Progression from insulitis to beta-cell destruction in NOD mouse requires L3T4+ T-lymphocytes.

abstract：:The hyperinsulinemia of obese rodents has been associated with a reduced number of hepatic insulin receptors except in hepatocytes from fatty Zucker rats. We isolated liver plasma membranes from 10-11-wk-old lean and fatty Zucker rats, some of which were injected with streptozotocin 2--4 wk earlier. We have determined...

journal_title：Diabetes

authors： Clark JB,Keen S,Clark CM Jr

更新日期：1982-10-01 00:00:00

abstract：:Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass (FM) of lean C57B6 mice fed a high-fat diet (HFD; FMC mice) was "cla...

journal_title：Diabetes

authors： Kirchner H,Hofmann SM,Fischer-Rosinský A,Hembree J,Abplanalp W,Ottaway N,Donelan E,Krishna R,Woods SC,Müller TD,Spranger J,Perez-Tilve D,Pfluger PT,Tschöp MH,Habegger KM

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of these metabolic abnormalities. We examined whether aging per se (in s...

journal_title：Diabetes

authors： Ghosh S,Lertwattanarak R,Lefort N,Molina-Carrion M,Joya-Galeana J,Bowen BP,Garduno-Garcia Jde J,Abdul-Ghani M,Richardson A,DeFronzo RA,Mandarino L,Van Remmen H,Musi N

更新日期：2011-08-01 00:00:00

abstract：:Transcription factor expression fluctuates during β-cell ontogeny, and disruptions in this pattern can affect the development or function of those cells. Here we uncovered that murine endocrine pancreatic progenitors express high levels of the homeodomain transcription factor Prox1, whereas both immature and mature β-...

journal_title：Diabetes

authors： Paul L,Walker EM,Drosos Y,Cyphert HA,Neale G,Stein R,South J,Grosveld G,Herrera PL,Sosa-Pineda B

更新日期：2016-03-01 00:00:00

abstract：:Activation of the receptor for advanced glycation end products (RAGE) reportedly triggers a variety of proinflammatory responses. However, our previous work revealed that RAGE-binding AGEs free of endotoxin were incapable of inducing vascular cell adhesion molecule-1 (VCAM-1) or tumor necrosis factor-alpha (TNF-alpha)...

journal_title：Diabetes

authors： Valencia JV,Mone M,Zhang J,Weetall M,Buxton FP,Hughes TE

更新日期：2004-03-01 00:00:00

abstract：:We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...

journal_title：Diabetes

authors： Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2017-07-01 00:00:00

abstract：:Neogenesis is crucial for the maintenance of beta-cell mass in the human pancreas and possibly for the outcome of clinical islet transplantation. To date, no studies have reported a stimulation of human beta-cell neogenesis in vivo. Therefore, we investigated whether human alpha-, beta-, and duct cell growth can be st...

journal_title：Diabetes

authors： Tyrberg B,Ustinov J,Otonkoski T,Andersson A

更新日期：2001-02-01 00:00:00

abstract：:Insulin requirements for meals were measured in eight insulin-dependent diabetic patients, using a closed-loop insulin infusion system. Patients required more insulin for breakfast than for an isocaloric lunch (35.7 +/- 5.5 mU/kcal/3 h versus 26.9 +/- 5.1 mU/kcal/3 h, P less than 0.02) or an isocaloric supper (35.7 +/...

journal_title：Diabetes

authors： Nestler JE,Gebhart SS,Blackard WG

更新日期：1984-03-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:We have biochemically treated (periodate, borohydride, neuraminidase, organic solvents) frozen sections of human pancreas and studied the reactivity of islet-cell-antibody-positive human sera and monoclonal antibodies. The autoantigen of pancreatic sections has the properties of sialic acid containing glycolipid. ...

journal_title：Diabetes

authors： Nayak RC,Omar MA,Rabizadeh A,Srikanta S,Eisenbarth GS

更新日期：1985-06-01 00:00:00

abstract：:To test the general applicability of the hypothesis that diabetes mellitus causes increased polyol pathway activity, decreased tissue free myo-inositol, and resultant pathological changes in tissues susceptible to the ravages of diabetes, we measured glucose, sorbitol, and myo-inositol with quantitative histochemical ...

journal_title：Diabetes

authors： Loy A,Lurie KG,Ghosh A,Wilson JM,MacGregor LC,Matschinsky FM

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：:In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to palmitate) on the function and survival of isolated human islets and investigated some of the possible mechanisms. Compared with ...

journal_title：Diabetes

authors： Lupi R,Dotta F,Marselli L,Del Guerra S,Masini M,Santangelo C,Patané G,Boggi U,Piro S,Anello M,Bergamini E,Mosca F,Di Mario U,Del Prato S,Marchetti P

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:Obesity is associated with increased activation of the c-Jun NH(2)-terminal kinase (JNK) in several metabolic organs, including adipose tissue, liver, and skeletal muscle. In this study, we aimed to define the role of JNK activation in adipose tissue in the development of obesity-related insulin resistance. ...

journal_title：Diabetes

authors： Zhang X,Xu A,Chung SK,Cresser JH,Sweeney G,Wong RL,Lin A,Lam KS

更新日期：2011-02-01 00:00:00

abstract：:The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a cl...

journal_title：Diabetes

authors： Kallionpää H,Somani J,Tuomela S,Ullah U,de Albuquerque R,Lönnberg T,Komsi E,Siljander H,Honkanen J,Härkönen T,Peet A,Tillmann V,Chandra V,Anagandula MK,Frisk G,Otonkoski T,Rasool O,Lund R,Lähdesmäki H,Knip M,Lahes

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes. RESEARCH DESIGN AND METHODS:Acutely diabetic NOD mice were tr...

journal_title：Diabetes

authors： Suarez-Pinzon WL,Power RF,Yan Y,Wasserfall C,Atkinson M,Rabinovitch A

更新日期：2008-12-01 00:00:00

abstract：:To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Ak...

journal_title：Diabetes

authors： Ozawa K,Miyazaki M,Matsuhisa M,Takano K,Nakatani Y,Hatazaki M,Tamatani T,Yamagata K,Miyagawa J,Kitao Y,Hori O,Yamasaki Y,Ogawa S

更新日期：2005-03-01 00:00:00

abstract：:We used mouse genetics to model how polygenic thresholds for the transition from impaired glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains selected for IGT and polygenic obesity, respectively. Their F1 male progeny consistently developed NIDDM. Genetic analysis of F2 males from ...

journal_title：Diabetes

authors： Leiter EH,Reifsnyder PC,Flurkey K,Partke HJ,Junger E,Herberg L

更新日期：1998-08-01 00:00:00

abstract：:The hormonal responses to low-level exercise in pregnancy have been studied in 13 insulin-requiring diabetic patients and 42 control subjects. We found no significant changes in plasma glucose, epinephrine, glucagon, or FFA with this level of exercise in the study group and control subjects; but plasma norepinephrine ...

journal_title：Diabetes

authors： Artal R,Wiswell R,Romem Y

更新日期：1985-06-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the biological activity of GIP in vivo is still largely unknown. In nonfasted anesthetized pigs given an intravenous infusion of ...

journal_title：Diabetes

authors： Deacon CF,Danielsen P,Klarskov L,Olesen M,Holst JJ

更新日期：2001-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps ...

journal_title：Diabetes

authors： Hamid YH,Urhammer SA,Jensen DP,Glümer C,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...

journal_title：Diabetes

authors： Gray SL,Nora ED,Grosse J,Manieri M,Stoeger T,Medina-Gomez G,Burling K,Wattler S,Russ A,Yeo GS,Chatterjee VK,O'Rahilly S,Voshol PJ,Cinti S,Vidal-Puig A

更新日期：2006-10-01 00:00:00

abstract：:We studied the effects of short-term (5 days) and long-term (2 wk) high carbohydrate (75%) feedings on insulin binding to isolated adipocytes and insulin sensitivity in vivo in normal subjects. Ingestion of the high carbohydrate diet led to daylong hyperinsulinemia in both short- and long-term groups. Insulin binding ...

journal_title：Diabetes

authors： Kolterman OG,Greenfield M,Reaven GM,Saekow M,Olefsky JM

更新日期：1979-08-01 00:00:00

abstract：:Fourteen rats of the spontaneously diabetic BB line were bled from the retroorbital sinus approximately every 10 days. Sera taken from an early age up to 20 days after the onset of overt diabetes were assayed for complement-fixing antibodies against antigens of the surface of islet cells (CFA). Dispersed islet cells f...

journal_title：Diabetes

authors： Martin DR,Logothetopoulos J

更新日期：1984-01-01 00:00:00

abstract：:Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

journal_title：Diabetes

authors： Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

更新日期：2020-07-01 00:00:00

abstract：:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...

journal_title：Diabetes

authors： Beitelshees AL,Leslie BR,Taylor SI

更新日期：2019-06-01 00:00:00

abstract：:Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI) in a nonhypertensive obese canine model. SI was measured using euglycemic-hyper...

journal_title：Diabetes

authors： Iyer MS,Bergman RN,Korman JE,Woolcott OO,Kabir M,Victor RG,Clegg DJ,Kolka C

更新日期：2016-11-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and chronic kidney disease-induced fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of diabetic nephropathy in a type 1 diabetic animal model, OVE26. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an HIF-1 inhibitor, red...

journal_title：Diabetes

authors： Nayak BK,Shanmugasundaram K,Friedrichs WE,Cavaglierii RC,Patel M,Barnes J,Block K

更新日期：2016-05-01 00:00:00

abstract：:Although the biochemical mechanism by which insulin and contractile activity affect protein turnover in muscle are still unclear, certain physiologic conclusions can be made; (a) Increased work can induce muscle hypertrophy even in the diabetic or starving animal. Thus, work-induced growth differs from normal growth o...

journal_title：Diabetes

authors： Goldberg AL

更新日期：1979-01-01 00:00:00