Abstract:
:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycerides, and free fatty acids and food intake without affecting the body weight. Its hypoglycemic activity was independent of its effect on food intake. Regranulation of islet beta-cells and increased pancreatic insulin content were observed in ob/ob mice treated for 41-44 days with 100 mg/kg/day ciglitazone. Ciglitazone showed no effect on food intake, blood glucose, or pancreatic islet beta-cells in a group of lean C57BL/6J-+/? mice concomitantly treated at a dose of 150 mg/kg/day. In C57BL/KsJ-db/db mice, ciglitazone decreased blood glucose and food intake. The untreated db/db mice lost weight despite hyperphagia, whereas the ciglitazone-treated db/db mice gained weight. In the spontaneously diabetic Chinese hamsters, ciglitazone showed no significant effect on food intake, body weight, blood glucose, or insulin content in either plasma or pancreas, but it lowered plasma lipids. In normal rats, ciglitazone failed to affect fasting blood glucose but improved glucose tolerance without increasing insulin secretory response to glucose. In streptozotocin-diabetic rats, it showed no effect on blood glucose or glycemic response to exogenous insulin. The hypoglycemic activity of ciglitazone was specific for obese-hyperglycemic and insulin-resistant animals.
journal_name
Diabetesjournal_title
Diabetesauthors
Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani ARdoi
10.2337/diab.32.9.830subject
Has Abstractpub_date
1983-09-01 00:00:00pages
830-8issue
9eissn
0012-1797issn
1939-327Xjournal_volume
32pub_type
杂志文章相关文献
DIABETES文献大全abstract:OBJECTIVE:Regulation of obesity development is an important issue to prevent metabolic syndromes. Gene-disrupted mice of phospholipase Cδ1 (PLCδ1), a key enzyme of phosphoinositide turnover, seemed to show leanness. Here we examined whether and how PLCδ1 is involved in obesity. RESEARCH DESIGN AND METHODS:Weight gain,...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-1500
更新日期:2011-07-01 00:00:00
abstract::Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the si...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0107
更新日期:2015-12-01 00:00:00
abstract::The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.47.2.244
更新日期:1998-02-01 00:00:00
abstract::The transcription factor nuclear factor-κB (NF-κB) mediates inflammation and stress signals in cells. To test NF-κB in the control of hepatic insulin sensitivity, we inactivated NF-κB in the livers of C57BL/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and Alb-cre mice to generate ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0242
更新日期:2015-10-01 00:00:00
abstract::To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Ak...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.54.3.657
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic insulin resistance. However, growth retardation is only reported with ho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db09-0787
更新日期:2009-12-01 00:00:00
abstract::Membrane glycoprotein plasma cell 1 (PC-1) has been shown to be increased in type 2 diabetes and involved in insulin resistance through inhibiting the insulin receptor tyrosine kinase, which was demonstrated using cultured breast cancer cells. However, other reports have shown contradictory results in Chinese hamster ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.48.7.1365
更新日期:1999-07-01 00:00:00
abstract::Diet-induced obesity is known to cause peripheral insulin resistance in rodents. We have recently found that feeding cod protein to high-fat-fed rats prevents the development of insulin resistance in skeletal muscle. In the present study, we have further explored the cellular mechanisms behind this beneficial effect o...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.52.1.29
更新日期:2003-01-01 00:00:00
abstract::Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.3.238
更新日期:1982-03-01 00:00:00
abstract::The effects of variations of glycemia from 1.7 to 35 mM on the activity of glycogen synthase and phosphorylase, on glycogen content, and on U-14C-glucose incorporation into glycogen in the liver of the near-term rat fetus were investigated. Hypoglycemia did not affect the activities of phosphorylase and synthase; tota...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.4.266
更新日期:1980-04-01 00:00:00
abstract::Using the hyperglycemic and euglycemic clamp, we demonstrated impaired β-cell function in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test (OGTT)-modeled β-cell function and incretin effect in obese adolescents spanning the range of glucose tolerance. β-Cell function parameters w...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-1951
更新日期:2014-11-01 00:00:00
abstract::We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.2.202
更新日期:1992-02-01 00:00:00
abstract::Pancreatic islets produce and secrete cytokines and chemokines in response to inflammatory and metabolic stress. The physiological role of these "isletokines" in health and disease is largely unknown. We observed that islets release multiple inflammatory mediators in patients undergoing islet transplants within hours ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0578
更新日期:2017-11-01 00:00:00
abstract::The objective of the study was to examine the potential differential effect of insulin and acipimox (both of which reduce free fatty acid [FFA] availability) on VLDL apolipoprotein (apo) B metabolism. We studied eight healthy men (age 40 +/- 4 years, BMI 25.8 +/- 0.9 kg/m2, plasma triglycerides 1.30 +/- 0.12 mmol/l) a...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diabetes.47.5.779
更新日期:1998-05-01 00:00:00
abstract::Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated ant...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,收录出版
doi:10.2337/diabetes.54.11.3089
更新日期:2005-11-01 00:00:00
abstract::Mutations in the NeuroD/BETA2 gene have been shown to associate with type 2 diabetes. In the present study, we examined mutations in the NeuroD/BETA2 gene for association with either type 1 or 2 diabetes. Three variants were identified in patients with type 2 diabetes: Ala45Thr (allelic frequency 0.36, 95% CI 0.31-0.4...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.5.876
更新日期:2000-05-01 00:00:00
abstract::Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-T-lymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of dia...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.7.877
更新日期:1987-07-01 00:00:00
abstract::We investigated the significance of the variants of the IRS-2 gene in patients with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by single-strand conformation polymorphism analysis in 40 Chinese and 40 Finnish patients with late-onset type 2 diabetes. The association of the variants of the IR...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.50.8.1949
更新日期:2001-08-01 00:00:00
abstract::Adiponectin, an adipocyte protein important in insulin sensitization and cardioprotection, has a strong genetic component. We hypothesized that variants in the adiponectin gene (adipocyte collagen-domain containing [ACDC]) contribute to adiponectin levels in a biracial adolescent cohort. We genotyped 11 ACDC single nu...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.55.02.06.db05-0446
更新日期:2006-02-01 00:00:00
abstract::I investigated biochemical parameters of sympathetic nerve function in spontaneously diabetic mice(C57 BL/KsJdb/db) and in their lean littermates. The concentration of norepinephrine (NE) in organs innervated by sympathetic nerves was significantly reduced in the heart, kidney, and salivary glands of mice (24 weeks ol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.27.10.969
更新日期:1978-10-01 00:00:00
abstract::Vasculopathy is a major complication of diabetes; however, molecular mechanisms mediating the development of vasculopathy and potential strategies for prevention have not been identified. We have previously reported that C-peptide prevents diabetic vasculopathy by inhibiting reactive oxygen species (ROS)-mediated endo...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db13-0039
更新日期:2013-11-01 00:00:00
abstract::IA-2, a member of the protein tyrosine phosphatase family, represents a major target autoantigen in type 1 diabetes. To study the regulation of IA-2 gene expression, we used INS-1 insulinoma cells to analyze beta-cell signal transduction pathways as well as the effect of metabolic and hormonal factors involved in the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diabetes.49.7.1137
更新日期:2000-07-01 00:00:00
abstract::More than 120 published reports have described associations between single nucleotide polymorphisms (SNPs) and type 2 diabetes. However, multiple studies of the same variant have often been discordant. From a literature search, we identified previously reported type 2 diabetes-associated SNPs. We initially genotyped 1...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db06-0461
更新日期:2007-01-01 00:00:00
abstract::The macro- and microvascular burden of type 2 diabetes is well established. A number of recent single risk factor intervention trials targeting hyperglycemia, dyslipidemia, hypertension, procoagulation, microalbumuria, and existing cardiovascular disorders have, however, shown major beneficial effects on long-term out...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diabetes.53.suppl_3.s39
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db10-0054
更新日期:2010-12-01 00:00:00
abstract::Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans. The full-length isoform (ChREBPα) has a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db15-0239
更新日期:2015-12-01 00:00:00
abstract::Recent large-scale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict the development of NIDDM and IDDM and are associated with the risk of several degenerative diseases, such as coronary and peripheral vessel atherosclerosis, hypertension, and dyslipidemia. The reliability...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.45.2.242
更新日期:1996-02-01 00:00:00
abstract::Enhanced platelet functions have been demonstrated in patients with non-insulin-dependent diabetes mellitus (NIDDM). This study evaluated abnormalities in platelet signal transduction in diabetic patients, including turnover of phosphoinositides, mobilization of intracellular Ca2+, and phosphorylation of 20,000- and 4...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.39.12.1561
更新日期:1990-12-01 00:00:00
abstract::To evaluate possible advantages of human insulin of recombinant DNA origin (HI) in the treatment of diabetic patients, we compared cellular and humoral immunoreactivities of HI and porcine insulin (PI). Anti-insulin IgE bound equal amounts of 125I-HI and 125I-PI. There was no difference between HI- and PI-stimulated l...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.6.516
更新日期:1983-06-01 00:00:00
abstract::Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas ina...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db12-1296
更新日期:2013-05-01 00:00:00