Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

abstract：:A polymorphic region 5' to the human insulin gene has been associated with diabetes in earlier studies. This polymorphic region is composed of tandem repeats that fall into 3 general size classes, designated class 1 (600 base pairs), class 2 (1300 base pairs), and class 3 (2500 base pairs). Frequencies of these classe...

journal_title：Diabetes

authors： Elbein S,Rotwein P,Permutt MA,Bell GI,Sanz N,Karam JH

更新日期：1985-05-01 00:00:00

abstract：:Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo i...

journal_title：Diabetes

authors： Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CD

更新日期：2003-05-01 00:00:00

abstract：:Extensive investigations of the solubility and fluorescence of collagen fibers in diabetes have revealed that there are significant changes in their physical properties. These changes are associated with increased cross-link formation. We used X-ray diffraction to study these changes in human extensor tendons at a mol...

journal_title：Diabetes

authors： James VJ,Delbridge L,McLennan SV,Yue DK

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS:The FinnDiane Study has character...

journal_title：Diabetes

authors： Hietala K,Forsblom C,Summanen P,Groop PH,FinnDiane Study Group.

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes. RESEARCH DESIGN AND METHODS:Acutely diabetic NOD mice were tr...

journal_title：Diabetes

authors： Suarez-Pinzon WL,Power RF,Yan Y,Wasserfall C,Atkinson M,Rabinovitch A

更新日期：2008-12-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...

journal_title：Diabetes

authors： Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

更新日期：2015-10-01 00:00:00

abstract：:The clinical features of the experimental hyperosmolar diabetic (EHD) rat model resemble those seen in the human syndrome--extreme hyperglycemia without ketoacidosis is common to both. The absence of ketoacidosis in the syndrome has been ascribed to both substrate (free fatty acid) deficiency and to interference with ...

journal_title：Diabetes

authors： Gordon EE,Duga J

更新日期：1975-03-01 00:00:00

abstract：:We have recently reported successful 72-h preservation of the canine pancreas with a new cold-storage solution developed at the University of Wisconsin (UW solution). Over 10 mo, we performed 11 combined pancreas-kidney and 4 isolated-pancreas transplants with this solution. In situ cooling of the donor pancreas was p...

journal_title：Diabetes

authors： D'Alessandro AM,Stratta RJ,Sollinger HW,Kalayoglu M,Pirsch JD,Belzer FO

更新日期：1989-01-01 00:00:00

abstract：:Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 (PAI-1) has been implicated in the vasculopathy of type 2 diabetes, typified by increased insulin, glucose, and triglycerides. However, short-term infusions of insulin have not increased PAI-1 in normal subjects. We hypothesized that induction of i...

journal_title：Diabetes

authors： Calles-Escandon J,Mirza SA,Sobel BE,Schneider DJ

更新日期：1998-02-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by reduced cardiac contractility due to direct changes in heart muscle function independent of vascular disease. An important contributor to contractile dysfunction in the diabetic state is an impaired sarcoplasmic reticulum (SR) function, leading to disturbed intracellular cal...

journal_title：Diabetes

authors： Trost SU,Belke DD,Bluhm WF,Meyer M,Swanson E,Dillmann WH

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:A major feature of type 1 diabetes is the appearance of islet autoantibodies before diagnosis. However, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs further investigation. The primary susceptibility loci in type 1 diabetes, the HLA class I and II genes, are ...

journal_title：Diabetes

authors： Howson JM,Stevens H,Smyth DJ,Walker NM,Chandler KA,Bingley PJ,Todd JA

更新日期：2011-10-01 00:00:00

abstract：:Islet antigens associated with type 1 diabetes include a recently identified protein tyrosine phosphatase-like molecule IA-2, which contains the intracellular fragment IA-2ic. To determine whether combinations of antibodies including those to IA-2 characterize and predict type 1 diabetes, we studied antibodies to IA-2...

journal_title：Diabetes

authors： Hawa M,Rowe R,Lan MS,Notkins AL,Pozzilli P,Christie MR,Leslie RD

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Antecedent hypoglycemia can blunt neuroendocrine and autonomic nervous system responses to next-day exercise in type 1 diabetes. The aim of this study was to determine whether antecedent increase of plasma cortisol is a mechanism responsible for this finding. RESEARCH DESIGN AND METHODS:For this study, 22 ty...

journal_title：Diabetes

authors： Bao S,Briscoe VJ,Tate DB,Davis SN

更新日期：2009-09-01 00:00:00

abstract：:This study examined the suitability of commercial U.S.P. insulin as a bacterial growth medium. Purified port insulin (Iletin II, Eli Lilly & Co., Indianapolis, Indiana) was inoculated with approximately 500,000 bacteria per ml of: (1) Staphylococcus epidermidis, (2) Staphylococcus aureus, or (3) Escherichia coli. All ...

journal_title：Diabetes

authors： Schade DS,Eaton RP

更新日期：1982-01-01 00:00:00

abstract：:Enteroviruses have been examined for their possible role in the etiology of IDDM for nearly 40 years, yet the evidence remains inconclusive. The mechanism of acute cytolytic infection of beta-cells, proposed by earlier studies, appears to be incompatible with the long preclinical period of autoimmunity preceding IDDM....

journal_title：Diabetes

authors： Graves PM,Norris JM,Pallansch MA,Gerling IC,Rewers M

更新日期：1997-02-01 00:00:00

abstract：:Eight manufacturing facilities participating in the National Institutes of Health-sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for the manufacture of allogeneic purified human pancreatic islet (PHPI) product evaluated in a phase 3 trial in subjects wi...

journal_title：Diabetes

authors： Ricordi C,Goldstein JS,Balamurugan AN,Szot GL,Kin T,Liu C,Czarniecki CW,Barbaro B,Bridges ND,Cano J,Clarke WR,Eggerman TL,Hunsicker LG,Kaufman DB,Khan A,Lafontant DE,Linetsky E,Luo X,Markmann JF,Naji A,Korsgren O

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct models of obesity. RESEARCH DESIGN AND METHODS:Male C57BL/6J mice were fed a high-fat/high-sucrose diet...

journal_title：Diabetes

authors： Sato A,Kawano H,Notsu T,Ohta M,Nakakuki M,Mizuguchi K,Itoh M,Suganami T,Ogawa Y

更新日期：2010-10-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...

journal_title：Diabetes

authors： Tennant KG,Lindsley SR,Kirigiti MA,True C,Kievit P

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Glomerular filtration rate (GFR) is used to assess the progression of renal disease. We performed linkage analysis to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/Gallbladder Study. We also examined the effect of genotype by diabetes interaction (G x DM) on t...

journal_title：Diabetes

authors： Puppala S,Arya R,Thameem F,Arar NH,Bhandari K,Lehman DM,Schneider J,Fowler S,Farook VS,Diego VP,Almasy L,Blangero J,Stern MP,Duggirala R,Abboud HE

更新日期：2007-11-01 00:00:00

abstract：:A new murine model of porcine islet-like cell cluster (ICC) xenograft rejection, avoiding interference of unspecific inflammation, was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) mice were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the ori...

journal_title：Diabetes

authors： Schmidt P,Krook H,Maeda A,Korsgren O,Benda B

更新日期：2003-05-01 00:00:00

abstract：:Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...

journal_title：Diabetes

authors： Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

更新日期：2012-07-01 00:00:00

abstract：:Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...

journal_title：Diabetes

authors： Young RJ,Ewing DJ,Clarke BF

更新日期：1983-02-01 00:00:00

abstract：:The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...

journal_title：Diabetes

authors： Brom M,Joosten L,Frielink C,Peeters H,Bos D,van Zanten M,Boerman O,Gotthardt M

更新日期：2018-10-01 00:00:00

abstract：:The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as in the Edmonton protocol. To determine whether CIT07 improves engraf...

journal_title：Diabetes

authors： Rickels MR,Liu C,Shlansky-Goldberg RD,Soleimanpour SA,Vivek K,Kamoun M,Min Z,Markmann E,Palangian M,Dalton-Bakes C,Fuller C,Chiou AJ,Barker CF,Luning Prak ET,Naji A

更新日期：2013-08-01 00:00:00

abstract：:One hundred fifty-four selected patients with nonketotic diabetes diagnosed between the ages of 35 and 75 yr and treated with diet or oral hypoglycemic agents for at least 1 yr were investigated for parameters of glycemic control (weight loss, blood glucose, and glycosylated hemoglobin), islet cell function (fasting a...

journal_title：Diabetes

authors： Groop LC,Bottazzo GF,Doniach D

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity in the hypothalamus...

journal_title：Diabetes

authors： Proulx K,Cota D,Woods SC,Seeley RJ

更新日期：2008-12-01 00:00:00

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Loss of GBM HS in dia...

journal_title：Diabetes

authors： Gil N,Goldberg R,Neuman T,Garsen M,Zcharia E,Rubinstein AM,van Kuppevelt T,Meirovitz A,Pisano C,Li JP,van der Vlag J,Vlodavsky I,Elkin M

更新日期：2012-01-01 00:00:00

abstract：:The virtually fatless A-ZIP/F-1 mouse is profoundly insulin resistant, diabetic, and a good model for humans with severe generalized lipoatrophy. Like a number of other mouse models of diabetes, the A-ZIP/F-1 mouse has elevated serum corticosterone levels. Leptin infusion lowers the corticosterone levels, suggesting t...

journal_title：Diabetes

authors： Haluzik M,Dietz KR,Kim JK,Marcus-Samuels B,Shulman GI,Gavrilova O,Reitman ML

更新日期：2002-07-01 00:00:00

abstract：:Determinants of proliferative diabetic retinopathy (PDR) that occur during the 2nd decade of insulin-dependent diabetes mellitus (IDDM) (early-onset PDR) were investigated in a nested case-control study. From an inception cohort of patients with juvenile-onset IDDM that now has 15-21 yr diabetes duration, the patients...

journal_title：Diabetes

authors： Krolewski AS,Barzilay J,Warram JH,Martin BC,Pfeifer M,Rand LI

更新日期：1992-04-01 00:00:00