Impaired Nociception in the Diabetic Ins2+/Akita Mouse.

abstract：:Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have unclear genetic defects, hampering our understanding of the development of the disease and preventing pathogenesis-oriented treatment. We used whole-genome sequencing with linkage analysis to study a consanguineous family with ea...

journal_title：Diabetes

authors： Simaite D,Kofent J,Gong M,Rüschendorf F,Jia S,Arn P,Bentler K,Ellaway C,Kühnen P,Hoffmann GF,Blau N,Spagnoli FM,Hübner N,Raile K

更新日期：2014-10-01 00:00:00

abstract：:Enhanced advanced glycosylation end product (AGE) formation has been shown to participate in the pathogenesis of diabetes-induced glomerular injury by mediating the increased extracellular matrix (ECM) deposition and altered cell growth and turnover leading to mesangial expansion. These effects could be exerted via an...

journal_title：Diabetes

authors： Pugliese G,Pricci F,Romeo G,Pugliese F,Mené P,Giannini S,Cresci B,Galli G,Rotella CM,Vlassara H,Di Mario U

更新日期：1997-11-01 00:00:00

abstract：:In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-restricted iNKT cells by alpha-galactosylceramide (alpha-GalCer) corrects these deficiencies and protects against spontaneous and...

journal_title：Diabetes

authors： Mi QS,Ly D,Zucker P,McGarry M,Delovitch TL

更新日期：2004-05-01 00:00:00

abstract：:In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...

journal_title：Diabetes

authors： Taskinen MR

更新日期：1992-10-01 00:00:00

abstract：:Results from experimental and gene-association studies suggest that IGF-II may influence body weight regulation and that individuals with low IGF-II levels may be more susceptible to weight gain and obesity. We therefore assessed the association between circulating concentrations of IGF-II and subsequent weight gain a...

journal_title：Diabetes

authors： Sandhu MS,Gibson JM,Heald AH,Dunger DB,Wareham NJ

更新日期：2003-06-01 00:00:00

abstract：:Previous studies have provided evidence for the transcripts of Cx43 and Cx45 within pancreatic islets. As of yet, however, it has proven difficult to unambiguously demonstrate the expression of these proteins by islet cells. We have investigated whether Cx36, a new connexin species recently identified in mammalian bra...

journal_title：Diabetes

authors： Serre-Beinier V,Le Gurun S,Belluardo N,Trovato-Salinaro A,Charollais A,Haefliger JA,Condorelli DF,Meda P

更新日期：2000-05-01 00:00:00

abstract：:Prolonged near-physiological pulsatile insulin infusion has a greater hypoglycemic effect than continuous insulin infusion. We have previously shown that continuous hyperinsulinemia induces insulin insensitivity. This study examines the mechanisms responsible for the greater hypoglycemic effect of pulsatile insulin ad...

journal_title：Diabetes

authors： Ward GM,Walters JM,Aitken PM,Best JD,Alford FP

更新日期：1990-04-01 00:00:00

abstract：:Insulin receptors on viable rat adipocytes were affinity-labeled using a biologically active and photosensitive analogue of insulin, 125I-B2(2-nitro, 4 azidophenylacetyl)-des-PheB1-insulin (125I-NAPA-DP-insulin). The radiolabeled proteins were identified by SDS polyacrylamide gel electrophoresis and autoradiography. B...

journal_title：Diabetes

authors： Heidenreich KA,Berhanu P,Brandenburg D,Olefsky JM

更新日期：1983-11-01 00:00:00

abstract：:Secondary hyperlipidemia is a major cardiovascular risk factor in individuals with type 2 diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins contributes to the elevated plasma levels, but the mechanism is poorly understood. Recent results have established that microsomal triglyce...

journal_title：Diabetes

authors： Bartels ED,Lauritsen M,Nielsen LB

更新日期：2002-04-01 00:00:00

abstract：:Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in diabetes, making glucagon an attractive target for therapeutic interventio...

journal_title：Diabetes

authors： Dean ED

更新日期：2020-04-01 00:00:00

abstract：:Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell clone from undifferentiated ES cells. The construction used allows the expression of a neomycin selection system under the control of the reg...

journal_title：Diabetes

authors： Soria B,Roche E,Berná G,León-Quinto T,Reig JA,Martín F

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:The Diabetes Control and Complications Trial (Diabetes 44:968-983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support...

journal_title：Diabetes

authors： Lachin JM,Genuth S,Nathan DM,Zinman B,Rutledge BN,DCCT\/EDIC Research Group.

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...

journal_title：Diabetes

authors： Varma V,Yao-Borengasser A,Bodles AM,Rasouli N,Phanavanh B,Nolen GT,Kern EM,Nagarajan R,Spencer HJ 3rd,Lee MJ,Fried SK,McGehee RE Jr,Peterson CA,Kern PA

更新日期：2008-02-01 00:00:00

abstract：:Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin receptor (LEPR) mutation (designated Lepr(db-5J)) producing juvenile obesity, hyperglycemia, hyperinsulinemia, and hyperleptinemia. This early type 2 diabetes syndrome suppressed intra-islet insulitis and permitted spontane...

journal_title：Diabetes

authors： Lee CH,Chen YG,Chen J,Reifsnyder PC,Serreze DV,Clare-Salzler M,Rodriguez M,Wasserfall C,Atkinson MA,Leiter EH

更新日期：2006-01-01 00:00:00

abstract：:We studied certain metabolic requirements for insulin-induced increases in phospholipids, and the relationship of phospholipid changes to the insulin-induced activation of pyruvate dehydrogenase, in rat adipocytes and fat pads in vitro. Increases in the contents of phosphatidylinositol and phosphatidylserine mass were...

journal_title：Diabetes

authors： Farese RV,Farese RV Jr,Sabir MA,Larson RE,Trudeau WL 3rd,Barnes D

更新日期：1984-07-01 00:00:00

abstract：:Diabetes diagnostic therapy and research would strongly benefit from noninvasive accurate imaging of the functional β-cells in the pancreas. Here, we developed an analysis of functional β-cell mass (BCM) by measuring manganese (Mn(2+)) uptake kinetics into glucose-stimulated β-cells by T1-weighted in vivo Mn(2+)-media...

journal_title：Diabetes

authors： Meyer A,Stolz K,Dreher W,Bergemann J,Holebasavanahalli Thimmashetty V,Lueschen N,Azizi Z,Khobragade V,Maedler K,Kuestermann E

更新日期：2015-06-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00

abstract：:When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS). Beta-cell stimulus-secretion coupling was investigated in islets isolated from DP P. obesus fed a low-energy (LE) diet (DP-LE) and after 5 days on a HE diet (DP-HE). ...

journal_title：Diabetes

authors： Pertusa JA,Nesher R,Kaiser N,Cerasi E,Henquin JC,Jonas JC

更新日期：2002-08-01 00:00:00

abstract：:Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4+CXCR...

journal_title：Diabetes

authors： Viisanen T,Ihantola EL,Näntö-Salonen K,Hyöty H,Nurminen N,Selvenius J,Juutilainen A,Moilanen L,Pihlajamäki J,Veijola R,Toppari J,Knip M,Ilonen J,Kinnunen T

更新日期：2017-02-01 00:00:00

abstract：:Kinetic studies were carried out on liver glycogen synthase and phosphorylase isolated from genetically diabetic db/db mice. Glycogen synthase a and b enzymes from diabetic mice had Vmax values 30% and 20% lower, respectively, than the enzymes from normal mice. Glycogen synthase b from diabetic mice also had a 30% low...

journal_title：Diabetes

authors： Roesler WJ,Khandelwal RL

更新日期：1986-02-01 00:00:00

abstract：:We examined the effects of activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice and investigated the mechanisms by which they improve insulin sensitivity. PPARalpha activation by its agonist, Wy-14,643, as well as PPARgamma activat...

journal_title：Diabetes

authors： Tsuchida A,Yamauchi T,Takekawa S,Hada Y,Ito Y,Maki T,Kadowaki T

更新日期：2005-12-01 00:00:00

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：:A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However, mechanisms underlying their activation are poorly understood. In this study, we demonstrated a previously unrecognized homeostatic role for the costimulatory B7 molecul...

journal_title：Diabetes

authors： Zhong J,Rao X,Braunstein Z,Taylor A,Narula V,Hazey J,Mikami D,Needleman B,Rutsky J,Sun Q,Deiuliis JA,Satoskar AR,Rajagopalan S

更新日期：2014-04-01 00:00:00

abstract：:Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue re...

journal_title：Diabetes

authors： Mayorek N,Kalderon B,Itach E,Bar-Tana J

更新日期：1997-12-01 00:00:00

abstract：:The cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) gene is implicated as an important regulator of body weight in mice and humans and is therefore a candidate gene for human obesity. Here, we characterize common CIDEA gene polymorphisms and investigate them for association with obesi...

journal_title：Diabetes

authors： Dahlman I,Kaaman M,Jiao H,Kere J,Laakso M,Arner P

更新日期：2005-10-01 00:00:00

abstract：:Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves' disease in comparison to healthy control subjects by st...

journal_title：Diabetes

authors： Kallmann BA,Hüther M,Tubes M,Feldkamp J,Bertrams J,Gries FA,Lampeter EF,Kolb H

更新日期：1997-02-01 00:00:00

abstract：:To explore metabolic changes associated with the sorbitol accumulation and myo-inositol depletion observed in glomeruli of rats with experimental diabetes, we examined total and ouabain-inhibited adenosine triphosphatase (ATPase) activity in glomeruli isolated from control and streptozocin (STZ)-diabetic rats. Glomeru...

journal_title：Diabetes

authors： Cohen MP,Dasmahapatra A,Shapiro E

更新日期：1985-11-01 00:00:00

abstract：:NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H2O2, which is essential for GSIS; an increase in ATP alone was insufficient for GSIS. The fast GSIS phas...

journal_title：Diabetes

authors： Plecitá-Hlavatá L,Jabůrek M,Holendová B,Tauber J,Pavluch V,Berková Z,Cahová M,Schröder K,Brandes RP,Siemen D,Ježek P

更新日期：2020-07-01 00:00:00

abstract：:Data based on the prospective study of Job et al. are reanalyzed while initial number of microaneurysms and duration of patient follow-up are controlled. The reported statistical difference in the rate of microaneurysm increase between the single- and the multiple-daily-injection groups may be due to a difference in a...

journal_title：Diabetes

authors： Ashikaga T,Borodic G,Sims EA

更新日期：1978-05-01 00:00:00

abstract：:Prostacyclin (PGI2) synthesis by vascular endothelial cells (ECs) decreases in diabetic subjects, possibly leading to the development of diabetic angiopathy, such as that seen in atherosclerosis. We recently found a novel bioactive peptide, prostacyclin-stimulating factor (PSF), which stimulates PGI2 synthesis by cult...

journal_title：Diabetes

authors： Sekiguchi N,Umeda F,Masakado M,Ono Y,Hashimoto T,Nawata H

更新日期：1997-10-01 00:00:00