Conference on insulin pump therapy in diabetes. Multicenter study effect on microvascular disease. Studies of retinopathy. Methodology for assessment and classification with fundus photographs.

abstract：:In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...

journal_title：Diabetes

authors： Taskinen MR

更新日期：1992-10-01 00:00:00

abstract：:Insulin replacement therapy in type 1 diabetes is imperfect because proper glycemic control is not always achieved. Most patients develop microvascular, macrovascular, and neurological complications, which increase with the degree of hyperglycemia. Engineered muscle cells continuously secreting basal levels of insulin...

journal_title：Diabetes

authors： Riu E,Mas A,Ferre T,Pujol A,Gros L,Otaegui P,Montoliu L,Bosch F

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:We evaluated the impact on diabetes-related intermediary traits of common novel type 2 diabetes-associated variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of ...

journal_title：Diabetes

authors： Grarup N,Andersen G,Krarup NT,Albrechtsen A,Schmitz O,Jørgensen T,Borch-Johnsen K,Hansen T,Pedersen O

更新日期：2008-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regula...

journal_title：Diabetes

authors： Baboota RK,Blüher M,Smith U

更新日期：2021-02-01 00:00:00

abstract：:The clearing of monoclonal and polyclonal and anti-insulin antibodies from homogeneous solutions at 100,000 X g was used to estimate the size of soluble insulin-antibody complexes at physiologic concentrations. Monoclonal antibodies cleared as a uniform population of 6.6 S independent of the insulin concentration. Pol...

journal_title：Diabetes

authors： Petersen KG,Storch MJ,Rother K,Licht T,Kerp L

更新日期：1985-08-01 00:00:00

abstract：:Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive. We aimed to define monocyte COX expression in type...

journal_title：Diabetes

authors： Beyan H,Goodier MR,Nawroly NS,Hawa MI,Bustin SA,Ogunkolade WB,Londei M,Yousaf N,Leslie RD

更新日期：2006-12-01 00:00:00

abstract：:In this study, we examined whether adenoviral-mediated glycerol kinase (AdV-CMV-GlyK) expression in isolated rat pancreatic islets could introduce glycerol-induced proinsulin biosynthesis. In AdV-CMV-GlyK-infected islets, specific glycerol-induced proinsulin biosynthesis translation and insulin secretion were observed...

journal_title：Diabetes

authors： Skelly RH,Wicksteed B,Antinozzi PA,Rhodes CJ

更新日期：2001-08-01 00:00:00

abstract：:The aim of this study was to investigate whether mutations in hepatocyte nuclear factor (HNF)-4gamma, a transcription factor homologous to HNF-4alpha, contribute to the etiology of early-onset type 2 diabetes. Linkage between diabetes and two polymorphic markers at the HNF-4gamma locus (D8S286 and D8S548) was evaluate...

journal_title：Diabetes

authors： Plengvidhya N,Antonellis A,Wogan LT,Poleev A,Borgschulze M,Warram JH,Ryffel GU,Krolewski AS,Doria A

更新日期：1999-10-01 00:00:00

abstract：:Cryopreservation of islets of Langerhans offers a number of important benefits for attempts to cure diabetes by transplantation. In the published literature, a variety of cooling rates, ranging from 0.25 to 75 degrees C/min, in conjunction with warming rates of 4-200 degrees C/min have been proposed to give optimal pr...

journal_title：Diabetes

authors： Taylor MJ,Benton MJ

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet unexpectedly experienced a dramatic reduc...

journal_title：Diabetes

authors： Cheng Y,Meng Q,Wang C,Li H,Huang Z,Chen S,Xiao F,Guo F

更新日期：2010-01-01 00:00:00

abstract：:Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two i...

journal_title：Diabetes

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Tsurumaru M,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2005-12-01 00:00:00

abstract：:Diabetes is associated with a loss of somatosensory and motor function, leading to impairments in gait, balance, and manual dexterity. Data-driven neuroimaging studies frequently report a negative impact of diabetes on sensorimotor regions in the brain; however, relationships with sensorimotor behavior are rarely cons...

journal_title：Diabetes

authors： Ferris JK,Inglis JT,Madden KM,Boyd LA

更新日期：2020-01-01 00:00:00

abstract：:We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma. We now report the results of further detailed pathophysiological evaluation of these subj...

journal_title：Diabetes

authors： Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

更新日期：2003-04-01 00:00:00

abstract：:One hundred fifty-four selected patients with nonketotic diabetes diagnosed between the ages of 35 and 75 yr and treated with diet or oral hypoglycemic agents for at least 1 yr were investigated for parameters of glycemic control (weight loss, blood glucose, and glycosylated hemoglobin), islet cell function (fasting a...

journal_title：Diabetes

authors： Groop LC,Bottazzo GF,Doniach D

更新日期：1986-02-01 00:00:00

abstract：:The isolated rat liver perfused for 12 hours at pH 7.10 with a suspension of bovine erythrocytes in Krebs-Ringer bicarbonate buffer containing 3 per cent bovine serum albumin has been used as a test system to study effects of glucagon and of dexamethasone in the presence and absence of insulin on net biosynthesis of r...

journal_title：Diabetes

authors： Miller LL

更新日期：1976-01-01 00:00:00

abstract：:Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in patients with newly...

journal_title：Diabetes

authors： Tezza S,Ben Nasr M,D'Addio F,Vergani A,Usuelli V,Falzoni S,Bassi R,Dellepiane S,Fotino C,Rossi C,Maestroni A,Solini A,Corradi D,Giani E,Mameli C,Bertuzzi F,Pezzolesi MG,Wasserfall CH,Atkinson MA,Füchtbauer EM,Rico

更新日期：2018-10-01 00:00:00

abstract：:Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail. This study is a longitudinal study in 60 children (33 male and 27 female subjects; 32 Caucasian and 28 African-American) examined at Tanner s...

journal_title：Diabetes

authors： Goran MI,Gower BA

更新日期：2001-11-01 00:00:00

abstract：:Susceptibility to insulin-dependent diabetes mellitus (IDDM) is greatly influenced by polymorphisms in the genes of the class II region of the human leukocyte antigen (HLA) complex. The complexity of this genetic association and the lack of a direct proof of involvement of HLA class II genes in human IDDM have continu...

journal_title：Diabetes

authors： van Endert PM,Liblau RS,Patel SD,Fugger L,Lopez T,Pociot F,Nerup J,McDevitt HO

更新日期：1994-01-01 00:00:00

abstract：:Type 1 diabetes appears to progress not as an uncontrolled autoimmune attack on the pancreatic islet beta-cells, but rather in a highly regulated manner. Leukocytic infiltration of the pancreatic islets by autoimmune cells, or insulitis, can persist for long periods of time before the terminal destruction of beta-cell...

journal_title：Diabetes

authors： Matos M,Park R,Mathis D,Benoist C

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Melanocortin 3 receptor (MC3R) plays a critical role in weight regulation of rodents, but its role in humans remains unclear. The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity. RESEARCH DESIGN AND METHODS:We screened 201 obese c...

journal_title：Diabetes

authors： Lee YS,Poh LK,Kek BL,Loke KY

更新日期：2007-10-01 00:00:00

abstract：:Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate mechanism remains to be elucidated. Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as major gatekeepers of the gonadotropic axis. Alteration in the hypothalamic KiSS-1...

journal_title：Diabetes

authors： Castellano JM,Navarro VM,Fernández-Fernández R,Roa J,Vigo E,Pineda R,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-09-01 00:00:00

abstract：:We addressed the question of whether newly diagnosed type I (insulin-dependent) diabetes mellitus patients showed an increased number of DR (la+) T-lymphocytes compared with nondiabetic siblings and normal control subjects. Two-color flow cytometry measurements of peripheral-blood lymphocytes showed a slight but stati...

journal_title：Diabetes

authors： Legendre CM,Schiffrin A,Weitzner G,Colle E,Guttmann RD

更新日期：1988-06-01 00:00:00

abstract：:RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells...

journal_title：Diabetes

authors： Rigby MR,Bortell R,Greiner DL,Czech MP,Klarlund JK,Mordes JP,Rossini AA

更新日期：1996-10-01 00:00:00

abstract：:Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD i...

journal_title：Diabetes

authors： Marshall AG,Lee-Kubli C,Azmi S,Zhang M,Ferdousi M,Mixcoatl-Zecuatl T,Petropoulos IN,Ponirakis G,Fineman MS,Fadavi H,Frizzi K,Tavakoli M,Jeziorska M,Jolivalt CG,Boulton AJM,Efron N,Calcutt NA,Malik RA

更新日期：2017-05-01 00:00:00

abstract：:Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...

journal_title：Diabetes

authors： Ginsberg HN

更新日期：1977-04-01 00:00:00

abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

journal_title：Diabetes

authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

更新日期：1986-04-01 00:00:00

abstract：:During epidemiologic investigations of vascular complications of diabetes in Warsaw the habit of cigarette smoking was analyzed in the subjects studied (4,530 diabetics). It was found that in the group of diabetics the number of ex-smokers was much greater (p less than 0.01) and that of present smokers lower (p less t...

journal_title：Diabetes

authors： Czyzyk A,Królewski AS

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVE:Haptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found in obesity, and low adiponectin have been implicated in the development of insulin resistance and hepatosteatosis. The aim of this work was...

journal_title：Diabetes

authors： Lisi S,Gamucci O,Vottari T,Scabia G,Funicello M,Marchi M,Galli G,Arisi I,Brandi R,D'Onofrio M,Pinchera A,Santini F,Maffei M

更新日期：2011-10-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the content and mRNA level of insulin in a mouse beta-cell line, MIN6, and primary-cultured mouse islets. We examined the mechanism of PTHrP-induced insulin expression. The PTHrP effect was markedly augmented by SB203580, a mitogen-activated protein (MAP) kinase in...

journal_title：Diabetes

authors： Zhang B,Hosaka M,Sawada Y,Torii S,Mizutani S,Ogata M,Izumi T,Takeuchi T

更新日期：2003-11-01 00:00:00

abstract：:The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr)-mediated apoB-containing lipoprotein ...

journal_title：Diabetes

authors： Borradaile NM,de Dreu LE,Huff MW

更新日期：2003-10-01 00:00:00