Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin.

abstract：:We conducted a prospective study to describe the course of the pancreatic beta-cell function from the time of clinical diagnosis of insulin-dependent (type I) diabetes to determine whether DR type, presence of islet cell antibodies (ICA), presence of insulin antibodies (IA), age at onset, and sex could help in the pre...

journal_title：Diabetes

authors： Schiffrin A,Suissa S,Poussier P,Guttmann R,Weitzner G

更新日期：1988-07-01 00:00:00

abstract：:The effects of elevated EPI and CORT levels on KG, SI, and SG were studied in dogs with alloxan-induced diabetes. Conscious dogs received SAL, EPI 20 ng.kg-1.min-1 for 30 min (short EPI) or 72 h (long EPI), or CORT 200 micrograms.kg-1.min-1 for 60 min (short CORT) or 72 h (long CORT) before assessment of glucose metab...

journal_title：Diabetes

authors： Sleeman MW,Christopher MJ,Martin IK,Ward GM,Alford FP,Best JD

更新日期：1992-11-01 00:00:00

abstract：:Hypothalamic "metabolic-sensing" neurons sense glucose and fatty acids (FAs) and play an integral role in the regulation of glucose, energy homeostasis, and the development of obesity and diabetes. Using pharmacologic agents, we previously found that ~50% of these neurons responded to oleic acid (OA) by using the FA t...

journal_title：Diabetes

authors： Le Foll C,Dunn-Meynell A,Musatov S,Magnan C,Levin BE

更新日期：2013-08-01 00:00:00

abstract：:ATP-sensitive potassium (K[ATP]) channels are an essential component of glucose-dependent insulin secretion in pancreatic islet beta-cells. These channels comprise the sulfonylurea receptor (SUR1) and Kir6.2, a member of the inward rectifier K+ channel family. Mutations in the SUR1 subunit are associated with familial...

journal_title：Diabetes

authors： Nestorowicz A,Inagaki N,Gonoi T,Schoor KP,Wilson BA,Glaser B,Landau H,Stanley CA,Thornton PS,Seino S,Permutt MA

更新日期：1997-11-01 00:00:00

abstract：:Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the phys...

journal_title：Diabetes

authors： Kaihara KA,Dickson LM,Jacobson DA,Tamarina N,Roe MW,Philipson LH,Wicksteed B

更新日期：2013-05-01 00:00:00

abstract：:RIN-m cells, cultured from a rat insulinoma, not only bind and secrete but also degrade insulin (Diabetes 1982; 31:521-31). The insulin-degrading activity resides in the cytosol and is similar to the insulin-specific proteases previously described in muscle and other tissues. It has an apparent Km of 0.15 microM for p...

journal_title：Diabetes

authors： Bhathena SJ,Timmers KI,Oie HK,Voyles NR,Recant L

更新日期：1985-02-01 00:00:00

abstract：:We previously reported a syndrome of severe hyperinsulinemia and early-onset hypertension in three patients with dominant-negative mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma. We now report the results of further detailed pathophysiological evaluation of these subj...

journal_title：Diabetes

authors： Savage DB,Tan GD,Acerini CL,Jebb SA,Agostini M,Gurnell M,Williams RL,Umpleby AM,Thomas EL,Bell JD,Dixon AK,Dunne F,Boiani R,Cinti S,Vidal-Puig A,Karpe F,Chatterjee VK,O'Rahilly S

更新日期：2003-04-01 00:00:00

abstract：:On its own, glucose is a major factor for proliferation of pancreatic beta-cells and is also an essential prerequisite for IGF-I and growth hormone-induced growth of these cells. p8 was originally identified as an emergency gene product upregulated in pancreatic acinar cells in response to acute pancreatitis. p8 was f...

journal_title：Diabetes

authors： Päth G,Opel A,Knoll A,Seufert J

更新日期：2004-02-01 00:00:00

abstract：:Evidence in rodents suggests that islet pretreatment to reduce islet immunogenicity will also require some form of immunosuppression of the recipient for islet allograft acceptance in highly reactive donor-recipient pairs. We attempted to ascertain whether outbred dogs would also require treatment of both donor islets...

journal_title：Diabetes

authors： Alejandro R,Latif Z,Noel J,Shienvold FL,Mintz DH

更新日期：1987-03-01 00:00:00

abstract：:To investigate the temporal relationship of diabetes-induced renal growth and its associated metabolic alterations to the early development of renal hyperfunction, parallel functional and metabolic studies were performed shortly after the onset of diabetes in rats. Hyperglycemia and hypoinsulinemia were evident 18 h a...

journal_title：Diabetes

authors： Cortes P,Dumler F,Goldman J,Levin NW

更新日期：1987-01-01 00:00:00

abstract：:To characterize the differentiation events that selectively target insulin-producing cells to interleukin (IL)-1beta-induced apoptosis, we studied IL-1beta signaling via mitogen-activated protein kinase (MAPK) and stress-activated protein kinase in 2 pancreatic endocrine cell lines. We studied the glucagon-secreting A...

journal_title：Diabetes

authors： Ammendrup A,Maillard A,Nielsen K,Aabenhus Andersen N,Serup P,Dragsbaek Madsen O,Mandrup-Poulsen T,Bonny C

更新日期：2000-09-01 00:00:00

abstract：:Hyperglycemia upon hospital admission in patients with ST-segment elevation myocardial infarction (STEMI) occurs frequently and is associated with adverse outcomes. It is, however, unsettled as to whether an elevated blood glucose level is the cause or consequence of increased myocardial damage. In addition, whether t...

journal_title：Diabetes

authors： Lønborg J,Vejlstrup N,Kelbæk H,Nepper-Christensen L,Jørgensen E,Helqvist S,Holmvang L,Saunamäki K,Bøtker HE,Kim WY,Clemmensen P,Treiman M,Engstrøm T

更新日期：2014-07-01 00:00:00

abstract：:Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...

journal_title：Diabetes

authors： Festa A,D'Agostino R Jr,Hanley AJ,Karter AJ,Saad MF,Haffner SM

更新日期：2004-06-01 00:00:00

abstract：:Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. In the current study, we demonstrate that adipocyte precursor cells ...

journal_title：Diabetes

authors： Macotela Y,Emanuelli B,Mori MA,Gesta S,Schulz TJ,Tseng YH,Kahn CR

更新日期：2012-07-01 00:00:00

abstract：:The aim of the present study was to evaluate and cor-relate islet to brown and white adipose tissue (WAT) blood perfusion in one obese rat and one nonobese rat with type 2 diabetes (obese Zucker [OZ] and GK rats, respectively). We measured blood perfusion with a microsphere technique in anesthetized animals and subseq...

journal_title：Diabetes

authors： Kampf C,Bodin B,Källskog O,Carlsson C,Jansson L

更新日期：2005-09-01 00:00:00

abstract：:We investigated the effects of obesity surgery-induced weight loss on transcription factor 7-like 2 gene (TCF7L2) alternative splicing in adipose tissue and liver. Furthermore, we determined the association of TCF7L2 splicing with the levels of plasma glucose and serum free fatty acids (FFAs) in three independent stud...

journal_title：Diabetes

authors： Kaminska D,Kuulasmaa T,Venesmaa S,Käkelä P,Vaittinen M,Pulkkinen L,Pääkkönen M,Gylling H,Laakso M,Pihlajamäki J

更新日期：2012-11-01 00:00:00

abstract：:The responsiveness of the isolated perfused rat liver to different metabolic effects of insulin was investigated during recycling perfusion. Infusion of porcine insulin at rates of 6, 9, 16 and 33 mU/hr. resulted in stable perfusate insulin levels averaging 41, 72, 120 and 229 muU/ml., respectively. Since the portal v...

journal_title：Diabetes

authors： Mondon CE,Dolkas CB,Olefsky JM,Reaven GM

更新日期：1975-02-01 00:00:00

abstract：:Cultured skin fibroblasts from clinically normal offspring of two parents with non-insulin-dependent diabetes have demonstrated premature senescence as a decreased ability of cells to establish colonies when inoculated at low density (plating efficiency). The present study tested the hypothesis that there is an inhere...

journal_title：Diabetes

authors： Rosenbloom AL,Rosenbloom EK

更新日期：1978-03-01 00:00:00

abstract：:We have shown previously that palmitate treatment of C2C12 skeletal muscle myotubes causes inhibition of the protein kinase B (PKB) pathway and hence reduces insulin-stimulated glycogen synthesis through the elevation of intracellular ceramide levels. Ceramide is known to activate both atypical protein kinase C (aPKC)...

journal_title：Diabetes

authors： Cazzolli R,Carpenter L,Biden TJ,Schmitz-Peiffer C

更新日期：2001-10-01 00:00:00

abstract：:This study assessed the site of increased glucose uptake resulting from insulin inhalation, quantified its effect under steady-state glucose concentrations, and identified the time to onset of effect. Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA origin)] Inhalation Powder; ...

journal_title：Diabetes

authors： Edgerton DS,Cherrington AD,Williams P,Neal DW,Scott M,Bowen L,Wilson W,Hobbs CH,Leach C,Kuo MC,Strack TR

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Many of the effects of angiotensin (Ang) II are mediated through specific plasma membrane receptors. However, Ang II also elicits biological effects from the interior of the cell (intracrine), some of which are not inhibited by Ang receptor blockers (ARBs). Recent in vitro studies have identified high glucose...

journal_title：Diabetes

authors： Singh VP,Le B,Khode R,Baker KM,Kumar R

更新日期：2008-12-01 00:00:00

abstract：:We performed a variance components linkage analysis of renal function, measured as glomerular filtration rate (GFR), in 63 extended families with multiple members with type 2 diabetes. GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives. Results for cy...

journal_title：Diabetes

authors： Placha G,Poznik GD,Dunn J,Smiles A,Krolewski B,Glew T,Puppala S,Schneider J,Rogus JJ,Rich SS,Duggirala R,Warram JH,Krolewski AS

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:The gene encoding the alpha2 Heremans-Schmid glycoprotein (AHSG) is a credible biological and positional candidate gene for type 2 diabetes and the metabolic syndrome, and previous attempts to relate AHSG variation with type 2 diabetes and obesity in Swedish and French Caucasians have been largely successful....

journal_title：Diabetes

authors： Andersen G,Burgdorf KS,Sparsø T,Borch-Johnsen K,Jørgensen T,Hansen T,Pedersen O

更新日期：2008-05-01 00:00:00

abstract：:Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating th...

journal_title：Diabetes

authors： Henquin JC,Ishiyama N,Nenquin M,Ravier MA,Jonas JC

更新日期：2002-02-01 00:00:00

abstract：:The rapid conversion of glucose to sorbitol by aldose reductase and the consequent hyperosmolarity of the cytoplasm has been shown to be the primary cause of the so-called "sugar" or "osmotic" cataract in many animal lenses. It is not as clear, however, that hyperosmolarity is the principal factor in the etiology of c...

journal_title：Diabetes

authors： Barnett PA,González RG,Chylack LT Jr,Cheng HM

更新日期：1986-04-01 00:00:00

abstract：:Insulin lispro is a human insulin analog that dissociates more rapidly than human regular insulin after subcutaneous injection, resulting in higher insulin levels at an earlier point in time and a shorter duration of action. The aim of the study was to evaluate if this pharmacokinetic difference would translate into b...

journal_title：Diabetes

authors： Zinman B,Tildesley H,Chiasson JL,Tsui E,Strack T

更新日期：1997-03-01 00:00:00

abstract：:The changes of the microvasculature of rat pancreas transplants during acute rejection were investigated and quantitatively analyzed. The vessels in pancreas transplants increased in caliber and decreased in density during acute rejection. These changes were marked in the exocrine pancreas, especially in central zones...

journal_title：Diabetes

authors： Nakai I,Aikawa I,Oka T

更新日期：1989-01-01 00:00:00

abstract：:Two similar intravenous infucion techniques have been utilized to investigate insulin sensitivity in young subjects with recent-onset ketosis-prone diabetes mellitus. All subjects presented initially with mild to moderately severe ketoacidosis and had been treated with daily insulin therapy for two to eight weeks at t...

journal_title：Diabetes

authors： Ginsberg HN

更新日期：1977-04-01 00:00:00

abstract：:The nutrient-sensitive kinase mammalian target of rapamycin (mTOR) and its downstream target S6 kinase (S6K) are involved in amino acid-induced insulin resistance. Whether the mTOR/S6K pathway directly modulates glucose metabolism in humans is unknown. We studied 11 healthy men (29 years old, BMI 23 kg/m(2)) twice in ...

journal_title：Diabetes

authors： Krebs M,Brunmair B,Brehm A,Artwohl M,Szendroedi J,Nowotny P,Roth E,Fürnsinn C,Promintzer M,Anderwald C,Bischof M,Roden M

更新日期：2007-06-01 00:00:00

abstract：:The effect of muscular exertion of moderate intensity on blood sugar (BS), plasma levels of growth hormone (GH), glucagon, and cortisol (F) has been studied in endocrinologically normal children with short stature and compared with children with clinical diabetes mellitus and obese children with normal and diminished ...

journal_title：Diabetes

authors： Garlaschi C,di Natale B,del Guercio MJ,Caccamo A,Gargantini L,Chiumello G

更新日期：1975-08-01 00:00:00