Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.

abstract：:Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...

journal_title：Diabetes

authors： Howard CF Jr

更新日期：1982-01-01 00:00:00

abstract：:Myoblasts from human skeletal muscle were isolated from needle biopsy samples of vastus lateralis and fused to differentiated multinucleated myotubes. Specific high-affinity insulin and insulin-like growth factor I (IGF-I) binding, glucose transporter proteins GLUT1 and GLUT4, glycogen synthase and pyruvate dehydrogen...

journal_title：Diabetes

authors： Henry RR,Abrams L,Nikoulina S,Ciaraldi TP

更新日期：1995-08-01 00:00:00

abstract：:In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow. The optimal d...

journal_title：Diabetes

authors： Bar-On H,Roheim PS,Eder HA

更新日期：1976-06-01 00:00:00

abstract：:In diabetic subjects, polyol pathway activity might inhibit neutrophil function and cause nerve damage. The effects of ponalrestat, an aldose reductase inhibitor, were assessed on neutrophil intracellular killing of Escherichia coli and on autonomic function in diabetic subjects in a randomized double-blind, placebo-c...

journal_title：Diabetes

authors： Boland OM,Blackwell CC,Clarke BF,Ewing DJ

更新日期：1993-02-01 00:00:00

abstract：:The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty-four subjects (32 males and 22 females, age 38 +/- 10 years [mean +/...

journal_title：Diabetes

authors： Heise T,Nosek L,Rønn BB,Endahl L,Heinemann L,Kapitza C,Draeger E

更新日期：2004-06-01 00:00:00

abstract：:Widely held theories of the pathogenesis of obesity-associated NIDDM have implicated apparently incompatible events as seminal: 1) insulin resistance in muscle, 2) abnormal secretion of insulin, and 3) increases in intra-abdominal fat. Altered circulating or tissue lipids are characteristic features of obesity and NID...

journal_title：Diabetes

authors： Prentki M,Corkey BE

更新日期：1996-03-01 00:00:00

abstract：:Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only pro...

journal_title：Diabetes

authors： Lu T,Chai Q,Yu L,d'Uscio LV,Katusic ZS,He T,Lee HC

更新日期：2012-07-01 00:00:00

abstract：:Previous studies have indicated that individuals with type 2 diabetes have an increased resting metabolic rate (RMR) but decreased insulin-induced thermogenesis (IIT) compared with those with normal glucose tolerance (NGT). When and by which mechanisms these abnormalities occur during the development of diabetes remai...

journal_title：Diabetes

authors： Weyer C,Bogardus C,Pratley RE

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice soon after birth has not allowed further insight into ...

journal_title：Diabetes

authors： Fukuda A,Kawaguchi Y,Furuyama K,Kodama S,Horiguchi M,Kuhara T,Kawaguchi M,Terao M,Doi R,Wright CV,Hoshino M,Chiba T,Uemoto S

更新日期：2008-09-01 00:00:00

abstract：:Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by hypertension and atherosclerosis. This cardiomyopathy may be due to either organ-based damage, such as fibrosis, or to direct damage to cardiomyocytes. Reactive oxygen species (ROS) have been proposed to contribute to ...

journal_title：Diabetes

authors： Ye G,Metreveli NS,Ren J,Epstein PN

更新日期：2003-03-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue lipolysis and consequent increased circulating free fatty acids (FFAs). Here we report that neither TNF-alpha nor glucose alone has a pronounced effect on lipolysis ...

journal_title：Diabetes

authors： Green A,Rumberger JM,Stuart CA,Ruhoff MS

更新日期：2004-01-01 00:00:00

abstract：:Impaired effectiveness of glucose to suppress endogenous glucose production (EGP) is an important cause of worsening hyperglycemia in type 2 diabetes. Elevated free fatty acids (FFAs) may impair glucose effectiveness via several mechanisms, including rapid changes in metabolic fluxes and/or more gradual changes in gen...

journal_title：Diabetes

authors： Kishore P,Tonelli J,Koppaka S,Fratila C,Bose A,Lee DE,Reddy K,Hawkins M

更新日期：2006-06-01 00:00:00

abstract：:Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI) in a nonhypertensive obese canine model. SI was measured using euglycemic-hyper...

journal_title：Diabetes

authors： Iyer MS,Bergman RN,Korman JE,Woolcott OO,Kabir M,Victor RG,Clegg DJ,Kolka C

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes. RESEARCH DESIGN AND METHODS:Embryos from nondiabetic and streptozotocin-induced diabeti...

journal_title：Diabetes

authors： Wentzel P,Gäreskog M,Eriksson UJ

更新日期：2008-12-01 00:00:00

abstract：:Troglitazone and pioglitazone, antidiabetic thiazolidinediones, are known to improve insulin resistance. However, the effect of these drugs on platelet aggregation remains unclear. The chemical structure of troglitazone contains vitamin E. Accordingly, we studied the effect of troglitazone, pioglitazone, and vitamin E...

journal_title：Diabetes

authors： Ishizuka T,Itaya S,Wada H,Ishizawa M,Kimura M,Kajita K,Kanoh Y,Miura A,Muto N,Yasuda K

更新日期：1998-09-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement ...

journal_title：Diabetes

authors： Wolford JK,Yeatts KA,Dhanjal SK,Black MH,Xiang AH,Buchanan TA,Watanabe RM

更新日期：2005-11-01 00:00:00

abstract：:African Americans are at increased risk of type 2 diabetes and many diabetes complications. We have carried out a genome-wide scan for African American type 2 diabetes using 638 affected sibling pairs (ASPs) from 247 families ascertained through impaired renal function to identify type 2 diabetes loci in this high-ris...

journal_title：Diabetes

authors： Sale MM,Freedman BI,Langefeld CD,Williams AH,Hicks PJ,Colicigno CJ,Beck SR,Brown WM,Rich SS,Bowden DW

更新日期：2004-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and CD20(+) cells) into and around pancreatic islets (insulitis). Recently, we reported that two distinct patterns of insulitis occur in patients with recent-onset ...

journal_title：Diabetes

authors： Leete P,Willcox A,Krogvold L,Dahl-Jørgensen K,Foulis AK,Richardson SJ,Morgan NG

更新日期：2016-05-01 00:00:00

abstract：:Because high D-glucose significantly stimulates endothelial cell death, we examined the molecular mechanisms of high D-glucose-induced endothelial apoptosis. Treatment of human aortic endothelial cells with high D-glucose (25 mmol/l), but not mannitol and L-glucose, resulted in a significant decrease in cell number an...

journal_title：Diabetes

authors： Nakagami H,Morishita R,Yamamoto K,Yoshimura SI,Taniyama Y,Aoki M,Matsubara H,Kim S,Kaneda Y,Ogihara T

更新日期：2001-06-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) exerts vasoprotective effects. Such benefit in diabetic vasculopathy, however, remains unclear. We hypothesize that bilirubin mediates HO-1-induced vascular benefits in diabetes. Diabetic db/db mice were treated with hemin (HO-1 inducer) for 2 weeks, and aortas were isolated for functional and ...

journal_title：Diabetes

authors： Liu J,Wang L,Tian XY,Liu L,Wong WT,Zhang Y,Han QB,Ho HM,Wang N,Wong SL,Chen ZY,Yu J,Ng CF,Yao X,Huang Y

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity ...

journal_title：Diabetes

authors： Ko HJ,Zhang Z,Jung DY,Jun JY,Ma Z,Jones KE,Chan SY,Kim JK

更新日期：2009-11-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotoci...

journal_title：Diabetes

authors： Kim YB,Kim WB,Jung WW,Jin X,Kim YS,Kim B,Han HC,Block GD,Colwell CS,Kim YI

更新日期：2018-03-01 00:00:00

abstract：:The transcription factor regulatory factor X (RFX)-3 regulates the expression of genes required for the growth and function of cilia. We show here that mouse RFX3 is expressed in developing and mature pancreatic endocrine cells during embryogenesis and in adults. RFX3 expression already is evident in early Ngn3-positi...

journal_title：Diabetes

authors： Ait-Lounis A,Baas D,Barras E,Benadiba C,Charollais A,Nlend Nlend R,Liègeois D,Meda P,Durand B,Reith W

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...

journal_title：Diabetes

authors： Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2017-07-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...

journal_title：Diabetes

authors： Tze WJ,Tai J

更新日期：1988-04-01 00:00:00

abstract：:The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knockout mouse model to test the hypothesis that Sox4 is essential for the m...

journal_title：Diabetes

authors： Xu EE,Sasaki S,Speckmann T,Nian C,Lynn FC

更新日期：2017-08-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (KDR) plays a critical role in mediating a variety of vasculogenic and angiogenic processes, including diabetic retinopathy. We previously demonstrated that the promoter activity of the KDR gene in retinal capillary endothelial cells (RCECs) was regulated in part by the re...

journal_title：Diabetes

authors： Sassa Y,Hata Y,Aiello LP,Taniguchi Y,Kohno K,Ishibashi T

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy, nondiabetic older adults. This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling. We hypothesized that, in older subjects, pharmacological restoration of insulin-induced capillary r...

journal_title：Diabetes

authors： Timmerman KL,Lee JL,Fujita S,Dhanani S,Dreyer HC,Fry CS,Drummond MJ,Sheffield-Moore M,Rasmussen BB,Volpi E

更新日期：2010-11-01 00:00:00