Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

abstract：:Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but local lipid availability has been implicated. The aim of this study was to examine the influence of three short-term physiological man...

journal_title：Diabetes

authors： Oakes ND,Bell KS,Furler SM,Camilleri S,Saha AK,Ruderman NB,Chisholm DJ,Kraegen EW

更新日期：1997-12-01 00:00:00

abstract：:An A-to-G transition in the mitochondrial tRNALeu(UUR) gene at base pair 3243 has been shown to be associated with the maternally transmitted clinical phenotype of NIDDM and sensorineural hearing loss in white and Japanese pedigrees. We have detected this mutation in 25 of 50 tested members of five white French pedigr...

journal_title：Diabetes

authors： Velho G,Byrne MM,Clément K,Sturis J,Pueyo ME,Blanché H,Vionnet N,Fiet J,Passa P,Robert JJ,Polonsky KS,Froguel P

更新日期：1996-04-01 00:00:00

abstract：:Widely held theories of the pathogenesis of obesity-associated NIDDM have implicated apparently incompatible events as seminal: 1) insulin resistance in muscle, 2) abnormal secretion of insulin, and 3) increases in intra-abdominal fat. Altered circulating or tissue lipids are characteristic features of obesity and NID...

journal_title：Diabetes

authors： Prentki M,Corkey BE

更新日期：1996-03-01 00:00:00

abstract：:The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr]...

journal_title：Diabetes

authors： Kobayashi T,Itoh T,Kosaka K,Sato K,Tsuji K

更新日期：1987-04-01 00:00:00

abstract：:To examine the mechanism of the arginine-induced rise in blood glucose concentration, splanchnic glucose output (SGO) and precursor uptake were studied during i.v. infusion of arginine (30 g/30 min) with and without somatostatin infusion (500 microgram/h, 90 min) in postabsorptive and in 60-h fasted healthy subjects. ...

journal_title：Diabetes

authors： Bratusch-Marrain P,Björkman O,Hagenfeldt L,Waldhäusl W,Wahren J

更新日期：1979-02-01 00:00:00

abstract：:Thymocytes from adult BB rats can adoptively transfer autoimmune diabetes to athymic recipients. It is also known that the development of BB rat T-cells is recapitulated in adult thymus organ cultures (ATOCs). Based on these observations, we tested the hypothesis that cells capable of the adoptive transfer of diabetes...

journal_title：Diabetes

authors： Whalen BJ,Marounek J,Weiser P,Appel MC,Greiner DL,Mordes JP,Rossini AA

更新日期：2001-05-01 00:00:00

abstract：:Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapies. Here we tested the hypothesis that obesity-associated disorders are caused by increased adipose tissue as opposed to excess dietary lipids. Fat mass (FM) of lean C57B6 mice fed a high-fat diet (HFD; FMC mice) was "cla...

journal_title：Diabetes

authors： Kirchner H,Hofmann SM,Fischer-Rosinský A,Hembree J,Abplanalp W,Ottaway N,Donelan E,Krishna R,Woods SC,Müller TD,Spranger J,Perez-Tilve D,Pfluger PT,Tschöp MH,Habegger KM

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impac...

journal_title：Diabetes

authors： Højbjerre L,Sonne MP,Alibegovic AC,Dela F,Vaag A,Meldgaard JB,Christensen KB,Stallknecht B

更新日期：2010-11-01 00:00:00

abstract：:The effect of nonenzymatic glycosylation on the biologic function of human antithrombin III was evaluated using a chromogenic thrombin substrate assay in the presence of catalytic amounts of heparin. Experimental conditions that increased the rate of nonenzymatic protein glycosylation were associated with decreases in...

journal_title：Diabetes

authors： Brownlee M,Vlassara H,Cerami A

更新日期：1984-06-01 00:00:00

abstract：:Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...

journal_title：Diabetes

authors： Nosadini R,del Prato S,Tiengo A,Duner E,Toffolo G,Cobelli C,Faronato PP,Moghetti P,Muggeo M

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVE:The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. RESEARCH DESIGN AND METHODS:Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospectiv...

journal_title：Diabetes

authors： Haring R,Völzke H,Felix SB,Schipf S,Dörr M,Rosskopf D,Nauck M,Schöfl C,Wallaschofski H

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2. RESEARCH DESIGN AND METHODS:Rat proximal-tubular epithelial cells (NRK...

journal_title：Diabetes

authors： Wang B,Koh P,Winbanks C,Coughlan MT,McClelland A,Watson A,Jandeleit-Dahm K,Burns WC,Thomas MC,Cooper ME,Kantharidis P

更新日期：2011-01-01 00:00:00

abstract：:Growth medium containing serum from young diabetic subjects caused a significant stimulation both of cell proliferation and of the outgrowth in cultures of rabbit aortic medial cells above that noted with normal human sera. The addition to the sera of guinea-pig human growth hormones antibody caused a marked inhibitio...

journal_title：Diabetes

authors： Ledet T

更新日期：1977-08-01 00:00:00

abstract：:Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenge...

journal_title：Diabetes

authors： Li H,O'Meara M,Zhang X,Zhang K,Seyoum B,Yi Z,Kaufman RJ,Monks TJ,Wang JM

更新日期：2019-06-01 00:00:00

abstract：:With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations betwee...

journal_title：Diabetes

authors： Elhadad MA,Jonasson C,Huth C,Wilson R,Gieger C,Matias P,Grallert H,Graumann J,Gailus-Durner V,Rathmann W,von Toerne C,Hauck SM,Koenig W,Sinner MF,Oprea TI,Suhre K,Thorand B,Hveem K,Peters A,Waldenberger M

更新日期：2020-12-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:The Diabetes Control and Complications Trial (Diabetes 44:968-983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support...

journal_title：Diabetes

authors： Lachin JM,Genuth S,Nathan DM,Zinman B,Rutledge BN,DCCT\/EDIC Research Group.

更新日期：2008-04-01 00:00:00

abstract：:Insulin secretion from the pancreas is pulsatile. The precise site and function of the pacemaker that regulates insulin periodicity in humans have not been determined. We isolated human pancreatic islets from five cadaver organ donors by collagenase digestion and density gradient purification. After 24 h of culture in...

journal_title：Diabetes

authors： Marchetti P,Scharp DW,Mclear M,Gingerich R,Finke E,Olack B,Swanson C,Giannarelli R,Navalesi R,Lacy PE

更新日期：1994-06-01 00:00:00

abstract：:Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory effect on beta-cell insulin processing and secretion. To study such interaction in more detail, IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed both before and after delivery in lean ...

journal_title：Diabetes

authors： Kautzky-Willer A,Thomaseth K,Ludvik B,Nowotny P,Rabensteiner D,Waldhäusl W,Pacini G,Prager R

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet unexpectedly experienced a dramatic reduc...

journal_title：Diabetes

authors： Cheng Y,Meng Q,Wang C,Li H,Huang Z,Chen S,Xiao F,Guo F

更新日期：2010-01-01 00:00:00

abstract：:Clinical factors related to the development and progression of renal lesions were studied in twenty-three diabetics by the use of serial renal biopsies or autopsy. The results were as follows: Most of the juvenile and intermediate type diabetics were poorly controlled, with the glomerular lesion progressing rather rap...

journal_title：Diabetes

authors： Takazakura E,Nakamoto Y,Hayakawa H,Kawai K,Muramoto S

更新日期：1975-01-01 00:00:00

abstract：:Although the biochemical mechanism by which insulin and contractile activity affect protein turnover in muscle are still unclear, certain physiologic conclusions can be made; (a) Increased work can induce muscle hypertrophy even in the diabetic or starving animal. Thus, work-induced growth differs from normal growth o...

journal_title：Diabetes

authors： Goldberg AL

更新日期：1979-01-01 00:00:00

abstract：:Rats with chronic streptozotocin (SZ) diabetes develop dilatation of the alimentary tract, loss of fecal consistency, and autonomic neuropathy involving unmyelinated axons of the extrinsic innervation of the small bowel. Diabetic autonomic neuropathy involving the ileal mesenteric nerves is characterized by modest to ...

journal_title：Diabetes

authors： Schmidt RE,Plurad SB,Olack BJ,Scharp DW

更新日期：1983-06-01 00:00:00

abstract：:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...

journal_title：Diabetes

authors： Beitelshees AL,Leslie BR,Taylor SI

更新日期：2019-06-01 00:00:00

abstract：:Aldose reductase (AR) was purified from rat seminal vesicles. Specific antibodies to this enzyme were prepared in rabbits and were used in the unlabeled antibody-enzyme (PAP) technique to localize AR in a number of tissues known to be sites of diabetic lesions. AR was localized in the following structures in the eye: ...

journal_title：Diabetes

authors： Ludvigson MA,Sorenson RL

更新日期：1980-06-01 00:00:00

abstract：:Evidence exists for an essential role of beta-cell apoptosis in the pathology of type 1 and type 2 diabetes. Current methods for diabetes-associated apoptosis detection, however, suffer the drawbacks of relying on in situ-based strategies. In this study, we attempted to measure, both in vitro and ex vivo, levels of be...

journal_title：Diabetes

authors： Medarova Z,Bonner-Weir S,Lipes M,Moore A

更新日期：2005-06-01 00:00:00

abstract：:The effect of 4 wk of streptozocin (STZ)-induced diabetes on the transmission time of the auditory-evoked brain stem response (ABR) was examined in conscious male Sprague-Dawley rats. Distal nerve transmission time of the auditory pathway (latency of peak II), which includes conduction along the 8th cranial nerve, inc...

journal_title：Diabetes

authors： Notvest RR,Inserra JJ

更新日期：1987-04-01 00:00:00

abstract：:We explore whether racial differences in a United States population influence disease prevalence and perinatal outcome in gestational diabetes mellitus (GDM). The data presented are based on 3744 consecutive patients who underwent universal screening at 24-28 wk gestation; those with a 1-h plasma glucose greater than ...

journal_title：Diabetes

authors： Dooley SL,Metzger BE,Cho NH

更新日期：1991-12-01 00:00:00

abstract：:An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. He...

journal_title：Diabetes

authors： Marek G,Pannu V,Shanmugham P,Pancione B,Mascia D,Crosson S,Ishimoto T,Sautin YY

更新日期：2015-02-01 00:00:00

abstract：:The GK rat model of type 2 diabetes is especially convenient to dissect the pathogenic mechanism necessary for the emergence of overt diabetes because all adult rats obtained in our department (GK/Par colony) to date have stable basal mild hyperglycemia and because overt diabetes is preceded by a period of normoglycem...

journal_title：Diabetes

authors： Portha B,Giroix MH,Serradas P,Gangnerau MN,Movassat J,Rajas F,Bailbe D,Plachot C,Mithieux G,Marie JC

更新日期：2001-02-01 00:00:00