Is cigarette smoking more frequent among insulin-treated diabetics?


:During epidemiologic investigations of vascular complications of diabetes in Warsaw the habit of cigarette smoking was analyzed in the subjects studied (4,530 diabetics). It was found that in the group of diabetics the number of ex-smokers was much greater (p less than 0.01) and that of present smokers lower (p less tan 0.01) than in a representative sample of the Warsaw population. Furthermore, it was observed that in the subgroup of insulin-treated diabetics the number of smokers was highest and the number of ex-smokers and nonsmokers was lowest in relations to other treatment subgroups.






Czyzyk A,Królewski AS




Has Abstract


1976-08-01 00:00:00














  • DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.

    abstract::The human leukocyte antigen (HLA) class II genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian populations. Its frequency in control populations (1-3%) is still, however, 1 order of magnitude higher than the p...


    pub_type: 杂志文章


    authors: Van der Auwera B,Van Waeyenberge C,Schuit F,Heimberg H,Vandewalle C,Gorus F,Flament J

    更新日期:1995-05-01 00:00:00

  • Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats.

    abstract::Chronic hyperglycemia causes near-total disappearance of glucose-induced insulin secretion. The etiology has been suggested to be a nonsustainable stimulation of insulin release that causes beta-cells to become unresponsive to glucose through an undefined mechanism. We used an inhibitor of insulin secretion, diazoxide...


    pub_type: 杂志文章


    authors: Leahy JL,Bumbalo LM,Chen C

    更新日期:1994-02-01 00:00:00

  • Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes.

    abstract::Leptin, a recently identified hormone, is believed to reduce appetite and maintain body weight. The mRNA of leptin is expressed only in mature adipose cells. To clarify the regulation of leptin gene expression in adipocytes, 3T3-L1 adipocytes were treated for 16 h with various agents known to modulate lipid metabolism...


    pub_type: 杂志文章


    authors: Kosaki A,Yamada K,Kuzuya H

    更新日期:1996-12-01 00:00:00

  • Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity.

    abstract:OBJECTIVE:Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obe...


    pub_type: 杂志文章


    authors: Wentworth JM,Naselli G,Brown WA,Doyle L,Phipson B,Smyth GK,Wabitsch M,O'Brien PE,Harrison LC

    更新日期:2010-07-01 00:00:00

  • Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35.

    abstract::Linkage results suggest that the region of chromosome 7 containing the leptin gene cosegregates with extreme obesity; however, leptin coding region mutations are rare. To investigate whether the leptin flanking sequence and/or a larger 40-cM region (7q22.1-7q35) contributes to obesity, we genotyped individuals from 20...


    pub_type: 杂志文章


    authors: Li WD,Li D,Wang S,Zhang S,Zhao H,Price RA

    更新日期:2003-06-01 00:00:00

  • Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.

    abstract::Changes in tissue levels of sorbitol, myo-inositol, and Na+-K+-ATPase enzyme activity have been implicated in the development of diabetic complications in animal models of the disease and in humans. The ability of the aldose reductase inhibitor sorbinil to reverse the hyperglycemia-induced changes in these lenticular ...


    pub_type: 杂志文章


    authors: Yeh LA,Rafford CE,Goddu KJ,Ashton MA,Beyer TA,Hutson NJ

    更新日期:1987-12-01 00:00:00

  • Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo.

    abstract::This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...


    pub_type: 杂志文章


    authors: Edgerton DS,Cherrington AD,Williams P,Neal DW,Scott M,Bowen L,Wilson W,Hobbs CH,Leach C,Kuo MC,Strack TR

    更新日期:2006-12-01 00:00:00

  • Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.

    abstract::Circadian rhythms are integral to the normal functioning of numerous physiological processes. Evidence from human and mouse studies suggests that loss of rhythm occurs in obesity and cardiovascular disease and may be a neglected contributor to pathophysiology. Obesity has been shown to impair the circadian clock mecha...


    pub_type: 杂志文章


    authors: Prasai MJ,Mughal RS,Wheatcroft SB,Kearney MT,Grant PJ,Scott EM

    更新日期:2013-06-01 00:00:00

  • Studies on the nature and mode of action of the insulin-sensitive glucoregulator receptor in the central nervous system.

    abstract::In vivo studies were undertaken in rats to provide evidence of the neural nature, tentative localization and mode of excitation of the insulin-sensitive central nervous system (CSN) glucoregulator center. In rats under light barbiturate anesthesia minute amounts of insulin injected into the carotid artery resulted in ...


    pub_type: 杂志文章


    authors: Szabo O,Szabo AJ

    更新日期:1975-04-01 00:00:00

  • Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

    abstract::Ectopic lipid accumulation in the liver is an almost universal feature of human and rodent models of generalized lipodystrophy and is also a common feature of type 2 diabetes, obesity, and metabolic syndrome. Here we explore the progression of fatty liver disease using a mouse model of lipodystrophy created by a fat-s...


    pub_type: 杂志文章


    authors: Softic S,Boucher J,Solheim MH,Fujisaka S,Haering MF,Homan EP,Winnay J,Perez-Atayde AR,Kahn CR

    更新日期:2016-08-01 00:00:00

  • Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach.

    abstract::Insulin sensitivity, glucose effectiveness, and endogenous glucose production (EGP) during stable-labeled, frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) were evaluated by a single-and two-compartment minimal model combined with nonparametric deconvolution in eleven nonobese Japanese ty...


    pub_type: 杂志文章


    authors: Nagasaka S,Tokuyama K,Kusaka I,Hayashi H,Rokkaku K,Nakamura T,Kawakami A,Higashiyama M,Ishikawa S,Saito T

    更新日期:1999-05-01 00:00:00

  • Effect of combined antisense oligonucleotides against high-glucose- and diabetes-induced overexpression of extracellular matrix components and increased vascular permeability.

    abstract::The effect of combined antisense oligonucleotides (AS-oligos) against overexpression of extracellular matrix (ECM) components, fibronectin, laminin, and collagen IV and on cell monolayer permeability was examined in rat microvascular endothelial cells (RMECs) grown in high glucose medium and on retinal vascular permea...


    pub_type: 杂志文章


    authors: Oshitari T,Polewski P,Chadda M,Li AF,Sato T,Roy S

    更新日期:2006-01-01 00:00:00

  • SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a.

    abstract::The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...


    pub_type: 杂志文章


    authors: Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

    更新日期:2017-08-01 00:00:00

  • Effect of tolbutamide on myocardial metabolism and mechanical performance of the diabetic rat.

    abstract::Exposure of the isolated, glucose-perfused rat heart to buffer containing 0.4 mM tolbutamide resulted in significant changes in both energy metabolism and myocardial contractility. In the nondiabetic, tolbutamide mediated only small increases in mechanical function at low atrial filling pressure, but this effect incre...


    pub_type: 杂志文章


    authors: Tan BH,Wilson GL,Schaffer SW

    更新日期:1984-12-01 00:00:00

  • Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes.

    abstract::Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially confounded by developmental adaptation of animal physiology. We aimed to adapt the technique of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents as a means of investigating the role ...


    pub_type: 杂志文章


    authors: Cleasby ME,Davey JR,Reinten TA,Graham MW,James DE,Kraegen EW,Cooney GJ

    更新日期:2005-09-01 00:00:00

  • Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats.

    abstract::We reported earlier that β-cell-specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic fatty (ZDF) rats wit...


    pub_type: 杂志文章


    authors: Mahadevan J,Parazzoli S,Oseid E,Hertzel AV,Bernlohr DA,Vallerie SN,Liu CQ,Lopez M,Harmon JS,Robertson RP

    更新日期:2013-10-01 00:00:00

  • MDL 29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice.

    abstract::MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P < 0.05) reduced plasma glucose (6.9 +/- 0.3 vs. 19.2 +/- 1.3 mM) and serum triglyceride (0.17 +/- 0.01 vs. 1.82 +/- 0.39 mM) levels in overnight-...


    pub_type: 杂志文章


    authors: Johnson MB,Heineke EW,Rhinehart BL,Sheetz MJ,Barnhart RL,Robinson KM

    更新日期:1993-08-01 00:00:00

  • Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myo-inositol.

    abstract::The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. However, little is...


    pub_type: 杂志文章


    authors: Kim J,Rushovich EH,Thomas TP,Ueda T,Agranoff BW,Greene DA

    更新日期:1991-11-01 00:00:00

  • Long-term follow-up of polyneuropathy in diabetic kidney transplant recipients.

    abstract::Nerve conduction and electromyography (EMG) of insulin-dependent (type 1) diabetic patients with end-stage nephropathy was studied before and up to 10 yr after kidney transplantation (KTx). A series of nondiabetic KTx patients served as a comparison group. Motor nerve conduction velocity (NCV) was measured in the ulna...


    pub_type: 杂志文章


    authors: Van der Vliet JA,Navarro X,Kennedy WR,Goetz FC,Barbosa JJ,Sutherland DE,Najarian JS

    更新日期:1988-09-01 00:00:00

  • Hyperglycemia suppresses the adrenal medullary response to hypoxemia.

    abstract::An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen...


    pub_type: 杂志文章


    authors: Cohen WR,Deutsch J

    更新日期:1994-05-01 00:00:00

  • Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2.

    abstract:OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...


    pub_type: 杂志文章,多中心研究


    authors: Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

    更新日期:2008-05-01 00:00:00

  • Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.

    abstract::Secondary hyperlipidemia is a major cardiovascular risk factor in individuals with type 2 diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins contributes to the elevated plasma levels, but the mechanism is poorly understood. Recent results have established that microsomal triglyce...


    pub_type: 杂志文章


    authors: Bartels ED,Lauritsen M,Nielsen LB

    更新日期:2002-04-01 00:00:00

  • Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.

    abstract::We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...


    pub_type: 杂志文章


    authors: Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

    更新日期:2017-07-01 00:00:00

  • Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans.

    abstract::Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 are incretins secreted by respective K and L enteroendocrine cells after eating and amplify glucose-stimulated insulin secretion (GSIS). This amplification has been termed the "incretin response." To determine the role(s) of K cells for the incretin response...


    pub_type: 杂志文章


    authors: Zhang S,Wang S,Puhl MD,Jiang X,Hyrc KL,Laciny E,Wallendorf MJ,Pappan KL,Coyle JT,Wice BM

    更新日期:2015-04-01 00:00:00

  • Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.

    abstract::The sulfonylurea receptor (SUR) is the important regulatory subunit of ATP-sensitive K+ channels. It is an ATP-binding cassette protein comprising 17 transmembrane helices. SUR is endowed with binding sites for channel blockers like the antidiabetic sulfonylurea glibenclamide and for the chemically very heterogeneous ...


    pub_type: 杂志文章


    authors: Hambrock A,Kayar T,Stumpp D,Osswald H

    更新日期:2004-12-01 00:00:00

  • Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.

    abstract::Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...


    pub_type: 杂志文章


    authors: Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

    更新日期:2012-07-01 00:00:00

  • High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

    abstract:OBJECTIVE:Recently, several drugs have been shown to exert beneficial effects for metabolic syndrome through mild regulation of mitochondrial function. Hence, we explored a strategy of targeting mitochondrial function to improve glucose and lipid metabolism. RESEARCH DESIGN AND METHODS:Mitochondrial membrane potential...


    pub_type: 杂志文章


    authors: Qiu BY,Turner N,Li YY,Gu M,Huang MW,Wu F,Pang T,Nan FJ,Ye JM,Li JY,Li J

    更新日期:2010-01-01 00:00:00

  • Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell-Derived Spheroids in Intraportal Islet Transplantation.

    abstract::Highly angiogenic bone marrow mononuclear cell-derived spheroids (BM-spheroids), formed by selective proliferation of the CD31+CD14+CD34+ monocyte subset via three-dimensional (3D) culture, have had robust angiogenetic capacity in rodent syngeneic renal subcapsular islet transplantation. We wondered whether the effica...


    pub_type: 杂志文章


    authors: Oh BJ,Jin SM,Hwang Y,Choi JM,Lee HS,Kim G,Kim G,Park HJ,Kim P,Kim SJ,Kim JH

    更新日期:2018-03-01 00:00:00

  • Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis.

    abstract::One hundred fifty-four selected patients with nonketotic diabetes diagnosed between the ages of 35 and 75 yr and treated with diet or oral hypoglycemic agents for at least 1 yr were investigated for parameters of glycemic control (weight loss, blood glucose, and glycosylated hemoglobin), islet cell function (fasting a...


    pub_type: 杂志文章


    authors: Groop LC,Bottazzo GF,Doniach D

    更新日期:1986-02-01 00:00:00

  • Culture and phenotype of activated T-cells from patients with type I diabetes mellitus.

    abstract::Blood T-cells from 28 patients with type I (insulin-dependent) diabetes (IDDM) of variable duration were examined for the Tac antigen by immunofluorescence, and for proliferation in the presence of interleukin 2 (IL 2). The mean percentage of Tac+ cells in patients whose IDDM was of less than 2-yr duration was 6.2% co...


    pub_type: 杂志文章


    authors: Hayward AR,Herberger M

    更新日期:1984-04-01 00:00:00