Environmental triggers and determinants of type 1 diabetes.

abstract：:Islets of Langerhans are micro-organs scattered throughout the pancreas that contain insulin-producing cells, called beta-cells. Although new light has been recently shed on beta-cell development, information on the phenotype and location of beta-stem cells remains scarce. Here, we provide evidence that beta-stem cell...

journal_title：Diabetes

authors： Duvillié B,Attali M,Aiello V,Quemeneur E,Scharfmann R

更新日期：2003-08-01 00:00:00

abstract：:The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between g...

journal_title：Diabetes

authors： Rosen ED,Kaestner KH,Natarajan R,Patti ME,Sallari R,Sander M,Susztak K

更新日期：2018-10-01 00:00:00

abstract：:Insulin stimulation of adipose and muscle cells results in the translocation of GLUT4 from an intracellular location to the plasma membrane; this translocation is defective in insulin resistance. Studies have suggested an important role for synaptobrevin and syntaxin homologues in this event, particularly the v-solubl...

journal_title：Diabetes

authors： Maier VH,Melvin DR,Lister CA,Chapman H,Gould GW,Murphy GJ

更新日期：2000-04-01 00:00:00

abstract：:The introduction of 13C magnetic resonance spectroscopy (MRS) has enabled noninvasive measurement of muscle glycogen synthesis in humans. Conclusions based on measurements by the MRS technique assume that glucose metabolism in gastrocnemius muscle is representative for all skeletal muscles and thus can be extrapolated...

journal_title：Diabetes

authors： Serlie MJ,de Haan JH,Tack CJ,Verberne HJ,Ackermans MT,Heerschap A,Sauerwein HP

更新日期：2005-05-01 00:00:00

abstract：:Infection of autoimmune New Zealand mice with the D variant of encephalomyocarditis (EMC) virus results in beta-cell damage and clinical diabetes. The induction of diabetes in parental NZB and NZW strains was independent of sex. However, the susceptibility to virus-induced diabetes in their F1 offspring was sex depend...

journal_title：Diabetes

authors： Yoon JW,Melez KA,Smathers PA,Archer JA,Steinberg AD

更新日期：1983-08-01 00:00:00

abstract：:To elucidate the precise significance of pancreatic A-cell hypersecretion in the pathogenesis of diabetes mellitus, the change in the immunoreactive glucagon (IRG) response to intravenous arginine was studied in both nonobese, hypoinsulinemic non-insulin-dependent (NIDDM) and insulin-dependent diabetic (IDDM) subjects...

journal_title：Diabetes

authors： Kawamori R,Shichiri M,Kikuchi M,Yamasaki Y,Abe H

更新日期：1980-09-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Dipeptidyl peptidase-4 (DPP4) inhibitors lower blood glucose in diabetic subjects; however, the mechanism of action through which these agents improve glucose homeostasis remains incompletely understood. Although glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) represent im...

journal_title：Diabetes

authors： Flock G,Baggio LL,Longuet C,Drucker DJ

更新日期：2007-12-01 00:00:00

abstract：:Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the ...

journal_title：Diabetes

authors： Janson J,Laedtke T,Parisi JE,O'Brien P,Petersen RC,Butler PC

更新日期：2004-02-01 00:00:00

abstract：:Myo-Inositol depletion as a result of hyperglycemia is considered one of the leading contributors to chronic diabetic complications. We investigated the possible mechanisms through which elevated extracellular glucose levels affect the loss of intracellular myo-inositol in rat lens. Short-term incubation (up to 4 h) i...

journal_title：Diabetes

authors： Mistry KP,Beyer-Mears A,Diecke FP

更新日期：1993-12-01 00:00:00

abstract：:Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic N...

journal_title：Diabetes

authors： Rodacki M,Svoren B,Butty V,Besse W,Laffel L,Benoist C,Mathis D

更新日期：2007-01-01 00:00:00

abstract：:Exercise-induced hyperinsulinism (EIHI) is an autosomal dominant disorder characterized by inappropriate insulin secretion in response to vigorous physical exercise or pyruvate injection. Activating mutations in the monocarboxylate transporter-1 (MCT1, SLC16A1) promoter have been linked to EIHI. Expression of this pyr...

journal_title：Diabetes

authors： Pullen TJ,Sylow L,Sun G,Halestrap AP,Richter EA,Rutter GA

更新日期：2012-07-01 00:00:00

abstract：:Genes of the Notch signaling pathway are expressed in different cell types and organs at different time points during embryonic development and adulthood. The Notch ligand Delta-like 1 (DLL1) controls the decision between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and loss of D...

journal_title：Diabetes

authors： Rubey M,Chhabra NF,Gradinger D,Sanz-Moreno A,Lickert H,Przemeck GKH,Hrabě de Angelis M

更新日期：2020-05-01 00:00:00

abstract：:Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-T-lymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of dia...

journal_title：Diabetes

authors： Haynes MK,Huber SA,Craighead JE

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:Nondiabetic obese humans adapt to insulin resistance by increasing beta-cell mass. In contrast, obese humans with type 2 diabetes have an approximately 60% deficit in beta-cell mass. Recent studies in rodents reveal that beta-cell mass is regulated, increasing in response to insulin resistance through increased beta-c...

journal_title：Diabetes

authors： Butler AE,Janson J,Soeller WC,Butler PC

更新日期：2003-09-01 00:00:00

abstract：:The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr)-mediated apoB-containing lipoprotein ...

journal_title：Diabetes

authors： Borradaile NM,de Dreu LE,Huff MW

更新日期：2003-10-01 00:00:00

abstract：:This article seeks to determine whether factors related to autoimmunity risk remain significant after the initiation of two or more diabetes-related autoantibodies and continue to contribute to type 1 diabetes (T1D) risk among autoantibody-positive children in The Environmental Determinants of Diabetes in the Young (T...

journal_title：Diabetes

authors： Krischer JP,Liu X,Lernmark Å,Hagopian WA,Rewers MJ,She JX,Toppari J,Ziegler AG,Akolkar B,TEDDY Study Group.

更新日期：2017-12-01 00:00:00

abstract：:Many humans with IDDM eventually lose the capacity to secrete epinephrine from their adrenal medullae. The mechanism for this pathological change is unknown. We hypothesized that this abnormality is attributable to neuropathic changes in the greater splanchnic nerves or in the chromaffin cells that they innervate. To ...

journal_title：Diabetes

authors： Wilke RA,Riley DA,Lelkes PI,Hillard CJ

更新日期：1993-06-01 00:00:00

abstract：:The effects of glucose and diabetes on the high-affinity lofentanil-displaceable opiate-receptor binding in mouse brain membranes were studied to determine if the attenuation of opiate actions by hyperglycemia previously observed in our laboratory was due to a modification of receptor affinity or number. With membrane...

journal_title：Diabetes

authors： Brase DA,Han YH,Dewey WL

更新日期：1987-10-01 00:00:00

abstract：:We reported earlier that β-cell-specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic fatty (ZDF) rats wit...

journal_title：Diabetes

authors： Mahadevan J,Parazzoli S,Oseid E,Hertzel AV,Bernlohr DA,Vallerie SN,Liu CQ,Lopez M,Harmon JS,Robertson RP

更新日期：2013-10-01 00:00:00

abstract：:The clearing of monoclonal and polyclonal and anti-insulin antibodies from homogeneous solutions at 100,000 X g was used to estimate the size of soluble insulin-antibody complexes at physiologic concentrations. Monoclonal antibodies cleared as a uniform population of 6.6 S independent of the insulin concentration. Pol...

journal_title：Diabetes

authors： Petersen KG,Storch MJ,Rother K,Licht T,Kerp L

更新日期：1985-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...

journal_title：Diabetes

authors： Gray SL,Nora ED,Grosse J,Manieri M,Stoeger T,Medina-Gomez G,Burling K,Wattler S,Russ A,Yeo GS,Chatterjee VK,O'Rahilly S,Voshol PJ,Cinti S,Vidal-Puig A

更新日期：2006-10-01 00:00:00

abstract：:The risk of insulin-dependent diabetes mellitus (IDDM) was examined in siblings of an unselected population (n = 194) of newly diagnosed diabetic individuals less than 30 yr old. From 1 July 1984 to 30 June 1987, diabetic subjects (proband) identified within a geographically defined area of southern Wisconsin were stu...

journal_title：Diabetes

authors： Allen C,Palta M,D'Alessio DJ

更新日期：1991-07-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism. PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. The aim of this study was to test the hypothesis that statins reduce PLTP activity and to examine the p...

journal_title：Diabetes

authors： Dallinga-Thie GM,van Tol A,Hattori H,Rensen PC,Sijbrands EJ

更新日期：2006-05-01 00:00:00

abstract：:This study examined the role of p38 mitogen-activated protein (MAP) kinase in transducing high glucose into deficits in nerve conduction velocity (NCV) that are characteristic of diabetic neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats treated with a p38 inhibitor, an aldose redu...

journal_title：Diabetes

authors： Price SA,Agthong S,Middlemas AB,Tomlinson DR

更新日期：2004-07-01 00:00:00

abstract：:The hormonal responses to low-level exercise in pregnancy have been studied in 13 insulin-requiring diabetic patients and 42 control subjects. We found no significant changes in plasma glucose, epinephrine, glucagon, or FFA with this level of exercise in the study group and control subjects; but plasma norepinephrine ...

journal_title：Diabetes

authors： Artal R,Wiswell R,Romem Y

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：:Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...

journal_title：Diabetes

authors： MacDonald MJ,Kowluru A

更新日期：1982-06-01 00:00:00

abstract：:Earlier investigations have revealed that polyethylene glycol-B1-insulin (PEG insulin) causes lower utilization of glucose in fat cells than does the unaltered hormone, even though the blood glucose-lowering activity of both preparations in intact animals is identical. The present study was aimed to establish whether ...

journal_title：Diabetes

authors： Neubauer HP,Obermeier R,Schöne HH

更新日期：1983-10-01 00:00:00