Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease.

abstract：:Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a gut hormone, is rapidly induced by bariatric surgery in rodents and humans. Administration of FGF19 achieves diabetes remission ind...

journal_title：Diabetes

authors： DePaoli AM,Zhou M,Kaplan DD,Hunt SC,Adams TD,Learned RM,Tian H,Ling L

更新日期：2019-06-01 00:00:00

abstract：:Fasting hypoglycemia occurred in a patient with a histologically benign mesothelioma; the serum insulin was low (2-4 muU./ml.), as was the glucose utilization rate. Splanchnic glucose output was markedly decreased on direct measurement (21 mg./min.; normal: 108-180 mg./min.). Splanchnic uptake of gluconeogenic substra...

journal_title：Diabetes

authors： Silbert CK,Rossini AA,Ghazvinian S,Widrich WC,Marks LJ,Sawin CT

更新日期：1976-03-01 00:00:00

abstract：:The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...

journal_title：Diabetes

authors： Ikeda H,Shino A,Matsuo T,Iwatsuka H,Suzuoki Z

更新日期：1981-12-01 00:00:00

abstract：:Apoptosis is a physiological form of cell death that occurs during normal development, and critical mediators of this process include caspases, reactive oxygen species, and Ca2+. Excessive apoptosis of the pancreatic beta-cell has been associated with diabetes. Consequently, apoptosis research has focused on how infil...

journal_title：Diabetes

authors： Chandra J,Zhivotovsky B,Zaitsev S,Juntti-Berggren L,Berggren PO,Orrenius S

更新日期：2001-02-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase (CaMK) activation induces mitochondrial biogenesis in response to increasing cytosolic calcium concentrations. Calcium leak from the ryanodine receptor (RyR) is regulated by reactive oxygen species (ROS), which is increased with high-fat feeding. We examined whether ROS-indu...

journal_title：Diabetes

authors： Jain SS,Paglialunga S,Vigna C,Ludzki A,Herbst EA,Lally JS,Schrauwen P,Hoeks J,Tupling AR,Bonen A,Holloway GP

更新日期：2014-06-01 00:00:00

abstract：:Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...

journal_title：Diabetes

authors： Tsuchiya K,Accili D

更新日期：2013-05-01 00:00:00

abstract：:The effect of 4 wk of streptozocin (STZ)-induced diabetes on the transmission time of the auditory-evoked brain stem response (ABR) was examined in conscious male Sprague-Dawley rats. Distal nerve transmission time of the auditory pathway (latency of peak II), which includes conduction along the 8th cranial nerve, inc...

journal_title：Diabetes

authors： Notvest RR,Inserra JJ

更新日期：1987-04-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients with type 2 diabetes. In...

journal_title：Diabetes

authors： Hansen SL,Bojsen-Møller KN,Lundsgaard AM,Hendrich FL,Nilas L,Sjøberg KA,Hingst JR,Serup AK,Olguín CH,Carl CS,Wernblad LF,Henneberg M,Lustrup KM,Hansen C,Jensen TE,Madsbad S,Wojtaszewski JFP,Richter EA,Kiens B

更新日期：2020-11-01 00:00:00

abstract：:Cytoplasmic islet cell antibody-negative (ICA-; less than 20 Juvenile Diabetes Foundation units, n = 1670) and ICA+ (n = 42) first-degree relatives of type I (insulin-dependent) diabetic individuals were studied for competitive insulin autoantibodies (CIAAs) with a radioassay. Overall, 3.7% of first-degree relatives (...

journal_title：Diabetes

authors： Ziegler AG,Ziegler R,Vardi P,Jackson RA,Soeldner JS,Eisenbarth GS

更新日期：1989-10-01 00:00:00

abstract：:Autoantibodies to glutamic acid decarboxylase (GAD) are frequent at or before the onset of insulin-dependent diabetes mellitus (IDDM). We have developed a simple, reproducible, and quantitative immunoprecipitation radioligand assay using as antigen in vitro transcribed and translated [35S]methionine-labeled human isle...

journal_title：Diabetes

authors： Petersen JS,Hejnaes KR,Moody A,Karlsen AE,Marshall MO,Høier-Madsen M,Boel E,Michelsen BK,Dyrberg T

更新日期：1994-03-01 00:00:00

abstract：:Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD i...

journal_title：Diabetes

authors： Marshall AG,Lee-Kubli C,Azmi S,Zhang M,Ferdousi M,Mixcoatl-Zecuatl T,Petropoulos IN,Ponirakis G,Fineman MS,Fadavi H,Frizzi K,Tavakoli M,Jeziorska M,Jolivalt CG,Boulton AJM,Efron N,Calcutt NA,Malik RA

更新日期：2017-05-01 00:00:00

abstract：:In adipose tissue from both obese mice and humans, plasminogen activator inhibitor 1 (PAI-1) expression has been reported to be upregulated to levels of increased plasma PAI-1. This elevated expression has been shown to be partly controlled by tumor necrosis factor (TNF)-alpha in mice. In humans, increased PAI-1 expre...

journal_title：Diabetes

authors： Alessi MC,Bastelica D,Morange P,Berthet B,Leduc I,Verdier M,Geel O,Juhan-Vague I

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：:A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). Frequencies of these classe...

journal_title：Diabetes

authors： Elbein S,Rotwein P,Permutt MA,Bell GI,Sanz N,Karam JH

更新日期：1985-05-01 00:00:00

abstract：:Children with permanent diabetes are usually assumed to have type 1 diabetes. It has recently been shown that there are genetic subgroups of diabetes that are often diagnosed during the neonatal period but may present later. A recent Italian study proposed that type 1 diabetes is rare before 6 months of age. We aimed ...

journal_title：Diabetes

authors： Edghill EL,Dix RJ,Flanagan SE,Bingley PJ,Hattersley AT,Ellard S,Gillespie KM

更新日期：2006-06-01 00:00:00

abstract：:Adiponectin is an adipose tissue-specific protein with insulin-sensitizing and antiatherogenic properties. Therefore, the adiponectin gene is a promising candidate gene for type 2 diabetes. We investigated the single nucleotide polymorphisms (SNPs) +45T/G and +276G/T of the adiponectin gene as predictors for the conve...

journal_title：Diabetes

authors： Zacharova J,Chiasson JL,Laakso M,STOP-NIDDM Study Group.

更新日期：2005-03-01 00:00:00

abstract：:A workshop sponsored by the National Institute of Child Health and Human Development was held in June 1988 to discuss the initial events in the pathogenesis of insulin-dependent diabetes and to make recommendations for future studies. Better definition of immunological markers to reliably predict the disease will enab...

journal_title：Diabetes

authors： Maclaren N,Schatz D,Drash A,Grave G

更新日期：1989-04-01 00:00:00

abstract：:Selective peroxisome proliferator-activated receptor (PPAR) gamma modulation is a new pharmacological approach that, based on selective receptor-cofactor interactions and target gene regulation, should result in potent insulin sensitization in the absence of PPARgamma-mediated adverse effects. Here, we characterize tw...

journal_title：Diabetes

authors： Schupp M,Clemenz M,Gineste R,Witt H,Janke J,Helleboid S,Hennuyer N,Ruiz P,Unger T,Staels B,Kintscher U

更新日期：2005-12-01 00:00:00

abstract：:It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nerv...

journal_title：Diabetes

authors： Bohlooly-Y M,Olsson B,Bruder CE,Lindén D,Sjögren K,Bjursell M,Egecioglu E,Svensson L,Brodin P,Waterton JC,Isaksson OG,Sundler F,Ahrén B,Ohlsson C,Oscarsson J,Törnell J

更新日期：2005-01-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SLI) concentrations were determined in human peripheral plasma using affinity chromatography followed by radioimmunoassay. In normal subjects, fasting SLI ranged from 2.9 to 22.0 pg/ml with a mean +/- SE value of 10.2 +/- 2.1 pg/ml. In totally pancreatectomized or gastrectomized pat...

journal_title：Diabetes

authors： Tsuda K,Sakurai H,Seino Y,Seino S,Tanigawa K,Kuzuya H,Imura H

更新日期：1981-06-01 00:00:00

abstract：:Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by t...

journal_title：Diabetes

authors： Blackshear PJ,Rohde TD,Grotting JC,Dorman FD,Perkins PR,Varco RL,Buchwald H

更新日期：1979-07-01 00:00:00

abstract：:In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K) enzyme system. In the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. To ...

journal_title：Diabetes

authors： Niswender KD,Morrison CD,Clegg DJ,Olson R,Baskin DG,Myers MG Jr,Seeley RJ,Schwartz MW

更新日期：2003-02-01 00:00:00

abstract：:This study investigated how maternal overnutrition and obesity regulate expression and activation of proteins that facilitate lipid transport in the placenta. To create a maternal overnutrition and obesity model, primiparous C57BL/6 mice were fed a high-fat (HF) diet throughout gestation. Fetuses from HF-fed dams had ...

journal_title：Diabetes

authors： Qiao L,Guo Z,Bosco C,Guidotti S,Wang Y,Wang M,Parast M,Schaack J,Hay WW Jr,Moore TR,Shao J

更新日期：2015-09-01 00:00:00

abstract：:Insulin antagonism characterizes infection, but the mechanism is unknown. Previous studies have been performed during the acute catabolic stage of infection, and the resultant metabolic changes reflect this decreased food intake and weight loss. To delineate metabolic alterations due to infection itself, rats with pye...

journal_title：Diabetes

authors： Davidson MB

更新日期：1975-10-01 00:00:00

abstract：:Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with d...

journal_title：Diabetes

authors： Benninger RKP,Hodson DJ

更新日期：2018-04-01 00:00:00

abstract：:Functional changes in slow-twitch soleus and fast-twitch extensor digitorum longus muscles were assessed after 2 mo of streptozocin-induced diabetes in rats. For soleus, there was a slowing of twitch times both for contraction and relaxation and a reduction of maximum tetanic relaxation rate. There was little effect o...

journal_title：Diabetes

authors： Cameron NE,Cotter MA,Robertson S

更新日期：1990-04-01 00:00:00

abstract：:There has been great interest in the browning of fat for the treatment of obesity. Although β-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose ...

journal_title：Diabetes

authors： Choi WH,Ahn J,Jung CH,Jang YJ,Ha TY

更新日期：2016-09-01 00:00:00

abstract：:Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammatory changes in obesity and contribute to insulin resistance, the properties of these cells are not well understood. We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory prope...

journal_title：Diabetes

authors： Lumeng CN,Deyoung SM,Bodzin JL,Saltiel AR

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-ce...

journal_title：Diabetes

authors： Cui J,Wang Z,Cheng Q,Lin R,Zhang XM,Leung PS,Copeland NG,Jenkins NA,Yao KM,Huang JD

更新日期：2011-01-01 00:00:00

abstract：:Obesity and family history of diabetes are both risk factors for non-insulin-dependent diabetes mellitus (NIDDM), but it has been proposed that lean individuals with NIDDM have a greater load of diabetes susceptibility genes. If this is the case, one might expect a high prevalence of NIDDM in relatives of diabetic ind...

journal_title：Diabetes

authors： Hanson RL,Pettitt DJ,Bennett PH,Narayan KM,Fernandes R,de Courten M,Knowler WC

更新日期：1995-04-01 00:00:00