Deciphering the Plasma Proteome of Type 2 Diabetes.

abstract：:The early steps of insulin biosynthesis occur in the endoplasmic reticulum (ER), and the beta-cell has a highly developed and active ER. All cells regulate the capacity of their ER to fold and process client proteins and they adapt to an imbalance between client protein load and folding capacity (so-called ER stress)....

journal_title：Diabetes

authors： Harding HP,Ron D

更新日期：2002-12-01 00:00:00

abstract：:The GK rat model of type 2 diabetes is especially convenient to dissect the pathogenic mechanism necessary for the emergence of overt diabetes because all adult rats obtained in our department (GK/Par colony) to date have stable basal mild hyperglycemia and because overt diabetes is preceded by a period of normoglycem...

journal_title：Diabetes

authors： Portha B,Giroix MH,Serradas P,Gangnerau MN,Movassat J,Rajas F,Bailbe D,Plachot C,Mithieux G,Marie JC

更新日期：2001-02-01 00:00:00

abstract：:The effects of varying concentrations of ethanol (1, 10, and 30 mM) and its metabolites (1 mM acetate and 1 and 10 mM acetaldehyde) on insulin and glucagon secretion induced by glucose (11.1 mM) and arginine (20 mM) were studied in isolated perfused pancreas of Sprague-Dawley rats. Ethanol and its metabolites did not ...

journal_title：Diabetes

authors： Tiengo A,Valerio A,Molinari M,Meneghel A,Lapolla A

更新日期：1981-09-01 00:00:00

abstract：:In nonobese diabetic (NOD) mice, a deficiency in the number and function of invariant natural killer T-cells (iNKT cells) contributes to the onset of type 1 diabetes. The activation of CD1d-restricted iNKT cells by alpha-galactosylceramide (alpha-GalCer) corrects these deficiencies and protects against spontaneous and...

journal_title：Diabetes

authors： Mi QS,Ly D,Zucker P,McGarry M,Delovitch TL

更新日期：2004-05-01 00:00:00

abstract：:The type I and type II isozymes of hexokinase coexist in insulin-sensitive tissues, such as cardiac and skeletal muscle and adipose tissue. Based on an early report that the purified type I isozyme was stable at 45 degrees C whereas the purified type II isozyme was not, investigators in a number of studies have used h...

journal_title：Diabetes

authors： Wilson JE

更新日期：1998-10-01 00:00:00

abstract：:Atrasentan, a selective endothelin A receptor antagonist, has been shown to reduce albuminuria in type 2 diabetes. We previously showed that the structural integrity of a glomerular endothelial glycocalyx is required to prevent albuminuria. Therefore we tested the potential of atrasentan to stabilize the endothelial g...

journal_title：Diabetes

authors： Boels MG,Avramut MC,Koudijs A,Dane MJ,Lee DH,van der Vlag J,Koster AJ,van Zonneveld AJ,van Faassen E,Gröne HJ,van den Berg BM,Rabelink TJ

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have indicated that individuals with type 2 diabetes have an increased resting metabolic rate (RMR) but decreased insulin-induced thermogenesis (IIT) compared with those with normal glucose tolerance (NGT). When and by which mechanisms these abnormalities occur during the development of diabetes remai...

journal_title：Diabetes

authors： Weyer C,Bogardus C,Pratley RE

更新日期：1999-08-01 00:00:00

abstract：:The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the a...

journal_title：Diabetes

authors： Watters K,Blaisdell P

更新日期：1989-12-01 00:00:00

abstract：:African Americans are at increased risk of type 2 diabetes and many diabetes complications. We have carried out a genome-wide scan for African American type 2 diabetes using 638 affected sibling pairs (ASPs) from 247 families ascertained through impaired renal function to identify type 2 diabetes loci in this high-ris...

journal_title：Diabetes

authors： Sale MM,Freedman BI,Langefeld CD,Williams AH,Hicks PJ,Colicigno CJ,Beck SR,Brown WM,Rich SS,Bowden DW

更新日期：2004-03-01 00:00:00

abstract：:Ciglitazone, 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione, is a new hypoglycemic agent orally active in the obese-hyperglycemic animal models. In C57BL/6J-ob/ob mice, treatment with 100 mg/kg ciglitazone for 2 days elicited a drastic fall in blood glucose. It also decreased plasma insulin, triglycer...

journal_title：Diabetes

authors： Chang AY,Wyse BM,Gilchrist BJ,Peterson T,Diani AR

更新日期：1983-09-01 00:00:00

abstract：:A 5-day culture of adult rat islets with human recombinant IL-1 beta (3 U/ml) resulted in the death of most alpha-cells and 50% of beta-cells. The IL-1--exposed islet tissue contained--in addition to poorly granulated beta-cells--patches of outgrowing monolayers and dispersed activated macrophages. In purified alpha- ...

journal_title：Diabetes

authors： Ling Z,In't Veld PA,Pipeleers DG

更新日期：1993-01-01 00:00:00

abstract：:The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell-enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juv...

journal_title：Diabetes

authors： Cyphert HA,Walker EM,Hang Y,Dhawan S,Haliyur R,Bonatakis L,Avrahami D,Brissova M,Kaestner KH,Bhushan A,Powers AC,Stein R

更新日期：2019-02-01 00:00:00

abstract：:The sulfonylurea receptor (SUR) is the important regulatory subunit of ATP-sensitive K+ channels. It is an ATP-binding cassette protein comprising 17 transmembrane helices. SUR is endowed with binding sites for channel blockers like the antidiabetic sulfonylurea glibenclamide and for the chemically very heterogeneous ...

journal_title：Diabetes

authors： Hambrock A,Kayar T,Stumpp D,Osswald H

更新日期：2004-12-01 00:00:00

abstract：:Hyperglycemia-induced oxidative stress is detrimental for endothelial cells, contributing to the vascular complications of diabetes. The mitochondrial permeability transition pore (PTP) is an oxidative stress-sensitive channel involved in cell death; therefore, we have examined its potential role in endothelial cells ...

journal_title：Diabetes

authors： Detaille D,Guigas B,Chauvin C,Batandier C,Fontaine E,Wiernsperger N,Leverve X

更新日期：2005-07-01 00:00:00

abstract：:The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...

journal_title：Diabetes

authors： James EA,Mallone R,Kent SC,DiLorenzo TP

更新日期：2020-07-01 00:00:00

abstract：:Hepatocyte nuclear factor (HNF)-4alpha is a transcription factor known as a key molecule in the development and functions of the beta-cells. In a previously performed genome-wide scan of Japanese type 2 diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a region in which the HNF4A gene ...

journal_title：Diabetes

authors： Hara K,Horikoshi M,Kitazato H,Ito C,Noda M,Ohashi J,Froguel P,Tokunaga K,Tobe K,Nagai R,Kadowaki T

更新日期：2006-05-01 00:00:00

abstract：:To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats infused for 48 h with a 50% glucose solution. To preserve the effects of in vivo hyperglycemia during in vitro handling for islet isolation, our standard isolatio...

journal_title：Diabetes

authors： Timmers KI,Powell AM,Voyles NR,Solomon D,Wilkins SD,Bhathena S,Recant L

更新日期：1990-11-01 00:00:00

abstract：:The strategy of positional cloning has been highly successful in identifying a number of single gene disorders that exhibit clear Mendelian patterns of inheritance. Positional cloning of insulin-dependent diabetes mellitus (IDDM) has been assisted by the expansion of molecular genetic tools and highly informative mark...

journal_title：Diabetes

authors： Rich SS

更新日期：1995-02-01 00:00:00

abstract：:Misregulated hormone secretion from the islet of Langerhans is central to the pathophysiology of diabetes. Although insulin plays a key role in glucose regulation, the importance of glucagon is increasingly acknowledged. However, the mechanisms that regulate glucagon secretion from α-cells are still unclear. We used p...

journal_title：Diabetes

authors： Reissaus CA,Piston DW

更新日期：2017-04-01 00:00:00

abstract：:Members of the tumor necrosis factor receptor superfamily play an important role in the initiation, expansion, and termination of an immune response. It has recently been demonstrated that one member of this family, CD30, plays a central role in maintaining peripheral tolerance by controlling the expansion of autoreac...

journal_title：Diabetes

authors： Siegmund T,Armitage N,Wicker LS,Peterson LB,Todd JA,Lyons PA

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasia...

journal_title：Diabetes

authors： Tiberti C,Giordano C,Locatelli M,Bosi E,Bottazzo GF,Buzzetti R,Cucinotta D,Galluzzo A,Falorni A,Dotta F

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Recently, several drugs have been shown to exert beneficial effects for metabolic syndrome through mild regulation of mitochondrial function. Hence, we explored a strategy of targeting mitochondrial function to improve glucose and lipid metabolism. RESEARCH DESIGN AND METHODS:Mitochondrial membrane potential...

journal_title：Diabetes

authors： Qiu BY,Turner N,Li YY,Gu M,Huang MW,Wu F,Pang T,Nan FJ,Ye JM,Li JY,Li J

更新日期：2010-01-01 00:00:00

abstract：:The interaction between insulin and its receptor was investigated using both monoclonal and polyclonal anti-insulin antibodies. After covalent cross-linking of 125I-insulin to the insulin receptor on cultured human lymphocytes (IM-9 cells) using disuccinimidyl suberate, we inquired whether the insulin-receptor complex...

journal_title：Diabetes

authors： Taylor SI,Schroer JA,Marcus-Samuels B,McElduff A,Bender TP

更新日期：1984-08-01 00:00:00

abstract：:Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

journal_title：Diabetes

authors： Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

更新日期：2012-02-01 00:00:00

abstract：:Studies have shown associations between exposure to hypoglycemia and increased mortality, raising the possibility that hypoglycemia has adverse cardiovascular effects. In this study, we determined the acute effects of hypoglycemia on cardiovascular autonomic control. Seventeen healthy volunteers were exposed to experi...

journal_title：Diabetes

authors： Rao AD,Bonyhay I,Dankwa J,Baimas-George M,Kneen L,Ballatori S,Freeman R,Adler GK

更新日期：2016-01-01 00:00:00

abstract：:Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts...

journal_title：Diabetes

authors： Nilsson E,Jansson PA,Perfilyev A,Volkov P,Pedersen M,Svensson MK,Poulsen P,Ribel-Madsen R,Pedersen NL,Almgren P,Fadista J,Rönn T,Klarlund Pedersen B,Scheele C,Vaag A,Ling C

更新日期：2014-09-01 00:00:00

abstract：:Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix protein accumulation are seen in diabetic glomerulopathy. Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which...

journal_title：Diabetes

authors： Singh LP,Andy J,Anyamale V,Greene K,Alexander M,Crook ED

更新日期：2001-10-01 00:00:00

abstract：:We have produced a monoclonal antibody 3A4 to the surface of islet cells by fusing spleen lymphocytes from nonobese diabetic (NOD) mice. To identify the molecular weight of specific target antigens reacting with 3A4, 125I-surface-labeled In-111 insulinoma cells were solubilized and extracts were absorbed with 3A4, and...

journal_title：Diabetes

authors： Hari J,Yokono K,Yonezawa K,Amano K,Yaso S,Shii K,Imamura Y,Baba S

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS:Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of chemerin. Serum chemerin was measured by enzy...

journal_title：Diabetes

authors： Tan BK,Chen J,Farhatullah S,Adya R,Kaur J,Heutling D,Lewandowski KC,O'Hare JP,Lehnert H,Randeva HS

更新日期：2009-09-01 00:00:00

abstract：:Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses insulin secretion and ...

journal_title：Diabetes

authors： Calabria AC,Li C,Gallagher PR,Stanley CA,De León DD

更新日期：2012-10-01 00:00:00