Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing.

abstract：:To evaluate the role of splanchnic and peripheral tissues in the disposal of an oral glucose load, splanchnic exchange of glucose, lactate, pyruvate, glycerol and amino acids was determined in ten healthy subjects in the basal state and for three hours following the oral ingestion of 100 gm. of glucose. Following glu...

journal_title：Diabetes

authors： Felig P,Wahren J,Hendler R

更新日期：1975-05-01 00:00:00

abstract：:The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as in the Edmonton protocol. To determine whether CIT07 improves engraf...

journal_title：Diabetes

authors： Rickels MR,Liu C,Shlansky-Goldberg RD,Soleimanpour SA,Vivek K,Kamoun M,Min Z,Markmann E,Palangian M,Dalton-Bakes C,Fuller C,Chiou AJ,Barker CF,Luning Prak ET,Naji A

更新日期：2013-08-01 00:00:00

abstract：:Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured...

journal_title：Diabetes

authors： Wajngot A,Alvarsson M,Glaser A,Efendic S,Luthman H,Grill V

更新日期：1994-12-01 00:00:00

abstract：:Myocardial dysfunction, perfusion abnormalities, and the extent to which these abnormalities may be reversed by C-peptide administration was assessed in type 1 diabetic patients. Eight patients were studied before and during a 0.84-mg/kg dipyridamole administration using a randomized double-blind crossover protocol wi...

journal_title：Diabetes

authors： Hansen A,Johansson BL,Wahren J,von Bibra H

更新日期：2002-10-01 00:00:00

abstract：:Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...

journal_title：Diabetes

authors： Johnson MB,De Franco E,Greeley SAW,Letourneau LR,Gillespie KM,International DS-PNDM Consortium.,Wakeling MN,Ellard S,Flanagan SE,Patel KA,Hattersley AT

更新日期：2019-07-01 00:00:00

abstract：:Eight manufacturing facilities participating in the National Institutes of Health-sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for the manufacture of allogeneic purified human pancreatic islet (PHPI) product evaluated in a phase 3 trial in subjects wi...

journal_title：Diabetes

authors： Ricordi C,Goldstein JS,Balamurugan AN,Szot GL,Kin T,Liu C,Czarniecki CW,Barbaro B,Bridges ND,Cano J,Clarke WR,Eggerman TL,Hunsicker LG,Kaufman DB,Khan A,Lafontant DE,Linetsky E,Luo X,Markmann JF,Naji A,Korsgren O

更新日期：2016-11-01 00:00:00

abstract：:The association of type 1 diabetes with the insulin gene (IDDM2 locus) has been mapped to a short haplotype encompassing two single nucleotide polymorphisms (SNPs) in perfect linkage disequilibrium (r(2) = 1) with each other and with the two allele classes at the variable number of tandem repeats (VNTR) polymorphism u...

journal_title：Diabetes

authors： Marchand L,Polychronakos C

更新日期：2007-03-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00

abstract：:Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose...

journal_title：Diabetes

authors： Tong J,Davis HW,Summer S,Benoit SC,Haque A,Bidlingmaier M,Tschöp MH,D'Alessio D

更新日期：2014-07-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, age 59 +/- 7 years (mean +/- SD), BMI 28.9 +/- 3.0 kg/m(2), HbA(1c) 6.5 +/- 0.6%, i...

journal_title：Diabetes

authors： Juhl CB,Hollingdal M,Sturis J,Jakobsen G,Agersø H,Veldhuis J,Pørksen N,Schmitz O

更新日期：2002-02-01 00:00:00

abstract：:For examining the effects of moderate exercise training on peripheral glucose effectiveness (S(g)(2)*), insulin sensitivity (S(i)(2)*), and endogenous glucose production (EGP), seven men and one woman (24.8 +/- 1.8 years) participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/we...

journal_title：Diabetes

authors： Nishida Y,Tokuyama K,Nagasaka S,Higaki Y,Shirai Y,Kiyonaga A,Shindo M,Kusaka I,Nakamura T,Ishibashi S,Tanaka H

更新日期：2004-02-01 00:00:00

abstract：:The Na+-pumping activity of the erythrocyte plasma membrane in diabetic subjects was studied together with the lipid composition. Insulin-dependent diabetes mellitus (IDDM) patients (n = 25) were divided into young (28.1 +/- 7.4 yr old, mean +/- SD; n = 16) and old (7.17 +/- 9.8 yr old; n = 10) subjects; the age of no...

journal_title：Diabetes

authors： Baldini P,Incerpi S,Lambert-Gardini S,Spinedi A,Luly P

更新日期：1989-07-01 00:00:00

abstract：:The objective of the study was to examine the potential differential effect of insulin and acipimox (both of which reduce free fatty acid [FFA] availability) on VLDL apolipoprotein (apo) B metabolism. We studied eight healthy men (age 40 +/- 4 years, BMI 25.8 +/- 0.9 kg/m2, plasma triglycerides 1.30 +/- 0.12 mmol/l) a...

journal_title：Diabetes

authors： Malmström R,Packard CJ,Caslake M,Bedford D,Stewart P,Yki-Järvinen H,Shepherd J,Taskinen MR

更新日期：1998-05-01 00:00:00

abstract：:This study investigated changes in levels of mRNAs encoding the three neurofilament (NF) proteins NF-L (low), NF-M (medium), and NF-H (high) and two growth-associated proteins, GAP-43 and T alpha 1 alpha-tubulin, in lumbar dorsal root ganglia of control and streptozocin-induced diabetic rats. After 8 weeks of diabetes...

journal_title：Diabetes

authors： Mohiuddin L,Fernyhough P,Tomlinson DR

更新日期：1995-01-01 00:00:00

abstract：:A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL encoding glutamine synthase, converting glutamic acid to glutamine. To f...

journal_title：Diabetes

authors： Pipino C,Shah H,Prudente S,Di Pietro N,Zeng L,Park K,Trischitta V,Pennathur S,Pandolfi A,Doria A

更新日期：2020-10-01 00:00:00

abstract：:Plasma dopamine-beta-hydroxylase (pDBH) activity is markedly elevated in chronic experimental streptozotocin (STZ) diabetes in the rat. Several possible explanations, all potentially relevant to the pathophysiology of diabetes, could explain this observation. The objective of this paper was to further delineate the be...

journal_title：Diabetes

authors： Schmidt RE,Geller DM,Johnson EM Jr

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS:We screened INS in 62 probands with MODY, 30 probands with suspected MODY,...

journal_title：Diabetes

authors： Molven A,Ringdal M,Nordbø AM,Raeder H,Støy J,Lipkind GM,Steiner DF,Philipson LH,Bergmann I,Aarskog D,Undlien DE,Joner G,Søvik O,Norwegian Childhood Diabetes Study Group.,Bell GI,Njølstad PR

更新日期：2008-04-01 00:00:00

abstract：:The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition o...

journal_title：Diabetes

authors： Virji MA,Steffes MW,Estensen RD

更新日期：1984-02-01 00:00:00

abstract：:Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+...

journal_title：Diabetes

authors： Nunemaker CS,Zhang M,Wasserman DH,McGuinness OP,Powers AC,Bertram R,Sherman A,Satin LS

更新日期：2005-12-01 00:00:00

abstract：:Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which...

journal_title：Diabetes

authors： Singh LP,Andy J,Anyamale V,Greene K,Alexander M,Crook ED

更新日期：2001-10-01 00:00:00

abstract：:It has been suggested that the hemodynamic derangements present in diabetic ketoacidosis are the results not only of profound volume depletion but also of the effects of increased production of vasodilating prostaglandins (PGs), principally PGI2, released by adipose tissue. In animal and in vitro models, prostaglandin...

journal_title：Diabetes

authors： Avogaro A,Crepaldi C,Piarulli F,Milan D,Valerio A,Pavan P,Sacerdoti D,Calabrò A,Macdonald I,Crepaldi G,Scognamiglio R,Tiengo A

更新日期：1996-05-01 00:00:00

abstract：:Increased hepatic gluconeogenesis maintains glycemia during fasting and has been considered responsible for elevated hepatic glucose output in type 2 diabetes. Glucose derived periportally via gluconeogenesis is partially taken up perivenously in perfused liver but not in adult rats whose mothers were protein-restrict...

journal_title：Diabetes

authors： Murphy HC,Regan G,Bogdarina IG,Clark AJ,Iles RA,Cohen RD,Hitman GA,Berry CL,Coade Z,Petry CJ,Burns SP

更新日期：2003-06-01 00:00:00

abstract：:We tested the hypothesis that activation of the protective arm of the renin angiotensin system, the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)]/Mas receptor axis, corrects the vasoreparative dysfunction typically seen in the CD34(+) cells isolated from diabetic individuals. Peripheral blood CD...

journal_title：Diabetes

authors： Jarajapu YP,Bhatwadekar AD,Caballero S,Hazra S,Shenoy V,Medina R,Kent D,Stitt AW,Thut C,Finney EM,Raizada MK,Grant MB

更新日期：2013-04-01 00:00:00

abstract：:The presence of the enzyme aldose reductase is increasingly being linked to diabetic complications. The distribution of this enzyme in human cornea, lens, retina, and optic nerve has been studied using specific antibodies against purified human placental aldose reductase raised in both rabbit and goat. The antisera fr...

journal_title：Diabetes

authors： Akagi Y,Yajima Y,Kador PF,Kuwabara T,Kinoshita JH

更新日期：1984-06-01 00:00:00

abstract：:Growth differentiation factor 11 (GDF11) has been shown to promote stem cell activity and rejuvenate the function of multiple organs in old mice, but little is known about the functions of GDF11 in the diabetic rat model of hindlimb ischemia. In this study, we found that systematic replenishment of GDF11 rescues angio...

journal_title：Diabetes

authors： Zhang J,Li Y,Li H,Zhu B,Wang L,Guo B,Xiang L,Dong J,Liu M,Xiang G

更新日期：2018-10-01 00:00:00

abstract：:Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...

journal_title：Diabetes

authors： Yao Y,Li Y,Song Q,Hu C,Xie W,Xu C,Chen Q,Wang QK

更新日期：2019-08-01 00:00:00

abstract：:The underlying pathophysiology of the metabolic syndrome is the subject of debate, with both insulin resistance and obesity considered as important factors. We evaluated the differential effects of insulin resistance and central body fat distribution in determining the metabolic syndrome as defined by the National Cho...

journal_title：Diabetes

authors： Carr DB,Utzschneider KM,Hull RL,Kodama K,Retzlaff BM,Brunzell JD,Shofer JB,Fish BE,Knopp RH,Kahn SE

更新日期：2004-08-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in more detail than previously done and, for the first time, analyzed the steady-state recycling and subseq...

journal_title：Diabetes

authors： Lauritzen HP,Galbo H,Brandauer J,Goodyear LJ,Ploug T

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages. RESEARCH DESIGN AND METHODS:We determined cytokine pro...

journal_title：Diabetes

authors： Su D,Coudriet GM,Hyun Kim D,Lu Y,Perdomo G,Qu S,Slusher S,Tse HM,Piganelli J,Giannoukakis N,Zhang J,Dong HH

更新日期：2009-11-01 00:00:00