Abstract:
:Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo interaction between platelets and atherogenic lipoproteins suggesting that atherogenic triglyceride-rich lipoproteins, such as VLDL, that are increased in diabetic dyslipidemia are important in this process. This study demonstrates that VLDL binds to the platelet receptor CD36, enhances platelet thromboxane A2 production, and causes increased collagen-mediated platelet aggregation. VLDL enhanced collagen-induced platelet aggregation by 1) shortening the time taken for aggregation to begin (lag time) to 70% of control (P = 0.001); 2) increasing maximum aggregation to 170% of control (P = 0.008); and 3) increasing thromboxane production to 3,318% of control (P = 0.004), where control represents platelets stimulated with collagen (100%). A monoclonal antibody against CD36 attenuated VLDL-enhanced collagen-induced platelet aggregation by 1) inhibiting binding of VLDL to platelets by 75% (P = 0.041); 2) lengthening lag time to 190% (P < 0.001); and 3) decreasing thromboxane production to 8% of control (P < 0.001). In support of this finding, platelets from Cd36-deficient rats showed no increase in aggregation, thromboxane production, and VLDL binding in contrast to platelets from rats expressing CD36. These data suggest that platelet Cd36 has a key role in VLDL-induced collagen-mediated platelet aggregation, possibly contributing to atherothrombosis associated with increased VLDL levels.
journal_name
Diabetesjournal_title
Diabetesauthors
Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CDdoi
10.2337/diabetes.52.5.1248subject
Has Abstractpub_date
2003-05-01 00:00:00pages
1248-55issue
5eissn
0012-1797issn
1939-327Xjournal_volume
52pub_type
杂志文章相关文献
DIABETES文献大全abstract::Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.4.278
更新日期:1977-04-01 00:00:00
abstract::Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of PPARδ in regulating vascular function is incompletely characterized. We investigate whether PPARδ activation improves endothelial funct...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0117
更新日期:2012-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER are only partially defined in these cells, ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.51.2007.s190
更新日期:2002-02-01 00:00:00
abstract::Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet-i...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0886
更新日期:2017-05-01 00:00:00
abstract::Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0281
更新日期:2020-03-01 00:00:00
abstract::Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1175
更新日期:2019-07-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM), cardiovascular morbidity, and vital prognosis are linked to diabetic nephropathy, which is probably determined by renal hemodynamic abnormalities and by a genetic predisposition. Angiotensin I converting enzyme (ACE) regulates systemic and renal circulations through angioten...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.43.3.384
更新日期:1994-03-01 00:00:00
abstract::Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.1.s37
更新日期:1982-01-01 00:00:00
abstract::EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1336
更新日期:2018-06-01 00:00:00
abstract::Enhanced advanced glycosylation end product (AGE) formation has been shown to participate in the pathogenesis of diabetes-induced glomerular injury by mediating the increased extracellular matrix (ECM) deposition and altered cell growth and turnover leading to mesangial expansion. These effects could be exerted via an...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.46.11.1881
更新日期:1997-11-01 00:00:00
abstract::Regulated exocytosis forms the basis for many intercellular signaling processes, for example, in hormone secretion or neurotransmitter release. During regulated exocytosis, the membrane of a secretory vesicle fuses with the plasma membrane in a tightly controlled reaction that is most often triggered by calcium. Recen...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.2007.s3
更新日期:2002-02-01 00:00:00
abstract::Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated ant...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,收录出版
doi:10.2337/diabetes.54.11.3089
更新日期:2005-11-01 00:00:00
abstract::Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement ...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/diabetes.54.11.3319
更新日期:2005-11-01 00:00:00
abstract::A single administration of complete Freund's adjuvant (CFA), type 1 carrageenan (Car), or silica 7, 2, and 2 days, respectively, before infection with a low dose (1 x 10(2) plaque-forming units/mouse) of encephalomyocarditis D (EMC-D) virus resulted in a significant increase in the incidence of diabetes in SJL/J mice ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1586
更新日期:1991-12-01 00:00:00
abstract::Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.3.338
更新日期:1989-03-01 00:00:00
abstract::Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.28.7.634
更新日期:1979-07-01 00:00:00
abstract::A 5-day culture of adult rat islets with human recombinant IL-1 beta (3 U/ml) resulted in the death of most alpha-cells and 50% of beta-cells. The IL-1--exposed islet tissue contained--in addition to poorly granulated beta-cells--patches of outgrowing monolayers and dispersed activated macrophages. In purified alpha- ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.1.56
更新日期:1993-01-01 00:00:00
abstract::We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.2.s121
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-1704
更新日期:2010-06-01 00:00:00
abstract::The effect of glyburide on glucose metabolism was examined in 10 non-insulin-dependent diabetic subjects (NIDDM) and 7 young, control subjects. After 3 mo of glyburide treatment in NIDDM, fasting plasma glucose declined from 198 to 141 mg/dl (P less than 0.01) without change in fasting insulin levels. Basal hepatic gl...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.33.9.838
更新日期:1984-09-01 00:00:00
abstract::Inhibition of glucose-stimulated insulin release by exogenous insulin has been demonstrated in pancreatic islets to be associated with a decrease of the NADPH/NADP ratio and the pentose-phosphate cycle activity. Batches of five islets were incubated for 15 and 90 minutes in 1 ml. of KRB buffer with 2 per cent albumin ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.26.9.857
更新日期:1977-09-01 00:00:00
abstract::To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.44.7.727
更新日期:1995-07-01 00:00:00
abstract::The ATP-sensitive K(+) channel (K(ATP) channel) in pancreatic beta-cells is a critical regulator in insulin secretion. We previously reported that transgenic mice expressing a dominant-negative form (Kir6.2G132S) of Kir6.2, a subunit of the K(ATP) channel, specifically in beta-cells develop severe hyperglycemia in adu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db05-1459
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Progranulin is an important molecule in inflammatory response. Chronic inflammation is frequently associated with central obesity and associated disturbances; however, the role of circulating progranulin in human obesity, type 2 diabetes, and dyslipidemia is unknown. RESEARCH DESIGN AND METHODS:For the measu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db08-1147
更新日期:2009-03-01 00:00:00
abstract::The antidiabetic thiazolidinediones, which include troglitazone and rosiglitazone, are ligands for the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma and exert their antihyperglycemic effects by regulation of PPAR-gamma-responsive genes. We report here that PPAR-gamma activation by troglitazo...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.4.539
更新日期:2000-04-01 00:00:00
abstract::Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particula...
journal_title:Diabetes
pub_type: 杂志文章,meta分析
doi:10.2337/db06-0930
更新日期:2007-03-01 00:00:00
abstract::Peripheral somatic and autonomic nerve function have been studied in 79 teenage (16-19 yr) diabetics and 20 age- and sex-matched normal controls. Almost three-quarters of the diabetics (72%) had abnormal peripheral somatic nerve function tests, and one-third (31%) had abnormal cardiac parasympathetic tests. Both motor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.2.142
更新日期:1983-02-01 00:00:00
abstract::The inhibitory actions of somatostatin (100 ng./ml.) on insulin release, stimulated by high glucose (20 mM), and on glucagon release, stimulated by arginine (15 mM), were studied with two in vitro systems: the isolated perifused rat islets prepared by the collagenase procedure and the isolated perfused rat pancreas. S...
journal_title:Diabetes
pub_type: 历史文章,杂志文章
doi:10.2337/diab.24.11.961
更新日期:1975-11-01 00:00:00
abstract::Dissociated human insulinoma cells were plated onto plastic multiwell dishes. Cells were maintained for 1 mo on plastic with three passages. Cultures consisted of small colonies with some areas of stratification and few intercellular spaces. Ultrastructural studies indicated that cultured cells had epithelial features...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.9.1279
更新日期:1988-09-01 00:00:00
abstract::Clinical studies have suggested that changes in peripheral nerve microcirculation may contribute to nerve damage in diabetic polyneuropathy (DN). High-sensitivity troponin T (hsTNT) assays have been recently shown to provide predictive values for both cardiac and peripheral microangiopathy in type 2 diabetes (T2D). Th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-1094
更新日期:2020-04-01 00:00:00