Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM.

abstract：:Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...

journal_title：Diabetes

authors： Vandal M,White PJ,Tremblay C,St-Amour I,Chevrier G,Emond V,Lefrançois D,Virgili J,Planel E,Giguere Y,Marette A,Calon F

更新日期：2014-12-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...

journal_title：Diabetes

authors： Tennant KG,Lindsley SR,Kirigiti MA,True C,Kievit P

更新日期：2019-07-01 00:00:00

abstract：:In an ongoing investigation of the effects of age on G protein-coupled receptor signaling in human atrial tissue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with age but reaches statistical significance only in patients with diabetes. Moreover, we find that in elderly ...

journal_title：Diabetes

authors： Richardson MD,Kilts JD,Kwatra MM

更新日期：2004-09-01 00:00:00

abstract：:The IGF system has been associated with development and progression of diabetic retinopathy. We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. A prospective observational study was performed in 103 pregnan...

journal_title：Diabetes

authors： Lauszus FF,Klebe JG,Bek T,Flyvbjerg A

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kina...

journal_title：Diabetes

authors： Kowluru A,Veluthakal R,Rhodes CJ,Kamath V,Syed I,Koch BJ

更新日期：2010-04-01 00:00:00

abstract：:To test the general applicability of the hypothesis that diabetes mellitus causes increased polyol pathway activity, decreased tissue free myo-inositol, and resultant pathological changes in tissues susceptible to the ravages of diabetes, we measured glucose, sorbitol, and myo-inositol with quantitative histochemical ...

journal_title：Diabetes

authors： Loy A,Lurie KG,Ghosh A,Wilson JM,MacGregor LC,Matschinsky FM

更新日期：1990-10-01 00:00:00

abstract：:This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is als...

journal_title：Diabetes

authors： Stewart AF,Hussain MA,García-Ocaña A,Vasavada RC,Bhushan A,Bernal-Mizrachi E,Kulkarni RN

更新日期：2015-06-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...

journal_title：Diabetes

authors： Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

更新日期：2015-10-01 00:00:00

abstract：:In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min)...

journal_title：Diabetes

authors： Lins PE,Wajngot A,Adamson U,Vranic M,Efendić S

更新日期：1983-07-01 00:00:00

abstract：:We have recently reported successful 72-h preservation of the canine pancreas with a new cold-storage solution developed at the University of Wisconsin (UW solution). Over 10 mo, we performed 11 combined pancreas-kidney and 4 isolated-pancreas transplants with this solution. In situ cooling of the donor pancreas was p...

journal_title：Diabetes

authors： D'Alessandro AM,Stratta RJ,Sollinger HW,Kalayoglu M,Pirsch JD,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Skeletal muscle insulin resistance in type 2 diabetes is associated with a shift from oxidative to glycolytic metabolism in myofibers. However, whether this metabolic switch is detrimental or adaptive for metabolic homeostasis has not been resolved. We recently demonstrated that the Baf60c/Deptor pathway promotes glyc...

journal_title：Diabetes

authors： Meng ZX,Wang L,Xiao Y,Lin JD

更新日期：2014-05-01 00:00:00

abstract：:Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of NEUROD1 during murine islet cell development and during the differentiation of human embryonic stem cells (HESCs) into insulin-producing cells. In mice, we determined that Neurod1 ...

journal_title：Diabetes

authors： Romer AI,Singer RA,Sui L,Egli D,Sussel L

更新日期：2019-12-01 00:00:00

abstract：:Low birth weight is a well-established risk factor for type 2 diabetes, but the risk at high birth weight levels remains uncertain. Potential sex differences in the associations are unexplored. We investigated whether sex influences the association of birth weight and adult type 2 diabetes, using a cohort of 113,801 m...

journal_title：Diabetes

authors： Zimmermann E,Gamborg M,Sørensen TI,Baker JL

更新日期：2015-12-01 00:00:00

abstract：:Genetic susceptibility to type I diabetes is partly determined by genes located in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed that the transmission of HLA-encoded susceptibility is influenced by parental sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to thei...

journal_title：Diabetes

authors： Bain SC,Rowe BR,Barnett AH,Todd JA

更新日期：1994-12-01 00:00:00

abstract：:Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with possible participation in the development of renal complications. The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction. The presen...

journal_title：Diabetes

authors： Thirone AC,Scarlett JA,Gasparetti AL,Araujo EP,Lima MH,Carvalho CR,Velloso LA,Saad MJ

更新日期：2002-07-01 00:00:00

abstract：:Liver IGF-1 deficient (LID) mice demonstrate a 75% reduction in circulating IGF-1 levels and a corresponding fourfold increase in growth hormone (GH) levels. At 16 weeks of age, LID mice demonstrate, using the hyperinsulinemic-euglycemic clamp, insulin insensitivity in muscle, liver, and fat tissues. In contrast, mice...

journal_title：Diabetes

authors： Haluzik M,Yakar S,Gavrilova O,Setser J,Boisclair Y,LeRoith D

更新日期：2003-10-01 00:00:00

abstract：:Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates autophagy. Using a mouse model with β-cell-specific deletion of Tsc2 (βTsc...

journal_title：Diabetes

authors： Bartolomé A,Kimura-Koyanagi M,Asahara S,Guillén C,Inoue H,Teruyama K,Shimizu S,Kanno A,García-Aguilar A,Koike M,Uchiyama Y,Benito M,Noda T,Kido Y

更新日期：2014-09-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic models provide conflicting evidence as to whether VEGF prevents or ac...

journal_title：Diabetes

authors： Wu LE,Meoli CC,Mangiafico SP,Fazakerley DJ,Cogger VC,Mohamad M,Pant H,Kang MJ,Powter E,Burchfield JG,Xirouchaki CE,Mikolaizak AS,Stöckli J,Kolumam G,van Bruggen N,Gamble JR,Le Couteur DG,Cooney GJ,Andrikopoulos S,Ja

更新日期：2014-08-01 00:00:00

abstract：:There is evidence from animal models of obesity and type 2 diabetes that increased parasympathetic vagal input to the pancreas contributes to hyperinsulinemia. Compared with Caucasians, Pima Indians have a high risk of type 2 diabetes and exhibit marked hyperinsulinemia and elevated plasma levels of pancreatic polypep...

journal_title：Diabetes

authors： Vozarova de Courten B,Weyer C,Stefan N,Horton M,DelParigi A,Havel P,Bogardus C,Tataranni PA

更新日期：2004-03-01 00:00:00

abstract：:In IDDM, the gluconeogenic turnover of amino acids is increased even if glycemia is well controlled and may be restored to normal by means of prehepatic insulin substitution. Therefore, the present study was designed 1) to investigate the influence of route of insulin administration (portal versus peripheral) on the u...

journal_title：Diabetes

authors： Freyse EJ,Rebrin K,Schneider T,Petrzika M,Fischer U

更新日期：1996-05-01 00:00:00

abstract：:Extensive investigations of the solubility and fluorescence of collagen fibers in diabetes have revealed that there are significant changes in their physical properties. These changes are associated with increased cross-link formation. We used X-ray diffraction to study these changes in human extensor tendons at a mol...

journal_title：Diabetes

authors： James VJ,Delbridge L,McLennan SV,Yue DK

更新日期：1991-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：:Many humans with IDDM eventually lose the capacity to secrete epinephrine from their adrenal medullae. The mechanism for this pathological change is unknown. We hypothesized that this abnormality is attributable to neuropathic changes in the greater splanchnic nerves or in the chromaffin cells that they innervate. To ...

journal_title：Diabetes

authors： Wilke RA,Riley DA,Lelkes PI,Hillard CJ

更新日期：1993-06-01 00:00:00

abstract：:Islet transplantation is a promising treatment for type 1 diabetes. However, islet grafts are submitted to multiple injuries, including immunosuppressive drug toxicity, hyperglycemia, hypoxia, unspecific inflammatory reactions, as well as allo- and autoimmune destruction. Therapeutic approaches to these damage mechani...

journal_title：Diabetes

authors： Ritz-Laser B,Oberholzer J,Toso C,Brulhart MC,Zakrzewska K,Ris F,Bucher P,Morel P,Philippe J

更新日期：2002-03-01 00:00:00

abstract：:In diabetic subjects, polyol pathway activity might inhibit neutrophil function and cause nerve damage. The effects of ponalrestat, an aldose reductase inhibitor, were assessed on neutrophil intracellular killing of Escherichia coli and on autonomic function in diabetic subjects in a randomized double-blind, placebo-c...

journal_title：Diabetes

authors： Boland OM,Blackwell CC,Clarke BF,Ewing DJ

更新日期：1993-02-01 00:00:00

abstract：:OKT3 has emerged as a highly effective antirejection therapy, but its efficacy in pancreas transplantation remains to be determined. During a 26-mo period, 46 vascularized pancreas transplants were performed with pancreaticoduodenocystostomy. Twenty-one patients (45.7%) were treated with OKT3. Indications for OKT3 use...

journal_title：Diabetes

authors： Stratta RJ,Sollinger HW,D'Alessandro AM,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Islet duodenal homeobox 1 (IDX-1/PF-1/STF-1/PDX-1), a homeodomain protein that transactivates the insulin promoter, has been shown by targeted gene ablation to be required for pancreatic development. After 90% pancreatectomy (Px), the adult pancreas regenerates in a process recapitulating embryonic development, starti...

journal_title：Diabetes

authors： Sharma A,Zangen DH,Reitz P,Taneja M,Lissauer ME,Miller CP,Weir GC,Habener JF,Bonner-Weir S

更新日期：1999-03-01 00:00:00

abstract：:Vasculopathy is a major complication of diabetes; however, molecular mechanisms mediating the development of vasculopathy and potential strategies for prevention have not been identified. We have previously reported that C-peptide prevents diabetic vasculopathy by inhibiting reactive oxygen species (ROS)-mediated endo...

journal_title：Diabetes

authors： Bhatt MP,Lim YC,Kim YM,Ha KS

更新日期：2013-11-01 00:00:00

abstract：:The relationship between plasma C-peptide and the frequency and severity of diabetic retinopathy was examined in a population-based study in Wisconsin in 1984-1986. Individuals with younger- (n = 835) and older- (n = 940) onset diabetes were included. C-peptide was measured by radioimmunoassay with Heding's M1230 anti...

journal_title：Diabetes

authors： Klein R,Moss SE,Klein BE,Davis MD,DeMets DL

更新日期：1990-11-01 00:00:00