Changes in skeletal muscle contractile properties in streptozocin-induced diabetic rats and role of polyol pathway and hypoinsulinemia.

abstract：:The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between g...

journal_title：Diabetes

authors： Rosen ED,Kaestner KH,Natarajan R,Patti ME,Sallari R,Sander M,Susztak K

更新日期：2018-10-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol (AG) was measured in 135 newly diagnosed patients who were referred for oral glucose tolerance tests. AG concentrations in the nondiabetic patients indicated that the mean value of normal AG concentration was 21.8 micrograms/ml (SD = 5.9 micrograms/ml, range 9.6-38.8 ...

journal_title：Diabetes

authors： Yamanouchi T,Akanuma H,Asano T,Konishi C,Akaoka I,Akanuma Y

更新日期：1987-06-01 00:00:00

abstract：:The natural history of progression from normal glucose tolerance (NGT) to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes is not well defined. We studied this progression using biennial oral glucose tolerance tests performed in the Baltimore Longitudinal Study of Aging and surviva...

journal_title：Diabetes

authors： Meigs JB,Muller DC,Nathan DM,Blake DR,Andres R,Baltimore Longitudinal Study of Aging.

更新日期：2003-06-01 00:00:00

abstract：:Body weight is tightly regulated by food intake and energy dissipation, and obesity is related to decreased energy expenditure (EE). Herein, we show that nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2, autotaxin) is an adipose-derived, secreted enzyme that controls adipose expansion, brown adipose tissue (BAT) ...

journal_title：Diabetes

authors： Nishimura S,Nagasaki M,Okudaira S,Aoki J,Ohmori T,Ohkawa R,Nakamura K,Igarashi K,Yamashita H,Eto K,Uno K,Hayashi N,Kadowaki T,Komuro I,Yatomi Y,Nagai R

更新日期：2014-12-01 00:00:00

abstract：:Tight glycemic control by intensive insulin therapy effectively delays the onset and slows the progression of diabetic complications but is associated with frequent dose adjustments and a high incidence of hypoglycemia. Successful pancreas transplantation corrects abnormal glucose metabolism but subjects patients to m...

journal_title：Diabetes

authors： Maki T,Otsu I,O'Neil JJ,Dunleavy K,Mullon CJ,Solomon BA,Monaco AP

更新日期：1996-03-01 00:00:00

abstract：:We investigated the effects of non-insulin-dependent diabetes mellitus (NIDDM) on lipoprotein(a) (Lp[a]) and apolipoprotein(a) (apo[a]) in a population of Mexican-Americans. In plasma samples from 536 subjects, we measured Lp(a) concentrations, and we estimated apo(a) isoform sizes following immunostaining of plasma p...

journal_title：Diabetes

authors： Rainwater DL,MacCluer JW,Stern MP,VandeBerg JL,Haffner SM

更新日期：1994-07-01 00:00:00

abstract：:The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many vertebrates including humans. The glucokinase-containing, insulin-produci...

journal_title：Diabetes

authors： Matschinsky FM,Magnuson MA,Zelent D,Jetton TL,Doliba N,Han Y,Taub R,Grimsby J

更新日期：2006-01-01 00:00:00

abstract：:This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...

journal_title：Diabetes

authors： Edgerton DS,Cherrington AD,Williams P,Neal DW,Scott M,Bowen L,Wilson W,Hobbs CH,Leach C,Kuo MC,Strack TR

更新日期：2006-12-01 00:00:00

abstract：:Pancreatic beta-cell survival is critical in the setting of diabetes as well as in islet transplantation. Transgenic mice overexpressing parathyroid hormone-related protein (PTHrP) targeted to beta-cells using the rat insulin II promoter (RIP) display hyperinsulinemia, hypoglycemia, and islet hyperplasia, without a co...

journal_title：Diabetes

authors： Cebrian A,García-Ocaña A,Takane KK,Sipula D,Stewart AF,Vasavada RC

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS:Eight subjects with risk-conferring TCF7L2 genotypes (TT o...

journal_title：Diabetes

authors： Villareal DT,Robertson H,Bell GI,Patterson BW,Tran H,Wice B,Polonsky KS

更新日期：2010-02-01 00:00:00

abstract：:Effects of oral administration of DG-5128, a new oral hypoglycemic agent, on glycemic control after a mixed meal and an in vivo glucose disposal were measured in subjects with nonobese non-insulin-dependent diabetes mellitus (NIDDM). Oral administration of DG-5128 significantly (P less than .05) enhanced insulin secre...

journal_title：Diabetes

authors： Kashiwagi A,Harano Y,Suzuki M,Kojima H,Harada M,Nishio Y,Shigeta Y

更新日期：1986-10-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. Podocytes are important for glomerular filtration barrier function and maintenance of size selectivity in protein filtration in the kidney. Podocyte damage is the basis of many glomerular diseases characterized by loss of interdigitatin...

journal_title：Diabetes

authors： Teng B,Schroder P,Müller-Deile J,Schenk H,Staggs L,Tossidou I,Dikic I,Haller H,Schiffer M

更新日期：2016-12-01 00:00:00

abstract：:Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...

journal_title：Diabetes

authors： Ginsberg HN

更新日期：1977-04-01 00:00:00

abstract：:Elevated levels of advanced glycosylation end products (AGEs) have been found in multiple tissues in association with diabetic vascular complications and during the microalbuminuric phase of diabetic nephropathy. In this study, we have used an AGE-specific enzyme-linked immunosorbent assay (ELISA) to measure skin AGEs...

journal_title：Diabetes

authors： Beisswenger PJ,Makita Z,Curphey TJ,Moore LL,Jean S,Brinck-Johnsen T,Bucala R,Vlassara H

更新日期：1995-07-01 00:00:00

abstract：:The changes of the microvasculature of rat pancreas transplants during acute rejection were investigated and quantitatively analyzed. The vessels in pancreas transplants increased in caliber and decreased in density during acute rejection. These changes were marked in the exocrine pancreas, especially in central zones...

journal_title：Diabetes

authors： Nakai I,Aikawa I,Oka T

更新日期：1989-01-01 00:00:00

abstract：:IA-2 and IA-2beta are members of the transmembrane protein tyrosine phosphatase family located in dense core vesicles of neuroendocrine cells, including the beta-cells of pancreatic islets. In the present study, by mating C57BL/6Nci IA-2(+/-) with IA-2beta(+/-) mice, we generated double knockout mice (IA-2(-/-)/IA-2be...

journal_title：Diabetes

authors： Kubosaki A,Nakamura S,Notkins AL

更新日期：2005-12-01 00:00:00

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior. Immunoprecipitation, immunofluorescent staining, and RT-PCR of human VSMCs showed that elevat...

journal_title：Diabetes

authors： Campbell M,Allen WE,Silversides JA,Trimble ER

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency...

journal_title：Diabetes

authors： Flotte T,Agarwal A,Wang J,Song S,Fenjves ES,Inverardi L,Chesnut K,Afione S,Loiler S,Wasserfall C,Kapturczak M,Ellis T,Nick H,Atkinson M

更新日期：2001-03-01 00:00:00

abstract：:Congenital malformations occur more frequently in the offspring of diabetic mothers. These in vivo and in vitro studies investigate the potential adverse effects of hyperglycemia on kidney development in the rat. Female rats were made hyperglycemic throughout gestation with a single injection of streptozotocin (STZ) o...

journal_title：Diabetes

authors： Amri K,Freund N,Vilar J,Merlet-Bénichou C,Lelièvre-Pégorier M

更新日期：1999-11-01 00:00:00

abstract：:The experiments reported here investigate the effects of two conditions of elevated lactogen activity on the threshold of glucose stimulation of insulin secretion and suprathreshold, glucose-stimulated insulin secretion in the isolated, perfused rat pancreas. In both the tumor-bearing animals and pregnant animals, the...

journal_title：Diabetes

authors： Sorenson RL,Parsons JA

更新日期：1985-04-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：:Insulin resistance and dysregulation of free fatty acid (FFA) metabolism are core defects in type 2 diabetic (T2DM) and obese normal glucose tolerant (NGT) individuals. Impaired muscle mitochondrial function (reduced ATP synthesis) also has been described in insulin-resistant T2DM and obese subjects. We examined wheth...

journal_title：Diabetes

authors： Daniele G,Eldor R,Merovci A,Clarke GD,Xiong J,Tripathy D,Taranova A,Abdul-Ghani M,DeFronzo RA

更新日期：2014-08-01 00:00:00

abstract：:Receptors for bradykinin (BK) were characterized in primary cultures of beating neonatal rat cardiomyocytes using [3H]BK was radioligand. Degradation studies demonstrated that [3H]BK was stable for at least 2 h when incubated with cardiomyocytes at 2 and 37 degrees C in the presence of bacitracin in combination with c...

journal_title：Diabetes

authors： Kasel AM,Faussner A,Pfeifer A,Müller U,Werdan K,Roscher AA

更新日期：1996-01-01 00:00:00

abstract：:Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that e...

journal_title：Diabetes

authors： Kjeldsen K,Braendgaard H,Sidenius P,Larsen JS,Nørgaard A

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impac...

journal_title：Diabetes

authors： Højbjerre L,Sonne MP,Alibegovic AC,Dela F,Vaag A,Meldgaard JB,Christensen KB,Stallknecht B

更新日期：2010-11-01 00:00:00

abstract：:A role for glucose in the control of feeding has been proposed, but its precise physiological importance is unknown. Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (ripglut1;glut2-/- mice). We showed that in the abs...

journal_title：Diabetes

authors： Bady I,Marty N,Dallaporta M,Emery M,Gyger J,Tarussio D,Foretz M,Thorens B

更新日期：2006-04-01 00:00:00

abstract：:Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control m...

journal_title：Diabetes

authors： Fiaschi-Taesch NM,Kleinberger JW,Salim FG,Troxell R,Wills R,Tanwir M,Casinelli G,Cox AE,Takane KK,Scott DK,Stewart AF

更新日期：2013-07-01 00:00:00