Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice.

abstract：:To examine the impact of diabetes and its treatment on plasma free-fatty acid (FFA) and oxidative fuel metabolism during hypoglycemia, we combined indirect calorimetry with [3-3H]glucose during a 4-h low-dose insulin infusion (plasma insulin approximately 2-fold above basal) in six poorly controlled and nine well-cont...

journal_title：Diabetes

authors： Caprio S,Amiel S,Tamborlane WV,Gelfand RA,Sherwin RS

更新日期：1990-02-01 00:00:00

abstract：:Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident precursors or through reprogramming of mature white adipocytes has been...

journal_title：Diabetes

authors： Shao M,Wang QA,Song A,Vishvanath L,Busbuso NC,Scherer PE,Gupta RK

更新日期：2019-10-01 00:00:00

abstract：:Liver fat accumulation is proposed to link obesity and insulin resistance. To dissect the role of liver fat in the insulin resistance of diet-induced obesity, we altered liver fat using a choline-deficient diet. C57Bl/6 mice were fed a low-fat (10% of calories) or high-fat (45% of calories) diet for 8 weeks; during th...

journal_title：Diabetes

authors： Raubenheimer PJ,Nyirenda MJ,Walker BR

更新日期：2006-07-01 00:00:00

abstract：:One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive oxygen species as signals. In isolated mouse islets and INS-1(832/13) cells, glucose increase...

journal_title：Diabetes

authors： Pi J,Bai Y,Zhang Q,Wong V,Floering LM,Daniel K,Reece JM,Deeney JT,Andersen ME,Corkey BE,Collins S

更新日期：2007-07-01 00:00:00

abstract：:An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. He...

journal_title：Diabetes

authors： Marek G,Pannu V,Shanmugham P,Pancione B,Mascia D,Crosson S,Ishimoto T,Sautin YY

更新日期：2015-02-01 00:00:00

abstract：:Fasting plasma glucose concentrations (FPG) predict development of type 2 diabetes. Whether hyperglycemia evolves from normoglycemia gradually over time or as a step increase is not known. We measured plasma glucose and insulin levels during oral glucose testing in 35- to 64-year-old men and nonpregnant women from a p...

journal_title：Diabetes

authors： Ferrannini E,Nannipieri M,Williams K,Gonzales C,Haffner SM,Stern MP

更新日期：2004-01-01 00:00:00

abstract：:Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene ...

journal_title：Diabetes

authors： Blackman SM,Commander CW,Watson C,Arcara KM,Strug LJ,Stonebraker JR,Wright FA,Rommens JM,Sun L,Pace RG,Norris SA,Durie PR,Drumm ML,Knowles MR,Cutting GR

更新日期：2013-10-01 00:00:00

abstract：:The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We aimed to evaluate whether this relationship is causal using a Mendelian randomization approach. In a sample of Swedish men aged 71 years (n = 942) from the Uppsala Longitudinal Study of Adult Men (ULSAM), ins...

journal_title：Diabetes

authors： Gao H,Fall T,van Dam RM,Flyvbjerg A,Zethelius B,Ingelsson E,Hägg S

更新日期：2013-04-01 00:00:00

abstract：:We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress,...

journal_title：Diabetes

authors： Lo CS,Shi Y,Chenier I,Ghosh A,Wu CH,Cailhier JF,Ethier J,Lattouf JB,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2017-07-01 00:00:00

abstract：:Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose...

journal_title：Diabetes

authors： Tong J,Davis HW,Summer S,Benoit SC,Haque A,Bidlingmaier M,Tschöp MH,D'Alessio D

更新日期：2014-07-01 00:00:00

abstract：:Skeletal muscle insulin resistance in type 2 diabetes is associated with a shift from oxidative to glycolytic metabolism in myofibers. However, whether this metabolic switch is detrimental or adaptive for metabolic homeostasis has not been resolved. We recently demonstrated that the Baf60c/Deptor pathway promotes glyc...

journal_title：Diabetes

authors： Meng ZX,Wang L,Xiao Y,Lin JD

更新日期：2014-05-01 00:00:00

abstract：:A new murine model of porcine islet-like cell cluster (ICC) xenograft rejection, avoiding interference of unspecific inflammation, was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) mice were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the ori...

journal_title：Diabetes

authors： Schmidt P,Krook H,Maeda A,Korsgren O,Benda B

更新日期：2003-05-01 00:00:00

abstract：:The farnesoid X receptor (FXR) and the liver x receptors (LXRs) are bile acid-activated receptors that are highly expressed in the enterohepatic tissues. The mechanisms that support the beneficial effects of bariatric surgery are only partially defined. We have investigated the effects of ileal interposition (IT), a s...

journal_title：Diabetes

authors： Mencarelli A,Renga B,D'Amore C,Santorelli C,Graziosi L,Bruno A,Monti MC,Distrutti E,Cipriani S,Donini A,Fiorucci S

更新日期：2013-10-01 00:00:00

abstract：:In this study we examined the effect of experimental diabetes and of treatment with an aldose reductase inhibitor on the level of sulfation of glomerular basement membrane (GBM) heparan sulfate, the principal glycosaminoglycan in this extracellular matrix. Glycosaminoglycans were isolated from GBM purified from contro...

journal_title：Diabetes

authors： Cohen MP,Klepser H,Wu VY

更新日期：1988-10-01 00:00:00

abstract：:Both genetic and nongenetic factors contribute to the development of type 1 diabetes. Many investigations, including prospective studies of high-risk children, have implicated virus infections as predisposing environmental agents. We previously reported that basal activity of the key antiviral enzyme 2'5'-oligoadenyla...

journal_title：Diabetes

authors： Field LL,Bonnevie-Nielsen V,Pociot F,Lu S,Nielsen TB,Beck-Nielsen H

更新日期：2005-05-01 00:00:00

abstract：:The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In this study, primary human skeletal muscle cells were cocultured with human fat cells or incubated with adipocyte-conditioned medium in the presence or absence of the globu...

journal_title：Diabetes

authors： Dietze-Schroeder D,Sell H,Uhlig M,Koenen M,Eckel J

更新日期：2005-07-01 00:00:00

abstract：:It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nerv...

journal_title：Diabetes

authors： Bohlooly-Y M,Olsson B,Bruder CE,Lindén D,Sjögren K,Bjursell M,Egecioglu E,Svensson L,Brodin P,Waterton JC,Isaksson OG,Sundler F,Ahrén B,Ohlsson C,Oscarsson J,Törnell J

更新日期：2005-01-01 00:00:00

abstract：:Retinal neovascularization is observed in progression of diabetic retinopathy. New vessels grow into the vitreous cavity in proliferative diabetic retinopathy, resulting in traction retinal detachment and vitreous hemorrhage. To overcome the catastrophic visual loss due to these complications, efforts have been focuse...

journal_title：Diabetes

authors： Lim Y,Jo DH,Kim JH,Ahn JH,Hwang YK,Kang DK,Chang SI,Yu YS,Yoon Y,Kim JH

更新日期：2012-06-01 00:00:00

abstract：:Endothelinlike immunoreactivity was detected by radioimmunoassay in medium conditioned by cultured endothelial cells obtained from bovine retinal microvessels (9.2 +/- 6.5 pM, n = 4). Sephadex G-25 column chromatography and fast-protein liquid chromatography revealed that most of the endothelinlike immunoreactivity wa...

journal_title：Diabetes

authors： Takahashi K,Brooks RA,Kanse SM,Ghatei MA,Kohner EM,Bloom SR

更新日期：1989-09-01 00:00:00

abstract：:The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP ...

journal_title：Diabetes

authors： Filipsson K,Kvist-Reimer M,Ahrén B

更新日期：2001-09-01 00:00:00

abstract：:Because the pathogenetic understanding of diabetic vascular complications remains fragmentary, and even the best available interventions may prove insufficient to arrest the progression of certain lesions, new avenuses of investigation should be pursued. One of these should be the early in vivo investigation of the ce...

journal_title：Diabetes

authors： Lorenzi M,Cagliero E

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization. RESEARCH DESIGN AND METHODS:PTRF expression was examined in different adipose depots of mice du...

journal_title：Diabetes

authors： Aboulaich N,Chui PC,Asara JM,Flier JS,Maratos-Flier E

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-me...

journal_title：Diabetes

authors： Carantoni M,Abbasi F,Azhar S,Chen YD,Klebanov M,Wang PW,Warmerdam F,Reaven GM

更新日期：1998-02-01 00:00:00

abstract：:The virtually fatless A-ZIP/F-1 mouse is profoundly insulin resistant, diabetic, and a good model for humans with severe generalized lipoatrophy. Like a number of other mouse models of diabetes, the A-ZIP/F-1 mouse has elevated serum corticosterone levels. Leptin infusion lowers the corticosterone levels, suggesting t...

journal_title：Diabetes

authors： Haluzik M,Dietz KR,Kim JK,Marcus-Samuels B,Shulman GI,Gavrilova O,Reitman ML

更新日期：2002-07-01 00:00:00

abstract：:A simple method for the elimination of labile glycohemoglobin in the chromatographic quantitation of glycosylated hemoglobin is described. Use is made of the instability of Schiff base adducts in acidic solution. Erythrocytes are lysed with a pH 5 buffer. At this pH dissociation reaches completion during sample prepar...

journal_title：Diabetes

authors： Bissé E,Berger W,Flückiger R

更新日期：1982-07-01 00:00:00

abstract：:Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

journal_title：Diabetes

authors： Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

更新日期：2012-11-01 00:00:00

abstract：:To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats infused for 48 h with a 50% glucose solution. To preserve the effects of in vivo hyperglycemia during in vitro handling for islet isolation, our standard isolatio...

journal_title：Diabetes

authors： Timmers KI,Powell AM,Voyles NR,Solomon D,Wilkins SD,Bhathena S,Recant L

更新日期：1990-11-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target ...

journal_title：Diabetes

authors： Grieco FA,Sebastiani G,Juan-Mateu J,Villate O,Marroqui L,Ladrière L,Tugay K,Regazzi R,Bugliani M,Marchetti P,Dotta F,Eizirik DL

更新日期：2017-01-01 00:00:00

abstract：:Insulin receptors from rat hepatoma cells (Fao) and human placenta were partially purified by detergent solubilization and lectin purification. The insulin receptor preparations were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under reducing or nonreducing conditions. The proteins were...

journal_title：Diabetes

authors： Maron R,Kahn CR,Jacobs S,Fujita-Yamaguchi Y

更新日期：1984-10-01 00:00:00

abstract：:A patient with functioning islet cell carcinoma is described who had amelioration of her hypoglycemia during the development of ectopic ACTH syndrome. Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome. At autopsy, she was found to h...

journal_title：Diabetes

authors： Sadoff L,Gordon J,Goldman S

更新日期：1975-06-01 00:00:00