Abstract:
:We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high-density lipoprotein cholesterol levels. In regression analyses that controlled for these and other potential risk factors, HbA1c remained significantly related to CVD among women. The relative odds of CVD increased 1.39-fold (95% confidence interval 1.06-1.83) for increases in HbA1c of 1% (e.g., for HbA1c from 5 to 6%). The relationship was not weakened when known diabetic subjects or subjects taking beta-blocker or thiazide medications were excluded from analysis. In contrast, there was no significant relationship between "casual" blood glucose and prevalent CVD. Our results reveal a strong, significant, independent association between hyperglycemia, measured by HbA1c, and CVD among older women.
journal_name
Diabetesjournal_title
Diabetesauthors
Singer DE,Nathan DM,Anderson KM,Wilson PW,Evans JCdoi
10.2337/diab.41.2.202subject
Has Abstractpub_date
1992-02-01 00:00:00pages
202-8issue
2eissn
0012-1797issn
1939-327Xjournal_volume
41pub_type
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