Antibodies to nucleic acids in juvenile-onset diabetes.

abstract：:Obesity and type 2 diabetes are associated with impaired mitochondrial function in adipose tissue. To study the effects of primary deficiency of mitochondrial energy metabolism in fat, we generated mice with adipose-specific deficiency of fumarate hydratase (FH), an integral Krebs cycle enzyme (AFHKO mice). AFHKO mice...

journal_title：Diabetes

authors： Yang H,Wu JW,Wang SP,Severi I,Sartini L,Frizzell N,Cinti S,Yang G,Mitchell GA

更新日期：2016-11-01 00:00:00

abstract：:Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the freque...

journal_title：Diabetes

authors： Sakurami T,Ueno Y,Nagaoka K,Kuno S,Iwaki Y,Park MS,Terasaki PI

更新日期：1982-02-01 00:00:00

abstract：:Capillary endothelial cells are thought to limit the transport of insulin across the endothelium, resulting in attenuated insulin action at target sites. Whether endothelial insulin transport is altered in dysglycemic insulin-resistant states is not clear and was therefore investigated in the JCR:LA-cp corpulent male ...

journal_title：Diabetes

authors： Wascher TC,Wölkart G,Russell JC,Brunner F

更新日期：2000-05-01 00:00:00

abstract：:Tight glycemic control by intensive insulin therapy effectively delays the onset and slows the progression of diabetic complications but is associated with frequent dose adjustments and a high incidence of hypoglycemia. Successful pancreas transplantation corrects abnormal glucose metabolism but subjects patients to m...

journal_title：Diabetes

authors： Maki T,Otsu I,O'Neil JJ,Dunleavy K,Mullon CJ,Solomon BA,Monaco AP

更新日期：1996-03-01 00:00:00

abstract：:Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...

journal_title：Diabetes

authors： Takazakura E,Nakamoto Y,Hayakawa H,Kawai K,Muramoto S

更新日期：1975-01-01 00:00:00

abstract：:The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent. Because metabolic pathways are also activated in the diabetic kidney, the present study aimed to determine whether renoprotection could...

journal_title：Diabetes

authors： Wilkinson-Berka JL,Kelly DJ,Koerner SM,Jaworski K,Davis B,Thallas V,Cooper ME

更新日期：2002-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity. IL-6 signals via a heterodimeric receptor complex consisting of a soluble IL-6 alpha-subunit (IL-6 receptor [IL6R]) and a signal transducing subunit (gp130). The IL6R gene maps ...

journal_title：Diabetes

authors： Hamid YH,Urhammer SA,Jensen DP,Glümer C,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2004-12-01 00:00:00

abstract：:We studied the effects of short-term (5 days) and long-term (2 wk) high carbohydrate (75%) feedings on insulin binding to isolated adipocytes and insulin sensitivity in vivo in normal subjects. Ingestion of the high carbohydrate diet led to daylong hyperinsulinemia in both short- and long-term groups. Insulin binding ...

journal_title：Diabetes

authors： Kolterman OG,Greenfield M,Reaven GM,Saekow M,Olefsky JM

更新日期：1979-08-01 00:00:00

abstract：:Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current stud...

journal_title：Diabetes

authors： Ludzki A,Paglialunga S,Smith BK,Herbst EA,Allison MK,Heigenhauser GJ,Neufer PD,Holloway GP

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression might therefore prev...

journal_title：Diabetes

authors： Oeser JK,Parekh VV,Wang Y,Jegadeesh NK,Sarkar SA,Wong R,Lee CE,Pound LD,Hutton JC,Van Kaer L,O'Brien RM

更新日期：2011-11-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(-)/db(-)) and control (db(-)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a...

journal_title：Diabetes

authors： Kassan M,Choi SK,Galán M,Bishop A,Umezawa K,Trebak M,Belmadani S,Matrougui K

更新日期：2013-06-01 00:00:00

abstract：:The hexokinases, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in movement of glucose into cells through the facilitative glucose transporters. GLUT4 and hexokinase (HK) II are the major transporter and hexokinase isoforms in skeletal muscle, heart, and adipose tissue, ...

journal_title：Diabetes

authors： Osawa H,Printz RL,Whitesell RR,Granner DK

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Obesity is associated with increased activation of the c-Jun NH(2)-terminal kinase (JNK) in several metabolic organs, including adipose tissue, liver, and skeletal muscle. In this study, we aimed to define the role of JNK activation in adipose tissue in the development of obesity-related insulin resistance. ...

journal_title：Diabetes

authors： Zhang X,Xu A,Chung SK,Cresser JH,Sweeney G,Wong RL,Lin A,Lam KS

更新日期：2011-02-01 00:00:00

abstract：:An A-to-G transition in the mitochondrial tRNALeu(UUR) gene at base pair 3243 has been shown to be associated with the maternally transmitted clinical phenotype of NIDDM and sensorineural hearing loss in white and Japanese pedigrees. We have detected this mutation in 25 of 50 tested members of five white French pedigr...

journal_title：Diabetes

authors： Velho G,Byrne MM,Clément K,Sturis J,Pueyo ME,Blanché H,Vionnet N,Fiet J,Passa P,Robert JJ,Polonsky KS,Froguel P

更新日期：1996-04-01 00:00:00

abstract：:The newly inbred Cohen diabetic rat is an exceptional experimental model of diet-induced type 2 diabetes mellitus that is the result of secondary inbreeding nearly 30 years after it originally had been established. Animals from the original colony were selectively inbred by stringent criteria for 10 additional generat...

journal_title：Diabetes

authors： Weksler-Zangen S,Yagil C,Zangen DH,Ornoy A,Jacob HJ,Yagil Y

更新日期：2001-11-01 00:00:00

abstract：:Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have unclear genetic defects, hampering our understanding of the development of the disease and preventing pathogenesis-oriented treatment. We used whole-genome sequencing with linkage analysis to study a consanguineous family with ea...

journal_title：Diabetes

authors： Simaite D,Kofent J,Gong M,Rüschendorf F,Jia S,Arn P,Bentler K,Ellaway C,Kühnen P,Hoffmann GF,Blau N,Spagnoli FM,Hübner N,Raile K

更新日期：2014-10-01 00:00:00

abstract：:Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by t...

journal_title：Diabetes

authors： Blackshear PJ,Rohde TD,Grotting JC,Dorman FD,Perkins PR,Varco RL,Buchwald H

更新日期：1979-07-01 00:00:00

abstract：:Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of one-ninth of patients with diabetes. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase ...

journal_title：Diabetes

authors： Corliss BA,Ray HC,Doty RW,Mathews C,Sheybani N,Fitzgerald K,Prince R,Kelly-Goss MR,Murfee WL,Chappell J,Owens GK,Yates PA,Peirce SM

更新日期：2020-07-01 00:00:00

abstract：:Genetic factors are important in conferring diabetic nephropathy (DN) risk. The insertion/deletion (I/D) polymorphism of the ACE gene has been described to be associated with DN risk and progression. The renal lesions underlying DN in type 2 diabetes are heterogeneous; only a subset of patients, characterized by a fas...

journal_title：Diabetes

authors： Solini A,Dalla Vestra M,Saller A,Nosadini R,Crepaldi G,Fioretto P

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Human islet amyloid polypeptide (hIAPP) aggregation plays a major role in the development of islet amyloidosis in type 2 diabetes. It is known that extracellular hIAPP oligomers are toxic to pancreatic beta-cells and associated with apoptosis. We therefore investigated the molecular mechanism by which extrace...

journal_title：Diabetes

authors： Casas S,Gomis R,Gribble FM,Altirriba J,Knuutila S,Novials A

更新日期：2007-09-01 00:00:00

abstract：:Linkage results suggest that the region of chromosome 7 containing the leptin gene cosegregates with extreme obesity; however, leptin coding region mutations are rare. To investigate whether the leptin flanking sequence and/or a larger 40-cM region (7q22.1-7q35) contributes to obesity, we genotyped individuals from 20...

journal_title：Diabetes

authors： Li WD,Li D,Wang S,Zhang S,Zhao H,Price RA

更新日期：2003-06-01 00:00:00

abstract：:Rats from four experimental treatment groups, including fed controls, 24- to 30-h fasted, dexamethasone-treated, and intraperitoneal glucose-treated, were used to assess the effects of these treatments on the immunohistochemically detectable islet amyloid polypeptide (IAPP) content in the pancreatic islets. Isolated p...

journal_title：Diabetes

authors： O'Brien TD,Westermark P,Johnson KH

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of these metabolic abnormalities. We examined whether aging per se (in s...

journal_title：Diabetes

authors： Ghosh S,Lertwattanarak R,Lefort N,Molina-Carrion M,Joya-Galeana J,Bowen BP,Garduno-Garcia Jde J,Abdul-Ghani M,Richardson A,DeFronzo RA,Mandarino L,Van Remmen H,Musi N

更新日期：2011-08-01 00:00:00

abstract：:Islets of Langerhans are micro-organs scattered throughout the pancreas that contain insulin-producing cells, called beta-cells. Although new light has been recently shed on beta-cell development, information on the phenotype and location of beta-stem cells remains scarce. Here, we provide evidence that beta-stem cell...

journal_title：Diabetes

authors： Duvillié B,Attali M,Aiello V,Quemeneur E,Scharfmann R

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:We sought to examine the molecular mechanisms underlying permanenent neonatal diabetes mellitus (PNDM) in a patient with a heterozygous de novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K(+) channel (K(ATP) channel). RESEARCH D...

journal_title：Diabetes

authors： Masia R,De Leon DD,MacMullen C,McKnight H,Stanley CA,Nichols CG

更新日期：2007-05-01 00:00:00

abstract：:Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...

journal_title：Diabetes

authors： Powe CE,Nodzenski M,Talbot O,Allard C,Briggs C,Leya MV,Perron P,Bouchard L,Florez JC,Scholtens DM,Lowe WL Jr,Hivert MF

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for associations of the variant displaying the most independent effect on FPG ...

journal_title：Diabetes

authors： Sparsø T,Bonnefond A,Andersson E,Bouatia-Naji N,Holmkvist J,Wegner L,Grarup N,Gjesing AP,Banasik K,Cavalcanti-Proença C,Marchand M,Vaxillaire M,Charpentier G,Jarvelin MR,Tichet J,Balkau B,Marre M,Lévy-Marchal C,Faerch

更新日期：2009-06-01 00:00:00

abstract：:The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to test whether this relationship is more pronounced among individuals with diabetes....

journal_title：Diabetes

authors： Liao D,Carnethon M,Evans GW,Cascio WE,Heiss G

更新日期：2002-12-01 00:00:00

abstract：:Embryo-culture techniques were used to study the effects of exposure to glucose-deficient culture media on rat embryos during organogenesis. Embryos and their extraembryonic membranes (explants) were cultured either in control media or in media with low or very low glucose concentrations. At the start of the culture t...

journal_title：Diabetes

authors： Ellington SK

更新日期：1987-12-01 00:00:00

abstract：:To develop somatic gene therapy for diabetes, we studied an animal model with proinsulin-producing fibroblasts with an immunological safety system. Cultured mouse fibroblasts of the Ltk- cell line were transfected first with the efficient human proinsulin expression vector pBMG-Neo-Ins. Initially, 2 x 10(6) cells with...

journal_title：Diabetes

authors： Kawakami Y,Yamaoka T,Hirochika R,Yamashita K,Itakura M,Nakauchi H

更新日期：1992-08-01 00:00:00