Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice.

abstract：OBJECTIVE:The proinflammatory cytokines/adipokines produced from adipose tissue act in an autocrine and/or endocrine manner to perpetuate local inflammation and to induce peripheral insulin resistance. The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on s...

journal_title：Diabetes

authors： Law IK,Xu A,Lam KS,Berger T,Mak TW,Vanhoutte PM,Liu JT,Sweeney G,Zhou M,Yang B,Wang Y

更新日期：2010-04-01 00:00:00

abstract：:Determinants of proliferative diabetic retinopathy (PDR) that occur during the 2nd decade of insulin-dependent diabetes mellitus (IDDM) (early-onset PDR) were investigated in a nested case-control study. From an inception cohort of patients with juvenile-onset IDDM that now has 15-21 yr diabetes duration, the patients...

journal_title：Diabetes

authors： Krolewski AS,Barzilay J,Warram JH,Martin BC,Pfeifer M,Rand LI

更新日期：1992-04-01 00:00:00

abstract：:Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes. Using pharmacologic agents, we previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA t...

journal_title：Diabetes

authors： Le Foll C,Dunn-Meynell A,Musatov S,Magnan C,Levin BE

更新日期：2013-08-01 00:00:00

abstract：:Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic gluc...

journal_title：Diabetes

authors： Ott V,Lehnert H,Staub J,Wönne K,Born J,Hallschmid M

更新日期：2015-03-01 00:00:00

abstract：:Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the l...

journal_title：Diabetes

authors： Emilsson V,Liu YL,Cawthorne MA,Morton NM,Davenport M

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which amplifies local tissue glucocorticoid concentrations. The reasons for this 11beta-HSD1 dysregulation are unknown. Here, we tested whether 11beta...

journal_title：Diabetes

authors： Nyirenda MJ,Carter R,Tang JI,de Vries A,Schlumbohm C,Hillier SG,Streit F,Oellerich M,Armstrong VW,Fuchs E,Seckl JR

更新日期：2009-12-01 00:00:00

abstract：:Monoclonal antibodies to T-cell coreceptors have been shown to tolerise autoreactive T-cells and prevent or even reverse autoimmune pathology. In type 1 diabetes, there is a loss of insulin-secreting beta-cells, and a cure for type 1 diabetes would require not only tolerance induction but also recovery of the function...

journal_title：Diabetes

authors： Phillips JM,O'Reilly L,Bland C,Foulis AK,Cooke A

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

journal_title：Diabetes

authors： Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

更新日期：2010-08-01 00:00:00

abstract：:Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrati...

journal_title：Diabetes

authors： Michels AW,Landry LG,McDaniel KA,Yu L,Campbell-Thompson M,Kwok WW,Jones KL,Gottlieb PA,Kappler JW,Tang Q,Roep BO,Atkinson MA,Mathews CE,Nakayama M

更新日期：2017-03-01 00:00:00

abstract：:Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...

journal_title：Diabetes

authors： Sylow L,Møller LLV,Kleinert M,D'Hulst G,De Groote E,Schjerling P,Steinberg GR,Jensen TE,Richter EA

更新日期：2017-06-01 00:00:00

abstract：:Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...

journal_title：Diabetes

authors： Yao Y,Li Y,Song Q,Hu C,Xie W,Xu C,Chen Q,Wang QK

更新日期：2019-08-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells respond to an insulin...

journal_title：Diabetes

authors： Spanier JA,Sahli NL,Wilson JC,Martinov T,Dileepan T,Burrack AL,Finger EB,Blazar BR,Michels AW,Moran A,Jenkins MK,Fife BT

更新日期：2017-12-01 00:00:00

abstract：:Mutations in several genes cause nonautoimmune diabetes, but numerous patients still have unclear genetic defects, hampering our understanding of the development of the disease and preventing pathogenesis-oriented treatment. We used whole-genome sequencing with linkage analysis to study a consanguineous family with ea...

journal_title：Diabetes

authors： Simaite D,Kofent J,Gong M,Rüschendorf F,Jia S,Arn P,Bentler K,Ellaway C,Kühnen P,Hoffmann GF,Blau N,Spagnoli FM,Hübner N,Raile K

更新日期：2014-10-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell-specific deficiency of TL...

journal_title：Diabetes

authors： Sha S,Pearson JA,Peng J,Hu Y,Huang J,Xing Y,Zhang L,Zhu Y,Zhao H,Wong FS,Chen L,Wen L

更新日期：2021-02-01 00:00:00

abstract：:Inhibition of glucose-stimulated insulin release by exogenous insulin has been demonstrated in pancreatic islets to be associated with a decrease of the NADPH/NADP ratio and the pentose-phosphate cycle activity. Batches of five islets were incubated for 15 and 90 minutes in 1 ml. of KRB buffer with 2 per cent albumin ...

journal_title：Diabetes

authors： Akhtar MS,Verspohl E,Hegner D,Ammon HP

更新日期：1977-09-01 00:00:00

abstract：:To determine the effect of inhibition of gluconeogenesis on liver glycogen stores in patients with non-insulin-dependent diabetes mellitus (NIDDM) after a 3-day fast, 10% ethanol (EtOH) was administered intravenously to nine obese patients with NIDDM and six obese nondiabetic subjects. Rates of glucose appearance (3-[...

journal_title：Diabetes

authors： Clore JN,Blackard WG

更新日期：1994-02-01 00:00:00

abstract：:We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...

journal_title：Diabetes

authors： Silverman BL,Rizzo T,Green OC,Cho NH,Winter RJ,Ogata ES,Richards GE,Metzger BE

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS:To efficiently search for genomic regions harborin...

journal_title：Diabetes

authors： Rogus JJ,Poznik GD,Pezzolesi MG,Smiles AM,Dunn J,Walker W,Wanic K,Moczulski D,Canani L,Araki S,Makita Y,Warram JH,Krolewski AS

更新日期：2008-09-01 00:00:00

abstract：:To assess the extent to which the progression of diabetic retinopathy can be arrested by improved glycemic control, 35 normal dogs were randomly divided into a nondiabetic and three alloxan-induced diabetic groups prospectively identified according to glycemic control: poor control for 5 yr (PC), good control for 5 yr...

journal_title：Diabetes

authors： Engerman RL,Kern TS

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-...

journal_title：Diabetes

authors： Consitt LA,Bell JA,Koves TR,Muoio DM,Hulver MW,Haynie KR,Dohm GL,Houmard JA

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Offspring of mothers with diabetes are at risk of obesity and glucose intolerance in later life. In adults, markers of subclinical inflammation (C-reactive protein [CRP] and interleukin [IL]-6) and endothelial activation (intracellular adhesion molecule [ICAM]-1) are associated with obesity and higher risk fo...

journal_title：Diabetes

authors： Nelson SM,Sattar N,Freeman DJ,Walker JD,Lindsay RS

更新日期：2007-11-01 00:00:00

abstract：:Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...

journal_title：Diabetes

authors： Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

更新日期：2017-05-01 00:00:00

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:Studies have been carried out on activities of lysosomal beta-N-acetylhexosaminidase (hex), beta-galactosidase (beta-gal), alpha-glucosidase (alpha-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (...

journal_title：Diabetes

authors： Bomback FM,Nakagawa S,Kumin S,Nitowsky HM

更新日期：1976-05-01 00:00:00

abstract：:Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evalua...

journal_title：Diabetes

authors： Véricel E,Januel C,Carreras M,Moulin P,Lagarde M

更新日期：2004-04-01 00:00:00

abstract：:Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

journal_title：Diabetes

authors： Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

更新日期：2012-11-01 00:00:00

abstract：:We addressed the question of whether newly diagnosed type I (insulin-dependent) diabetes mellitus patients showed an increased number of DR (la+) T-lymphocytes compared with nondiabetic siblings and normal control subjects. Two-color flow cytometry measurements of peripheral-blood lymphocytes showed a slight but stati...

journal_title：Diabetes

authors： Legendre CM,Schiffrin A,Weitzner G,Colle E,Guttmann RD

更新日期：1988-06-01 00:00:00

abstract：:Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The lipolytic action of t...

journal_title：Diabetes

authors： Mei J,Holst LS,Landström TR,Holm C,Brindley D,Manganiello V,Degerman E

更新日期：2002-03-01 00:00:00

abstract：:To investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cGMP) concentrations, we determined by a radioimmunoassay the cGMP values in the platelet-rich plasma (PRP) obtained from 17 healthy volunteers and incubated for 3 min with different concentr...

journal_title：Diabetes

authors： Trovati M,Massucco P,Mattiello L,Mularoni E,Cavalot F,Anfossi G

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00