Leptin resistance during aging is independent of fat mass.

abstract：OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...

journal_title：Diabetes

authors： Villarreal-Molina MT,Flores-Dorantes MT,Arellano-Campos O,Villalobos-Comparan M,Rodríguez-Cruz M,Miliar-García A,Huertas-Vazquez A,Menjivar M,Romero-Hidalgo S,Wacher NH,Tusie-Luna MT,Cruz M,Aguilar-Salinas CA,Canizales-Quintero

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Glomerular filtration rate (GFR) is used to assess the progression of renal disease. We performed linkage analysis to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/Gallbladder Study. We also examined the effect of genotype by diabetes interaction (G x DM) on t...

journal_title：Diabetes

authors： Puppala S,Arya R,Thameem F,Arar NH,Bhandari K,Lehman DM,Schneider J,Fowler S,Farook VS,Diego VP,Almasy L,Blangero J,Stern MP,Duggirala R,Abboud HE

更新日期：2007-11-01 00:00:00

abstract：:Effects of oral administration of DG-5128, a new oral hypoglycemic agent, on glycemic control after a mixed meal and an in vivo glucose disposal were measured in subjects with nonobese non-insulin-dependent diabetes mellitus (NIDDM). Oral administration of DG-5128 significantly (P less than .05) enhanced insulin secre...

journal_title：Diabetes

authors： Kashiwagi A,Harano Y,Suzuki M,Kojima H,Harada M,Nishio Y,Shigeta Y

更新日期：1986-10-01 00:00:00

abstract：:Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In di...

journal_title：Diabetes

authors： Ishibashi T,Tanaka K,Taniguchi Y

更新日期：1981-07-01 00:00:00

abstract：:Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this "glucose effectiveness" is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous system have been shown to regulate EGP in humans and rodents. We examined the ...

journal_title：Diabetes

authors： Carey M,Lontchi-Yimagou E,Mitchell W,Reda S,Zhang K,Kehlenbrink S,Koppaka S,Maginley SR,Aleksic S,Bhansali S,Huffman DM,Hawkins M

更新日期：2020-06-01 00:00:00

abstract：:Mitochondria are the essential eukaryotic organelles that produce most cellular energy. The energy production and supply by mitochondria appear closely associated with the continuous shape change of mitochondria mediated by fission and fusion, as evidenced not only by the hereditary diseases caused by mutations in fis...

journal_title：Diabetes

authors： Galloway CA,Lee H,Nejjar S,Jhun BS,Yu T,Hsu W,Yoon Y

更新日期：2012-08-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：:Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...

journal_title：Diabetes

authors： Vandal M,White PJ,Tremblay C,St-Amour I,Chevrier G,Emond V,Lefrançois D,Virgili J,Planel E,Giguere Y,Marette A,Calon F

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has been reported to provide...

journal_title：Diabetes

authors： Smyth DJ,Cooper JD,Howson JM,Clarke P,Downes K,Mistry T,Stevens H,Walker NM,Todd JA

更新日期：2011-11-01 00:00:00

abstract：:The expression of nephropathy in type 2 diabetes has several levels of abnormalities. To define the primary abnormalities of diabetic nephropathy, we conducted an autopsy study of 186 consecutive patients with type 2 diabetes to determine correlations among the aldose reductase gene, renal histopathologies, extracellu...

journal_title：Diabetes

authors： Zhao HL,Tong PC,Lai FM,Tomlinson B,Chan JC

更新日期：2004-11-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS:Eight subjects with risk-conferring TCF7L2 genotypes (TT o...

journal_title：Diabetes

authors： Villareal DT,Robertson H,Bell GI,Patterson BW,Tran H,Wice B,Polonsky KS

更新日期：2010-02-01 00:00:00

abstract：:Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In the conscious dog, insulin was infused into the hepatic Po vein or a peripheral (Pe) vein at a rate fou...

journal_title：Diabetes

authors： Gregory JM,Kraft G,Scott MF,Neal DW,Farmer B,Smith MS,Hastings JR,Allen EJ,Donahue EP,Rivera N,Winnick JJ,Edgerton DS,Nishimura E,Fledelius C,Brand CL,Cherrington AD

更新日期：2015-10-01 00:00:00

abstract：:Finland has the world's highest incidence of type 1 diabetes, and it is steadily increasing. We determined concordance rates and estimated heritability for type 1 diabetes in the Finnish Twin Cohort, a population-based twin cohort of 22,650 twin pairs. In addition, we studied age of onset in the first affected twin an...

journal_title：Diabetes

authors： Hyttinen V,Kaprio J,Kinnunen L,Koskenvuo M,Tuomilehto J

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most patients. Mice deficient for the transcription factors E2F1 and E2F2 suffer from a chronic pancreatitis-like syndrome and become diabetic. Su...

journal_title：Diabetes

authors： Tessem JS,Jensen JN,Pelli H,Dai XM,Zong XH,Stanley ER,Jensen J,DeGregori J

更新日期：2008-06-01 00:00:00

abstract：:Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-s...

journal_title：Diabetes

authors： Softic S,Boucher J,Solheim MH,Fujisaka S,Haering MF,Homan EP,Winnay J,Perez-Atayde AR,Kahn CR

更新日期：2016-08-01 00:00:00

abstract：:Inadequate beta-cell function is an essential component of all forms of diabetes. The most obvious problem is a failure to maintain sufficient beta-cell mass and function to cope with whatever insulin resistance is present. The most striking functional defect is a loss of acute glucose-induced insulin secretion (GIIS)...

journal_title：Diabetes

authors： Weir GC,Laybutt DR,Kaneto H,Bonner-Weir S,Sharma A

更新日期：2001-02-01 00:00:00

abstract：:Our aim was to isolate and determine the contribution of partial pancreatectomy, systemic delivery of pancreatic hormones, and duct obliteration to glucose regulation after segmental pancreas transplantation in dogs. Fasting, postprandial, and intravenous glucose-stimulated glucose, insulin, glucagon, pancreatic polyp...

journal_title：Diabetes

authors： van der Burg MP,Gooszen HG,Guicherit OR,Jansen JB,Frölich M,van Haastert FA,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen...

journal_title：Diabetes

authors： Cohen WR,Deutsch J

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and...

journal_title：Diabetes

authors： Qi L,Rifai N,Hu FB

更新日期：2009-01-01 00:00:00

abstract：:C57BL/6 (B6) mice develop glucose intolerance with age, whereas C3H/He (C3H) mice do not. In this study, we examined whether this differential glucose homeostasis was associated with differences of proteolytic activation of pancreatic prohormones. Radioimmunoassays showed comparable levels of fasting plasma insulin be...

journal_title：Diabetes

authors： Schmidt G,Sirois F,Anini Y,Kauri LM,Gyamera-Acheampong C,Fleck E,Scott FW,Chrétien M,Mbikay M

更新日期：2006-02-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：:Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...

journal_title：Diabetes

authors： Kautzky-Willer A,Thomaseth K,Ludvik B,Nowotny P,Rabensteiner D,Waldhäusl W,Pacini G,Prager R

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Anti-tissue transglutaminase (TG2) antibodies are the serological marker of celiac disease. Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children. RESEARCH DESIGN AND METHO...

journal_title：Diabetes

authors： Maglio M,Florian F,Vecchiet M,Auricchio R,Paparo F,Spadaro R,Zanzi D,Rapacciuolo L,Franzese A,Sblattero D,Marzari R,Troncone R

更新日期：2009-07-01 00:00:00

abstract：:Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity....

journal_title：Diabetes

authors： Hivert MF,Christophi CA,Franks PW,Jablonski KA,Ehrmann DA,Kahn SE,Horton ES,Pollin TI,Mather KJ,Perreault L,Barrett-Connor E,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

更新日期：2016-02-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations are the most common cause of maturity-onset diabetes of the young. HNF-1alpha homozygous knockout mice exhibit a renal Fanconi syndrome with glucosuria and generalized aminoaciduria in addition to diabetes. We investigated glucosuria and aminoaciduria in patients...

journal_title：Diabetes

authors： Bingham C,Ellard S,Nicholls AJ,Pennock CA,Allen J,James AJ,Satchell SC,Salzmann MB,Hattersley AT

更新日期：2001-09-01 00:00:00

abstract：:Persistent nutrient excess results in a compensatory increase in the β-cell number in mammals. It is unknown whether this response occurs in nonmammalian vertebrates, including zebrafish, a model for genetics and chemical genetics. We investigated the response of zebrafish β-cells to nutrient excess and the underlying...

journal_title：Diabetes

authors： Maddison LA,Chen W

更新日期：2012-10-01 00:00:00

abstract：:The changes of the microvasculature of rat pancreas transplants during acute rejection were investigated and quantitatively analyzed. The vessels in pancreas transplants increased in caliber and decreased in density during acute rejection. These changes were marked in the exocrine pancreas, especially in central zones...

journal_title：Diabetes

authors： Nakai I,Aikawa I,Oka T

更新日期：1989-01-01 00:00:00

abstract：:Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...

journal_title：Diabetes

authors： Goran MI,Gower BA

更新日期：2001-11-01 00:00:00