Abstract:
:Tight glycemic control by intensive insulin therapy effectively delays the onset and slows the progression of diabetic complications but is associated with frequent dose adjustments and a high incidence of hypoglycemia. Successful pancreas transplantation corrects abnormal glucose metabolism but subjects patients to morbidity and mortality associated with chronic immunosuppression. A vascularized artificial pancreas device containing pancreatic islets is designed to provide glycemic control without immunosuppression. We report here that devices seeded with porcine islets implanted into pancreatectomized severely diabetic dogs maintained a marked improvement in glycemic control with reduced exogenous insulin requirements for up to 9 months with improved glucose tolerance and a reduction in glycosylated hemoglobin levels. No immunosuppression was used. Thus, use of a vascularized artificial pancreas containing xenogeneic porcine islets could be an alternative to intensive insulin therapy and pancreatic transplantation in treating diabetic patients before the development of severe diabetic complications.
journal_name
Diabetesjournal_title
Diabetesauthors
Maki T,Otsu I,O'Neil JJ,Dunleavy K,Mullon CJ,Solomon BA,Monaco APdoi
10.2337/diab.45.3.342subject
Has Abstractpub_date
1996-03-01 00:00:00pages
342-7issue
3eissn
0012-1797issn
1939-327Xjournal_volume
45pub_type
杂志文章相关文献
DIABETES文献大全abstract::Previous studies have indicated that individuals with type 2 diabetes have an increased resting metabolic rate (RMR) but decreased insulin-induced thermogenesis (IIT) compared with those with normal glucose tolerance (NGT). When and by which mechanisms these abnormalities occur during the development of diabetes remai...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.8.1607
更新日期:1999-08-01 00:00:00
abstract::The antihyperglycemic drug dimethylbiguanide (DMB, also known as metformin) reduces the risk of cardiovascular complications in type 2 diabetes, although the mechanism(s) involved are unclear. DMB reduces glycosylation-related protein cross-linking, a process similar to fibrin cross-linking catalyzed by activated fact...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.1.189
更新日期:2002-01-01 00:00:00
abstract::Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4+CXCR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0714
更新日期:2017-02-01 00:00:00
abstract::Blood-retinal barrier (BRB) breakdown is a hallmark of diabetic retinopathy, but the molecular changes that cause this pathology are unclear. Occludin is a transmembrane component of interendothelial tight junctions that may regulate permeability at the BRB. In this study, we examined the effects of vascular endotheli...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.47.12.1953
更新日期:1998-12-01 00:00:00
abstract::The transcription factor regulatory factor X (RFX)-3 regulates the expression of genes required for the growth and function of cilia. We show here that mouse RFX3 is expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults. RFX3 expression already is evident in early Ngn3-positi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1187
更新日期:2007-04-01 00:00:00
abstract::Diabetes is associated with a loss of somatosensory and motor function, leading to impairments in gait, balance, and manual dexterity. Data-driven neuroimaging studies frequently report a negative impact of diabetes on sensorimotor regions in the brain; however, relationships with sensorimotor behavior are rarely cons...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/db19-0321
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Obesity is associated with increased activation of the c-Jun NH(2)-terminal kinase (JNK) in several metabolic organs, including adipose tissue, liver, and skeletal muscle. In this study, we aimed to define the role of JNK activation in adipose tissue in the development of obesity-related insulin resistance. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0650
更新日期:2011-02-01 00:00:00
abstract::Although most patients with type 1 diabetes (T1D) continue to produce small amounts of insulin decades after disease onset, very few β-cells persist within their pancreata. Consequently, the source of persistent insulin secretion within T1D remains unclear. We hypothesized that low-level insulin content within non-β-c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0305
更新日期:2019-03-01 00:00:00
abstract::We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or underwent an acute ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-1334
更新日期:2017-08-01 00:00:00
abstract::Fetal hyperinsulinemia causes fetal arterial hypoxia because fetal O2 use increases, whereas the supply of O2 to the fetus does not. To find which of the fetal tissues accounts for such an increase in fetal O2 use, we examined the effect of plasma hyperinsulinemia on O2, glucose, and lactate use by the hindquarters of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.5.597
更新日期:1989-05-01 00:00:00
abstract::Duct-occluded segmental-pancreas transplants develop progressive fibrotic atrophy, even though endocrine function seems to be unaffected. To determine end-stage size of the graft and to evaluate magnetic resonance imaging (MRI) and computed tomography (CT), these imaging techniques were applied in eight patients with ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.1.s24
更新日期:1989-01-01 00:00:00
abstract::Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.11.2444
更新日期:2001-11-01 00:00:00
abstract::Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db20-0373
更新日期:2021-02-01 00:00:00
abstract::Insulin resistance is of pathogenic importance in several common human disorders including type 2 diabetes, hypertension, obesity and hyperlipidemia, but the underlying mechanisms are unknown. The spontaneously hypertensive rat (SHR) is a model of these human insulin resistance syndromes. Quantitative trait loci (QTLs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.12.2222
更新日期:2000-12-01 00:00:00
abstract::Recently, missense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-peptide production to...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-0878
更新日期:2012-04-01 00:00:00
abstract::There is controversy over the extent to which fatty acids (FAs) derived from plasma free FAs (FFAs) or from hydrolysis of plasma triglycerides (TGFAs) form communal or separate pools and what the contribution of each FA source is to cellular FA metabolism. Chylomicrons and lipid emulsions were labeled with [(3)H]triol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.3.614
更新日期:2003-03-01 00:00:00
abstract::Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator-activated receptor (PPAR)-gamma response elements in v...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.5.1149
更新日期:2001-05-01 00:00:00
abstract::The effects of elevated EPI and CORT levels on KG, SI, and SG were studied in dogs with alloxan-induced diabetes. Conscious dogs received SAL, EPI 20 ng.kg-1.min-1 for 30 min (short EPI) or 72 h (long EPI), or CORT 200 micrograms.kg-1.min-1 for 60 min (short CORT) or 72 h (long CORT) before assessment of glucose metab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.11.1446
更新日期:1992-11-01 00:00:00
abstract::Susceptibility to insulin-dependent diabetes mellitus (IDDM) is greatly influenced by polymorphisms in the genes of the class II region of the human leukocyte antigen (HLA) complex. The complexity of this genetic association and the lack of a direct proof of involvement of HLA class II genes in human IDDM have continu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.1.110
更新日期:1994-01-01 00:00:00
abstract::Glucagon-like peptide 1 receptor (GLP-1R) imaging with radiolabeled exendin has proven to be a powerful tool to quantify β-cell mass (BCM) in vivo. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose (BG) levels on GLP-1R-mediated exendin uptake in both murine ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db20-0616
更新日期:2020-11-01 00:00:00
abstract::To investigate how the D-cell recognizes the glucose stimulus, the hormone response to (1) glucose, (2) the trioses glyceraldehyde and dihydroxyacetone, (3) the metabolic blocker, mannoheptulose, and (4) the low- or nonmetabolized sugars galactose, fructose, or ribose were studied using the isolated dog pancreas. We f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.3.203
更新日期:1981-03-01 00:00:00
abstract::Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-T-lymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of dia...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.7.877
更新日期:1987-07-01 00:00:00
abstract::Treatment of male sand rats kept on a balanced laboratory chow diet ad libitum with beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a hypolipidemic effect accompanied by an extensive reduction in adiposity, with a concomitant hypoglycemic-hypoinsulinemic effect. The overall effect was s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.12.1618
更新日期:1988-12-01 00:00:00
abstract::Allotransplantation of pancreatic islets represents a promising approach to treat type 1 diabetes. Destruction of beta-cells in islet allografts involves multiple immune mechanisms that lead to activation of caspases and apoptotic cell death. The X-linked inhibitor of apoptosis (XIAP) inhibits apoptosis induced by a v...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.9.2533
更新日期:2005-09-01 00:00:00
abstract::Glucose tolerance depends on a complex interaction among insulin secretion from the beta-cells, clearance of the hormone, and the actions of insulin to accelerate glucose disappearance and inhibit endogenous glucose production. An additional factor, less well recognized, is the ability of glucose per se, independent o...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.38.12.1512
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy of adipocytes. However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis. RESEARCH DESIGN AND METHODS:We have developed ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-1749
更新日期:2007-06-01 00:00:00
abstract::The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical dia...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-1115
更新日期:2016-03-01 00:00:00
abstract::Based on studies of both man and rat, it is proposed that at least three distinct syndromes of hypertriglyceridemia occur as the result of abnormalities of carbohydrate metabolism. We believe that these syndromes are the predictable results of the changes in plasma insulin and/or free fatty acid (FFA) concentration th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.2.s66
更新日期:1981-01-01 00:00:00
abstract::Prostaglandin E (PGE) infusion in normal man inhibits the acute insulin response to glucose. In order to determine whether endogenously released PGE might also inhibit insulin secretion, glucose-stimulated insulin responses were investigated in normal volunteers after furosemide (40 mg i.v.), a stimulator of endogenou...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.28.9.841
更新日期:1979-09-01 00:00:00
abstract::Clinical studies indicate that significant loss of functional islet mass occurs in the peritransplant period. Islets are injured as a result of detrimental effects of brain death, pancreas preservation, islet isolation, hypoxia, hyperglycemia, and immune-mediated events. In addition, recent studies demonstrated that i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.11.2804
更新日期:2004-11-01 00:00:00