Perfect normalization of excessive glucagon responses to intravenous arginine in human diabetes mellitus with the artificial beta-cell.

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Observations of elevated circulating concentrations of visfatin (PBEF/Nampt) in obesity and diabetes suggest that this recently described adipokine is involved in the regulation of body weight and metabolism. We examined in humans whether visfatin is found in cerebrospinal fluid (CSF) and, if so, how CSF visf...

journal_title：Diabetes

authors： Hallschmid M,Randeva H,Tan BK,Kern W,Lehnert H

更新日期：2009-03-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:It is unknown whether and to what extent changes in various endothelial functions and adrenergic responsiveness are related to the development of microvascular complications in type 1 diabetes. Therefore, endothelium-dependent and endothelium-independent vasodilatation, endothelium-dependent hemostatic factors, and on...

journal_title：Diabetes

authors： Huvers FC,De Leeuw PW,Houben AJ,De Haan CH,Hamulyak K,Schouten H,Wolffenbuttel BH,Schaper NC

更新日期：1999-06-01 00:00:00

abstract：:The aim of this study was to compare the effects of insulin and the insulinomimetic agent, englitazone, on functional end points and putative mediators of insulin action in 3T3-L1 adipocytes. Cells were incubated with englitazone for 48 h or with insulin for 10 or 30 min, or both, and 2-deoxy-D-[3H]glucose (2DG) uptak...

journal_title：Diabetes

authors： Stevenson RW,Kreutter DK,Andrews KM,Genereux PE,Gibbs EM

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sha...

journal_title：Diabetes

authors： Parker A,Meyer J,Lewitzky S,Rennich JS,Chan G,Thomas JD,Orho-Melander M,Lehtovirta M,Forsblom C,Hyrkkö A,Carlsson M,Lindgren C,Groop LC

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Since vascular dysfunction is a main trait of obese subjects, in the present study we evaluated the vascular impact of resistin, a recently discovered hormone markedly increased in obesity. RESEARCH DESIGN AND METHODS:We performed our analysis on aortic and mesenteric segments from young and old C57BL/6 mice...

journal_title：Diabetes

authors： Gentile MT,Vecchione C,Marino G,Aretini A,Di Pardo A,Antenucci G,Maffei A,Cifelli G,Iorio L,Landolfi A,Frati G,Lembo G

更新日期：2008-03-01 00:00:00

abstract：:The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Peeters H,Bos D,van Zanten M,Boerman O,Gotthardt M

更新日期：2018-10-01 00:00:00

abstract：:GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by accumulated studies. Here,...

journal_title：Diabetes

authors： Xu F,Li Z,Zheng X,Liu H,Liang H,Xu H,Chen Z,Zeng K,Weng J

更新日期：2014-11-01 00:00:00

abstract：:Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cells. Insulin receptor...

journal_title：Diabetes

authors： Ren D,Sun J,Mao L,Ye H,Polonsky KS

更新日期：2014-10-01 00:00:00

abstract：:Changes in intracellular Ca(2+) concentration play a key role in the regulation of insulin secretion by glucose and other secretagogues. Here, we explore the importance of the secretory pathway Ca(2+)-ATPase, plasma membrane-related Ca(2+)-ATPase-1 (PMR1; human orthologue ATP2C1) in intracellular Ca(2+) homeostasis in...

journal_title：Diabetes

authors： Mitchell KJ,Tsuboi T,Rutter GA

更新日期：2004-02-01 00:00:00

abstract：:Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The antidiabetic thiazolidinediones shift the energy balance toward storage, leading to an increase in whole-body adiposity. These studies examine the effects of pioglitazone (Pio) on adipose tissue phy...

journal_title：Diabetes

authors： de Souza CJ,Eckhardt M,Gagen K,Dong M,Chen W,Laurent D,Burkey BF

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects of deleting the ZnT8 gene...

journal_title：Diabetes

authors： Nicolson TJ,Bellomo EA,Wijesekara N,Loder MK,Baldwin JM,Gyulkhandanyan AV,Koshkin V,Tarasov AI,Carzaniga R,Kronenberger K,Taneja TK,da Silva Xavier G,Libert S,Froguel P,Scharfmann R,Stetsyuk V,Ravassard P,Parker H,Gri

更新日期：2009-09-01 00:00:00

abstract：:In 112 obese compared with 42 lean children, we found that serum leptin is elevated early in the evolution of childhood-onset obesity (28.4 +/- 1.4 vs. 4.5 +/- 0.4 ng/ml in lean children, P < 0.0001) and correlates with adiposity. Obese children also had higher serum leptin normalized to fat mass. Despite high serum l...

journal_title：Diabetes

authors： Lahlou N,Landais P,De Boissieu D,Bougnères PF

更新日期：1997-06-01 00:00:00

abstract：:Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass (FM) of lean C57B6 mice fed a high-fat diet (HFD; FMC mice) was "cla...

journal_title：Diabetes

authors： Kirchner H,Hofmann SM,Fischer-Rosinský A,Hembree J,Abplanalp W,Ottaway N,Donelan E,Krishna R,Woods SC,Müller TD,Spranger J,Perez-Tilve D,Pfluger PT,Tschöp MH,Habegger KM

更新日期：2012-11-01 00:00:00

abstract：:The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

journal_title：Diabetes

authors：

更新日期：1977-05-01 00:00:00

abstract：:With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations betwee...

journal_title：Diabetes

authors： Elhadad MA,Jonasson C,Huth C,Wilson R,Gieger C,Matias P,Grallert H,Graumann J,Gailus-Durner V,Rathmann W,von Toerne C,Hauck SM,Koenig W,Sinner MF,Oprea TI,Suhre K,Thorand B,Hveem K,Peters A,Waldenberger M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS A...

journal_title：Diabetes

authors： McGee SL,van Denderen BJ,Howlett KF,Mollica J,Schertzer JD,Kemp BE,Hargreaves M

更新日期：2008-04-01 00:00:00

abstract：:A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

journal_title：Diabetes

authors： Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

更新日期：2020-10-01 00:00:00

abstract：:Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown. In this study, we showed that fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to ad...

journal_title：Diabetes

authors： Kuang J,Zhang Y,Liu Q,Shen J,Pu S,Cheng S,Chen L,Li H,Wu T,Li R,Li Y,Zou M,Zhang Z,Jiang W,Xu G,Qu A,Xie W,He J

更新日期：2017-05-01 00:00:00

abstract：:The natural history of progression from normal glucose tolerance (NGT) to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes is not well defined. We studied this progression using biennial oral glucose tolerance tests performed in the Baltimore Longitudinal Study of Aging and surviva...

journal_title：Diabetes

authors： Meigs JB,Muller DC,Nathan DM,Blake DR,Andres R,Baltimore Longitudinal Study of Aging.

更新日期：2003-06-01 00:00:00

abstract：:Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

journal_title：Diabetes

authors： Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

更新日期：2020-07-01 00:00:00

abstract：:Recently, missense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-peptide production to...

journal_title：Diabetes

authors： Liu M,Lara-Lemus R,Shan SO,Wright J,Haataja L,Barbetti F,Guo H,Larkin D,Arvan P

更新日期：2012-04-01 00:00:00

abstract：:Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell-mediated autoimmune disease. However, B-cells may also play a critical role in disease pathogenesis, as genetically B-cell-deficient NOD mice (NOD.microMT) have been shown to be protected from type 1 diabetes and to display reduced responses to ...

journal_title：Diabetes

authors： Chiu PP,Serreze DV,Danska JS

更新日期：2001-04-01 00:00:00

abstract：:Growth medium containing serum from young diabetic subjects caused a significant stimulation both of cell proliferation and of the outgrowth in cultures of rabbit aortic medial cells above that noted with normal human sera. The addition to the sera of guinea-pig human growth hormones antibody caused a marked inhibitio...

journal_title：Diabetes

authors： Ledet T

更新日期：1977-08-01 00:00:00

abstract：:The N6-methyladenosine (m6A) RNA modification is essential during embryonic development of various organs. However, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 ...

journal_title：Diabetes

authors： Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

更新日期：2020-08-01 00:00:00

abstract：:Diet-induced obesity is known to cause peripheral insulin resistance in rodents. We have recently found that feeding cod protein to high-fat-fed rats prevents the development of insulin resistance in skeletal muscle. In the present study, we have further explored the cellular mechanisms behind this beneficial effect o...

journal_title：Diabetes

authors： Tremblay F,Lavigne C,Jacques H,Marette A

更新日期：2003-01-01 00:00:00

abstract：:Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI) in a nonhypertensive obese canine model. SI was measured using euglycemic-hyper...

journal_title：Diabetes

authors： Iyer MS,Bergman RN,Korman JE,Woolcott OO,Kabir M,Victor RG,Clegg DJ,Kolka C

更新日期：2016-11-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is characterized by a metabolic and hormonal disarray that may be more evident during exercise. However, the metabolic response to exercise of different intensities has not been evaluated in IDDM. We therefore used stable isotope techniques and indirect calorimetry to quantif...

journal_title：Diabetes

authors： Raguso CA,Coggan AR,Gastaldelli A,Sidossis LS,Bastyr EJ 3rd,Wolfe RR

更新日期：1995-09-01 00:00:00