Effect of cerebral intraventricular insulin on pancreatic insulin secretion in the dog.

abstract：:Studies in 10 nonketotic diabetic subjects (five juvenile- and five adult-onset) before and after control of carbohydrate metabolism showed a high degree of correlation between hemoglobin AIc (HbAIc) concentrations and serum triglyceride levels. Serum triglyceride levels were found to correlate more closely with Hb AI...

journal_title：Diabetes

authors： Peterson CM,Koenig RJ,Jones RL,Saudek CD,Cerami A

更新日期：1977-05-01 00:00:00

abstract：:We studied the effects of short-term (5 days) and long-term (2 wk) high carbohydrate (75%) feedings on insulin binding to isolated adipocytes and insulin sensitivity in vivo in normal subjects. Ingestion of the high carbohydrate diet led to daylong hyperinsulinemia in both short- and long-term groups. Insulin binding ...

journal_title：Diabetes

authors： Kolterman OG,Greenfield M,Reaven GM,Saekow M,Olefsky JM

更新日期：1979-08-01 00:00:00

abstract：:The uptake of 2-deoxy-D-[1-14C]-glucose, in the presence and absence of insulin, was measured in adipocytes from normal and streptozotocin-diabetic animals, over a wide temperature range (25-45 degrees C). Optimum temperatures for uptake in the presence of maximally stimulating insulin concentrations occurred near phy...

journal_title：Diabetes

authors： Sauerheber RD,Kuhn CE,Hyslop PA

更新日期：1984-03-01 00:00:00

abstract：:Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell-mediated autoimmune disease. However, B-cells may also play a critical role in disease pathogenesis, as genetically B-cell-deficient NOD mice (NOD.microMT) have been shown to be protected from type 1 diabetes and to display reduced responses to ...

journal_title：Diabetes

authors： Chiu PP,Serreze DV,Danska JS

更新日期：2001-04-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a mitogen required for β-cell replication during pregnancy. To determine whether HGF/c-Met signaling is required for β-cell regeneration, we characterized mice with pancreatic deletion of the HGF receptor, c-Met (PancMet KO mice), in two models of reduced β-cell mass and regeneration:...

journal_title：Diabetes

authors： Alvarez-Perez JC,Ernst S,Demirci C,Casinelli GP,Mellado-Gil JM,Rausell-Palamos F,Vasavada RC,Garcia-Ocaña A

更新日期：2014-01-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM), cardiovascular morbidity, and vital prognosis are linked to diabetic nephropathy, which is probably determined by renal hemodynamic abnormalities and by a genetic predisposition. Angiotensin I converting enzyme (ACE) regulates systemic and renal circulations through angioten...

journal_title：Diabetes

authors： Marre M,Bernadet P,Gallois Y,Savagner F,Guyene TT,Hallab M,Cambien F,Passa P,Alhenc-Gelas F

更新日期：1994-03-01 00:00:00

abstract：:The natural history of progression from normal glucose tolerance (NGT) to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes is not well defined. We studied this progression using biennial oral glucose tolerance tests performed in the Baltimore Longitudinal Study of Aging and surviva...

journal_title：Diabetes

authors： Meigs JB,Muller DC,Nathan DM,Blake DR,Andres R,Baltimore Longitudinal Study of Aging.

更新日期：2003-06-01 00:00:00

abstract：:We examined the effects of activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice and investigated the mechanisms by which they improve insulin sensitivity. PPARalpha activation by its agonist, Wy-14,643, as well as PPARgamma activat...

journal_title：Diabetes

authors： Tsuchida A,Yamauchi T,Takekawa S,Hada Y,Ito Y,Maki T,Kadowaki T

更新日期：2005-12-01 00:00:00

abstract：:Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is an oxidative stress-sensitive channel involved in cell death; therefore, we have examined its potential role in endothelial cells ...

journal_title：Diabetes

authors： Detaille D,Guigas B,Chauvin C,Batandier C,Fontaine E,Wiernsperger N,Leverve X

更新日期：2005-07-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet amyloid polypeptide (IAPP, amylin). The mechanism of islet amyloido-genesis is not known, but other products (e.g., apolipoprotein E and perlecan) contained within islet amyloid may be nece...

journal_title：Diabetes

authors： Andrikopoulos S,Verchere CB,Teague JC,Howell WM,Fujimoto WY,Wight TN,Kahn SE

更新日期：1999-10-01 00:00:00

abstract：:Increased hepatic gluconeogenesis maintains glycemia during fasting and has been considered responsible for elevated hepatic glucose output in type 2 diabetes. Glucose derived periportally via gluconeogenesis is partially taken up perivenously in perfused liver but not in adult rats whose mothers were protein-restrict...

journal_title：Diabetes

authors： Murphy HC,Regan G,Bogdarina IG,Clark AJ,Iles RA,Cohen RD,Hitman GA,Berry CL,Coade Z,Petry CJ,Burns SP

更新日期：2003-06-01 00:00:00

abstract：:Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7's precise exocytotic actions in β-cells remain unknown. We show that Syt-7 is abundant in human β-cells. Adeno...

journal_title：Diabetes

authors： Dolai S,Xie L,Zhu D,Liang T,Qin T,Xie H,Kang Y,Chapman ER,Gaisano HY

更新日期：2016-07-01 00:00:00

abstract：:Studies were conducted to explore altered substrate utilization and metabolism in GLUT4 null mice. Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative pha...

journal_title：Diabetes

authors： Ranalletta M,Jiang H,Li J,Tsao TS,Stenbit AE,Yokoyama M,Katz EB,Charron MJ

更新日期：2005-04-01 00:00:00

abstract：:Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle and therefore represents an important alternative to stimulate glucose uptake in insulin-resistant muscle. Both Rac1 and AMPK have been shown to partly regulate contraction-stimulated muscle glucose uptake, but whether those two signali...

journal_title：Diabetes

authors： Sylow L,Møller LLV,Kleinert M,D'Hulst G,De Groote E,Schjerling P,Steinberg GR,Jensen TE,Richter EA

更新日期：2017-06-01 00:00:00

abstract：:Glucose homeostasis, a defining characteristic of physiological glucose metabolism, is the result of complex feedback relationships with both genetic and environmental determinants that influence insulin sensitivity and beta-cell function. Relatively little is known about the genetic basis of glucose homeostasis pheno...

journal_title：Diabetes

authors： Palmer ND,Langefeld CD,Campbell JK,Williams AH,Saad M,Norris JM,Haffner SM,Rotter JI,Wagenknecht LE,Bergman RN,Rich SS,Bowden DW

更新日期：2006-04-01 00:00:00

abstract：:Leptin induces weight loss in rodents via its effects on food intake and energy expenditure. High-fat diets induce weight gain, but the mechanism is not well understood. Previous studies have not found an effect of dietary fat content on fasting leptin. There is a nocturnal increase of leptin, however, which is relate...

journal_title：Diabetes

authors： Havel PJ,Townsend R,Chaump L,Teff K

更新日期：1999-02-01 00:00:00

abstract：:We previously described a prosthetic group methodology for incorporating 18F into peptides and showed that 18F-labeled insulin (18F-insulin) binds to insulin receptors on human cells (IM-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). We now report studies using 18F-insulin with positron emi...

journal_title：Diabetes

authors： Eastman RC,Carson RE,Jacobson KA,Shai Y,Channing MA,Dunn BB,Bacher JD,Baas E,Jones E,Kirk KL

更新日期：1992-07-01 00:00:00

abstract：:Pioglitazone is widely used for the treatment of diabetic patients with insulin resistance. The mechanism of pioglitazone to improve insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistanc...

journal_title：Diabetes

authors： Kanatani Y,Usui I,Ishizuka K,Bukhari A,Fujisaka S,Urakaze M,Haruta T,Kishimoto T,Naka T,Kobayashi M

更新日期：2007-03-01 00:00:00

abstract：:Inhibition of fatty acid synthase (FAS) induces a rapid decline in fat stores in mice, suggesting a role for this enzyme in energy homeostasis. The human FAS gene (FAS) maps to chromosome 17q25, a region previously shown to have suggestive linkage to adiposity in a genome-wide linkage scan for genetic determinants of ...

journal_title：Diabetes

authors： Kovacs P,Harper I,Hanson RL,Infante AM,Bogardus C,Tataranni PA,Baier LJ

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adi...

journal_title：Diabetes

authors： HAPO Study Cooperative Research Group.

更新日期：2009-02-01 00:00:00

abstract：:Streptozocin-induced diabetic (STZ-D) mice have reduced brain concentrations of tryptophan, a precursor substance for 5-hydroxytryptamine, and show lengthened immobility in Porsolt's swim test, a putative animal model of depression. This study investigated whether tryptophan affects behavior in Porsolt's swim test in ...

journal_title：Diabetes

authors： Hilakivi-Clarke LA

更新日期：1991-12-01 00:00:00

abstract：:Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of PPARδ in regulating vascular function is incompletely characterized. We investigate whether PPARδ activation improves endothelial funct...

journal_title：Diabetes

authors： Tian XY,Wong WT,Wang N,Lu Y,Cheang WS,Liu J,Liu L,Liu Y,Lee SS,Chen ZY,Cooke JP,Yao X,Huang Y

更新日期：2012-12-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Vasculopathy is a major complication of diabetes; however, molecular mechanisms mediating the development of vasculopathy and potential strategies for prevention have not been identified. We have previously reported that C-peptide prevents diabetic vasculopathy by inhibiting reactive oxygen species (ROS)-mediated endo...

journal_title：Diabetes

authors： Bhatt MP,Lim YC,Kim YM,Ha KS

更新日期：2013-11-01 00:00:00

abstract：:To determine the relationship between insulin sensitivity and beta-cell function, we quantified the insulin sensitivity index using the minimal model in 93 relatively young, apparently healthy human subjects of varying degrees of obesity (55 male, 38 female; 18-44 yr of age; body mass index 19.5-52.2 kg/m2) and with f...

journal_title：Diabetes

authors： Kahn SE,Prigeon RL,McCulloch DK,Boyko EJ,Bergman RN,Schwartz MW,Neifing JL,Ward WK,Beard JC,Palmer JP

更新日期：1993-11-01 00:00:00

abstract：:The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...

journal_title：Diabetes

authors： Sun L,Lin JD

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Leptin released from adipocytes plays a key role in the control of food intake, energy balance, and glucose homeostasis. In addition to its central action, leptin directly affects pancreatic beta-cells, inhibiting insulin secretion, and, thus, modulating glucose homeostasis. However, despite the importance of...

journal_title：Diabetes

authors： Tudurí E,Marroquí L,Soriano S,Ropero AB,Batista TM,Piquer S,López-Boado MA,Carneiro EM,Gomis R,Nadal A,Quesada I

更新日期：2009-07-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sha...

journal_title：Diabetes

authors： Parker A,Meyer J,Lewitzky S,Rennich JS,Chan G,Thomas JD,Orho-Melander M,Lehtovirta M,Forsblom C,Hyrkkö A,Carlsson M,Lindgren C,Groop LC

更新日期：2001-03-01 00:00:00

abstract：:Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in type 1 diabetic LDL receptor-deficient mi...

journal_title：Diabetes

authors： Zang M,Xu S,Maitland-Toolan KA,Zuccollo A,Hou X,Jiang B,Wierzbicki M,Verbeuren TJ,Cohen RA

更新日期：2006-08-01 00:00:00