Abstract:
:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the maximal synthetic rate of this substance in the rats. Treatment of diabetic rats with this regime prevented the decrease in activity of granulation tissue prolyl hydroxylase (PRLase), an AA-dependent enzyme required for maintaining the normal properties of collagen. The decreased plasma AA concentration and granulation tissue PRLase activity in diabetes can also be normalized by the aldose reductase inhibitor tolrestat. We conclude that in diabetic animals there is a true deficiency of AA that may be responsible for some of the changes of collagen observed in diabetes. Treatment with AA or an aldose reductase inhibitor may prevent some of the diabetic complications with underlying collagen abnormalities.
journal_name
Diabetesjournal_title
Diabetesauthors
McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JRdoi
10.2337/diab.37.3.359subject
Has Abstractpub_date
1988-03-01 00:00:00pages
359-61issue
3eissn
0012-1797issn
1939-327Xjournal_volume
37pub_type
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