C-peptide exerts beneficial effects on myocardial blood flow and function in patients with type 1 diabetes.

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a d...

journal_title：Diabetes

authors： Chibber R,Molinatti PA,Wong JS,Mirlees D,Kohner EM

更新日期：1994-06-01 00:00:00

abstract：:Brain lactate may be involved in the development of impaired awareness of hypoglycemia (IAH), a condition that affects approximately 25% of patients with type 1 diabetes and increases the risk of severe hypoglycemia. The aim of this study was to investigate the effect of acute hypoglycemia on brain lactate concentrati...

journal_title：Diabetes

authors： Wiegers EC,Rooijackers HM,Tack CJ,Heerschap A,de Galan BE,van der Graaf M

更新日期：2016-06-01 00:00:00

abstract：:The transplantation of human fetal pancreas has been suggested as a means of treatment of insulin-dependent diabetes in man. We have obtained human fetal pancreata during the second trimester of pregnancy and transplanted 1-mm3 explants subcutaneously (s.c.) into both diabetic and nondiabetic nude mice, some of the ti...

journal_title：Diabetes

authors： Tuch BE,Ng AB,Jones A,Turtle JR

更新日期：1984-12-01 00:00:00

abstract：:Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...

journal_title：Diabetes

authors： Sandhu MS,Gibson JM,Heald AH,Dunger DB,Wareham NJ

更新日期：2003-06-01 00:00:00

abstract：:Cryopreservation of islets of Langerhans offers a number of important benefits for attempts to cure diabetes by transplantation. In the published literature, a variety of cooling rates, ranging from 0.25 to 75 degrees C/min, in conjunction with warming rates of 4-200 degrees C/min have been proposed to give optimal pr...

journal_title：Diabetes

authors： Taylor MJ,Benton MJ

更新日期：1987-01-01 00:00:00

abstract：:We have recently reported successful 72-h preservation of the canine pancreas with a new cold-storage solution developed at the University of Wisconsin (UW solution). Over 10 mo, we performed 11 combined pancreas-kidney and 4 isolated-pancreas transplants with this solution. In situ cooling of the donor pancreas was p...

journal_title：Diabetes

authors： D'Alessandro AM,Stratta RJ,Sollinger HW,Kalayoglu M,Pirsch JD,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma. We now report the results of further detailed pathophysiological evaluation of these subj...

journal_title：Diabetes

authors： Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

更新日期：2003-04-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors effici...

journal_title：Diabetes

authors： Leibowitz G,Beattie GM,Kafri T,Cirulli V,Lopez AD,Hayek A,Levine F

更新日期：1999-04-01 00:00:00

abstract：:Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...

journal_title：Diabetes

authors： Henry RR,Abrams L,Nikoulina S,Ciaraldi TP

更新日期：1995-08-01 00:00:00

abstract：:Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and transmission of its biological signals, bound insulin undergoes receptor-mediated endocytosis and consequent degradation. An inactive insulin derivative that is not recognized by the receptor has a longer circulation li...

journal_title：Diabetes

authors： Gershonov E,Shechter Y,Fridkin M

更新日期：1999-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow-derived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment an...

journal_title：Diabetes

authors： Hayward JA,Ellis CE,Seeberger K,Lee T,Salama B,Mulet-Sierra A,Kuppan P,Adesida A,Korbutt GS

更新日期：2017-05-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：:We investigated the effects of non-insulin-dependent diabetes mellitus (NIDDM) on lipoprotein(a) (Lp[a]) and apolipoprotein(a) (apo[a]) in a population of Mexican-Americans. In plasma samples from 536 subjects, we measured Lp(a) concentrations, and we estimated apo(a) isoform sizes following immunostaining of plasma p...

journal_title：Diabetes

authors： Rainwater DL,MacCluer JW,Stern MP,VandeBerg JL,Haffner SM

更新日期：1994-07-01 00:00:00

abstract：:The role of interferons, either pathogenic or protective, during autoimmune diabetes remains controversial. Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]). ...

journal_title：Diabetes

authors： Carrero JA,Benshoff ND,Nalley K,Unanue ER

更新日期：2018-09-01 00:00:00

abstract：:Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable h...

journal_title：Diabetes

authors： Fatehi M,Raja M,Carter C,Soliman D,Holt A,Light PE

更新日期：2012-01-01 00:00:00

abstract：:Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) often coexist and as such represent a potent risk factor for subsequent development of type 2 diabetes. beta-Cell mass is approximately 50% deficient in IFG and approximately 65% deficient in type 2 diabetes. To establish the effect of a approximately...

journal_title：Diabetes

authors： Matveyenko AV,Veldhuis JD,Butler PC

更新日期：2006-08-01 00:00:00

abstract：:To assess the relationship between beta-cell function and the level and duration of hyperglycemia during generalized beta-cell impairment, we studied the effects of acute and prolonged infusion of somatostatin in seven normal men. Twenty minutes after beginning an acute infusion of somatostatin (200 microgram/h) plus ...

journal_title：Diabetes

authors： Ward WK,Halter JB,Best JD,Beard JC,Porte D Jr

更新日期：1983-10-01 00:00:00

abstract：:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...

journal_title：Diabetes

authors： McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JR

更新日期：1988-03-01 00:00:00

abstract：:Growth differentiation factor 11 (GDF11) has been shown to promote stem cell activity and rejuvenate the function of multiple organs in old mice, but little is known about the functions of GDF11 in the diabetic rat model of hindlimb ischemia. In this study, we found that systematic replenishment of GDF11 rescues angio...

journal_title：Diabetes

authors： Zhang J,Li Y,Li H,Zhu B,Wang L,Guo B,Xiang L,Dong J,Liu M,Xiang G

更新日期：2018-10-01 00:00:00

abstract：:Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves' disease in comparison to healthy control subjects by st...

journal_title：Diabetes

authors： Kallmann BA,Hüther M,Tubes M,Feldkamp J,Bertrams J,Gries FA,Lampeter EF,Kolb H

更新日期：1997-02-01 00:00:00

abstract：:Monoclonal antibodies to T-cell coreceptors have been shown to tolerise autoreactive T-cells and prevent or even reverse autoimmune pathology. In type 1 diabetes, there is a loss of insulin-secreting beta-cells, and a cure for type 1 diabetes would require not only tolerance induction but also recovery of the function...

journal_title：Diabetes

authors： Phillips JM,O'Reilly L,Bland C,Foulis AK,Cooke A

更新日期：2007-03-01 00:00:00

abstract：:Kinetic studies were carried out on liver glycogen synthase and phosphorylase isolated from genetically diabetic db/db mice. Glycogen synthase a and b enzymes from diabetic mice had Vmax values 30% and 20% lower, respectively, than the enzymes from normal mice. Glycogen synthase b from diabetic mice also had a 30% low...

journal_title：Diabetes

authors： Roesler WJ,Khandelwal RL

更新日期：1986-02-01 00:00:00

abstract：:Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is an oxidative stress-sensitive channel involved in cell death; therefore, we have examined its potential role in endothelial cells ...

journal_title：Diabetes

authors： Detaille D,Guigas B,Chauvin C,Batandier C,Fontaine E,Wiernsperger N,Leverve X

更新日期：2005-07-01 00:00:00

abstract：:To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Ak...

journal_title：Diabetes

authors： Ozawa K,Miyazaki M,Matsuhisa M,Takano K,Nakatani Y,Hatazaki M,Tamatani T,Yamagata K,Miyagawa J,Kitao Y,Hori O,Yamasaki Y,Ogawa S

更新日期：2005-03-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of end-stage renal disease requiring dialysis in developed countries. In this study, we demonstrated the therapeutic effect of hepatocyte growth factor (HGF) on advanced rather than early diabetic nephropathy using a rat model of streptozotocin-induced diabetes. Early diabetic ne...

journal_title：Diabetes

authors： Cruzado JM,Lloberas N,Torras J,Riera M,Fillat C,Herrero-Fresneda I,Aran JM,Alperovich G,Vidal A,Grinyó JM

更新日期：2004-04-01 00:00:00

abstract：:The association of type 1 diabetes with the insulin gene (IDDM2 locus) has been mapped to a short haplotype encompassing two single nucleotide polymorphisms (SNPs) in perfect linkage disequilibrium (r(2) = 1) with each other and with the two allele classes at the variable number of tandem repeats (VNTR) polymorphism u...

journal_title：Diabetes

authors： Marchand L,Polychronakos C

更新日期：2007-03-01 00:00:00

abstract：:Dissociated human insulinoma cells were plated onto plastic multiwell dishes. Cells were maintained for 1 mo on plastic with three passages. Cultures consisted of small colonies with some areas of stratification and few intercellular spaces. Ultrastructural studies indicated that cultured cells had epithelial features...

journal_title：Diabetes

authors： Thivolet CH,Demidem A,Haftek M,Durand A,Bertrand J

更新日期：1988-09-01 00:00:00