind GM,Steiner DF,Philipson LH,Bergmann I,Aarskog D,Undlien DE,Joner G,Søvik O,Norwegian Childhood Diabetes Study Group.,Bell GI,Njølstad PR

更新日期：2008-04-01 00:00:00

abstract：:Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has ...

journal_title：Diabetes

authors： Finegold D,Lattimer SA,Nolle S,Bernstein M,Greene DA

更新日期：1983-11-01 00:00:00

abstract：:Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet amyloid when fed a breeder chow but not regular chow. Because the breeder chow contained incre...

journal_title：Diabetes

authors： Hull RL,Andrikopoulos S,Verchere CB,Vidal J,Wang F,Cnop M,Prigeon RL,Kahn SE

更新日期：2003-02-01 00:00:00

abstract：:Persistent nutrient excess results in a compensatory increase in the β-cell number in mammals. It is unknown whether this response occurs in nonmammalian vertebrates, including zebrafish, a model for genetics and chemical genetics. We investigated the response of zebrafish β-cells to nutrient excess and the underlying...

journal_title：Diabetes

authors： Maddison LA,Chen W

更新日期：2012-10-01 00:00:00

abstract：:We report the results of cross-sectional, prospective, and longitudinal studies identifying etiologic metabolic factors in the susceptibility to type 2 diabetes mellitus of the Pima Indians of Arizona, whose prevalence and incidence rates of the disease are the highest in the world. Diabetic Pima Indians are metabolic...

journal_title：Diabetes

authors： Bogardus C,Tataranni PA

更新日期：2002-02-01 00:00:00

abstract：:Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis. Here we report that HDAC9, another class IIa HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box O (FoxO) family transcription factor, FoxO1, together with HD...

journal_title：Diabetes

authors： Chen J,Wang N,Dong M,Guo M,Zhao Y,Zhuo Z,Zhang C,Chi X,Pan Y,Jiang J,Tang H,Niu J,Yang D,Li Z,Han X,Wang Q,Chen X

更新日期：2015-12-01 00:00:00

abstract：:Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...

journal_title：Diabetes

authors： Blackman JD,Polonsky KS,Jaspan JB,Sturis J,Van Cauter E,Thistlethwaite JR

更新日期：1992-10-01 00:00:00

abstract：:Although the biochemical mechanism by which insulin and contractile activity affect protein turnover in muscle are still unclear, certain physiologic conclusions can be made; (a) Increased work can induce muscle hypertrophy even in the diabetic or starving animal. Thus, work-induced growth differs from normal growth o...

journal_title：Diabetes

authors： Goldberg AL

更新日期：1979-01-01 00:00:00

abstract：:Altered proteoglycan metabolism may play a role in the development of diabetic glomerulopathy. This study was conducted to examine the effects of glucose on the production and physical characteristics of proteoglycans generated by rat mesangial cells in culture. Rat mesangial cells were exposed to elevated glucose med...

journal_title：Diabetes

authors： Silbiger S,Schlondorff D,Crowley S,Rosenberg L,Choi H,Hatcher V,Gordon P

更新日期：1993-12-01 00:00:00

abstract：:We examined the effects of high-dosage vitamin E treatment over a 12-month period on the vascular reactivity of micro- and macrocirculation and left ventricular function in diabetic patients. Subjects (n = 89) were randomized to vitamin E (1,800 IU daily) or placebo and were followed for 12 months. High-resolution ult...

journal_title：Diabetes

authors： Economides PA,Khaodhiar L,Caselli A,Caballero AE,Keenan H,Bursell SE,King GL,Johnstone MT,Horton ES,Veves A

更新日期：2005-01-01 00:00:00

abstract：:Genes of the Notch signaling pathway are expressed in different cell types and organs at different time points during embryonic development and adulthood. The Notch ligand Delta-like 1 (DLL1) controls the decision between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and loss of D...

journal_title：Diabetes

authors： Rubey M,Chhabra NF,Gradinger D,Sanz-Moreno A,Lickert H,Przemeck GKH,Hrabě de Angelis M

更新日期：2020-05-01 00:00:00

abstract：:Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

journal_title：Diabetes

authors： Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

更新日期：1982-03-01 00:00:00

abstract：:Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...

journal_title：Diabetes

authors： Vandal M,White PJ,Tremblay C,St-Amour I,Chevrier G,Emond V,Lefrançois D,Virgili J,Planel E,Giguere Y,Marette A,Calon F

更新日期：2014-12-01 00:00:00