Abstract:
:Insulin-dependent diabetes mellitus (IDDM), cardiovascular morbidity, and vital prognosis are linked to diabetic nephropathy, which is probably determined by renal hemodynamic abnormalities and by a genetic predisposition. Angiotensin I converting enzyme (ACE) regulates systemic and renal circulations through angiotensin II formation and kinins metabolism. Plasma and cellular ACE levels are genetically determined; an insertion/deletion polymorphism of the ACE gene is strongly associated with ACE levels, subjects homozygote for insertion (genotype II) having the lowest plasma values. We studied the relationship between the ACE gene polymorphism or plasma levels and microcirculatory disorders of IDDM through two independent studies: one involved 57 subjects with or without diabetic retinopathy, and the other compared 62 IDDM subjects with diabetic nephropathy to 62 diabetic control subjects with the same characteristics (including retinopathy severity) but with normal kidney function. The ACE genotype distribution was not different in diabetic subjects with or without retinopathy and in a healthy population. Conversely, an imbalance of ACE genotype distribution, with a low proportion of II subjects, was observed in IDDM subjects with diabetic nephropathy compared with their control subjects (P = 0.006). Plasma ACE levels were mildly elevated in all diabetic groups, independently of retinopathy, but they were higher in subjects with nephropathy than in those without nephropathy (P = 0.0022). The II genotype of ACE gene is a marker for reduced risk for diabetic nephropathy.
journal_name
Diabetesjournal_title
Diabetesauthors
Marre M,Bernadet P,Gallois Y,Savagner F,Guyene TT,Hallab M,Cambien F,Passa P,Alhenc-Gelas Fdoi
10.2337/diab.43.3.384subject
Has Abstractpub_date
1994-03-01 00:00:00pages
384-8issue
3eissn
0012-1797issn
1939-327Xjournal_volume
43pub_type
杂志文章相关文献
DIABETES文献大全abstract::The relative effects of time versus ambient glucose concentration on insulin-stimulated glucose uptake was estimated by performing 5-h insulin clamp studies in patients with NIDDM. Each experimental subject was studied three times, at steady-state plasma insulin levels approximately 2000 microU/ml, but at different st...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.7.643
更新日期:1984-07-01 00:00:00
abstract::Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly affect mitochondrial f...
journal_title:Diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/db14-0667
更新日期:2015-04-01 00:00:00
abstract::Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0184
更新日期:2018-11-01 00:00:00
abstract::Fetuin-A interferes with insulin action in animal studies, but data on fetuin-A and diabetes risk in humans are sparse and the role of nonalcoholic fatty liver disease in this association is unknown. From 2000 to 2006, we prospectively identified 470 matched incident diabetes case-control pairs in the Nurses' Health S...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0372
更新日期:2013-01-01 00:00:00
abstract::The Diabetes Association of greater Cleveland screened 307,000 individuals in the metropolitan area for diabetes with a 75-gm. oral load of carbohydrate. Of these subjects 12,600 (4.1 per cent) had a two-capillary blood glucose level of greater than 139 mg. per cent and were defined as positive. Seventy per cent of th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.25.12.1110
更新日期:1976-12-01 00:00:00
abstract::The effects of ethanol, acetaldehyde, and the two novel metabolites of ethanol 2,3-butanediol and 1,2-propanediol on basal and insulin-stimulated adipocyte lipogenesis and glucose oxidation in vitro were investigated. Whereas ethanol and acetaldehyde inhibited both processes at concentrations far greater than those fo...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.7.912
更新日期:1988-07-01 00:00:00
abstract::These studies of a rat model for non-insulin-dependent diabetes mellitus (NIDDM) were performed to determine whether hyperglycemia occurs when capacity to synthesize insulin is exceeded. The neonatal streptozocin (STZ)-treated rat has acute hyperglycemia with marked destruction of pancreatic beta-cells, followed by gr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.3.235
更新日期:1985-03-01 00:00:00
abstract::Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0079
更新日期:2019-09-01 00:00:00
abstract::The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.12.3384
更新日期:2002-12-01 00:00:00
abstract::In pancreatic β-cells, closure of the ATP-sensitive K(+) (K(ATP)) channel is an initial process triggering glucose-stimulated insulin secretion. In addition, constitutive opening of background nonselective cation channels (NSCCs) is essentially required to effectively evoke depolarization as a consequence of K(ATP) ch...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1868
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The liver plays a critical role in integrating and controlling glucose metabolism. Thus, it is important that the liver receive and react to signals from other tissues regarding the nutrient status of the body. Leptin, which is produced and secreted from adipose tissue, is a hormone that relays information re...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0074
更新日期:2010-12-01 00:00:00
abstract::Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.8.724
更新日期:1982-08-01 00:00:00
abstract::Linkage results suggest that the region of chromosome 7 containing the leptin gene cosegregates with extreme obesity; however, leptin coding region mutations are rare. To investigate whether the leptin flanking sequence and/or a larger 40-cM region (7q22.1-7q35) contributes to obesity, we genotyped individuals from 20...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.6.1557
更新日期:2003-06-01 00:00:00
abstract::Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particula...
journal_title:Diabetes
pub_type: 杂志文章,meta分析
doi:10.2337/db06-0930
更新日期:2007-03-01 00:00:00
abstract::Infection of autoimmune New Zealand mice with the D variant of encephalomyocarditis (EMC) virus results in beta-cell damage and clinical diabetes. The induction of diabetes in parental NZB and NZW strains was independent of sex. However, the susceptibility to virus-induced diabetes in their F1 offspring was sex depend...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.8.755
更新日期:1983-08-01 00:00:00
abstract::Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves' disease in comparison to healthy control subjects by st...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.2.237
更新日期:1997-02-01 00:00:00
abstract::The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.10.2099
更新日期:1999-10-01 00:00:00
abstract::In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atheroscleros...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.3.s129
更新日期:1996-07-01 00:00:00
abstract::Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in diabetes, making glucagon an attractive target for therapeutic interventio...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi19-0021
更新日期:2020-04-01 00:00:00
abstract::Antibodies to an islet protein of 64,000 Mr (64K antibodies) were measured in 15 diabetic children who were followed prospectively for up to 3 yr after onset of type I (insulin-dependent) diabetes. Of the 15 children, 12 were positive for 64K antibodies at diagnosis. Those patients who were negative for these antibodi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.6.653
更新日期:1990-06-01 00:00:00
abstract::Kinetic studies were carried out on liver glycogen synthase and phosphorylase isolated from genetically diabetic db/db mice. Glycogen synthase a and b enzymes from diabetic mice had Vmax values 30% and 20% lower, respectively, than the enzymes from normal mice. Glycogen synthase b from diabetic mice also had a 30% low...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.2.210
更新日期:1986-02-01 00:00:00
abstract::Both the coding and control regions of mitochondrial DNA (mtDNA) play roles in the generation of diabetes; however, no studies have thoroughly reported on the combined diabetogenic effects of variants in the two regions. We determined the mitochondrial haplogroup and the mtDNA sequence of the control region in 859 sub...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db11-1369
更新日期:2012-10-01 00:00:00
abstract::A group of insulin-dependent diabetic patients was studied in order to determine the possible short-term regulatory effect of insulin and that of an antilipolytic drug on serum triglycerides. Subcutaneous crystalline insulin (one third of the usual morning dose of intermediate long-acting insulin, NPH) and an oral dos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.7.615
更新日期:1977-07-01 00:00:00
abstract::We addressed the question of whether newly diagnosed type I (insulin-dependent) diabetes mellitus patients showed an increased number of DR (la+) T-lymphocytes compared with nondiabetic siblings and normal control subjects. Two-color flow cytometry measurements of peripheral-blood lymphocytes showed a slight but stati...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.6.792
更新日期:1988-06-01 00:00:00
abstract::The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.3.515
更新日期:2001-03-01 00:00:00
abstract::Pancreatic islets produce and secrete cytokines and chemokines in response to inflammatory and metabolic stress. The physiological role of these "isletokines" in health and disease is largely unknown. We observed that islets release multiple inflammatory mediators in patients undergoing islet transplants within hours ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0578
更新日期:2017-11-01 00:00:00
abstract::In man a small dose of somatostatin (50 micrograms/h) suppressed moderately basal insulin (5 microU/ml) and glucagon (40 pg/ml) levels. This resulted in a short-lasting hypoglycemia, which was then followed by marginal hyperglycemia throughout the experiment. The addition of a minimal dose of glucagon (0.50 ng/kg/min)...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.7.633
更新日期:1983-07-01 00:00:00
abstract::Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the si...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0107
更新日期:2015-12-01 00:00:00
abstract::Accumulation of brown products in long-lived proteins might be an important factor in determining long-term diabetic complications. Fluorescent chromophore 2-(2-furoyl)-4-(5)-(2-furanyl)-1H-imidazole (FFI), isolated from hydrolyzed brown products synthesized in vitro, was proposed as a specific brown product responsib...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.39.1.57
更新日期:1990-01-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) or amylin is a newly identified 37-amino acid COOH-terminal-amidated polypeptide that is the major protein constituent of amyloid deposits in insulinomas and amyloid deposits in pancreatic islets of non-insulin-dependent (type II) diabetic humans and adult diabetic cats. IAPP is stored...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.40.3.310
更新日期:1991-03-01 00:00:00