Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.

abstract：:Islet transplantation for the treatment of autoimmune diabetes is more difficult because of the additional barrier presented by the autoimmunity. We tested the ability of hamster anti-rat CD154 to prevent recurrence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimmune diab...

journal_title：Diabetes

authors： Kover KL,Geng Z,Hess DM,Benjamin CD,Moore WV

更新日期：2000-10-01 00:00:00

abstract：:Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

journal_title：Diabetes

authors： Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

更新日期：2005-04-01 00:00:00

abstract：:Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insul...

journal_title：Diabetes

authors： Klymiuk N,van Buerck L,Bähr A,Offers M,Kessler B,Wuensch A,Kurome M,Thormann M,Lochner K,Nagashima H,Herbach N,Wanke R,Seissler J,Wolf E

更新日期：2012-06-01 00:00:00

abstract：:Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic...

journal_title：Diabetes

authors： Castellano JM,Guinda A,Delgado T,Rada M,Cayuela JA

更新日期：2013-06-01 00:00:00

abstract：:Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another cholesterol transpor...

journal_title：Diabetes

authors： Kruit JK,Wijesekara N,Westwell-Roper C,Vanmierlo T,de Haan W,Bhattacharjee A,Tang R,Wellington CL,LütJohann D,Johnson JD,Brunham LR,Verchere CB,Hayden MR

更新日期：2012-03-01 00:00:00

abstract：:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...

journal_title：Diabetes

authors： Hayward AR,Herberger M

更新日期：1984-04-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：:The effect of nonenzymatic glycosylation on the biologic function of human antithrombin III was evaluated using a chromogenic thrombin substrate assay in the presence of catalytic amounts of heparin. Experimental conditions that increased the rate of nonenzymatic protein glycosylation were associated with decreases in...

journal_title：Diabetes

authors： Brownlee M,Vlassara H,Cerami A

更新日期：1984-06-01 00:00:00

abstract：:Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin resistance in the genetically obese Zucker rat. To determine whether FA uptake and disposal are altered in insulin-resistant muscle, we measured palmitate uptake, oxidation, and incorporation into di- and triglycerides in isolat...

journal_title：Diabetes

authors： Turcotte LP,Swenberger JR,Zavitz Tucker M,Yee AJ

更新日期：2001-06-01 00:00:00

abstract：:Transcription factor expression fluctuates during β-cell ontogeny, and disruptions in this pattern can affect the development or function of those cells. Here we uncovered that murine endocrine pancreatic progenitors express high levels of the homeodomain transcription factor Prox1, whereas both immature and mature β-...

journal_title：Diabetes

authors： Paul L,Walker EM,Drosos Y,Cyphert HA,Neale G,Stein R,South J,Grosveld G,Herrera PL,Sosa-Pineda B

更新日期：2016-03-01 00:00:00

abstract：:Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA), based on stable isotope dilution mass spectrometry. A known amount of a deuterated analog of insulin was used as an internal standard and added to the serum samples before sample processing. After isolation by immunoaffinity chrom...

journal_title：Diabetes

authors： Stöcklin R,Vu L,Vadas L,Cerini F,Kippen AD,Offord RE,Rose K

更新日期：1997-01-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel approach to treatment of experimental peripheral diabetic neuropathy (PDN). However, long-term inhibition of PARP, an enzyme involved in DNA repair, can potentially result in premature aging, loss of genome stability, and other side ...

journal_title：Diabetes

authors： Li F,Drel VR,Szabó C,Stevens MJ,Obrosova IG

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in dete...

journal_title：Diabetes

authors： Koutsari C,Ali AH,Mundi MS,Jensen MD

更新日期：2011-08-01 00:00:00

abstract：:Recently, a missense mutation replacing tryptophan with arginine at codon 64 of the beta 3-adrenergic receptor gene was shown to be associated with insulin resistance in nondiabetic subjects and to an earlier onset of NIDDM in Pima Indians. We studied whether the codon 64 amino acid polymorphism of the beta 3-adrenerg...

journal_title：Diabetes

authors： Urhammer SA,Clausen JO,Hansen T,Pedersen O

更新日期：1996-08-01 00:00:00

abstract：:A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) of linkage on the proximal end of chromosome 1. This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2. In the current st...

journal_title：Diabetes

authors： Hill NJ,Lyons PA,Armitage N,Todd JA,Wicker LS,Peterson LB

更新日期：2000-10-01 00:00:00

abstract：:Aging is closely associated with muscle insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. We examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering the distribution patt...

journal_title：Diabetes

authors： Flannery C,Dufour S,Rabøl R,Shulman GI,Petersen KF

更新日期：2012-11-01 00:00:00

abstract：:EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...

journal_title：Diabetes

authors： Sun H,Lee P,Yan C,Gao N,Wang J,Fan X,Yu FS

更新日期：2018-06-01 00:00:00

abstract：:Adiponectin, one of the most abundant gene transcript proteins in human fat cells, has been shown to improve insulin action and is also suggested to exert antiatherogenic effects. We measured circulating adiponectin levels and risk factors for atherosclerosis in 45 healthy first-degree relatives of type 2 diabetic sub...

journal_title：Diabetes

authors： Pellmé F,Smith U,Funahashi T,Matsuzawa Y,Brekke H,Wiklund O,Taskinen MR,Jansson PA

更新日期：2003-05-01 00:00:00

abstract：:In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...

journal_title：Diabetes

authors： Bar-On H,Roheim PS,Eder HA

更新日期：1976-06-01 00:00:00

abstract：:In patients with diabetes, altered diurnal blood pressure (BP) regulation (high night-to-day [N/D] ratio, or "nondipping") is associated with increases in albumin excretion and a decline in the glomerular filtration rate (GFR) by an unknown mechanism. Because it is known that renin angiotensin system (RAS) activation ...

journal_title：Diabetes

authors： Miller JA,Curtis JR,Sochett EB

更新日期：2003-07-01 00:00:00

abstract：:Pancreatic islets produce and secrete cytokines and chemokines in response to inflammatory and metabolic stress. The physiological role of these "isletokines" in health and disease is largely unknown. We observed that islets release multiple inflammatory mediators in patients undergoing islet transplants within hours ...

journal_title：Diabetes

authors： Yoshimatsu G,Kunnathodi F,Saravanan PB,Shahbazov R,Chang C,Darden CM,Zurawski S,Boyuk G,Kanak MA,Levy MF,Naziruddin B,Lawrence MC

更新日期：2017-11-01 00:00:00

abstract：:GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. SIRT1, an NAD(+)-dependent protein deacetylase, has been considered as a crucial regulator in hepatic lipid homeostasis by accumulated studies. Here,...

journal_title：Diabetes

authors： Xu F,Li Z,Zheng X,Liu H,Liang H,Xu H,Chen Z,Zeng K,Weng J

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2. RESEARCH DESIGN AND METHODS:Rat proximal-tubular epithelial cells (NRK...

journal_title：Diabetes

authors： Wang B,Koh P,Winbanks C,Coughlan MT,McClelland A,Watson A,Jandeleit-Dahm K,Burns WC,Thomas MC,Cooper ME,Kantharidis P

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Physiologically elevated insulin concentrations promote access of macromolecules to skeletal muscle in dogs. We investigated whether insulin has a stimulating effect on the access of macromolecules to insulin-sensitive tissues in humans as well. RESEARCH DESIGN AND METHODS:In a randomized, controlled trial, ...

journal_title：Diabetes

authors： Weinhandl H,Pachler C,Mader JK,Ikeoka D,Mautner A,Falk A,Suppan M,Pieber TR,Ellmerer M

更新日期：2007-09-01 00:00:00

abstract：:We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or underwent an acute ...

journal_title：Diabetes

authors： Lee HY,Lee JS,Alves T,Ladiges W,Rabinovitch PS,Jurczak MJ,Choi CS,Shulman GI,Samuel VT

更新日期：2017-08-01 00:00:00

abstract：:Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructiv...

journal_title：Diabetes

authors： Duennwald T,Bernardi L,Gordin D,Sandelin A,Syreeni A,Fogarty C,Kytö JP,Gatterer H,Lehto M,Hörkkö S,Forsblom C,Burtscher M,Groop PH,FinnDiane Study Group.

更新日期：2013-12-01 00:00:00

abstract：:We assessed our speculation that 2-cyclohexen-1-one (CHX) impairs glucose-induced insulin secretion through inactivation of glucokinase. Treatment of pancreatic islets with CHX at concentrations (0-5 mM) that caused a dose-dependent inactivation of glucokinase activity similarly inhibited glucose-induced insulin secre...

journal_title：Diabetes

authors： Miwa I,Murata T,Mitsuyama S,Okuda J

更新日期：1990-10-01 00:00:00

abstract：:Type 1 diabetes is characterized by autoimmune destruction of pancreatic β-cells in genetically susceptible individuals. Triggers of islet autoimmunity, time course, and the precise mechanisms responsible for the progressive β-cell failure are not completely understood. The recent escalation of obesity in affluent cou...

journal_title：Diabetes

authors： Galgani M,Nugnes R,Bruzzese D,Perna F,De Rosa V,Procaccini C,Mozzillo E,Cilio CM,Elding Larsson H,Lernmark A,La Cava A,Franzese A,Matarese G

更新日期：2013-07-01 00:00:00

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00