Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM.

abstract：:Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin-resistant, and predisposed to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then it has become in...

journal_title：Diabetes

authors： Ruderman N,Chisholm D,Pi-Sunyer X,Schneider S

更新日期：1998-05-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...

journal_title：Diabetes

authors： Carantoni M,Abbasi F,Azhar S,Chen YD,Klebanov M,Wang PW,Warmerdam F,Reaven GM

更新日期：1998-02-01 00:00:00

abstract：:Many humans with IDDM eventually lose the capacity to secrete epinephrine from their adrenal medullae. The mechanism for this pathological change is unknown. We hypothesized that this abnormality is attributable to neuropathic changes in the greater splanchnic nerves or in the chromaffin cells that they innervate. To ...

journal_title：Diabetes

authors： Wilke RA,Riley DA,Lelkes PI,Hillard CJ

更新日期：1993-06-01 00:00:00

abstract：:Platelet aggregation and related plasma factors have been studied in experimentally diabetic dogs, experimentally galactosemic dogs, and in normal dogs. Platelet aggregation, when induced in vitro by ADP (up to 22 microM) or collagen (up to 4 micrograms/ml), was not significantly different from normal in the diabetic ...

journal_title：Diabetes

authors： Kern TS,Engerman RL

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:A number of studies have found that reduced birth weight is associated with type 2 diabetes later in life; however, the underlying mechanism for this correlation remains unresolved. Recently, association has been demonstrated between low birth weight and single nucleotide polymorphisms (SNPs) at the CDKAL1 an...

journal_title：Diabetes

authors： Zhao J,Li M,Bradfield JP,Wang K,Zhang H,Sleiman P,Kim CE,Annaiah K,Glaberson W,Glessner JT,Otieno FG,Thomas KA,Garris M,Hou C,Frackelton EC,Chiavacci RM,Berkowitz RI,Hakonarson H,Grant SF

更新日期：2009-10-01 00:00:00

abstract：:Halofenate has been shown previously to lower triglycerides in dyslipidemic subjects. In addition, significant decreases in fasting plasma glucose were observed but only in type 2 diabetic patients. We hypothesized that halofenate might be an insulin sensitizer, and we present data to suggest that halofenate is a sele...

journal_title：Diabetes

authors： Allen T,Zhang F,Moodie SA,Clemens LE,Smith A,Gregoire F,Bell A,Muscat GE,Gustafson TA

更新日期：2006-09-01 00:00:00

abstract：:This study examined the suitability of commercial U.S.P. insulin as a bacterial growth medium. Purified port insulin (Iletin II, Eli Lilly & Co., Indianapolis, Indiana) was inoculated with approximately 500,000 bacteria per ml of: (1) Staphylococcus epidermidis, (2) Staphylococcus aureus, or (3) Escherichia coli. All ...

journal_title：Diabetes

authors： Schade DS,Eaton RP

更新日期：1982-01-01 00:00:00

abstract：:The influence of insulin on the intracellular free sodium and potassium ion concentrations ([Na+]i, [K+]i) and resting membrane potential of rat epididymal adipocytes was examined to determine its potential for mediating insulin's action on other cellular processes. Direct intracellular measurements of [Na+]i, [K+]i, ...

journal_title：Diabetes

authors： Stark RJ,Read PD,O'Doherty J

更新日期：1980-12-01 00:00:00

abstract：:Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...

journal_title：Diabetes

authors： Blackman JD,Polonsky KS,Jaspan JB,Sturis J,Van Cauter E,Thistlethwaite JR

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...

journal_title：Diabetes

authors： Rogus JJ,Poznik GD,Pezzolesi MG,Smiles AM,Dunn J,Walker W,Wanic K,Moczulski D,Canani L,Araki S,Makita Y,Warram JH,Krolewski AS

更新日期：2008-09-01 00:00:00

abstract：:Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains con...

journal_title：Diabetes

authors： Sun W,Oates PJ,Coutcher JB,Gerhardinger C,Lorenzi M

更新日期：2006-10-01 00:00:00

abstract：:Although the biochemical mechanism by which insulin and contractile activity affect protein turnover in muscle are still unclear, certain physiologic conclusions can be made; (a) Increased work can induce muscle hypertrophy even in the diabetic or starving animal. Thus, work-induced growth differs from normal growth o...

journal_title：Diabetes

authors： Goldberg AL

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-ce...

journal_title：Diabetes

authors： Cui J,Wang Z,Cheng Q,Lin R,Zhang XM,Leung PS,Copeland NG,Jenkins NA,Yao KM,Huang JD

更新日期：2011-01-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donor...

journal_title：Diabetes

authors： Anquetil F,Mondanelli G,Gonzalez N,Rodriguez Calvo T,Zapardiel Gonzalo J,Krogvold L,Dahl-Jørgensen K,Van den Eynde B,Orabona C,Grohmann U,von Herrath MG

更新日期：2018-09-01 00:00:00

abstract：:Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI) in a nonhypertensive obese canine model. SI was measured using euglycemic-hyper...

journal_title：Diabetes

authors： Iyer MS,Bergman RN,Korman JE,Woolcott OO,Kabir M,Victor RG,Clegg DJ,Kolka C

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Kumashiro N,Tamura Y,Uchida T,Ogihara T,Fujitani Y,Hirose T,Mochizuki H,Kawamori R,Watada H

更新日期：2008-08-01 00:00:00

abstract：:Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of ty...

journal_title：Diabetes

authors： Knip M,Veijola R,Virtanen SM,Hyöty H,Vaarala O,Akerblom HK

更新日期：2005-12-01 00:00:00

abstract：:Autoantibodies against several cytoplasmic autoantigens such as glutamic acid decarboxylase, heat shock protein 65, insulin, and carboxypeptidase H have been identified in the sera of patients with IDDM. To investigate whether type II DNA topoisomerase (TopII) is an autoantigen in IDDM patients, we have constructed a ...

journal_title：Diabetes

authors： Chang YH,Hwang J,Shang HF,Tsai ST

更新日期：1996-04-01 00:00:00

abstract：:A total of 32 pairs of obese fathers or mothers and their obese offsprings, aged 20 yr or younger, from 25 families with established hyperinsulinemic obesity aged 11-20 yr equally showed an insulin hyperresponse to glucose, the offspring 10 yr or younger revealed a rather normal insulin response, despite the presence ...

journal_title：Diabetes

authors： Maruhama Y,Abe R

更新日期：1981-01-01 00:00:00

abstract：:Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little is known about their effect on islet function and beta-cell viability. In this study, we report that tacrolimus, sirolimus, and mycophenol...

journal_title：Diabetes

authors： Hui H,Khoury N,Zhao X,Balkir L,D'Amico E,Bullotta A,Nguyen ED,Gambotto A,Perfetti R

更新日期：2005-02-01 00:00:00

abstract：:ATP-sensitive potassium (K[ATP]) channels are an essential component of glucose-dependent insulin secretion in pancreatic islet beta-cells. These channels comprise the sulfonylurea receptor (SUR1) and Kir6.2, a member of the inward rectifier K+ channel family. Mutations in the SUR1 subunit are associated with familial...

journal_title：Diabetes

authors： Nestorowicz A,Inagaki N,Gonoi T,Schoor KP,Wilson BA,Glaser B,Landau H,Stanley CA,Thornton PS,Seino S,Permutt MA

更新日期：1997-11-01 00:00:00

abstract：:Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...

journal_title：Diabetes

authors： Tze WJ,Tai J

更新日期：1988-04-01 00:00:00

abstract：:It has long been recognized that islet cell function is rapidly altered in vitro, but can be maintained, at least in part, when cells are layered on defined extracellular matrices. The present work addresses the influence of short-term cell-matrix interactions on islet beta-cell function and provides first insight int...

journal_title：Diabetes

authors： Bosco D,Meda P,Halban PA,Rouiller DG

更新日期：2000-02-01 00:00:00

abstract：:The effect of strict glycemic control on retinal volumetric blood flow rate (Q) was investigated in 13 insulin-dependent diabetic patients with laser Doppler velocimetry and monochromatic fundus photography. Strict glycemic control was achieved by glucose monitoring and four daily insulin injections. Q was determined ...

journal_title：Diabetes

authors： Grunwald JE,Brucker AJ,Schwartz SS,Braunstein SN,Baker L,Petrig BL,Riva CE

更新日期：1990-05-01 00:00:00

abstract：:Peptide-YY (PYY) is secreted from endocrine L-cells of the gastrointestinal tract in response to caloric ingestion and may mediate postprandial satiety through the hypothalamic neuropeptide Y2 receptor (Y2R). We examined whether variants in the genes encoding PYY and Y2R might be associated with obesity-related phenot...

journal_title：Diabetes

authors： Hung CC,Pirie F,Luan J,Lank E,Motala A,Yeo GS,Keogh JM,Wareham NJ,O'Rahilly S,Farooqi IS

更新日期：2004-09-01 00:00:00

abstract：:Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

journal_title：Diabetes

authors： Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Leukocyte infiltration of adipose is a critical determinant of obesity-related metabolic diseases. Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in atherosclerosis, but its role in adipose inflammation and type 2 diabetes is unknown. ...

journal_title：Diabetes

authors： Shah R,Hinkle CC,Ferguson JF,Mehta NN,Li M,Qu L,Lu Y,Putt ME,Ahima RS,Reilly MP

更新日期：2011-05-01 00:00:00

abstract：:Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adip...

journal_title：Diabetes

authors： Vozarova de Courten B,Hanson RL,Funahashi T,Lindsay RS,Matsuzawa Y,Tanaka S,Thameem F,Gruber JD,Froguel P,Wolford JK

更新日期：2005-01-01 00:00:00

abstract：:Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in many insulin-resistant states, although the mechanism for this downregulation is unclear. In this study, we have investigated the early events in the insulin pathway that trigger the degradation of IRS-1. Incubation of the adipocytes with ins...

journal_title：Diabetes

authors： Pederson TM,Kramer DL,Rondinone CM

更新日期：2001-01-01 00:00:00

abstract：:A single administration of complete Freund's adjuvant (CFA), type 1 carrageenan (Car), or silica 7, 2, and 2 days, respectively, before infection with a low dose (1 x 10(2) plaque-forming units/mouse) of encephalomyocarditis D (EMC-D) virus resulted in a significant increase in the incidence of diabetes in SJL/J mice ...

journal_title：Diabetes

authors： Baek HS,Yoon JW

更新日期：1991-12-01 00:00:00