Insulin and metformin regulate circulating and adipose tissue chemerin.

Abstract:

OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzyme-linked immunosorbent assay. We investigated the in vivo effects of insulin on serum chemerin levels via a prolonged insulin-glucose infusion. Ex vivo effects of insulin, metformin, and steroid hormones on adipose tissue chemerin protein production and secretion into conditioned media were assessed by Western blotting and enzyme-linked immunosorbent assay, respectively. RESULTS:Serum chemerin, subcutaneous, and omental adipose tissue chemerin were significantly higher in women with PCOS (n = 14; P < 0.05, P < 0.01). Hyperinsulinemic induction in human subjects significantly increased serum chemerin levels (n = 6; P < 0.05, P < 0.01). In adipose tissue explants, insulin significantly increased (n = 6; P < 0.05, P < 0.01) whereas metformin significantly decreased (n = 6; P < 0.05, P < 0.01) chemerin protein production and secretion into conditioned media, respectively. After 6 months of metformin treatment, there was a significant decrease in serum chemerin (n = 21; P < 0.01). Importantly, changes in homeostasis model assessment-insulin resistance were predictive of changes in serum chemerin (P = 0.046). CONCLUSIONS:Serum and adipose tissue chemerin levels are increased in women with PCOS and are upregulated by insulin. Metformin treatment decreases serum chemerin in these women.

journal_name

Diabetes

journal_title

Diabetes

authors

Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

doi

10.2337/db08-1528

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

1971-7

issue

9

eissn

0012-1797

issn

1939-327X

pii

db08-1528

journal_volume

58

pub_type

杂志文章

相关文献

DIABETES文献大全
  • Determination of encephalomyocarditis viral diabetogenicity by a putative binding site of the viral capsid protein.

    abstract::The molecular mechanism by which some, but not all, variants of encephalomyocarditis (EMC) virus selectively infect pancreatic beta-cells in mice and induce IDDM has been an enigma for more than a decade. We report here that the binding site of the EMC viral capsid protein VP1 determines viral diabetogenicity. Recombi...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.47.4.576

    authors: Jun HS,Kang Y,Yoon HS,Kim KH,Notkins AL,Yoon JW

    更新日期:1998-04-01 00:00:00

  • Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats.

    abstract::In view of reports that accessory pathways of glucose oxidation are enhanced in the diabetic state, we have determined the levels of key enzymes of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Genetically diabetic mice (db/db) were found to have increased levels of two NADP-linked enzymes of...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.28.9.793

    authors: Tulsiani DR,Touster O

    更新日期:1979-09-01 00:00:00

  • Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes.

    abstract::Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive. We aimed to define monocyte COX expression in type...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-0447

    authors: Beyan H,Goodier MR,Nawroly NS,Hawa MI,Bustin SA,Ogunkolade WB,Londei M,Yousaf N,Leslie RD

    更新日期:2006-12-01 00:00:00

  • Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.

    abstract::Changes in tissue levels of sorbitol, myo-inositol, and Na+-K+-ATPase enzyme activity have been implicated in the development of diabetic complications in animal models of the disease and in humans. The ability of the aldose reductase inhibitor sorbinil to reverse the hyperglycemia-induced changes in these lenticular ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.36.12.1414

    authors: Yeh LA,Rafford CE,Goddu KJ,Ashton MA,Beyer TA,Hutson NJ

    更新日期:1987-12-01 00:00:00

  • Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the atherosclerosis risk in communities (ARIC) study.

    abstract::The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.12.3524

    authors: Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

    更新日期:2002-12-01 00:00:00

  • Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo.

    abstract::This study was undertaken to test two assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo. For the assumption that incorporation into glucose of products of [14C]acetate metabolism does not affect the distribution of label within the glucose molecule, we infused [2-14C]acetate in 17 healt...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.42.5.732

    authors: Consoli A,Nurjhan N,Capani F,Pangburn T,Lapenna D,Gerich J

    更新日期:1993-05-01 00:00:00

  • Cellular Origins of Beige Fat Cells Revisited.

    abstract::Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db19-0308

    authors: Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

    更新日期:2019-10-01 00:00:00

  • Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control.

    abstract::Impairment of suppressor-cell activity may be important in the pathogenesis and maintenance of insulin-dependent diabetes mellitus (IDDM). In 23 recent-onset IDDM patients, lymphocyte sensitivity in vitro to theophylline was tested both in basal conditions and after improvement of metabolic control. This pharmacologic...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.35.9.1053

    authors: Crosti F,Secchi A,Ferrero E,Falqui L,Inverardi L,Pontiroli AE,Ciboddo GF,Pavoni D,Protti P,Rugarli C

    更新日期:1986-09-01 00:00:00

  • Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome.

    abstract::Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0062

    authors: Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

    更新日期:2020-11-01 00:00:00

  • Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians.

    abstract::We examined the hypothesis that imprinted genes may affect the propensity to type 2 diabetes and obesity in Pima Indians. Multipoint variance component methods were used to assess linkage of BMI (kg/m(2)) and age-adjusted diabetes to loci derived from either father (LOD(FA)) or mother (LOD(MO)) in a genome-wide scan. ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.50.12.2850

    authors: Lindsay RS,Kobes S,Knowler WC,Bennett PH,Hanson RL

    更新日期:2001-12-01 00:00:00

  • Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture.

    abstract::The Edwin Bierman Award Lecture is presented in honor of the memory of Edwin L. Bierman, MD, an exemplary scientist, mentor, and leader in the field of diabetes, obesity, hyperlipidemia, and atherosclerosis. The award and lecture recognizes a leading scientist in the field of macrovascular complications and contributi...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/db16-0152

    authors: King GL,Park K,Li Q

    更新日期:2016-06-01 00:00:00

  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.

    abstract::Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db14-0375

    authors: Vandal M,White PJ,Tremblay C,St-Amour I,Chevrier G,Emond V,Lefrançois D,Virgili J,Planel E,Giguere Y,Marette A,Calon F

    更新日期:2014-12-01 00:00:00

  • Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes.

    abstract::Elevated levels of advanced glycosylation end products (AGEs) have been found in multiple tissues in association with diabetic vascular complications and during the microalbuminuric phase of diabetic nephropathy. In this study, we have used an AGE-specific enzyme-linked immunosorbent assay (ELISA) to measure skin AGEs...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.44.7.824

    authors: Beisswenger PJ,Makita Z,Curphey TJ,Moore LL,Jean S,Brinck-Johnsen T,Bucala R,Vlassara H

    更新日期:1995-07-01 00:00:00

  • Lack of association of the polymorphic locus in the 5'-flanking region of the human insulin gene and diabetes in American blacks.

    abstract::A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). Frequencies of these classe...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.34.5.433

    authors: Elbein S,Rotwein P,Permutt MA,Bell GI,Sanz N,Karam JH

    更新日期:1985-05-01 00:00:00

  • Control of adipose tissue inflammation through TRB1.

    abstract:OBJECTIVE:Based on its role as an energy storage compartment and endocrine organ, white adipose tissue (WAT) fulfills a critical function in the maintenance of whole-body energy homeostasis. Indeed, WAT dysfunction is connected to obesity-related type 2 diabetes triggered at least partly by an inflammatory response in ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1537

    authors: Ostertag A,Jones A,Rose AJ,Liebert M,Kleinsorg S,Reimann A,Vegiopoulos A,Berriel Diaz M,Strzoda D,Yamamoto M,Satoh T,Akira S,Herzig S

    更新日期:2010-08-01 00:00:00

  • Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.

    abstract:OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1593

    authors: Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

    更新日期:2010-08-01 00:00:00

  • A new murine model of islet xenograft rejection: graft destruction is dependent on a major histocompatibility-specific interaction between T-cells and macrophages.

    abstract::A new murine model of porcine islet-like cell cluster (ICC) xenograft rejection, avoiding interference of unspecific inflammation, was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) mice were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the ori...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.52.5.1111

    authors: Schmidt P,Krook H,Maeda A,Korsgren O,Benda B

    更新日期:2003-05-01 00:00:00

  • Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

    abstract::One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the gene encoding hepatocyte nuclear factor (HNF)-1 alpha. We generated transgenic mice expressing a naturally occurring dominant-negative form of human HNF-1 alpha (P291fsinsC) in pancreatic beta-cells. A progressive hyperglycemia ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.1.114

    authors: Yamagata K,Nammo T,Moriwaki M,Ihara A,Iizuka K,Yang Q,Satoh T,Li M,Uenaka R,Okita K,Iwahashi H,Zhu Q,Cao Y,Imagawa A,Tochino Y,Hanafusa T,Miyagawa J,Matsuzawa Y

    更新日期:2002-01-01 00:00:00

  • Glucose-induced increases in renal hemodynamic function. Possible modulation by renal prostaglandins.

    abstract::Increased glomerular filtration rate and kidney size early in the course of experimental and human diabetes may be important in the pathogenesis of diabetic nephropathy. Factors causing these renal functional changes are unknown. The isolated, perfused rat kidney (IPRK) was used to study the effects of elevated glucos...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.34.4.360

    authors: Kasiske BL,O'Donnell MP,Keane WF

    更新日期:1985-04-01 00:00:00

  • Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study.

    abstract::Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0630

    authors: Bamberg F,Hetterich H,Rospleszcz S,Lorbeer R,Auweter SD,Schlett CL,Schafnitzel A,Bayerl C,Schindler A,Saam T,Müller-Peltzer K,Sommer W,Zitzelsberger T,Machann J,Ingrisch M,Selder S,Rathmann W,Heier M,Linkohr B,Meisi

    更新日期:2017-01-01 00:00:00

  • ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes.

    abstract::Type 1 diabetes results from the destruction of β-cells by an autoimmune T-cell response assisted by antigen-presenting B cells producing autoantibodies. CD8(+) T-cell responses against islet cell antigens, thought to play a central role in diabetes pathogenesis, can be monitored using enzyme-linked immunosorbent spot...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-0071

    authors: Énée É,Kratzer R,Arnoux JB,Barilleau E,Hamel Y,Marchi C,Beltrand J,Michaud B,Chatenoud L,Robert JJ,van Endert P

    更新日期:2012-07-01 00:00:00

  • Cumulative risk, age at onset, and sex-specific differences for developing end-stage renal disease in young patients with type 1 diabetes: a nationwide population-based cohort study.

    abstract:OBJECTIVE:This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS:In Sweden, all incident ca...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1744

    authors: Möllsten A,Svensson M,Waernbaum I,Berhan Y,Schön S,Nyström L,Arnqvist HJ,Dahlquist G,Swedish Childhood Diabetes Study Group.,Diabetes Incidence Study in Sweden.,Swedish Renal Registry.

    更新日期:2010-07-01 00:00:00

  • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs.

    abstract::Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the biological activity of GIP in vivo is still largely unknown. In nonfasted anesthetized pigs given an intravenous infusion of ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.50.7.1588

    authors: Deacon CF,Danielsen P,Klarskov L,Olesen M,Holst JJ

    更新日期:2001-07-01 00:00:00

  • Effects of hyperinsulinemia in the primate fetus.

    abstract::Nonhuman primate models of gestational diabetes have produced fetopathies most similar to those of the human infant of the mother with gestational diabetes (IGDM). Fetal hyperglycemia, hyperinsulinemia, macrosomia, selective organomegaly, intrauterine death, and placental hyperplasia are hallmarks of the fetopathy of ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.34.2.s36

    authors: Susa JB,Schwartz R

    更新日期:1985-06-01 00:00:00

  • High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

    abstract:OBJECTIVE:Recently, several drugs have been shown to exert beneficial effects for metabolic syndrome through mild regulation of mitochondrial function. Hence, we explored a strategy of targeting mitochondrial function to improve glucose and lipid metabolism. RESEARCH DESIGN AND METHODS:Mitochondrial membrane potential...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-0223

    authors: Qiu BY,Turner N,Li YY,Gu M,Huang MW,Wu F,Pang T,Nan FJ,Ye JM,Li JY,Li J

    更新日期:2010-01-01 00:00:00

  • Lactate production in pancreatic islets.

    abstract::Lactate production, glucose utilization, glucose oxidation, and insulin release were studied in islets from rat and ob/ob mice. Lactate was determined with a highly sensitive method, based on esterification, subsequent separation, and quantitation with high-performance liquid chromatography. There was a significant la...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.47.8.1219

    authors: Tamarit-Rodriguez J,Idahl LA,Giné E,Alcazar O,Sehlin J

    更新日期:1998-08-01 00:00:00

  • 6-Phosphogluconate/glucose-6-phosphate ratio in rat pancreatic islets during inhibition of insulin release by exogenous insulin.

    abstract::Inhibition of glucose-stimulated insulin release by exogenous insulin has been demonstrated in pancreatic islets to be associated with a decrease of the NADPH/NADP ratio and the pentose-phosphate cycle activity. Batches of five islets were incubated for 15 and 90 minutes in 1 ml. of KRB buffer with 2 per cent albumin ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.26.9.857

    authors: Akhtar MS,Verspohl E,Hegner D,Ammon HP

    更新日期:1977-09-01 00:00:00

  • Elevated islet amyloid pancreatic polypeptide and proinsulin in lean gestational diabetes.

    abstract::Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.46.4.607

    authors: Kautzky-Willer A,Thomaseth K,Ludvik B,Nowotny P,Rabensteiner D,Waldhäusl W,Pacini G,Prager R

    更新日期:1997-04-01 00:00:00

  • CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.

    abstract::Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. Podocytes are important for glomerular filtration barrier function and maintenance of size selectivity in protein filtration in the kidney. Podocyte damage is the basis of many glomerular diseases characterized by loss of interdigitatin...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db16-0081

    authors: Teng B,Schroder P,Müller-Deile J,Schenk H,Staggs L,Tossidou I,Dikic I,Haller H,Schiffer M

    更新日期:2016-12-01 00:00:00

  • Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

    abstract::Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following treatment. Patients with established type 1 diabetes (duration 4-24 mont...

    journal_title:Diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/db16-0823

    authors: Haller MJ,Gitelman SE,Gottlieb PA,Michels AW,Perry DJ,Schultz AR,Hulme MA,Shuster JJ,Zou B,Wasserfall CH,Posgai AL,Mathews CE,Brusko TM,Atkinson MA,Schatz DA

    更新日期:2016-12-01 00:00:00