Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals.

abstract：:Rat islets contain the acid-labile activator of phosphofructokinase, fructose-2,6-bisphosphate. The islet content in activator is higher in islets exposed to glucose (16.7 mM) than in islets deprived of glucose. The islets display fructose-6-phosphate, 2-kinase activity with a Km for fructose-6-phosphate close to 0.08...

journal_title：Diabetes

authors： Malaisse WJ,Malaisse-Lagae F,Sener A

更新日期：1982-01-01 00:00:00

abstract：:We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid-associated loci. We used data of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort ...

journal_title：Diabetes

authors： Sluijs I,Holmes MV,van der Schouw YT,Beulens JW,Asselbergs FW,Huerta JM,Palmer TM,Arriola L,Balkau B,Barricarte A,Boeing H,Clavel-Chapelon F,Fagherazzi G,Franks PW,Gavrila D,Kaaks R,Khaw KT,Kühn T,Molina-Montes E,Mo

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Progranulin is an important molecule in inflammatory response. Chronic inflammation is frequently associated with central obesity and associated disturbances; however, the role of circulating progranulin in human obesity, type 2 diabetes, and dyslipidemia is unknown. RESEARCH DESIGN AND METHODS:For the measu...

journal_title：Diabetes

authors： Youn BS,Bang SI,Klöting N,Park JW,Lee N,Oh JE,Pi KB,Lee TH,Ruschke K,Fasshauer M,Stumvoll M,Blüher M

更新日期：2009-03-01 00:00:00

abstract：:The allelic forms of the human leukocyte antigen (HLA)-DQ beta-chain (DQB1) have been recognized as the best markers of insulin-dependent diabetes mellitus (IDDM) susceptibility. We describe a method that allows the recognition of these DQB1 alleles without the use of either allele-specific oligonucleotide probes or r...

journal_title：Diabetes

authors： Trucco G,Fritsch R,Giorda R,Trucco M

更新日期：1989-12-01 00:00:00

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00

abstract：:Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructiv...

journal_title：Diabetes

authors： Duennwald T,Bernardi L,Gordin D,Sandelin A,Syreeni A,Fogarty C,Kytö JP,Gatterer H,Lehto M,Hörkkö S,Forsblom C,Burtscher M,Groop PH,FinnDiane Study Group.

更新日期：2013-12-01 00:00:00

abstract：:A major goal of the study was to assess the methodologies available for the quantification of retinal lesions suitable for application in trials of metabolic management. We describe the methods used for grading stereoscopic color fundus photographs. Overall retinopathy severity level for each eye ranging from normal (...

journal_title：Diabetes

authors： Davis MD,Hubbard LD,Trautman J,Klein R

更新日期：1985-08-01 00:00:00

abstract：:We tested the hypothesis that activation of the protective arm of the renin angiotensin system, the angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)]/Mas receptor axis, corrects the vasoreparative dysfunction typically seen in the CD34(+) cells isolated from diabetic individuals. Peripheral blood CD...

journal_title：Diabetes

authors： Jarajapu YP,Bhatwadekar AD,Caballero S,Hazra S,Shenoy V,Medina R,Kent D,Stitt AW,Thut C,Finney EM,Raizada MK,Grant MB

更新日期：2013-04-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular complications of type 2 diabetes. In liver, extracellular hepara...

journal_title：Diabetes

authors： Olsson U,Egnell AC,Lee MR,Lundén GO,Lorentzon M,Salmivirta M,Bondjers G,Camejo G

更新日期：2001-09-01 00:00:00

abstract：:An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen...

journal_title：Diabetes

authors： Cohen WR,Deutsch J

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

journal_title：Diabetes

authors： Edfalk S,Steneberg P,Edlund H

更新日期：2008-09-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...

journal_title：Diabetes

authors： Wang T,Singh B,Warnock GL,Rajotte RV

更新日期：1992-01-01 00:00:00

abstract：:The antihyperglycemic drug dimethylbiguanide (DMB, also known as metformin) reduces the risk of cardiovascular complications in type 2 diabetes, although the mechanism(s) involved are unclear. DMB reduces glycosylation-related protein cross-linking, a process similar to fibrin cross-linking catalyzed by activated fact...

journal_title：Diabetes

authors： Standeven KF,Ariëns RA,Whitaker P,Ashcroft AE,Weisel JW,Grant PJ

更新日期：2002-01-01 00:00:00

abstract：:Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically ...

journal_title：Diabetes

authors： Seino Y,Ikeda M,Kurahachi H,Taminato T,Sakurai H,Goto Y,Inoue Y,Kadowaki S,Mori K,Imura H

更新日期：1978-12-01 00:00:00

abstract：:Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress. The oxidative stress attacks DNA, lipids, and proteins and is also tho...

journal_title：Diabetes

authors： Taniguchi N,Kaneto H,Asahi M,Takahashi M,Wenyi C,Higashiyama S,Fujii J,Suzuki K,Kayanoki Y

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Recent work has shown that insulin stimulates its own secretion in insulin-sensitive humans, suggesting that insulin resistance in the β-cell could cause β-cell dysfunction. We have tested whether insulin exposure and insulin sensitivity modulate β-cell function in subjects with normal glucose tolerance (NGT)...

journal_title：Diabetes

authors： Mari A,Tura A,Natali A,Anderwald C,Balkau B,Lalic N,Walker M,Ferrannini E,RISC Investigators.

更新日期：2011-12-01 00:00:00

abstract：:Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-alpha expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-alpha in one of these models imp...

journal_title：Diabetes

authors： Hotamisligil GS,Spiegelman BM

更新日期：1994-11-01 00:00:00

abstract：:Mutation of tub gene in mice induces obesity, suggesting that tub could be an important regulator of energy balance. In the current study, we investigated whether insulin, leptin, and obesity can modulate Tub in vivo in hypothalamic nuclei, and we investigated possible consequences on energy balance, neuropeptide expr...

journal_title：Diabetes

authors： Prada PO,Quaresma PG,Caricilli AM,Santos AC,Guadagnini D,Morari J,Weissmann L,Ropelle ER,Carvalheira JB,Velloso LA,Saad MJ

更新日期：2013-01-01 00:00:00

abstract：:Using the hyperglycemic and euglycemic clamp, we demonstrated impaired β-cell function in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test (OGTT)-modeled β-cell function and incretin effect in obese adolescents spanning the range of glucose tolerance. β-Cell function parameters w...

journal_title：Diabetes

authors： Michaliszyn SF,Mari A,Lee S,Bacha F,Tfayli H,Farchoukh L,Ferrannini E,Arslanian S

更新日期：2014-11-01 00:00:00

abstract：:Changes in tissue levels of sorbitol, myo-inositol, and Na+-K+-ATPase enzyme activity have been implicated in the development of diabetic complications in animal models of the disease and in humans. The ability of the aldose reductase inhibitor sorbinil to reverse the hyperglycemia-induced changes in these lenticular ...

journal_title：Diabetes

authors： Yeh LA,Rafford CE,Goddu KJ,Ashton MA,Beyer TA,Hutson NJ

更新日期：1987-12-01 00:00:00

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:Fasting hyperglycemia occurs when an excessive rate of endogenous glucose production (EGP) is not accompanied by an adequate compensatory increase in the rate of glucose disappearance (Rd). The situation following food ingestion is more complex as the amount of glucose that reaches the circulation for disposal is a fu...

journal_title：Diabetes

authors： Rizza RA,Toffolo G,Cobelli C

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:In part, activation of invariant natural killer T (iNKT)-cells with the superagonist alpha-galactosylceramide (alpha-GalCer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by inducing the downstream differentiation of antigen-presenting dendritic cells (DCs) to an immunotol...

journal_title：Diabetes

authors： Driver JP,Scheuplein F,Chen YG,Grier AE,Wilson SB,Serreze DV

更新日期：2010-02-01 00:00:00

abstract：:Tissue sensitivity to insulin was studied using the euglycemic insulin clamp technique (delta plasma insulin above basal 90 microU/ml) in eight patients with type I diabetes mellitus (IDDM) before and after 4-8 mo of continuous subcutaneous insulin infusion (CSII) and in 36 age-matched control subjects. Institution of...

journal_title：Diabetes

authors： Simonson DC,Tamborlane WV,Sherwin RS,Smith JD,DeFronzo RA

更新日期：1985-08-01 00:00:00

abstract：:Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...

journal_title：Diabetes

authors： Gray SM,Niu J,Zhang A,Svendsen B,Campbell JE,D'Alessio DA,Tong J

更新日期：2019-09-01 00:00:00

abstract：:The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr]...

journal_title：Diabetes

authors： Kobayashi T,Itoh T,Kosaka K,Sato K,Tsuji K

更新日期：1987-04-01 00:00:00

abstract：:GLUT2 glucose transporter mRNA has been shown to be underexpressed in pancreatic islets of numerous animal models of non-insulin-dependent diabetes mellitus (NIDDM). It has been proposed that this molecular defect contributes to the pathogenesis of diabetes, although information concerning the expression of GLUT2 in h...

journal_title：Diabetes

authors： Ferrer J,Benito C,Gomis R

更新日期：1995-12-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is characterized by a metabolic and hormonal disarray that may be more evident during exercise. However, the metabolic response to exercise of different intensities has not been evaluated in IDDM. We therefore used stable isotope techniques and indirect calorimetry to quantif...

journal_title：Diabetes

authors： Raguso CA,Coggan AR,Gastaldelli A,Sidossis LS,Bastyr EJ 3rd,Wolfe RR

更新日期：1995-09-01 00:00:00