Effect of anti-Ia antibodies, culture, and cyclosporin on prolongation of canine islet allograft survival.

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization. RESEARCH DESIGN AND METHODS:PTRF expression was examined in different adipose depots of mice du...

journal_title：Diabetes

authors： Aboulaich N,Chui PC,Asara JM,Flier JS,Maratos-Flier E

更新日期：2011-03-01 00:00:00

abstract：:Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., r...

journal_title：Diabetes

authors： Lara-Castro C,Luo N,Wallace P,Klein RL,Garvey WT

更新日期：2006-01-01 00:00:00

abstract：:Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular...

journal_title：Diabetes

authors： McMillan DE

更新日期：1976-01-01 00:00:00

abstract：:Filtered proteins including insulin are absorbed in the proximal tubule by means of pinocytosis. The first step in this process is binding of the protein to brush border membrane. As it is not known whether absorption exhibits specificity, we set out to determine whether specific binding sites for insulin are present ...

journal_title：Diabetes

authors： Rabkin R,Petersen J,Mamelok R

更新日期：1982-07-01 00:00:00

abstract：:Rapamycin is used frequently in both transplantation and oncology. Although historically thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This Review draws evidence for rapamycin toxicity from clinical studies of islet and renal transplantation, and of rapamycin as an anticance...

journal_title：Diabetes

authors： Barlow AD,Nicholson ML,Herbert TP

更新日期：2013-08-01 00:00:00

abstract：:Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by t...

journal_title：Diabetes

authors： Blackshear PJ,Rohde TD,Grotting JC,Dorman FD,Perkins PR,Varco RL,Buchwald H

更新日期：1979-07-01 00:00:00

abstract：:We have applied cell-attached capacitance measurements to investigate whether synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic beta-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and 2.4-fold upon stimulation with 10 mmol/l glucose in ...

journal_title：Diabetes

authors： MacDonald PE,Obermüller S,Vikman J,Galvanovskis J,Rorsman P,Eliasson L

更新日期：2005-03-01 00:00:00

abstract：:The IGF system has been associated with development and progression of diabetic retinopathy. We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. A prospective observational study was performed in 103 pregnan...

journal_title：Diabetes

authors： Lauszus FF,Klebe JG,Bek T,Flyvbjerg A

更新日期：2003-03-01 00:00:00

abstract：:AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and T...

journal_title：Diabetes

authors： Wang S,Kobayashi K,Kogure Y,Yamanaka H,Yamamoto S,Yagi H,Noguchi K,Dai Y

更新日期：2018-01-01 00:00:00

abstract：:In an initial cross-sectional study, 29 female and 25 male nondiabetic weaned nonobese diabetic (NOD) mice of various ages (age range 30-300 days, mean 108 +/- 10 days) and 11 unweaned NOD pups were evaluated for competitive insulin autoantibodies (CIAAs) with a fluid-phase radioassay. Eleven of 54 (20%) weaned NOD mi...

journal_title：Diabetes

authors： Ziegler AG,Vardi P,Ricker AT,Hattori M,Soeldner JS,Eisenbarth GS

更新日期：1989-03-01 00:00:00

abstract：:Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be different in lean and...

journal_title：Diabetes

authors： Moon HS,Huh JY,Dincer F,Schneider BE,Hasselgren PO,Mantzoros CS

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：:The IgG from a patient (Italy 2 [I2]) with hypoglycemia, due to autoantibodies to the insulin receptor, was purified on protein A Sepharose into two fractions that were tested in various human tissues and cells. The IgG fraction that bound protein A (absorbed IgG [IgGa]) nearly completely inhibited the binding of 125I...

journal_title：Diabetes

authors： Sesti G,Marini MA,Montemurro A,Condorelli L,Borboni P,Haring HU,Ullrich A,Goldfine ID,De Pirro R,Lauro R

更新日期：1992-01-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:Efforts to map non-major histocompatibility complex (MHC) genes causing type 1 diabetes in NOD mice identified Slc11a1, formerly Nramp1, as the leading candidate gene in the Idd5.2 region. Slc11a1 is a membrane transporter of bivalent cations that is expressed in late endosomes and lysosomes of macrophages an...

journal_title：Diabetes

authors： Dai YD,Marrero IG,Gros P,Zaghouani H,Wicker LS,Sercarz EE

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:A major feature of type 1 diabetes is the appearance of islet autoantibodies before diagnosis. However, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs further investigation. The primary susceptibility loci in type 1 diabetes, the HLA class I and II genes, are ...

journal_title：Diabetes

authors： Howson JM,Stevens H,Smyth DJ,Walker NM,Chandler KA,Bingley PJ,Todd JA

更新日期：2011-10-01 00:00:00

abstract：:Incubation of 3T3-L1 adipocytes with C2- and C6-ceramides (N-acetyl- and N-hexanoylsphingosines) but not dihydro-C2-ceramide increased 2-deoxyglucose uptake in the absence of insulin. This effect was inhibited by PD 98059, LY 294002, and rapamycin, which block the activation of mitogen-activated protein kinase, phosph...

journal_title：Diabetes

authors： Wang CN,O'Brien L,Brindley DN

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct models of obesity. RESEARCH DESIGN AND METHODS:Male C57BL/6J mice were fed a high-fat/high-sucrose diet...

journal_title：Diabetes

authors： Sato A,Kawano H,Notsu T,Ohta M,Nakakuki M,Mizuguchi K,Itoh M,Suganami T,Ogawa Y

更新日期：2010-10-01 00:00:00

abstract：:Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves end...

journal_title：Diabetes

authors： Rickels MR,Fuller C,Dalton-Bakes C,Markmann E,Palanjian M,Cullison K,Tiao J,Kapoor S,Liu C,Naji A,Teff KL

更新日期：2015-05-01 00:00:00

abstract：:We explore whether racial differences in a United States population influence disease prevalence and perinatal outcome in gestational diabetes mellitus (GDM). The data presented are based on 3744 consecutive patients who underwent universal screening at 24-28 wk gestation; those with a 1-h plasma glucose greater than ...

journal_title：Diabetes

authors： Dooley SL,Metzger BE,Cho NH

更新日期：1991-12-01 00:00:00

abstract：:Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent a...

journal_title：Diabetes

authors： Alto N,Carlisle Michel JJ,Dodge KL,Langeberg LK,Scott JD

更新日期：2002-12-01 00:00:00

abstract：:Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin receptors (IR) specifically in skeletal muscle (IRMOE). On normal chow, IRMOE mice have body weight similar to that of controls but an inc...

journal_title：Diabetes

authors： Wang G,Yu Y,Cai W,Batista TM,Suk S,Noh HL,Hirshman M,Nigro P,Li ME,Softic S,Goodyear L,Kim JK,Kahn CR

更新日期：2020-11-01 00:00:00

abstract：:Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transp...

journal_title：Diabetes

authors： Cabello-Kindelan C,Mackey S,Sands A,Rodriguez J,Vazquez C,Pugliese A,Bayer AL

更新日期：2020-02-01 00:00:00

abstract：:A workshop sponsored by the National Institute of Child Health and Human Development was held in June 1988 to discuss the initial events in the pathogenesis of insulin-dependent diabetes and to make recommendations for future studies. Better definition of immunological markers to reliably predict the disease will enab...

journal_title：Diabetes

authors： Maclaren N,Schatz D,Drash A,Grave G

更新日期：1989-04-01 00:00:00

abstract：:Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...

journal_title：Diabetes

authors： Festa A,D'Agostino R Jr,Hanley AJ,Karter AJ,Saad MF,Haffner SM

更新日期：2004-06-01 00:00:00

abstract：:A cohort of 372 insulin-dependent diabetic children, diagnosed between October 1949 and December 1960, were followed-up until December 1976 by the same team of physicians. At the time of diagnosis all patients were under 16 yr of age and were given standardized treatment which did not change from 1949 to 1976. The the...

journal_title：Diabetes

authors： Lestradet H,Papoz L,Hellouin de Menibus C,Levavasseur F,Besse J,Billaud L,Battistelli F,Tric P,Lestradet F

更新日期：1981-03-01 00:00:00

abstract：:Inhibition of glucose-stimulated insulin release by exogenous insulin has been demonstrated in pancreatic islets to be associated with a decrease of the NADPH/NADP ratio and the pentose-phosphate cycle activity. Batches of five islets were incubated for 15 and 90 minutes in 1 ml. of KRB buffer with 2 per cent albumin ...

journal_title：Diabetes

authors： Akhtar MS,Verspohl E,Hegner D,Ammon HP

更新日期：1977-09-01 00:00:00

abstract：:Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

journal_title：Diabetes

authors： Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

更新日期：2012-11-01 00:00:00

abstract：:Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D2 receptors (D2R) decline with age and may be altered in obesity. Understanding the relationships betwee...

journal_title：Diabetes

authors： Pepino MY,Eisenstein SA,Bischoff AN,Klein S,Moerlein SM,Perlmutter JS,Black KJ,Hershey T

更新日期：2016-09-01 00:00:00