Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.

abstract：:IA-2 and IA-2beta are members of the transmembrane protein tyrosine phosphatase family located in dense core vesicles of neuroendocrine cells, including the beta-cells of pancreatic islets. In the present study, by mating C57BL/6Nci IA-2(+/-) with IA-2beta(+/-) mice, we generated double knockout mice (IA-2(-/-)/IA-2be...

journal_title：Diabetes

authors： Kubosaki A,Nakamura S,Notkins AL

更新日期：2005-12-01 00:00:00

abstract：:Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates autophagy. Using a mouse model with β-cell-specific deletion of Tsc2 (βTsc...

journal_title：Diabetes

authors： Bartolomé A,Kimura-Koyanagi M,Asahara S,Guillén C,Inoue H,Teruyama K,Shimizu S,Kanno A,García-Aguilar A,Koike M,Uchiyama Y,Benito M,Noda T,Kido Y

更新日期：2014-09-01 00:00:00

abstract：:Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...

journal_title：Diabetes

authors： Rickels MR,Fuller C,Dalton-Bakes C,Markmann E,Palanjian M,Cullison K,Tiao J,Kapoor S,Liu C,Naji A,Teff KL

更新日期：2015-05-01 00:00:00

abstract：:Recently, a missense mutation replacing tryptophan with arginine at codon 64 of the beta 3-adrenergic receptor gene was shown to be associated with insulin resistance in nondiabetic subjects and to an earlier onset of NIDDM in Pima Indians. We studied whether the codon 64 amino acid polymorphism of the beta 3-adrenerg...

journal_title：Diabetes

authors： Urhammer SA,Clausen JO,Hansen T,Pedersen O

更新日期：1996-08-01 00:00:00

abstract：:Insulin autoantibodies (IAAs) are currently the subject of intensive investigation as potential markers for autoimmune insulitis. However, the results of different reports vary widely. In an attempt to elucidate the reasons for the discrepant reports and to initiate standardization procedures, the International Diabet...

journal_title：Diabetes

authors： Wilkin TJ,Schoenfeld SL,Diaz JL,Kruse V,Bonifacio E,Palmer JP

更新日期：1989-02-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes hav...

journal_title：Diabetes

authors： Schatz DA,Lang F,Cantor AB,Riley WJ,Maclaren NK,Sleasman JW,Barrett DJ

更新日期：1991-10-01 00:00:00

abstract：:To investigate the effects of insulin on platelets in obesity and in non-insulin-dependent diabetes mellitus (NIDDM)--classic insulin-resistant states--we determined ADP-induced platelet aggregation and platelet cGMP (guanosine 3',5'-cyclic monophosphate) content in platelet-rich plasma obtained from nine obese subjec...

journal_title：Diabetes

authors： Trovati M,Mularoni EM,Burzacca S,Ponziani MC,Massucco P,Mattiello L,Piretto V,Cavalot F,Anfossi G

更新日期：1995-11-01 00:00:00

abstract：:Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging mammals and are frequently associated with leptin resistance and increased plasma leptin levels. To examine whether leptin's failure in aging is due to aging per se or to changes in body fat mass or distribution, we studied a...

journal_title：Diabetes

authors： Gabriely I,Ma XH,Yang XM,Rossetti L,Barzilai N

更新日期：2002-04-01 00:00:00

abstract：:Increased susceptibility of LDL to oxidation has been shown to be associated with the presence of coronary heart disease and may account for the accelerated vascular disease seen in diabetes. The response of LDL to in vitro oxidative stress has been proposed as a measure of the predisposition of LDL to the in vivo sub...

journal_title：Diabetes

authors： Jenkins AJ,Klein RL,Chassereau CN,Hermayer KL,Lopes-Virella MF

更新日期：1996-06-01 00:00:00

abstract：:The regulation of insulin secretion from pancreatic beta-cells depends critically on the activities of their plasma membrane ion channels. ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane potential. The activity...

journal_title：Diabetes

authors： Seino S,Iwanaga T,Nagashima K,Miki T

更新日期：2000-03-01 00:00:00

abstract：:Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control m...

journal_title：Diabetes

authors： Fiaschi-Taesch NM,Kleinberger JW,Salim FG,Troxell R,Wills R,Tanwir M,Casinelli G,Cox AE,Takane KK,Scott DK,Stewart AF

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present in islets, re...

journal_title：Diabetes

authors： Olerud J,Johansson M,Lawler J,Welsh N,Carlsson PO

更新日期：2008-07-01 00:00:00

abstract：:Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, a key component of the immunosuppressiv...

journal_title：Diabetes

authors： Zhang N,Su D,Qu S,Tse T,Bottino R,Balamurugan AN,Xu J,Bromberg JS,Dong HH

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative stress. We investigated whether Klotho levels and signaling modulate inflammation in diabetic kidneys. RESEARCH DESIGN AND METHODS:Renal Klotho expression w...

journal_title：Diabetes

authors： Zhao Y,Banerjee S,Dey N,LeJeune WS,Sarkar PS,Brobey R,Rosenblatt KP,Tilton RG,Choudhary S

更新日期：2011-07-01 00:00:00

abstract：:Type 1 diabetes is preceded by islet β-cell dysfunction, but the mechanisms leading to β-cell dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior to overt diabetes, we hypothesized that activation of inflammatory cascades and appearance of endoplasmic reticulum (ER) stress in β-...

journal_title：Diabetes

authors： Tersey SA,Nishiki Y,Templin AT,Cabrera SM,Stull ND,Colvin SC,Evans-Molina C,Rickus JL,Maier B,Mirmira RG

更新日期：2012-04-01 00:00:00

abstract：:We have recently reported successful 72-h preservation of the canine pancreas with a new cold-storage solution developed at the University of Wisconsin (UW solution). Over 10 mo, we performed 11 combined pancreas-kidney and 4 isolated-pancreas transplants with this solution. In situ cooling of the donor pancreas was p...

journal_title：Diabetes

authors： D'Alessandro AM,Stratta RJ,Sollinger HW,Kalayoglu M,Pirsch JD,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:The interaction of insulin with the vascular endothelium was studied using bovine aortic endothelial cells in monolayer cultures. Confluent cell cultures exhibited specific binding of 125I-insulin to high- and low-affinity cell surface receptor sites. Binding was reversible, saturable, and accompanied by internalizati...

journal_title：Diabetes

authors： Kaiser N,Vlodavsky I,Tur-Sinai A,Fuks Z,Cerasi E

更新日期：1982-12-01 00:00:00

abstract：:This study was undertaken to test two assumptions critical for use of [2-14C]acetate to measure gluconeogenesis in vivo. For the assumption that incorporation into glucose of products of [14C]acetate metabolism does not affect the distribution of label within the glucose molecule, we infused [2-14C]acetate in 17 healt...

journal_title：Diabetes

authors： Consoli A,Nurjhan N,Capani F,Pangburn T,Lapenna D,Gerich J

更新日期：1993-05-01 00:00:00

abstract：:Acute elevations of plasma free fatty acid (FFA) levels augment glucose-stimulated insulin secretion (GSIS). Prolonged elevations of FFA levels reportedly impair GSIS, but no one has previously compared GSIS after prolonged exposure to saturated or unsaturated fat. Rats received a low-fat diet (Low-Fat) or one enriche...

journal_title：Diabetes

authors： Dobbins RL,Szczepaniak LS,Myhill J,Tamura Y,Uchino H,Giacca A,McGarry JD

更新日期：2002-06-01 00:00:00

abstract：:Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...

journal_title：Diabetes

authors： Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

更新日期：2005-03-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：:Representative longitudinal muscle strips (6 x 10 mm) from distal small intestine were obtained from rats after 1, 2, and 3 mo of streptozocin-induced diabetes. The strips were stretched to their optimum lengths and subjected to electrical field stimulation (1-ms pulse duration, 30-270 mA, 10 Hz) in the presence of Kr...

journal_title：Diabetes

authors： Nowak TV,Harrington B,Kalbfleisch J

更新日期：1990-08-01 00:00:00

abstract：:A simple method for the elimination of labile glycohemoglobin in the chromatographic quantitation of glycosylated hemoglobin is described. Use is made of the instability of Schiff base adducts in acidic solution. Erythrocytes are lysed with a pH 5 buffer. At this pH dissociation reaches completion during sample prepar...

journal_title：Diabetes

authors： Bissé E,Berger W,Flückiger R

更新日期：1982-07-01 00:00:00

abstract：:Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable h...

journal_title：Diabetes

authors： Fatehi M,Raja M,Carter C,Soliman D,Holt A,Light PE

更新日期：2012-01-01 00:00:00

abstract：:Hexokinase (HK) II plays an important role in intracellular glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate. HKII is considered to be a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the frequency of vari...

journal_title：Diabetes

authors： Laakso M,Malkki M,Deeb SS

更新日期：1995-03-01 00:00:00

abstract：:A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a necessary step in the conversion of ceramide to glycosphingolipids. In...

journal_title：Diabetes

authors： Aerts JM,Ottenhoff R,Powlson AS,Grefhorst A,van Eijk M,Dubbelhuis PF,Aten J,Kuipers F,Serlie MJ,Wennekes T,Sethi JK,O'Rahilly S,Overkleeft HS

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2. RESEARCH DESIGN AND METHODS:Rat proximal-tubular epithelial cells (NRK...

journal_title：Diabetes

authors： Wang B,Koh P,Winbanks C,Coughlan MT,McClelland A,Watson A,Jandeleit-Dahm K,Burns WC,Thomas MC,Cooper ME,Kantharidis P

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or ...

journal_title：Diabetes

authors： Klinger S,Poussin C,Debril MB,Dolci W,Halban PA,Thorens B

更新日期：2008-03-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00