Impaired insulin-induced platelet antiaggregating effect in obesity and in obese NIDDM patients.

abstract：:Patients with type 2 diabetes respond poorly to treatments for peripheral arterial disease (PAD) and are more likely to present with the most severe manifestation of the disease, critical limb ischemia. The underlying mechanisms linking type 2 diabetes and the severity of PAD manifestation are not well understood. We ...

journal_title：Diabetes

authors： Ryan TE,Schmidt CA,Green TD,Spangenburg EE,Neufer PD,McClung JM

更新日期：2016-09-01 00:00:00

abstract：:Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...

journal_title：Diabetes

authors： Karam JH,Sanz N,Salamon E,Nolte MS

更新日期：1986-12-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:Data is accumulating indicating that impaired insulin action predisposes to increased vascular smooth muscle (VSM) tone, the hallmark of hypertension associated with diabetes. During the last several years, it has been established that VSM is an insulin-sensitive tissue like skeletal muscle and adipocytes. Investigato...

journal_title：Diabetes

authors： Sowers JR

更新日期：1996-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...

journal_title：Diabetes

authors： Vastani N,Guenther F,Gentry C,Austin AL,King AJ,Bevan S,Andersson DA

更新日期：2018-08-01 00:00:00

abstract：:In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min)...

journal_title：Diabetes

authors： Lins PE,Wajngot A,Adamson U,Vranic M,Efendić S

更新日期：1983-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00

abstract：:Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We hav...

journal_title：Diabetes

authors： Gould CL,McMannama KG,Bigley NJ,Giron DJ

更新日期：1985-12-01 00:00:00

abstract：:The effect of muscular exertion of moderate intensity on blood sugar (BS), plasma levels of growth hormone (GH), glucagon, and cortisol (F) has been studied in endocrinologically normal children with short stature and compared with children with clinical diabetes mellitus and obese children with normal and diminished ...

journal_title：Diabetes

authors： Garlaschi C,di Natale B,del Guercio MJ,Caccamo A,Gargantini L,Chiumello G

更新日期：1975-08-01 00:00:00

abstract：:Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with the potential to mobilize Ca2+, to inhibit apoptosis, and to promote mitogenesis. Sphingosine kinase (SPHK) and S1P were characterized in INS-1 insulinoma cells and isolated rat islets of Langerhans. SPHK activity increased in INS-1 cell homogenates treate...

journal_title：Diabetes

authors： Mastrandrea LD,Sessanna SM,Laychock SG

更新日期：2005-05-01 00:00:00

abstract：:To establish potential effects of glucagon-like peptide I (GLP-I) on blood glucose control in insulin-deficient states, GLP-I [GLP-I(7-36) amide; 10 pmol x kg(-1) x min(-1)] was infused intravenously in six fasting, canine C-peptide-negative, chronically diabetic dogs for 8 h. Blood samples were saved for the analysis...

journal_title：Diabetes

authors： Freyse EJ,Becher T,El-Hag O,Knospe S,Göke B,Fischer U

更新日期：1997-05-01 00:00:00

abstract：:Rhesus monkeys frequently develop obesity and insulin resistance followed by type 2 diabetes when allowed free access to chow. This insulin resistance is partly due to defective glucose transport into skeletal muscle. In this study, we examined signaling factors required for insulin-stimulated glucose transport in mus...

journal_title：Diabetes

authors： Standaert ML,Ortmeyer HK,Sajan MP,Kanoh Y,Bandyopadhyay G,Hansen BC,Farese RV

更新日期：2002-10-01 00:00:00

abstract：:Variation at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes, including type 1 diabetes, polycystic ovary syndrome, and birth weight. Case-control studies have suggested that class III VNTR alleles are also associated with type 2 diabetes, but r...

journal_title：Diabetes

authors： Huxtable SJ,Saker PJ,Haddad L,Walker M,Frayling TM,Levy JC,Hitman GA,O'Rahilly S,Hattersley AT,McCarthy MI

更新日期：2000-01-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00

abstract：:Insulin antibodies are known to interfere with the radioimmunoassay of insulin. We tested intravenous glucose tolerance on 25 insulin autoantibody-positive (IAA+) patients and 25 IAA- controls, who were matched for sex, age, and body mass index, to establish if IAA could also interfere with insulin assay. Insulin cont...

journal_title：Diabetes

authors： Armitage M,Wilkin T,Wood P,Casey C,Loveless R

更新日期：1988-10-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator-activated receptor (PPAR)-gamma response elements in v...

journal_title：Diabetes

authors： Ryder JW,Portocarrero CP,Song XM,Cui L,Yu M,Combatsiaris T,Galuska D,Bauman DE,Barbano DM,Charron MJ,Zierath JR,Houseknecht KL

更新日期：2001-05-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is diabetes susceptible and the C57BL/6J (B6) strain is diabetes resistan...

journal_title：Diabetes

authors： Lan H,Rabaglia ME,Stoehr JP,Nadler ST,Schueler KL,Zou F,Yandell BS,Attie AD

更新日期：2003-03-01 00:00:00

abstract：:The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior. Immunoprecipitation, immunofluorescent staining, and RT-PCR of human VSMCs showed that elevat...

journal_title：Diabetes

authors： Campbell M,Allen WE,Silversides JA,Trimble ER

更新日期：2003-02-01 00:00:00

abstract：:A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease. ...

journal_title：Diabetes

authors： Nisticò L,Giorgi G,Giordano M,Galgani A,Petrone A,D'Alfonso S,Federici M,Di Mario U,Pozzilli P,Buzzetti R,Cascino I

更新日期：2002-05-01 00:00:00

abstract：:To investigate the early events in insulin signal transmission in liver, isolated rat hepatocytes were labeled with 32P, and proteins phosphorylated in response to insulin were detected by immunoprecipitation with anti-phosphotyrosine and anti-receptor antibodies and analyzed by sodium dodecyl sulfate (SDS)-polyacryla...

journal_title：Diabetes

authors： Okamoto M,Karasik A,White MF,Kahn CR

更新日期：1991-01-01 00:00:00

abstract：:Islet antigens associated with type 1 diabetes include a recently identified protein tyrosine phosphatase-like molecule IA-2, which contains the intracellular fragment IA-2ic. To determine whether combinations of antibodies including those to IA-2 characterize and predict type 1 diabetes, we studied antibodies to IA-2...

journal_title：Diabetes

authors： Hawa M,Rowe R,Lan MS,Notkins AL,Pozzilli P,Christie MR,Leslie RD

更新日期：1997-08-01 00:00:00

abstract：:Diabetic nephropathy is characterized by hypertension and a relentless decline in kidney function. Angiotensin-converting enzyme inhibitors have been claimed to preserve kidney function better than an equal blood pressure (BP) reduction with conventional antihypertensive treatment (renoprotection). We compared the eff...

journal_title：Diabetes

authors： Nielsen FS,Rossing P,Gall MA,Skøtt P,Smidt UM,Parving HH

更新日期：1994-09-01 00:00:00

abstract：:In the fasted rat, efficient glucose-stimulated insulin secretion (GSIS) is absolutely dependent on an elevated level of circulating free fatty acids (FFAs). To determine if this is also true in humans, nonobese volunteers were fasted for 24 h (n = 5) or 48 h (n = 5), after which they received an infusion of either sa...

journal_title：Diabetes

authors： Dobbins RL,Chester MW,Daniels MB,McGarry JD,Stein DT

更新日期：1998-10-01 00:00:00

abstract：:Coxsackievirus B infections have been associated with clinical manifestation of insulin-dependent diabetes mellitus (IDDM) in several studies, but their initiating role in the slowly progressing beta-cell damage is not known. This is the first prospective study designed to assess the role of coxsackie B and other ente...

journal_title：Diabetes

authors： Hyöty H,Hiltunen M,Knip M,Laakkonen M,Vähäsalo P,Karjalainen J,Koskela P,Roivainen M,Leinikki P,Hovi T

更新日期：1995-06-01 00:00:00

abstract：:Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...

journal_title：Diabetes

authors： Mezza T,Ferraro PM,Sun VA,Moffa S,Cefalo CMA,Quero G,Cinti F,Sorice GP,Pontecorvi A,Folli F,Mari A,Alfieri S,Giaccari A

更新日期：2018-11-01 00:00:00

abstract：:Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenge...

journal_title：Diabetes

authors： Li H,O'Meara M,Zhang X,Zhang K,Seyoum B,Yi Z,Kaufman RJ,Monks TJ,Wang JM

更新日期：2019-06-01 00:00:00