Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes.

abstract：OBJECTIVE:The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 in pancreatic beta-cell function was recently observed in the mouse model, we assessed the association of this ...

journal_title：Diabetes

authors： Villarreal-Molina MT,Flores-Dorantes MT,Arellano-Campos O,Villalobos-Comparan M,Rodríguez-Cruz M,Miliar-García A,Huertas-Vazquez A,Menjivar M,Romero-Hidalgo S,Wacher NH,Tusie-Luna MT,Cruz M,Aguilar-Salinas CA,Canizales-Quintero

更新日期：2008-02-01 00:00:00

abstract：:Recently, peptides with opioid-like activity have been demonstrated in peptic digests of dietary protein. The present study was designed to determine the effect of digested and undigested gluten on postprandial insulin and glucagon levels in conscious dogs. The intragastric instillation of digested gluten (25 g) elici...

journal_title：Diabetes

authors： Schusdziarra V,Henrichs I,Holland A,Klier M,Pfeiffer EF

更新日期：1981-04-01 00:00:00

abstract：:Dietary methionine restriction (MR) produces a rapid and persistent remodeling of white adipose tissue (WAT), an increase in energy expenditure (EE), and enhancement of insulin sensitivity. Recent work established that hepatic expression of FGF21 is robustly increased by MR. Fgf21-/- mice were used to test whether FGF...

journal_title：Diabetes

authors： Wanders D,Forney LA,Stone KP,Burk DH,Pierse A,Gettys TW

更新日期：2017-04-01 00:00:00

abstract：:Long before reaching diagnostic cutoff levels for type 2 diabetes, fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young European sib-pairs including obese children, with adjustment for sex, age, and BMI. We identified...

journal_title：Diabetes

authors： Fradin D,Heath S,Lathrop M,Bougnères P

更新日期：2007-06-01 00:00:00

abstract：:Fourteen rats of the spontaneously diabetic BB line were bled from the retroorbital sinus approximately every 10 days. Sera taken from an early age up to 20 days after the onset of overt diabetes were assayed for complement-fixing antibodies against antigens of the surface of islet cells (CFA). Dispersed islet cells f...

journal_title：Diabetes

authors： Martin DR,Logothetopoulos J

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS:Characterization of clinical and biochemical parameters and β-cell function of 411 Medalists with correlation wi...

journal_title：Diabetes

authors： Keenan HA,Sun JK,Levine J,Doria A,Aiello LP,Eisenbarth G,Bonner-Weir S,King GL

更新日期：2010-11-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：:The effects of sulfated cholecystokinin (CCK-8S) and glucose on insulin secretion and polyphosphoinositide (PPI) metabolism were studied in isolated rat islets. Both agonists stimulate PPI hydrolysis, inositol phosphate accumulation, 3H efflux from [3H]inositol-prelabeled tissue, and 45Ca efflux from prelabeled cells....

journal_title：Diabetes

authors： Zawalich W,Takuwa N,Takuwa Y,Diaz VA,Rasmussen H

更新日期：1987-04-01 00:00:00

abstract：:Infection of autoimmune New Zealand mice with the D variant of encephalomyocarditis (EMC) virus results in beta-cell damage and clinical diabetes. The induction of diabetes in parental NZB and NZW strains was independent of sex. However, the susceptibility to virus-induced diabetes in their F1 offspring was sex depend...

journal_title：Diabetes

authors： Yoon JW,Melez KA,Smathers PA,Archer JA,Steinberg AD

更新日期：1983-08-01 00:00:00

abstract：:Obesity and family history of diabetes are both risk factors for non-insulin-dependent diabetes mellitus (NIDDM), but it has been proposed that lean individuals with NIDDM have a greater load of diabetes susceptibility genes. If this is the case, one might expect a high prevalence of NIDDM in relatives of diabetic ind...

journal_title：Diabetes

authors： Hanson RL,Pettitt DJ,Bennett PH,Narayan KM,Fernandes R,de Courten M,Knowler WC

更新日期：1995-04-01 00:00:00

abstract：:The mechanism of protection from type 1 diabetes conferred by regulatory T-cells induced by oral insulin treatment of NOD mice is not well understood. We demonstrate that oral insulin feeding of NOD mice induces the function of insulin B-chain reactive CD4+ regulatory T-cells, which compete with diabetogenic effector ...

journal_title：Diabetes

authors： Bergerot I,Arreaza GA,Cameron MJ,Burdick MD,Strieter RM,Chensue SW,Chakrabarti S,Delovitch TL

更新日期：1999-09-01 00:00:00

abstract：:Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have explored the role of genetics in this phenomenon, using C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 x 129)F2 mice on a low- or high-fat diet. Over an 18-week period, B6 and F2 mice gained more weight, had higher leve...

journal_title：Diabetes

authors： Almind K,Kahn CR

更新日期：2004-12-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...

journal_title：Diabetes

authors： Ke B,Zhao Z,Ye X,Gao Z,Manganiello V,Wu B,Ye J

更新日期：2015-10-01 00:00:00

abstract：:In patients with diabetes, altered diurnal blood pressure (BP) regulation (high night-to-day [N/D] ratio, or "nondipping") is associated with increases in albumin excretion and a decline in the glomerular filtration rate (GFR) by an unknown mechanism. Because it is known that renin angiotensin system (RAS) activation ...

journal_title：Diabetes

authors： Miller JA,Curtis JR,Sochett EB

更新日期：2003-07-01 00:00:00

abstract：:Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell-mediated anti-β-cell-specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Consistent with immun...

journal_title：Diabetes

authors： Russell MA,Redick SD,Blodgett DM,Richardson SJ,Leete P,Krogvold L,Dahl-Jørgensen K,Bottino R,Brissova M,Spaeth JM,Babon JAB,Haliyur R,Powers AC,Yang C,Kent SC,Derr AG,Kucukural A,Garber MG,Morgan NG,Harlan DM

更新日期：2019-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potential to improve islet engraftment and survival. We assessed the effect human bone marrow-derived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment an...

journal_title：Diabetes

authors： Hayward JA,Ellis CE,Seeberger K,Lee T,Salama B,Mulet-Sierra A,Kuppan P,Adesida A,Korbutt GS

更新日期：2017-05-01 00:00:00

abstract：:Nerve conduction and electromyography (EMG) of insulin-dependent (type 1) diabetic patients with end-stage nephropathy was studied before and up to 10 yr after kidney transplantation (KTx). A series of nondiabetic KTx patients served as a comparison group. Motor nerve conduction velocity (NCV) was measured in the ulna...

journal_title：Diabetes

authors： Van der Vliet JA,Navarro X,Kennedy WR,Goetz FC,Barbosa JJ,Sutherland DE,Najarian JS

更新日期：1988-09-01 00:00:00

abstract：:The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...

journal_title：Diabetes

authors： McLennan S,Yue DK,Fisher E,Capogreco C,Heffernan S,Ross GR,Turtle JR

更新日期：1988-03-01 00:00:00

abstract：:The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical dia...

journal_title：Diabetes

authors： Zhao LP,Alshiekh S,Zhao M,Carlsson A,Larsson HE,Forsander G,Ivarsson SA,Ludvigsson J,Kockum I,Marcus C,Persson M,Samuelsson U,Örtqvist E,Pyo CW,Nelson WC,Geraghty DE,Lernmark Å,Better Diabetes Diagnosis (BDD) Study Grou

更新日期：2016-03-01 00:00:00

abstract：:Both pancreatic volume reduction and lipomatosis have been observed in subjects with diabetes. The underlying molecular and pathological mechanisms are, however, poorly known, and it has been speculated that both features are secondary to diabetes. We have recently described pancreatic atrophy and lipomatosis in diabe...

journal_title：Diabetes

authors： Raeder H,Haldorsen IS,Ersland L,Grüner R,Taxt T,Søvik O,Molven A,Njølstad PR

更新日期：2007-02-01 00:00:00

abstract：:Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...

journal_title：Diabetes

authors： Mezza T,Ferraro PM,Sun VA,Moffa S,Cefalo CMA,Quero G,Cinti F,Sorice GP,Pontecorvi A,Folli F,Mari A,Alfieri S,Giaccari A

更新日期：2018-11-01 00:00:00

abstract：:Diabetic glomerulosclerosis is defined by increased glomerular extracellular matrix (ECM) that is mainly synthesized by mesangial cells that underwent an activation mediated by cytokines and growth factors from various cellular origins. In this study, we tested whether macrophages could infiltrate the glomeruli and in...

journal_title：Diabetes

authors： Sassy-Prigent C,Heudes D,Mandet C,Bélair MF,Michel O,Perdereau B,Bariéty J,Bruneval P

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:The G-protein-coupled receptor Gpr40 is expressed in beta-cells where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion. However, other sites of Gpr40 expression, including the intestine, have been suggested. The transcription factor IPF1/PDX1 was recently shown to bi...

journal_title：Diabetes

authors： Edfalk S,Steneberg P,Edlund H

更新日期：2008-09-01 00:00:00

abstract：:Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg f...

journal_title：Diabetes

authors： Salković M,Lacković Z

更新日期：1992-09-01 00:00:00

abstract：:Rat pancreatic islets were incubated in vitro with L-[4,5-3H]leucine or with L-[2,3-3H]tryptophan in Krebs-Ringer bicarbonate buffer, containing 0, 5, or 20 mM glucose. Incorporation of labeled amino acids in islet cells was evaluated quantitatively by a validated radioautographic procedure. Incorporation of labeled l...

journal_title：Diabetes

authors： Logothetopoulos J,Jain K

更新日期：1980-10-01 00:00:00

abstract：:In diabetic patients, elevated plasma levels of t-PA and PAI-1 accompany impaired fibrinolysis. To identify mechanisms for these abnormalities, we examined whether vascular endothelial cells exposed to high glucose upregulate t-PA and PAI-1 production and whether ambient PA activity is decreased concomitantly. In 17 c...

journal_title：Diabetes

authors： Maiello M,Boeri D,Podesta F,Cagliero E,Vichi M,Odetti P,Adezati L,Lorenzi M

更新日期：1992-08-01 00:00:00

abstract：:Using the hyperglycemic and euglycemic clamp, we demonstrated impaired β-cell function in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test (OGTT)-modeled β-cell function and incretin effect in obese adolescents spanning the range of glucose tolerance. β-Cell function parameters w...

journal_title：Diabetes

authors： Michaliszyn SF,Mari A,Lee S,Bacha F,Tfayli H,Farchoukh L,Ferrannini E,Arslanian S

更新日期：2014-11-01 00:00:00

abstract：:Dietary gluten has been associated with an increased risk of type 1 diabetes. We have evaluated inflammation and the mucosal immune response to gliadin in the jejunum of patients with type 1 diabetes. Small intestinal biopsies from 17 children with type 1 diabetes without serological markers of celiac disease and from...

journal_title：Diabetes

authors： Auricchio R,Paparo F,Maglio M,Franzese A,Lombardi F,Valerio G,Nardone G,Percopo S,Greco L,Troncone R

更新日期：2004-07-01 00:00:00

abstract：:The relationship of plasma glucose levels to risk of death over a five-year follow-up period was studied in 2,770 male survivors of myocardial infarction in the placebo group of the Coronary Drug Project (CDP). In univariate analyses, a positive association was observed between mortality rates and both fasting and one...

journal_title：Diabetes

authors：

更新日期：1977-05-01 00:00:00

abstract：:Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cells. Insulin receptor...

journal_title：Diabetes

authors： Ren D,Sun J,Mao L,Ye H,Polonsky KS

更新日期：2014-10-01 00:00:00