Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.

abstract：:Glucokinase from rat liver or transplantable, radiation-induced insulinomas was partially purified by ion exchange chromatography using DEAE-Cibacron Blue F3GA agarose. Phosphorylation of alpha,beta-D-mannose by glucokinase occurred with cooperative rate dependence on mannose concentration (nH: 1.50). Half-maximal pho...

journal_title：Diabetes

authors： Meglasson MD,Schinco M,Matschinsky FM

更新日期：1983-12-01 00:00:00

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：:It has been proposed that p38 mitogen-activated protein kinase (MAPK) isoforms sensitive to the pyridinylimidazole compounds SB 203580 and SB 202190 may participate in the acute insulin-dependent activation of glucose transporters recruited to the plasma membrane of adipocytes and skeletal muscle. Here, we explore whe...

journal_title：Diabetes

authors： Turban S,Beardmore VA,Carr JM,Sakamoto K,Hajduch E,Arthur JS,Hundal HS

更新日期：2005-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was c...

journal_title：Diabetes

authors： Gray SL,Nora ED,Grosse J,Manieri M,Stoeger T,Medina-Gomez G,Burling K,Wattler S,Russ A,Yeo GS,Chatterjee VK,O'Rahilly S,Voshol PJ,Cinti S,Vidal-Puig A

更新日期：2006-10-01 00:00:00

abstract：:Hypoglycemia causes substantial morbidity and some mortality in insulin-dependent diabetes mellitus (IDDM). It is often the limiting factor in attempts to achieve euglycemia. The prevention or correction of hypoglycemia normally involves both dissipation of insulin and activation of glucose counterregulatory systems. ...

journal_title：Diabetes

authors： Cryer PE,Binder C,Bolli GB,Cherrington AD,Gale EA,Gerich JE,Sherwin RS

更新日期：1989-09-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel approach to treatment of experimental peripheral diabetic neuropathy (PDN). However, long-term inhibition of PARP, an enzyme involved in DNA repair, can potentially result in premature aging, loss of genome stability, and other side ...

journal_title：Diabetes

authors： Li F,Drel VR,Szabó C,Stevens MJ,Obrosova IG

更新日期：2005-05-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS:Eight subjects with risk-conferring TCF7L2 genotypes (TT o...

journal_title：Diabetes

authors： Villareal DT,Robertson H,Bell GI,Patterson BW,Tran H,Wice B,Polonsky KS

更新日期：2010-02-01 00:00:00

abstract：:Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...

journal_title：Diabetes

authors： Festa A,D'Agostino R Jr,Hanley AJ,Karter AJ,Saad MF,Haffner SM

更新日期：2004-06-01 00:00:00

abstract：:Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

journal_title：Diabetes

authors： Muona P,Sollberg S,Peltonen J,Uitto J

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress. RESEARCH DES...

journal_title：Diabetes

authors： Ravier MA,Daro D,Roma LP,Jonas JC,Cheng-Xue R,Schuit FC,Gilon P

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:Eight dogs with previously established kidney allografts, immunosuppressed with cyclosporin A, received islet allografts from their respective original kidney donors. The median islet-graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving only islet allo...

journal_title：Diabetes

authors： Guy AJ,Griffin SM,Alderson D,Farndon JR

更新日期：1989-01-01 00:00:00

abstract：:The effect of cerebral intraventricular insulin on pancreatic insulin secretion was investigated. An extracorporeal pancreatic blood circuit was established after laparotomy to monitor blood flow and insulin concentration directly from the superior pancreaticoduodenal vein. Phentolamine was infused throughout (0.2 mg....

journal_title：Diabetes

authors： Chen M,Woods SC,Porte D Jr

更新日期：1975-10-01 00:00:00

abstract：:Metabolic interactions between glucose and amino acids were studied with isolated rat islets using glucose utilization and lactate formation as indicators. Certain amino acids (8-10 mM) are capable of greatly stimulating lactate formation from 5mM glucose. On a molar basis L-isoleucine is the most potent stimulator in...

journal_title：Diabetes

authors： Pace CS,Ellerman J,Hover BA,Stillings SN,Matschinsky FM

更新日期：1975-05-01 00:00:00

abstract：:Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontaneous HU mouse model ...

journal_title：Diabetes

authors： Lu J,He Y,Cui L,Xing X,Liu Z,Li X,Zhang H,Li H,Sun W,Ji A,Wang Y,Yin H,Li C

更新日期：2020-06-01 00:00:00

abstract：:New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observe...

journal_title：Diabetes

authors： Pinies JA,Fu Y,Vazquez JA,Faustman D

更新日期：1997-03-01 00:00:00

abstract：:There is an unexplained excess of type 1 diabetes and other organ-specific autoimmune diseases in children with Down's syndrome, but the immunogenetic characteristics of diabetes in Down's syndrome have not been investigated. We studied the frequency of islet autoantibodies in 106 children with Down's syndrome and no ...

journal_title：Diabetes

authors： Gillespie KM,Dix RJ,Williams AJ,Newton R,Robinson ZF,Bingley PJ,Gale EA,Shield JP

更新日期：2006-11-01 00:00:00

abstract：:A new approach has been developed to examine insulin sensitivity and resistance in vivo in man. In it, tracer methods are used, which permit the assessment of nonsteady state glucose kinetics by a method that is noninvasive and does not use pharmacologic agents. Graded doses of glucagon, infused intravenously, are use...

journal_title：Diabetes

authors： Vranic M,Morita S,Steiner G

更新日期：1980-03-01 00:00:00

abstract：:Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...

journal_title：Diabetes

authors： Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

更新日期：1999-05-01 00:00:00

abstract：:Diabetic states are characterized by a raised serum/islet level of triglycerides and a lowered EC50 (concentration at half-maximal stimulation) for glucose-induced insulin secretion. Culturing islets with long-chain fatty acids (FAs) replicates the basal insulin hypersecretion. In a previous study, we showed that the ...

journal_title：Diabetes

authors： Liu YQ,Tornheim K,Leahy JL

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

journal_title：Diabetes

authors： Wentzel P,Gäreskog M,Eriksson UJ

更新日期：2008-12-01 00:00:00

abstract：:This study measured the accumulation of substance P-like immunoreactivity (SPLI) proximal and distal to 12-h constricting ligatures applied to rat sciatic nerves. There were three separate experiments, and the baseline for each consisted of control and age-matched rats with 3 wk of untreated streptozocin-induced diabe...

journal_title：Diabetes

authors： Tomlinson DR,Robinson JP,Willars GB,Keen P

更新日期：1988-04-01 00:00:00

abstract：:Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...

journal_title：Diabetes

authors： Nosadini R,del Prato S,Tiengo A,Duner E,Toffolo G,Cobelli C,Faronato PP,Moghetti P,Muggeo M

更新日期：1982-04-01 00:00:00

abstract：:Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with insulin pump (continuous subcutaneous insulin infusion [CSII]), known as artificial pancreas, can help optimize glycemic control in diabetes. We present a fundamental modular concept for CLC design, illustrated by clinical studies...

journal_title：Diabetes

authors： Breton M,Farret A,Bruttomesso D,Anderson S,Magni L,Patek S,Dalla Man C,Place J,Demartini S,Del Favero S,Toffanin C,Hughes-Karvetski C,Dassau E,Zisser H,Doyle FJ 3rd,De Nicolao G,Avogaro A,Cobelli C,Renard E,Kovatche

更新日期：2012-09-01 00:00:00

abstract：:Isologous pancreatic islets were implanted into the portal vein of rats with streptozotocin-induced diabetes. At intervals of from one to 32 days after transplantation, the intrahepatic islet grafts were examined histologically and ultrastructurally, and their vascular supply was determined by later perfusion studies....

journal_title：Diabetes

authors： Griffith RC,Scharp DW,Hartman BK,Ballinger WF,Lacy PE

更新日期：1977-03-01 00:00:00

abstract：:Troglitazone and pioglitazone, antidiabetic thiazolidinediones, are known to improve insulin resistance. However, the effect of these drugs on platelet aggregation remains unclear. The chemical structure of troglitazone contains vitamin E. Accordingly, we studied the effect of troglitazone, pioglitazone, and vitamin E...

journal_title：Diabetes

authors： Ishizuka T,Itaya S,Wada H,Ishizawa M,Kimura M,Kajita K,Kanoh Y,Miura A,Muto N,Yasuda K

更新日期：1998-09-01 00:00:00

abstract：:We investigated the effects of non-insulin-dependent diabetes mellitus (NIDDM) on lipoprotein(a) (Lp[a]) and apolipoprotein(a) (apo[a]) in a population of Mexican-Americans. In plasma samples from 536 subjects, we measured Lp(a) concentrations, and we estimated apo(a) isoform sizes following immunostaining of plasma p...

journal_title：Diabetes

authors： Rainwater DL,MacCluer JW,Stern MP,VandeBerg JL,Haffner SM

更新日期：1994-07-01 00:00:00

abstract：:Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endoge...

journal_title：Diabetes

authors： Tang Y,Zhang MJ,Hellmann J,Kosuri M,Bhatnagar A,Spite M

更新日期：2013-02-01 00:00:00

abstract：:Mutation of tub gene in mice induces obesity, suggesting that tub could be an important regulator of energy balance. In the current study, we investigated whether insulin, leptin, and obesity can modulate Tub in vivo in hypothalamic nuclei, and we investigated possible consequences on energy balance, neuropeptide expr...

journal_title：Diabetes

authors： Prada PO,Quaresma PG,Caricilli AM,Santos AC,Guadagnini D,Morari J,Weissmann L,Ropelle ER,Carvalheira JB,Velloso LA,Saad MJ

更新日期：2013-01-01 00:00:00