Abstract:
:In an ongoing investigation of the effects of age on G protein-coupled receptor signaling in human atrial tissue, we have found that the density of atrial muscarinic acetylcholine receptor (mAChR) increases with age but reaches statistical significance only in patients with diabetes. Moreover, we find that in elderly subjects of similar ages, those with diabetes have 1.7-fold higher levels of Galpha(i2) and twofold higher levels of Gbeta(1). Diabetes does not affect other atrial G proteins, including Galpha(i3,) Galpha(s), Galpha(o), and Gbeta(2). These data represent the first demonstration of an increase in a G(i)-coupled receptor, Galpha(i2), and Gbeta(1), in atrium of patients with diabetes. These findings suggest a molecular explanation for the increased risk of cardiac disease in patients with diabetes, because increased signaling through G(i) has been shown to lead to the development of dilated cardiomyopathy.
journal_name
Diabetesjournal_title
Diabetesauthors
Richardson MD,Kilts JD,Kwatra MMdoi
10.2337/diabetes.53.9.2392subject
Has Abstractpub_date
2004-09-01 00:00:00pages
2392-6issue
9eissn
0012-1797issn
1939-327Xpii
53/9/2392journal_volume
53pub_type
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