Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes.

abstract：:Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitiv...

journal_title：Diabetes

authors： Nielsen K,Karlsen AE,Deckert M,Madsen OD,Serup P,Mandrup-Poulsen T,Nerup J

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. RESEARCH DESI...

journal_title：Diabetes

authors： Rutanen J,Yaluri N,Modi S,Pihlajamäki J,Vänttinen M,Itkonen P,Kainulainen S,Yamamoto H,Lagouge M,Sinclair DA,Elliott P,Westphal C,Auwerx J,Laakso M

更新日期：2010-04-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...

journal_title：Diabetes

authors： Pace CS,Ellerman J,Hover BA,Stillings SN,Matschinsky FM

更新日期：1975-05-01 00:00:00

abstract：:Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sha...

journal_title：Diabetes

authors： Parker A,Meyer J,Lewitzky S,Rennich JS,Chan G,Thomas JD,Orho-Melander M,Lehtovirta M,Forsblom C,Hyrkkö A,Carlsson M,Lindgren C,Groop LC

更新日期：2001-03-01 00:00:00

abstract：:Activation of the hepatoportal glucose sensors by portal glucose infusion leads to increased glucose clearance and induction of hypoglycemia. Here, we investigated whether glucagon-like peptide-1 (GLP-1) could modulate the activity of these sensors. Mice were therefore infused with saline (S-mice) or glucose (P-mice) ...

journal_title：Diabetes

authors： Burcelin R,Da Costa A,Drucker D,Thorens B

更新日期：2001-08-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy of adipocytes. However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis. RESEARCH DESIGN AND METHODS:We have developed ...

journal_title：Diabetes

authors： Nishimura S,Manabe I,Nagasaki M,Hosoya Y,Yamashita H,Fujita H,Ohsugi M,Tobe K,Kadowaki T,Nagai R,Sugiura S

更新日期：2007-06-01 00:00:00

abstract：:Marked improvement in glycemic control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there is major weight loss. The objective of this study was to determine whether the magnitude of this change is primarily due to caloric restriction or is unique to ...

journal_title：Diabetes

authors： Jackness C,Karmally W,Febres G,Conwell IM,Ahmed L,Bessler M,McMahon DJ,Korner J

更新日期：2013-09-01 00:00:00

abstract：:The preferential channeling of different fuels to fat and changes in the transcription profile of adipose tissue and skeletal muscle are poorly understood processes involved in the pathogenesis of obesity and insulin resistance. Carbohydrate and lipid metabolism may play relevant roles in this context. Freely moving l...

journal_title：Diabetes

authors： Fabris R,Nisoli E,Lombardi AM,Tonello C,Serra R,Granzotto M,Cusin I,Rohner-Jeanrenaud F,Federspil G,Carruba MO,Vettor R

更新日期：2001-03-01 00:00:00

abstract：:Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin receptors (IR) specifically in skeletal muscle (IRMOE). On normal chow, IRMOE mice have body weight similar to that of controls but an inc...

journal_title：Diabetes

authors： Wang G,Yu Y,Cai W,Batista TM,Suk S,Noh HL,Hirshman M,Nigro P,Li ME,Softic S,Goodyear L,Kim JK,Kahn CR

更新日期：2020-11-01 00:00:00

abstract：:Hyperinsulinemia is commonly associated with obesity, but it has not been determined which defect comes first. Some have proposed that hyperinsulinemia may precede obesity in populations prone to NIDDM, such as Pima Indians or Pacific Islanders. In contrast, longitudinal studies in adults show that insulin sensitivity...

journal_title：Diabetes

authors： Odeleye OE,de Courten M,Pettitt DJ,Ravussin E

更新日期：1997-08-01 00:00:00

abstract：:Evidence exists for an essential role of beta-cell apoptosis in the pathology of type 1 and type 2 diabetes. Current methods for diabetes-associated apoptosis detection, however, suffer the drawbacks of relying on in situ-based strategies. In this study, we attempted to measure, both in vitro and ex vivo, levels of be...

journal_title：Diabetes

authors： Medarova Z,Bonner-Weir S,Lipes M,Moore A

更新日期：2005-06-01 00:00:00

abstract：:Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-A...

journal_title：Diabetes

authors： Peppa M,Brem H,Ehrlich P,Zhang JG,Cai W,Li Z,Croitoru A,Thung S,Vlassara H

更新日期：2003-11-01 00:00:00

abstract：:The efficacy of gangliosides in enhancing axonal regeneration and maturation in the early stages of diabetic neuropathy was assessed by quantitative analysis of immunostained serial sections of the sciatic nerve. Sprague-Dawley rats were made diabetic with a single injection of alloxan (100 mg/kg). One week later they...

journal_title：Diabetes

authors： Triban C,Guidolin D,Fabris M,Marini P,Schiavinato A,Donà M,Bortolami MC,Di Giamberardino L,Fiori MG

更新日期：1989-08-01 00:00:00

abstract：:Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructiv...

journal_title：Diabetes

authors： Duennwald T,Bernardi L,Gordin D,Sandelin A,Syreeni A,Fogarty C,Kytö JP,Gatterer H,Lehto M,Hörkkö S,Forsblom C,Burtscher M,Groop PH,FinnDiane Study Group.

更新日期：2013-12-01 00:00:00

abstract：:Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...

journal_title：Diabetes

authors： Karam JH,Sanz N,Salamon E,Nolte MS

更新日期：1986-12-01 00:00:00

abstract：:OKT3 has emerged as a highly effective antirejection therapy, but its efficacy in pancreas transplantation remains to be determined. During a 26-mo period, 46 vascularized pancreas transplants were performed with pancreaticoduodenocystostomy. Twenty-one patients (45.7%) were treated with OKT3. Indications for OKT3 use...

journal_title：Diabetes

authors： Stratta RJ,Sollinger HW,D'Alessandro AM,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...

journal_title：Diabetes

authors： Sun L,Lin JD

更新日期：2019-05-01 00:00:00

abstract：:We have recently reported an A to G transition at nucleotide position 3243 in the mitochondrial DNA (mtDNA) tRNA(Leu(UUR)) gene in a large family with non-insulin-dependent diabetes mellitus (NIDDM). Characteristic was its maternal transmission and an associated sensorineural hearing loss. In a screening of a Dutch an...

journal_title：Diabetes

authors： van den Ouweland JM,Lemkes HH,Trembath RC,Ross R,Velho G,Cohen D,Froguel P,Maassen JA

更新日期：1994-06-01 00:00:00

abstract：:Antibodies to single stranded (SS-) and double stranded (DS-) DNA and RNA were determined by a passive microhemagglutination assay in sera from 80 children with juvenile-onset diabetes mellitus (JDM) and 129 children with asthma. The latter group was chosen for comparison with the JDM group because of their increased ...

journal_title：Diabetes

authors： Huang SW,Maclaren NK

更新日期：1978-11-01 00:00:00

abstract：:We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance. The proband's mother and younger brother were also found to be heterozygous for the muta...

journal_title：Diabetes

authors： Haruta T,Takata Y,Iwanishi M,Maegawa H,Imamura T,Egawa K,Itazu T,Kobayashi M

更新日期：1993-12-01 00:00:00

abstract：:As part of an ongoing search for susceptibility genes in obese families, we performed linkage analyses in 101 French families between qualitative and quantitative traits related to morbid obesity and polymorphisms located in or near 15 candidate genes whose products are involved in body weight regulation. These includ...

journal_title：Diabetes

authors： Clément K,Dina C,Basdevant A,Chastang N,Pelloux V,Lahlou N,Berlan M,Langin D,Guy-Grand B,Froguel P

更新日期：1999-02-01 00:00:00

abstract：:Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...

journal_title：Diabetes

authors： Mezza T,Ferraro PM,Sun VA,Moffa S,Cefalo CMA,Quero G,Cinti F,Sorice GP,Pontecorvi A,Folli F,Mari A,Alfieri S,Giaccari A

更新日期：2018-11-01 00:00:00

abstract：:Earlier investigations have revealed that polyethylene glycol-B1-insulin (PEG insulin) causes lower utilization of glucose in fat cells than does the unaltered hormone, even though the blood glucose-lowering activity of both preparations in intact animals is identical. The present study was aimed to establish whether ...

journal_title：Diabetes

authors： Neubauer HP,Obermeier R,Schöne HH

更新日期：1983-10-01 00:00:00

abstract：:These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...

journal_title：Diabetes

authors： Giddings SJ,Orland MJ,Weir GC,Bonner-Weir S,Permutt MA

更新日期：1985-03-01 00:00:00

abstract：:Liver fat accumulation is proposed to link obesity and insulin resistance. To dissect the role of liver fat in the insulin resistance of diet-induced obesity, we altered liver fat using a choline-deficient diet. C57Bl/6 mice were fed a low-fat (10% of calories) or high-fat (45% of calories) diet for 8 weeks; during th...

journal_title：Diabetes

authors： Raubenheimer PJ,Nyirenda MJ,Walker BR

更新日期：2006-07-01 00:00:00

abstract：:The effect of elevated glucagon concentrations on insulin requirements and on blood glucose concentrations was studied in five insulin-requiring diabetic subjects during feedback control of hyperglycemia with an automated glucose-controlled insulin infusion system (artificial endocrine pancreas) for six to eight hours...

journal_title：Diabetes

authors： Clarke WL,Santiago JV,Kipnis DM

更新日期：1978-06-01 00:00:00

abstract：:Nerve regeneration in diabetic animals is delayed and qualitatively impaired, but the mechanisms responsible for these defects have not been elucidated. The extracellular matrix protein laminin promotes the extension of neuronal processes, and recent studies have localized neurite-promoting activity to a lysine-contai...

journal_title：Diabetes

authors： Federoff HJ,Lawrence D,Brownlee M

更新日期：1993-04-01 00:00:00

abstract：:The dysregulation of receptor tyrosine kinases (RTKs) in multiple cell types during chronic inflammation is indicative of their pathogenic role in autoimmune diseases. Among the many RTKs, vascular endothelial growth factor receptor (VEGFR) stands out for its multiple effects on immunity, vascularization, and cell mig...

journal_title：Diabetes

authors： Villalta SA,Lang J,Kubeck S,Kabre B,Szot GL,Calderon B,Wasserfall C,Atkinson MA,Brekken RA,Pullen N,Arch RH,Bluestone JA

更新日期：2013-08-01 00:00:00