Abstract:
:Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activated CTLs potently inhibits their recruitment and prevents β-cell death. Since recent studies on human pancreata from T1D patients have indicated that both ligand and receptor are abundantly present, we reevaluated whether their interaction constitutes a pivotal node within the chemokine network associated with T1D. Our present data in a viral mouse model challenge the notion that specific blockade of the CXCL10/CXCR3 chemokine axis halts T1D onset and progression.
journal_name
Diabetesjournal_title
Diabetesauthors
Coppieters KT,Amirian N,Pagni PP,Baca Jones C,Wiberg A,Lasch S,Hintermann E,Christen U,von Herrath MGdoi
10.2337/db12-1370subject
Has Abstractpub_date
2013-07-01 00:00:00pages
2492-9issue
7eissn
0012-1797issn
1939-327Xpii
db12-1370journal_volume
62pub_type
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