Gestational diabetes mellitus. Influence of race on disease prevalence and perinatal outcome in a U.S. population.

abstract：:We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors effici...

journal_title：Diabetes

authors： Leibowitz G,Beattie GM,Kafri T,Cirulli V,Lopez AD,Hayek A,Levine F

更新日期：1999-04-01 00:00:00

abstract：:The hyperinsulinemia of obese rodents has been associated with a reduced number of hepatic insulin receptors except in hepatocytes from fatty Zucker rats. We isolated liver plasma membranes from 10-11-wk-old lean and fatty Zucker rats, some of which were injected with streptozotocin 2--4 wk earlier. We have determined...

journal_title：Diabetes

authors： Clark JB,Keen S,Clark CM Jr

更新日期：1982-10-01 00:00:00

abstract：:The Diabetes Control and Complications Trial (DCCT) is a multicenter randomized clinical trial studying the effect of intensive insulin therapy on the early vascular and neurological complications of insulin-dependent diabetes mellitus (IDDM). During the feasibility phase of the DCCT, baseline neurological histories, ...

journal_title：Diabetes

authors：

更新日期：1988-04-01 00:00:00

abstract：:Diabetic hearts exhibit decreased responsiveness to stimulation by beta-adrenoreceptor (beta-AR) agonists. This decrease in activity may be due to changes in expression and/or signaling of beta-AR. Recently we showed that right atrial strips from 14-week streptozotocin (STZ)-induced diabetic rat hearts exhibit decreas...

journal_title：Diabetes

authors： Dinçer UD,Bidasee KR,Güner S,Tay A,Ozçelikay AT,Altan VM

更新日期：2001-02-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement ...

journal_title：Diabetes

authors： Wolford JK,Yeatts KA,Dhanjal SK,Black MH,Xiang AH,Buchanan TA,Watanabe RM

更新日期：2005-11-01 00:00:00

abstract：:The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1, a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet neogenesis and differentiation of i...

journal_title：Diabetes

authors： Noguchi H,Kaneto H,Weir GC,Bonner-Weir S

更新日期：2003-07-01 00:00:00

abstract：:Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the ...

journal_title：Diabetes

authors： Janson J,Laedtke T,Parisi JE,O'Brien P,Petersen RC,Butler PC

更新日期：2004-02-01 00:00:00

abstract：:Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in type 1 diabetic LDL receptor-deficient mi...

journal_title：Diabetes

authors： Zang M,Xu S,Maitland-Toolan KA,Zuccollo A,Hou X,Jiang B,Wierzbicki M,Verbeuren TJ,Cohen RA

更新日期：2006-08-01 00:00:00

abstract：:The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...

journal_title：Diabetes

authors： Simonson DC,Ferrannini E,Bevilacqua S,Smith D,Barrett E,Carlson R,DeFronzo RA

更新日期：1984-09-01 00:00:00

abstract：:In 112 obese compared with 42 lean children, we found that serum leptin is elevated early in the evolution of childhood-onset obesity (28.4 +/- 1.4 vs. 4.5 +/- 0.4 ng/ml in lean children, P < 0.0001) and correlates with adiposity. Obese children also had higher serum leptin normalized to fat mass. Despite high serum l...

journal_title：Diabetes

authors： Lahlou N,Landais P,De Boissieu D,Bougnères PF

更新日期：1997-06-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：:Progression to clinical type 1 diabetes varies among children who develop β-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar ...

journal_title：Diabetes

authors： Endesfelder D,Zu Castell W,Bonifacio E,Rewers M,Hagopian WA,She JX,Lernmark Å,Toppari J,Vehik K,Williams AJK,Yu L,Akolkar B,Krischer JP,Ziegler AG,Achenbach P,TEDDY Study Group.

更新日期：2019-01-01 00:00:00

abstract：:The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine sentinel cells that maintain glucose homeostasis in many vertebrates including humans. The glucokinase-containing, insulin-produci...

journal_title：Diabetes

authors： Matschinsky FM,Magnuson MA,Zelent D,Jetton TL,Doliba N,Han Y,Taub R,Grimsby J

更新日期：2006-01-01 00:00:00

abstract：:Prostacyclin (PGI2) synthesis by vascular endothelial cells (ECs) decreases in diabetic subjects, possibly leading to the development of diabetic angiopathy, such as that seen in atherosclerosis. We recently found a novel bioactive peptide, prostacyclin-stimulating factor (PSF), which stimulates PGI2 synthesis by cult...

journal_title：Diabetes

authors： Sekiguchi N,Umeda F,Masakado M,Ono Y,Hashimoto T,Nawata H

更新日期：1997-10-01 00:00:00

abstract：:A double-blind crossover study of fludrocortisone, 0,1 mg. twice daily, and placebo is reported in six diabetics with troublesome symptoms of postural hypotension due to autonomic neuropathy. During treatment with the active preparation there was an increase in the lying and tilted systolic blood pressure, a decrease ...

journal_title：Diabetes

authors： Campbell IW,Ewing DJ,Clarke BF

更新日期：1975-04-01 00:00:00

abstract：:Although non-insulin-dependent diabetes mellitus (NIDDM) is associated with defects in insulin action, the molecular basis of this resistance is unknown. We studied fibroblasts from a markedly insulin-resistant patient with NIDDM but without acanthosis nigricans. Her fibroblasts were resistant to insulin when alpha-am...

journal_title：Diabetes

authors： Sbraccia P,Goodman PA,Maddux BA,Wong KY,Chen YD,Reaven GM,Goldfine ID

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:Short sleep duration is associated with impaired glucose tolerance and an increased risk of diabetes. The effects of sleep restriction on insulin sensitivity have not been established. This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects...

journal_title：Diabetes

authors： Buxton OM,Pavlova M,Reid EW,Wang W,Simonson DC,Adler GK

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of these metabolic abnormalities. We examined whether aging per se (in s...

journal_title：Diabetes

authors： Ghosh S,Lertwattanarak R,Lefort N,Molina-Carrion M,Joya-Galeana J,Bowen BP,Garduno-Garcia Jde J,Abdul-Ghani M,Richardson A,DeFronzo RA,Mandarino L,Van Remmen H,Musi N

更新日期：2011-08-01 00:00:00

abstract：:The epidemic of obesity and type 2 diabetes has increased interest in pathways that affect energy balance in mammalian systems. Brown fat, in all of its dimensions, can increase energy expenditure through the dissipation of chemical energy in the form of heat, using mitochondrial uncoupling and perhaps other pathways....

journal_title：Diabetes

authors： Cohen P,Spiegelman BM

更新日期：2015-07-01 00:00:00

abstract：:Mutations in the melanocortin-4 receptor (MC4R) gene are the most frequent monogenic causes of severe obesity. Most mutations have been described as heterozygous with loss of function, suggesting that haploinsufficiency is the most likely mechanism of dominant inheritance. We detected a heterozygous mutation, D90N, in...

journal_title：Diabetes

authors： Biebermann H,Krude H,Elsner A,Chubanov V,Gudermann T,Grüters A

更新日期：2003-12-01 00:00:00

abstract：:The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying management of reactive oxygen species (ROS) gain interest as crucial factors in cell integrity, questions arise about the role of redox cues in the regulation and...

journal_title：Diabetes

authors： Rabbani PS,Soares MA,Hameedi SG,Kadle RL,Mubasher A,Kowzun M,Ceradini DJ

更新日期：2019-01-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activate...

journal_title：Diabetes

authors： Coppieters KT,Amirian N,Pagni PP,Baca Jones C,Wiberg A,Lasch S,Hintermann E,Christen U,von Herrath MG

更新日期：2013-07-01 00:00:00

abstract：:ATP is known to be coreleased with insulin from pancreatic beta-cells. To monitor insulin secretion from single beta-cells, a single beta-cell was surrounded in culture by Fura 2-loaded calf pulmonary artery endothelium (CPAE) cells, which can detect the ATP. CPAE cells did not respond with an elevation in cytoplasmic...

journal_title：Diabetes

authors： Kuromi H,Mizuno N,Seino S

更新日期：1995-10-01 00:00:00

abstract：:Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complicati...

journal_title：Diabetes

authors： Hu M,Wu Y,Yang C,Wang X,Wang W,Zhou L,Zeng T,Zhou J,Wang C,Lao G,Yan L,Ren M

更新日期：2020-10-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：:To evaluate possible advantages of human insulin of recombinant DNA origin (HI) in the treatment of diabetic patients, we compared cellular and humoral immunoreactivities of HI and porcine insulin (PI). Anti-insulin IgE bound equal amounts of 125I-HI and 125I-PI. There was no difference between HI- and PI-stimulated l...

journal_title：Diabetes

authors： Kumar D,Alexander CM,Zeidler A,Rhodes JJ,Boarman CC,Hoopes MT

更新日期：1983-06-01 00:00:00

abstract：:Antibodies to an islet protein of 64,000 Mr (64K antibodies) were measured in 15 diabetic children who were followed prospectively for up to 3 yr after onset of type I (insulin-dependent) diabetes. Of the 15 children, 12 were positive for 64K antibodies at diagnosis. Those patients who were negative for these antibodi...

journal_title：Diabetes

authors： Christie MR,Daneman D,Champagne P,Delovitch TL

更新日期：1990-06-01 00:00:00

abstract：:The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte...

journal_title：Diabetes

authors： Gambaro G,Baggio B,Cicerello E,Mastrosimone S,Marzaro G,Borsatti A,Crepaldi G

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

journal_title：Diabetes

authors： Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, and several of its products induce apo...

journal_title：Diabetes

authors： McDuffie M,Maybee NA,Keller SR,Stevens BK,Garmey JC,Morris MA,Kropf E,Rival C,Ma K,Carter JD,Tersey SA,Nunemaker CS,Nadler JL

更新日期：2008-01-01 00:00:00