Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility.

abstract：:Autoantibodies against several cytoplasmic autoantigens such as glutamic acid decarboxylase, heat shock protein 65, insulin, and carboxypeptidase H have been identified in the sera of patients with IDDM. To investigate whether type II DNA topoisomerase (TopII) is an autoantigen in IDDM patients, we have constructed a ...

journal_title：Diabetes

authors： Chang YH,Hwang J,Shang HF,Tsai ST

更新日期：1996-04-01 00:00:00

abstract：:With the aim of investigating glucose-mediated glucose disposal (glucose effectiveness [GE]) in 15 (3 female and 12 male subjects) insulin-resistant normoglycemic relatives of patients with type 2 diabetes (DM2), and 15 age-, sex-, and BMI-matched control subjects without a family history of DM2, we performed 2 studie...

journal_title：Diabetes

authors： Henriksen JE,Levin K,Thye-Rønn P,Alford F,Hother-Nielsen O,Holst JJ,Beck-Nielsen H

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, and several of its products induce apo...

journal_title：Diabetes

authors： McDuffie M,Maybee NA,Keller SR,Stevens BK,Garmey JC,Morris MA,Kropf E,Rival C,Ma K,Carter JD,Tersey SA,Nunemaker CS,Nadler JL

更新日期：2008-01-01 00:00:00

abstract：:More than 120 published reports have described associations between single nucleotide polymorphisms (SNPs) and type 2 diabetes. However, multiple studies of the same variant have often been discordant. From a literature search, we identified previously reported type 2 diabetes-associated SNPs. We initially genotyped 1...

journal_title：Diabetes

authors： Willer CJ,Bonnycastle LL,Conneely KN,Duren WL,Jackson AU,Scott LJ,Narisu N,Chines PS,Skol A,Stringham HM,Petrie J,Erdos MR,Swift AJ,Enloe ST,Sprau AG,Smith E,Tong M,Doheny KF,Pugh EW,Watanabe RM,Buchanan TA,Vall

更新日期：2007-01-01 00:00:00

abstract：:Skeletal muscle insulin resistance plays a key role in the pathogenesis of type 2 diabetes. It recently has been hypothesized that excessive activity of the inhibitor of kappaB (IkappaB)/nuclear factor kappaB (NFkappaB) inflammatory pathway is a mechanism underlying skeletal muscle insulin resistance. However, it is n...

journal_title：Diabetes

authors： Sriwijitkamol A,Christ-Roberts C,Berria R,Eagan P,Pratipanawatr T,DeFronzo RA,Mandarino LJ,Musi N

更新日期：2006-03-01 00:00:00

abstract：:The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency...

journal_title：Diabetes

authors： Flotte T,Agarwal A,Wang J,Song S,Fenjves ES,Inverardi L,Chesnut K,Afione S,Loiler S,Wasserfall C,Kapturczak M,Ellis T,Nick H,Atkinson M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：:Three hundred and seventy-seven children and adolescents aged 5-17 yr from the biracial (black-white) community of Bogalusa, Louisiana, were evaluated for Tanner stage of sexual development, plasma glucose, and insulin levels during an oral glucose tolerance test. Children of the two races were of similar age, weight,...

journal_title：Diabetes

authors： Svec F,Nastasi K,Hilton C,Bao W,Srinivasan SR,Berenson GS

更新日期：1992-03-01 00:00:00

abstract：:Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another cholesterol transpor...

journal_title：Diabetes

authors： Kruit JK,Wijesekara N,Westwell-Roper C,Vanmierlo T,de Haan W,Bhattacharjee A,Tang R,Wellington CL,LütJohann D,Johnson JD,Brunham LR,Verchere CB,Hayden MR

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Regulation of obesity development is an important issue to prevent metabolic syndromes. Gene-disrupted mice of phospholipase Cδ1 (PLCδ1), a key enzyme of phosphoinositide turnover, seemed to show leanness. Here we examined whether and how PLCδ1 is involved in obesity. RESEARCH DESIGN AND METHODS:Weight gain,...

journal_title：Diabetes

authors： Hirata M,Suzuki M,Ishii R,Satow R,Uchida T,Kitazumi T,Sasaki T,Kitamura T,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2011-07-01 00:00:00

abstract：:Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...

journal_title：Diabetes

authors： Massaqué J,Czech MP

更新日期：1980-11-01 00:00:00

abstract：:We present a patient who developed insulin-requiring diabetes several years after the onset of symptoms of anterior hypopituitarism. It is likely that the hypopituitarism protected him against the development of diabetic retinopathy and glomerular basement membrane thickening but not against neuropathy and atheroma. T...

journal_title：Diabetes

authors： Greenwood RH,Ireland JT,Jones DH,Mahler RF

更新日期：1975-11-01 00:00:00

abstract：:The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of beta-cell death responsible for the development of IDDM. Apoptotic cells were present within the islets of Langerhans in hematoxylin and eosin-stained sections of pancreases harvested from 3- to 18-week-old female NOD/Lt ...

journal_title：Diabetes

authors： O'Brien BA,Harmon BV,Cameron DP,Allan DJ

更新日期：1997-05-01 00:00:00

abstract：:The introduction of 13C magnetic resonance spectroscopy (MRS) has enabled noninvasive measurement of muscle glycogen synthesis in humans. Conclusions based on measurements by the MRS technique assume that glucose metabolism in gastrocnemius muscle is representative for all skeletal muscles and thus can be extrapolated...

journal_title：Diabetes

authors： Serlie MJ,de Haan JH,Tack CJ,Verberne HJ,Ackermans MT,Heerschap A,Sauerwein HP

更新日期：2005-05-01 00:00:00

abstract：:Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts...

journal_title：Diabetes

authors： Nilsson E,Jansson PA,Perfilyev A,Volkov P,Pedersen M,Svensson MK,Poulsen P,Ribel-Madsen R,Pedersen NL,Almgren P,Fadista J,Rönn T,Klarlund Pedersen B,Scheele C,Vaag A,Ling C

更新日期：2014-09-01 00:00:00

abstract：:Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22-producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically,...

journal_title：Diabetes

authors： Zhou X,Johnson JS,Spakowicz D,Zhou W,Zhou Y,Sodergren E,Snyder M,Weinstock GM

更新日期：2020-08-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement ...

journal_title：Diabetes

authors： Wolford JK,Yeatts KA,Dhanjal SK,Black MH,Xiang AH,Buchanan TA,Watanabe RM

更新日期：2005-11-01 00:00:00

abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

journal_title：Diabetes

authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

更新日期：2001-02-01 00:00:00

abstract：:Livers from 9-10-wk-old genetically obese and hyperinsulinemic (fa/fa) rats contained more DNA, proteins, and lipids than livers of age-matched controls. Actually, the increase in liver mass of fa/fa rats was mainly due to an increased cell number. On perfusion with insulin (1.75-16 nM), livers of obese fa/fa rats rem...

journal_title：Diabetes

authors： Karakash C,Jeanrenaud B

更新日期：1983-07-01 00:00:00

abstract：:Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic β-cells and associated metabolic dysfunction. Combined genetic and immunological studies now highlight deficiencies in both the interleukin-2 (IL-2) receptor and its downstream signaling pa...

journal_title：Diabetes

authors： Hulme MA,Wasserfall CH,Atkinson MA,Brusko TM

更新日期：2012-01-01 00:00:00

abstract：:Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...

journal_title：Diabetes

authors： Mezza T,Ferraro PM,Sun VA,Moffa S,Cefalo CMA,Quero G,Cinti F,Sorice GP,Pontecorvi A,Folli F,Mari A,Alfieri S,Giaccari A

更新日期：2018-11-01 00:00:00

abstract：:Human fetal pancreas has been obtained after the therapeutic termination of pregnancy with prostaglandin F2 alpha. Pancreatic explants were studied in a perifusion system and maintained in organ culture for up to 3 wk. Insulin biosynthesis was stimulated by glucose; however, the incorporation of 3H-L-leucine into proi...

journal_title：Diabetes

authors： Maitland JE,Parry DG,Turtle JR

更新日期：1980-01-01 00:00:00

abstract：:To investigate the temporal relationship of diabetes-induced renal growth and its associated metabolic alterations to the early development of renal hyperfunction, parallel functional and metabolic studies were performed shortly after the onset of diabetes in rats. Hyperglycemia and hypoinsulinemia were evident 18 h a...

journal_title：Diabetes

authors： Cortes P,Dumler F,Goldman J,Levin NW

更新日期：1987-01-01 00:00:00

abstract：:The strategy of positional cloning has been highly successful in identifying a number of single gene disorders that exhibit clear Mendelian patterns of inheritance. Positional cloning of insulin-dependent diabetes mellitus (IDDM) has been assisted by the expansion of molecular genetic tools and highly informative mark...

journal_title：Diabetes

authors： Rich SS

更新日期：1995-02-01 00:00:00

abstract：:Exciting new findings have been reported in the past few years that indicate that islets can be transplanted successfully across major histocompatibility barriers without the continuous use of immunosuppressive agents by techniques designed to eliminate passenger leukocytes. In vitro culture of donor islets either at ...

journal_title：Diabetes

authors： Faustman D,Lacy PE,Davie JM

更新日期：1982-08-01 00:00:00

abstract：:Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating 3-HIB is elevated according to levels of hyperglycemia and estab...

journal_title：Diabetes

authors： Nilsen MS,Jersin RÅ,Ulvik A,Madsen A,McCann A,Svensson PA,Svensson MK,Nedrebø BG,Gudbrandsen OA,Tell GS,Kahn CR,Ueland PM,Mellgren G,Dankel SN

更新日期：2020-09-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00

abstract：:The decline of leptin (Ob protein) concentrations during fasting is implicated as a signal for increasing the expression of the orexigenic peptide neuropeptide Y (NPY) in the hypothalamus. To test the hypothesis that the effects of food intake on arcuate nucleus NPY activation are mediated by leptin, we performed simu...

journal_title：Diabetes

authors： Baskin DG,Breininger JF,Schwartz MW

更新日期：1999-04-01 00:00:00

abstract：:The researchers conducted this study to test the hypothesis that risk of type 2 diabetes is less following reductions in body size and central adiposity. The Diabetes Prevention Program (DPP) recruited and randomized individuals with impaired glucose tolerance to treatment with placebo, metformin, or lifestyle modific...

journal_title：Diabetes

authors： Fujimoto WY,Jablonski KA,Bray GA,Kriska A,Barrett-Connor E,Haffner S,Hanson R,Hill JO,Hubbard V,Stamm E,Pi-Sunyer FX,Diabetes Prevention Program Research Group.

更新日期：2007-06-01 00:00:00

abstract：:Membrane glycoprotein plasma cell 1 (PC-1) has been shown to be increased in type 2 diabetes and involved in insulin resistance through inhibiting the insulin receptor tyrosine kinase, which was demonstrated using cultured breast cancer cells. However, other reports have shown contradictory results in Chinese hamster ...

journal_title：Diabetes

authors： Sakoda H,Ogihara T,Anai M,Funaki M,Inukai K,Katagiri H,Fukushima Y,Onishi Y,Ono H,Yazaki Y,Kikuchi M,Oka Y,Asano T

更新日期：1999-07-01 00:00:00