Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.

abstract：:It has been proposed that insulin-mediated changes in muscle perfusion modulate insulin-mediated glucose uptake. However, the putative effects of insulin on the microcirculation that permit such modulation have not been studied in humans. We examined the effects of systemic hyperinsulinemia on skin microvascular funct...

journal_title：Diabetes

authors： Serné EH,IJzerman RG,Gans RO,Nijveldt R,De Vries G,Evertz R,Donker AJ,Stehouwer CD

更新日期：2002-05-01 00:00:00

abstract：:Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the freque...

journal_title：Diabetes

authors： Sakurami T,Ueno Y,Nagaoka K,Kuno S,Iwaki Y,Park MS,Terasaki PI

更新日期：1982-02-01 00:00:00

abstract：:The "M" variant of the encephalomyocarditis (EMC) virus causes a diabetes-like disease in some, but not all, strains of mice. The genetic basis for either resistance or susceptibility to the diabetogenic effect of the virus is not known. After infection with EMC, C57BL/6 mice seldom develop hyperglycemia and the insul...

journal_title：Diabetes

authors： D'Andrea BJ,Wilson GL,Craighead JE

更新日期：1981-05-01 00:00:00

abstract：:Oxidative stress is implicated in diabetes complications, during which endogenous antioxidant defenses have important pathophysiological consequences. To date, the significance of endogenous antioxidants such as metallothioneins I and II (MT-I+II) in type 2 diabetes remains unclear. To examine the MT-I+II-mediated ant...

journal_title：Diabetes

authors： Scheede-Bergdahl C,Penkowa M,Hidalgo J,Olsen DB,Schjerling P,Prats C,Boushel R,Dela F

更新日期：2005-11-01 00:00:00

abstract：:Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPR(dn)) reveal progressive deterioration of glu...

journal_title：Diabetes

authors： Renner S,Römisch-Margl W,Prehn C,Krebs S,Adamski J,Göke B,Blum H,Suhre K,Roscher AA,Wolf E

更新日期：2012-08-01 00:00:00

abstract：:The clearing of monoclonal and polyclonal and anti-insulin antibodies from homogeneous solutions at 100,000 X g was used to estimate the size of soluble insulin-antibody complexes at physiologic concentrations. Monoclonal antibodies cleared as a uniform population of 6.6 S independent of the insulin concentration. Pol...

journal_title：Diabetes

authors： Petersen KG,Storch MJ,Rother K,Licht T,Kerp L

更新日期：1985-08-01 00:00:00

abstract：:Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human be...

journal_title：Diabetes

authors： Guénantin AC,Briand N,Capel E,Dumont F,Morichon R,Provost C,Stillitano F,Jeziorowska D,Siffroi JP,Hajjar RJ,Fève B,Hulot JS,Collas P,Capeau J,Vigouroux C

更新日期：2017-06-01 00:00:00

abstract：:Activation of the receptor for advanced glycation end products (RAGE) reportedly triggers a variety of proinflammatory responses. However, our previous work revealed that RAGE-binding AGEs free of endotoxin were incapable of inducing vascular cell adhesion molecule-1 (VCAM-1) or tumor necrosis factor-alpha (TNF-alpha)...

journal_title：Diabetes

authors： Valencia JV,Mone M,Zhang J,Weetall M,Buxton FP,Hughes TE

更新日期：2004-03-01 00:00:00

abstract：:The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency. Although a given HLA molecule presents a vast array of peptides, only those recogniz...

journal_title：Diabetes

authors： James EA,Mallone R,Kent SC,DiLorenzo TP

更新日期：2020-07-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...

journal_title：Diabetes

authors： Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ

更新日期：2019-04-01 00:00:00

abstract：:Genes play a role in many processes underlying late diabetic complications, but efforts to identify genetic variants have produced disappointing and contradictory results. Here, we evaluate whether the study designs and analytic methods commonly being used are optimal for finding susceptibility genes for diabetic comp...

journal_title：Diabetes

authors： Rogus JJ,Warram JH,Krolewski AS

更新日期：2002-06-01 00:00:00

abstract：:We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and w...

journal_title：Diabetes

authors： Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Gastaldelli A,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,ACT NOW Study.

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by beta-cell-specific killing by autoreactive T-cells. Less is known about beta-cell numbers and phenotype remaining at diabetes onset and the fate of other pancreatic endocrine cellular constituents. RESEARCH DESIGN AND...

journal_title：Diabetes

authors： Pechhold K,Zhu X,Harrison VS,Lee J,Chakrabarty S,Koczwara K,Gavrilova O,Harlan DM

更新日期：2009-05-01 00:00:00

abstract：:The human leukocyte antigen (HLA) class II genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian populations. Its frequency in control populations (1-3%) is still, however, 1 order of magnitude higher than the p...

journal_title：Diabetes

authors： Van der Auwera B,Van Waeyenberge C,Schuit F,Heimberg H,Vandewalle C,Gorus F,Flament J

更新日期：1995-05-01 00:00:00

abstract：:Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...

journal_title：Diabetes

authors： Bertrand S,De Paepe M,Vigeant C,Yale JF

更新日期：1992-10-01 00:00:00

abstract：:Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

journal_title：Diabetes

authors： Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

更新日期：2019-10-01 00:00:00

abstract：:Neonatal morbidity was assessed in the offspring of 878 mothers with gestational diabetes mellitus (GDM), 132 mothers with pre-GDM, and 380 control subjects. Compared with the control group, the GDM group had a higher incidence of complications, including macrosomia, hypoglycemia, hyperbilirubinemia, hypocalcemia, pol...

journal_title：Diabetes

authors： Hod M,Merlob P,Friedman S,Schoenfeld A,Ovadia J

更新日期：1991-12-01 00:00:00

abstract：:Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin induces the phosphorylation of extracellular signal-related kinase (ERK)-1/2 proteins and increases CCK release (EC(50) = 0.23 nmol/l) in CCK-secr...

journal_title：Diabetes

authors： Guilmeau S,Buyse M,Tsocas A,Laigneau JP,Bado A

更新日期：2003-07-01 00:00:00

abstract：:Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...

journal_title：Diabetes

authors： Jones RL,Paradise C,Peterson CM

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance. RESEARCH DESIGN AND METHODS:TSP1 gene expression was quantified in subcutaneous adipose tiss...

journal_title：Diabetes

authors： Varma V,Yao-Borengasser A,Bodles AM,Rasouli N,Phanavanh B,Nolen GT,Kern EM,Nagarajan R,Spencer HJ 3rd,Lee MJ,Fried SK,McGehee RE Jr,Peterson CA,Kern PA

更新日期：2008-02-01 00:00:00

abstract：:As part of an ongoing search for susceptibility loci for NIDDM, we tested 19 genes whose products are implicated in insulin secretion or action for linkage with NIDDM. Loci included the G-protein-coupled inwardly rectifying potassium channels expressed in beta-cells (KCNJ3 and KCNJ7), glucagon (GCG), glucokinase regul...

journal_title：Diabetes

authors： Vionnet N,Hani EH,Lesage S,Philippi A,Hager J,Varret M,Stoffel M,Tanizawa Y,Chiu KC,Glaser B,Permutt MA,Passa P,Demenais F,Froguel P

更新日期：1997-06-01 00:00:00

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00

abstract：:Toxin from the scorpion Leiurus quinquestriatus was used to release norepinephrine from sympathetic nerve endings in the perfused rat pancrease. Addition of toxin, 10 mug./ml., to perfusate containing 0.3 mg./ml. glucose caused a large increase in release of norepinephrine and glucagon. Glucagon secretion was suppress...

journal_title：Diabetes

authors： Johnson DG,Ensinck JW

更新日期：1976-08-01 00:00:00

abstract：:Estrogen-related receptor γ (ERRγ) is a major positive regulator of hepatic gluconeogenesis. Its transcriptional activity is suppressed by phosphorylation signaled by insulin in the fed state, but whether posttranslational modification alters its gluconeogenic activity in the fasted state is not known. Metabolically a...

journal_title：Diabetes

authors： Misra J,Kim DK,Jung YS,Kim HB,Kim YH,Yoo EK,Kim BG,Kim S,Lee IK,Harris RA,Kim JS,Lee CH,Cho JW,Choi HS

更新日期：2016-10-01 00:00:00

abstract：:Nine offspring of two diabetic parents and 18 normals were studied with two intravenous glucose loads (o.5 gm./kg. body weight), 60 minutes apart. By thus stressing the beta cell, subtle defects could be identified in the prediabetics: (1) An inverse relationship between insulin peak response and insulin concentration...

journal_title：Diabetes

authors： Koncz L,Soeldner JS,Otto H,Smith TM,Gleason RE

更新日期：1977-12-01 00:00:00

abstract：:Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction of vascular smooth muscle cell (VSMC) apoptosis. We aimed to study the role of transforming growth factor (TGF)-beta in rat aortic VSMC. Pioglitazone at 100 micr...

journal_title：Diabetes

authors： Redondo S,Ruiz E,Santos-Gallego CG,Padilla E,Tejerina T

更新日期：2005-03-01 00:00:00

abstract：:The possible influence of diabetes on the higher mnestic and cognitive functions has been investigated. The P300 wave latency, an endogenous electrophysiological event, was explored and compared with the multimodal short-latency evoked potential (EP) recordings (visual [VEP], brainstem auditory [BAEP], and median and ...

journal_title：Diabetes

authors： Pozzessere G,Valle E,de Crignis S,Cordischi VM,Fattapposta F,Rizzo PA,Pietravalle P,Cristina G,Morano S,di Mario U

更新日期：1991-08-01 00:00:00

abstract：:Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endoto...

journal_title：Diabetes

authors： Cani PD,Amar J,Iglesias MA,Poggi M,Knauf C,Bastelica D,Neyrinck AM,Fava F,Tuohy KM,Chabo C,Waget A,Delmée E,Cousin B,Sulpice T,Chamontin B,Ferrières J,Tanti JF,Gibson GR,Casteilla L,Delzenne NM,Alessi MC,Burceli

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to character...

journal_title：Diabetes

authors： Grarup N,Rose CS,Andersson EA,Andersen G,Nielsen AL,Albrechtsen A,Clausen JO,Rasmussen SS,Jørgensen T,Sandbaek A,Lauritzen T,Schmitz O,Hansen T,Pedersen O

更新日期：2007-12-01 00:00:00

abstract：:The effect of Ca2+ and calmodulin has been studied on adenylate cyclase activity in homogenates of rat islets of Langerhans. EGTA had a stimulatory effect on the enzyme in accord with the known inhibitory effect of Ca2+. In contrast, the addition of Ca2+ together with calmodulin is stimulatory and demonstrates the exi...

journal_title：Diabetes

authors： Sharp GW,Wiedenkeller DE,Kaelin D,Siegel EG,Wollheim CB

更新日期：1980-01-01 00:00:00