HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice.

abstract：:Diabetes-induced alterations in heme and hemoproteins, as well as its relationship to drug-mediated induction of ALA Synthase (ALA-S), were examined in female Sprague-Dawley rats. Animals were rendered diabetic by a single i.v. injection of streptozotocin (STZ, 65 mg/kg) and measurements were made at various times aft...

journal_title：Diabetes

authors： Bitar M,Weiner M

更新日期：1984-01-01 00:00:00

abstract：:Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear. Our goal was to elucidate mechanisms underlying the negative correlation between UCP3 and insulin resistance in muscle. We determined effects of physio...

journal_title：Diabetes

authors： MacLellan JD,Gerrits MF,Gowing A,Smith PJ,Wheeler MB,Harper ME

更新日期：2005-08-01 00:00:00

abstract：:The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...

journal_title：Diabetes

authors： Vastani N,Guenther F,Gentry C,Austin AL,King AJ,Bevan S,Andersson DA

更新日期：2018-08-01 00:00:00

abstract：:Determinants of proliferative diabetic retinopathy (PDR) that occur during the 2nd decade of insulin-dependent diabetes mellitus (IDDM) (early-onset PDR) were investigated in a nested case-control study. From an inception cohort of patients with juvenile-onset IDDM that now has 15-21 yr diabetes duration, the patients...

journal_title：Diabetes

authors： Krolewski AS,Barzilay J,Warram JH,Martin BC,Pfeifer M,Rand LI

更新日期：1992-04-01 00:00:00

abstract：:Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progres...

journal_title：Diabetes

authors： Triolo G,Davi' G,Giardina E,Cardella F,Meli F,La Grutta A,Strano A,Bompiani GD

更新日期：1984-08-01 00:00:00

abstract：:Enhanced advanced glycosylation end product (AGE) formation has been shown to participate in the pathogenesis of diabetes-induced glomerular injury by mediating the increased extracellular matrix (ECM) deposition and altered cell growth and turnover leading to mesangial expansion. These effects could be exerted via an...

journal_title：Diabetes

authors： Pugliese G,Pricci F,Romeo G,Pugliese F,Mené P,Giannini S,Cresci B,Galli G,Rotella CM,Vlassara H,Di Mario U

更新日期：1997-11-01 00:00:00

abstract：:In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K) enzyme system. In the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. To ...

journal_title：Diabetes

authors： Niswender KD,Morrison CD,Clegg DJ,Olson R,Baskin DG,Myers MG Jr,Seeley RJ,Schwartz MW

更新日期：2003-02-01 00:00:00

abstract：:Prostaglandin E (PGE) infusion in normal man inhibits the acute insulin response to glucose. In order to determine whether endogenously released PGE might also inhibit insulin secretion, glucose-stimulated insulin responses were investigated in normal volunteers after furosemide (40 mg i.v.), a stimulator of endogenou...

journal_title：Diabetes

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1979-09-01 00:00:00

abstract：:Previous studies of diabetic renovascular complications have measured morphologic changes in relatively few glomerular vessels by electron microscopy. The present study samples 20,000 to 80,000 glomeruli from each of ten nondiabetic and ten diabetic age- and sex-matched subjects. Glomeruli were isolated and fractionat...

journal_title：Diabetes

authors： Klein L,Butcher DL,Sudilovsky O,Kikkawa R,Miller M

更新日期：1975-12-01 00:00:00

abstract：:Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause a reciprocal decrease in glucose oxidation, which might impair insulin sensitivity and glucose tolerance. We therefore investigated wha...

journal_title：Diabetes

authors： Keung W,Ussher JR,Jaswal JS,Raubenheimer M,Lam VH,Wagg CS,Lopaschuk GD

更新日期：2013-03-01 00:00:00

abstract：:Spleen cells from conventional BALB/c or athymic mice with streptozotocin (SZ)-induced hyperglycemia failed to raise blood sugar levels when injected into athymic or thymus-sufficient recipients. Passive transfer efforts were unsuccessful despite variations in donor-recipient pairs with respect to age, thymic function...

journal_title：Diabetes

authors： Beattie G,Lannom R,Lipsick J,Kaplan NO,Osler AG

更新日期：1980-02-01 00:00:00

abstract：:Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...

journal_title：Diabetes

authors： Ueda K,Takimoto E,Lu Q,Liu P,Fukuma N,Adachi Y,Suzuki R,Chou S,Baur W,Aronovitz MJ,Greenberg AS,Komuro I,Karas RH

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:This study investigated changes in levels of mRNAs encoding the three neurofilament (NF) proteins NF-L (low), NF-M (medium), and NF-H (high) and two growth-associated proteins, GAP-43 and T alpha 1 alpha-tubulin, in lumbar dorsal root ganglia of control and streptozocin-induced diabetic rats. After 8 weeks of diabetes...

journal_title：Diabetes

authors： Mohiuddin L,Fernyhough P,Tomlinson DR

更新日期：1995-01-01 00:00:00

abstract：:Tolbutamide (1 g/kg body wt) was administered to male rats for 3 days to determine the effects of this pretreatment on subsequent insulin biosynthesis and compartmental storage characteristics of freshly isolated islets. Islets were isolated 16 h after the last tolbutamide administration, at a time when fed plasma glu...

journal_title：Diabetes

authors： Gold G,Pou J,Gishizky ML,Landahl HD,Grodsky GM

更新日期：1986-01-01 00:00:00

abstract：:Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

journal_title：Diabetes

authors： Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

更新日期：2005-04-01 00:00:00

abstract：:Patients with diabetes are at an increased risk for developing corneal disorders, often as a result of surgical and nonsurgical trauma. This study investigated whether intensive treatment of diabetes with the goal of maintaining blood glucose concentrations close to the normal range could ameliorate the delayed cornea...

journal_title：Diabetes

authors： Zagon IS,Sassani JW,McLaughlin PJ

更新日期：2006-04-01 00:00:00

abstract：:Islets from male B10.BR mice (H-2k) were isolated by the collagenase technique, handpicked with a Pasteur pipette, and incubated (either intact or after dispersion with Dispase) for 0, 3, 5, 7, 10, or 14 days in tissue culture medium supplemented with either lymphokine supernatants or recombinant murine interferon-gam...

journal_title：Diabetes

authors： Wright JR Jr,Lacy PE,Unanue ER,Muszynski C,Hauptfeld V

更新日期：1986-10-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ...

journal_title：Diabetes

authors： Grarup N,Andersen G,Krarup NT,Albrechtsen A,Schmitz O,Jørgensen T,Borch-Johnsen K,Hansen T,Pedersen O

更新日期：2008-09-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations are the most common cause of maturity-onset diabetes of the young. HNF-1alpha homozygous knockout mice exhibit a renal Fanconi syndrome with glucosuria and generalized aminoaciduria in addition to diabetes. We investigated glucosuria and aminoaciduria in patients...

journal_title：Diabetes

authors： Bingham C,Ellard S,Nicholls AJ,Pennock CA,Allen J,James AJ,Satchell SC,Salzmann MB,Hattersley AT

更新日期：2001-09-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge, higher height, and, paradoxically, higher BMI. We aimed to replicate the strength and effect size of these associations in independent samples and to assess the un...

journal_title：Diabetes

authors： Yaghootkar H,Stancáková A,Freathy RM,Vangipurapu J,Weedon MN,Xie W,Wood AR,Ferrannini E,Mari A,Ring SM,Lawlor DA,Davey Smith G,Jørgensen T,Hansen T,Pedersen O,Steinthorsdottir V,Guðbjartsson DF,Thorleifsson G,Thorstei

更新日期：2015-06-01 00:00:00

abstract：:We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...

journal_title：Diabetes

authors： Wang H,Rissanen J,Miettinen R,Kärkkäinen P,Kekäläinen P,Kuusisto J,Mykkänen L,Karhapää P,Laakso M

更新日期：2001-08-01 00:00:00

abstract：:The effect of nonenzymatic glycosylation on the biologic function of human antithrombin III was evaluated using a chromogenic thrombin substrate assay in the presence of catalytic amounts of heparin. Experimental conditions that increased the rate of nonenzymatic protein glycosylation were associated with decreases in...

journal_title：Diabetes

authors： Brownlee M,Vlassara H,Cerami A

更新日期：1984-06-01 00:00:00

abstract：:The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...

journal_title：Diabetes

authors： Sales VM,Gonçalves-Zillo T,Castoldi A,Burgos M,Branquinho J,Batista C,Oliveira V,Silva E,Castro CHM,Câmara N,Mori MA,Pesquero JB

更新日期：2019-08-01 00:00:00

abstract：:In 112 obese compared with 42 lean children, we found that serum leptin is elevated early in the evolution of childhood-onset obesity (28.4 +/- 1.4 vs. 4.5 +/- 0.4 ng/ml in lean children, P < 0.0001) and correlates with adiposity. Obese children also had higher serum leptin normalized to fat mass. Despite high serum l...

journal_title：Diabetes

authors： Lahlou N,Landais P,De Boissieu D,Bougnères PF

更新日期：1997-06-01 00:00:00

abstract：:The changes of the microvasculature of rat pancreas transplants during acute rejection were investigated and quantitatively analyzed. The vessels in pancreas transplants increased in caliber and decreased in density during acute rejection. These changes were marked in the exocrine pancreas, especially in central zones...

journal_title：Diabetes

authors： Nakai I,Aikawa I,Oka T

更新日期：1989-01-01 00:00:00

abstract：:Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging mammals and are frequently associated with leptin resistance and increased plasma leptin levels. To examine whether leptin's failure in aging is due to aging per se or to changes in body fat mass or distribution, we studied a...

journal_title：Diabetes

authors： Gabriely I,Ma XH,Yang XM,Rossetti L,Barzilai N

更新日期：2002-04-01 00:00:00

abstract：:Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...

journal_title：Diabetes

authors： Sandler S,Andersson A,Hellerström C,Petersson B,Swenne I,Björkén C,Groth CG

更新日期：1982-03-01 00:00:00