Abstract:
:Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% compared with 2% in patients whose IDDM was of 3 or more years' duration, or in healthy controls. The percentage of Tac+ cells in the patients' blood correlated positively with the amount of thymidine uptake in a 24-h culture of blood mononuclear cells and with the percentage of T-cell blasts generated in a 6-day culture. The patients' T-cell blasts stained with OKT 4 or OKT 8, suggesting that each of these subsets is present in the activated T-cell population in the patients' blood. The T-cell blasts did not show specificity for pork insulin in an antigen restimulation assay. There was no correlation between increased Tac+ cells and the presence or absence of islet cell antibodies. If T-cell activation in IDDM occurs as a result of recognition of islet cell antigens, our results suggest that both HLA-DR-restricted (OKT 4+) and A-, B-, and C-restricted (OKT 8+) T-cell subsets contribute.
journal_name
Diabetesjournal_title
Diabetesauthors
Hayward AR,Herberger Mdoi
10.2337/diab.33.4.319subject
Has Abstractpub_date
1984-04-01 00:00:00pages
319-23issue
4eissn
0012-1797issn
1939-327Xjournal_volume
33pub_type
杂志文章相关文献
DIABETES文献大全abstract::Continuous subcutaneous insulin infusion (CSII) was combined with antirejection therapy in four diabetic recipients of pancreas and kidney grafts with persisting hyperglycemia due to pancreas rejection. In three of the patients, full function of the pancreas was restored after as many as 40, 86, and 139 days of CSII. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.1.s71
更新日期:1989-01-01 00:00:00
abstract::Glucagonlike peptide I (7-37) [GLP-I-(7-37)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perf...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.38.3.338
更新日期:1989-03-01 00:00:00
abstract::Not all patients with type 2 diabetes develop renal dysfunction. Identifying those at risk is problematic because even microalbuminuria, often used clinically as an indicator of future renal dysfunction, does not always precede worsening renal function. We sought to identify clinical risk factors at diagnosis of type ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db05-1620
更新日期:2006-06-01 00:00:00
abstract::To explore metabolic changes associated with the sorbitol accumulation and myo-inositol depletion observed in glomeruli of rats with experimental diabetes, we examined total and ouabain-inhibited adenosine triphosphatase (ATPase) activity in glomeruli isolated from control and streptozocin (STZ)-diabetic rats. Glomeru...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.11.1071
更新日期:1985-11-01 00:00:00
abstract::Studies from several laboratories suggest that oxidized LDL may play an important role in atherogenesis. Our group previously showed that treatment of aortic endothelial cells with low levels of MM-LDL caused increased expression of MCP-1, M-CSF, tissue factor, and a monocyte-binding protein. In these studies MM-LDL w...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.s74
更新日期:1992-10-01 00:00:00
abstract::Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.2007.s60
更新日期:2002-02-01 00:00:00
abstract::Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity....
journal_title:Diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/db15-0950
更新日期:2016-02-01 00:00:00
abstract::Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular complications of type 2 diabetes. In liver, extracellular hepara...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.9.2126
更新日期:2001-09-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biologi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/dbi19-0023
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by at...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1278
更新日期:2011-06-01 00:00:00
abstract::This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0718
更新日期:2006-12-01 00:00:00
abstract::Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population in the U.S. The vision-threatening processes of neuroglial and vascular dysfunction in DR occur in concert, driven by hyperglycemia and propelled by a pathway of inflammation, ischemia, vasodegeneration, and breakdown of the bloo...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db14-1030
更新日期:2015-12-01 00:00:00
abstract::Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stre...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1032
更新日期:2018-06-01 00:00:00
abstract::Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent a...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.51.2007.s385
更新日期:2002-12-01 00:00:00
abstract::Pancreatic islets produce and secrete cytokines and chemokines in response to inflammatory and metabolic stress. The physiological role of these "isletokines" in health and disease is largely unknown. We observed that islets release multiple inflammatory mediators in patients undergoing islet transplants within hours ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0578
更新日期:2017-11-01 00:00:00
abstract::Two previously described pedigrees with familial hyperproinsulinemia have elevated proinsulin conversion intermediates resulting from amino acid substitutions in the proinsulin molecule. In contrast, a third family with elevated levels of an apparently normal proinsulin molecule may have a defect in the converting pro...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.8.821
更新日期:1985-08-01 00:00:00
abstract::Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., r...
journal_title:Diabetes
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Stimulation of cardiomyocyte guanosine 3',5'-cyclic monophosphate (cyclic GMP) via endothelial-derived nitric oxide (NO) is an important mechanism by which bradykinin and ACE inhibitors prevent hypertrophy. Endothelial NO dysfunction and cardiac hypertrophy are morbid features of diabetes not entirely prevented by ACE...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.9.2389
更新日期:2003-09-01 00:00:00
abstract::Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endoge...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-0684
更新日期:2013-02-01 00:00:00
abstract::Concentrations of glycosylated hemoglobin (GHb) are elevated in diabetes mellitus and are believed to reflect previous metabolic control. To better define possible determinants of GHb in man, we investigated the relationship between GHb and both fasting plasma glucose (FPG) and basal insulin (IRI) in 42 normal subject...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.27.8.834
更新日期:1978-08-01 00:00:00
abstract::Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0308
更新日期:2019-10-01 00:00:00
abstract::We conducted autosomal genome scans to map loci for metabolic syndrome (MES) and related traits in the Hong Kong Family Diabetes Study. We selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on MES. We also selected 179 families with 897 members (2,127 relati...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.53.10.2676
更新日期:2004-10-01 00:00:00
abstract::Two sisters presented with severe insulin resistance and markedly decreased insulin binding to erythrocytes, cultured fibroblasts, and transformed lymphocytes. The dose-response curve of insulin-stimulated amino acid uptake in the fibroblasts was shifted to the right. The molecular weight of the insulin receptor on th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.5.653
更新日期:1988-05-01 00:00:00
abstract::Spirometry was performed on 88 children with insulin-dependent diabetes mellitus (IDDM) and 216 healthy controls living in Sheffield. Children with IDDM had significantly lower percentage predicted forced vital capacity (FVC) than did control children or reference norms. There was no evidence that the reduced FVC was ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.3.324
更新日期:1987-03-01 00:00:00
abstract::Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture med...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.34.9.850
更新日期:1985-09-01 00:00:00
abstract::Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1178
更新日期:2019-08-01 00:00:00
abstract::Although type 1 diabetes (T1D) is primarily perceived as a T cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced by autoreactive B cells, the activation of which is largely dependent on the function of CD4+CXCR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db16-0714
更新日期:2017-02-01 00:00:00
abstract::A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.24.6.600
更新日期:1975-06-01 00:00:00
abstract::Data is accumulating indicating that impaired insulin action predisposes to increased vascular smooth muscle (VSM) tone, the hallmark of hypertension associated with diabetes. During the last several years, it has been established that VSM is an insulin-sensitive tissue like skeletal muscle and adipocytes. Investigato...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.3.s47
更新日期:1996-07-01 00:00:00
abstract::Proinsulin is converted to insulin by the concerted action of two sequence-specific subtilisin-like proteases termed prohormone convertase 2 (PC2) and prohormone convertase 3 (PC3). PC3 is a type I proinsulin-processing enzyme that initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.7.897
更新日期:1996-07-01 00:00:00